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11. 发明公开

EP1105834A1 METHOD AND SYSTEM FOR THE COMPUTERIZED ANALYSIS OF BONE MASS AND STRUCTURE 审中-公开
标题翻译：方法和系统骨量和结构的计算机分析
公开(公告)号：EP1105834A1
公开(公告)日：2001-06-13
申请号：EP99968265.1
申请日：1999-08-27
申请人： Arch Development Corporation
发明人： JIANG, Chunsheng , CHINANDER, Michael, R. , GIGER, Maryellen, L.
IPC分类号： G06K9/00 , G06K9/62 , G01N15/02 , G01N23/06
CPC分类号： G06T7/0012
摘要： An automated method (Figure 1(a)), storage medium, and system (1000) for analyzing bone. Digitized image data corresponding to an image of the bone are obtained. Next, there is determined, based on the digital images, a measure of bone mineral density (BMD) and at least one of a measure of bone geometry, a Minkowski Dimension, and a trabecular orientation. The strength of the bone is estimated based upon the measure of BMD and at least one of the measure of bone geometry, the Minkowski Dimension, and the trabecular orientation. To improve bone texture analysis, the present invention also provides a novel automated method, storage medium, and system in which digital image data corresponding to an image of the bone is obtained, and a region of interest (ROI) is selected within the bone (Figure 11(b)). A fractal characteristic of the image data within the ROI using an artificial neural network is extracted. The strength of the bone is estimated based at least in part on the extracted fractal characteristic. To perform bone analysis with an improved measure of bone mineral density, the present invention also provides a novel automated method, storage medium, and system in which digital image data corresponding to an image of the bone is obtained. A measure of normalized bone density (BMD) corresponding to a volumetric bone mineral density of the bone is determined, and the strength of the bone is estimated based at least in part on the normalized BMD (Figure 10(b)).

12. 发明公开

EP1055239A1 ULTRASENSITIVE SURVEILLANCE OF SENSORS AND PROCESSES 有权
标题翻译：超灵敏监测传感器和进程
公开(公告)号：EP1055239A1
公开(公告)日：2000-11-29
申请号：EP99903131.3
申请日：1999-01-14
申请人： ARCH DEVELOPMENT CORPORATION
发明人： WEGERICH, Stephan, W. , JARMAN, Kristin, K. , GROSS, Kenneth, C.
IPC分类号： G21C7/00
CPC分类号： G21D3/001 , G21C17/00 , Y02E30/40
摘要： A method and apparatus for monitoring a source of data for determining an operating state of a working system. The method includes determining a sensor (or source of data) arrangement associated with monitoring the source of data for a system, activating a method for performing a sequential probability ratio test if the data source includes a single data (sensor) source, activating a second method for performing a regression sequential possibility ratio testing procedure if the arrangement includes a pair of sensors (data sources) with signals which are linearly of non-linearly related; activating a third method for performing a bounded angle ratio test procedure if the sensor arrangement includes multiple sensors and utilizing at least one of the first, second and third methods to accumulate sensor signals and determining the operating state of the system.

13. 发明公开

EP0998721A1 METHOD FOR DETECTING INTERVAL CHANGES IN RADIOGRAPHS 失效
标题翻译：用于确定期改变在X线片
公开(公告)号：EP0998721A1
公开(公告)日：2000-05-10
申请号：EP98936980.6
申请日：1998-07-24
申请人： Arch Development Corporation
发明人： DOI, Kunio , ISHIDA, Takayuki , KATSURAGAWA, Shigehiko
IPC分类号： G06K9/60
CPC分类号： G06T7/0016 , G06T3/0081 , G06T5/50 , G06T7/254 , G06T7/337 , G06T2207/10116 , G06T2207/30061
摘要： A method and computerized automated initial image matching algorithm technique for enhancing detection of interval changes between temporally subsequent radiographic images via image subtraction. The method includes the steps of digitizing images (100), normalizing density and contrast in the digital images (102), correcting for lateral inclination in the digital images (104), detecting edges of a same feature in each image (106), converting the images into low resolution matrices (108), blurring the low resolution images (110), segmenting portions of the blurred low resolution matrices based on the detected edges (112), matching the digital images based on a cross-correlation match between the segmented portions, performing non-linear warping to further match Regions of Interest (ROI), and performing image subtraction between the matched digital images (120). The low resolution matrices are greater than 64x64 in size and are produced by averaging. Blurring of the low resolution matrices is performed via a Gaussian filter that removes fine structure in each image such as small vessels, bronchia, etc. The method may be performed by a computer system according to instructions stored on a computer readable medium.

14. 发明授权

EP0621874B1 SOMATOSTATIN RECEPTORS 失效
标题翻译： SOMATOSTATINREZEPTOREN
公开(公告)号：EP0621874B1
公开(公告)日：2000-04-05
申请号：EP93902841.1
申请日：1992-12-30
申请人： ARCH DEVELOPMENT CORPORATION
发明人： BELL, Graeme, I. , YAMADA, Yuichiro , SEINO, Susumu
IPC分类号： C12N15/12 , C07K14/72 , C07K16/28 , C12N15/63 , C12Q1/00
CPC分类号： C07K14/723
摘要： The invention relates generally to compositions of and methods for obtaining somatostatin receptors. The invention relates as well to the DNA sequences encoding somatostatin receptors, the recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant somatostatin receptor polypeptides. By way of example, the invention discloses th cloning and functional expression of at least three different somatostatin receptors, SSTR1, SSTR2 and SSTR3 from two different mammalian sources. The invention includes as well, methods for using the isolated, recombinant receptor polypeptides in assays designed to select and improve substances capable of interacting with somatostatin receptor polypeptides for use in diagnostic, drug design and therapeutic applications.

15. 发明公开

EP0986648A1 PLANT ARTIFICIAL CHROMOSOME (PLAC) COMPOSITIONS AND METHODS 失效
标题翻译：组合物，并根据植物人工染色体的方法（PLAC）
公开(公告)号：EP0986648A1
公开(公告)日：2000-03-22
申请号：EP98923903.3
申请日：1998-06-03
申请人： Arch Development Corporation
发明人： COPENHAVER, Gregory , PREUSS, Daphne
IPC分类号： C12N15/82 , C12N1/21 , C12N5/10 , A01H5/00
CPC分类号： C07K14/415 , C12N15/82 , C12N15/8242 , C12N15/8257 , C12N15/8258 , C12N15/8261 , Y02A40/146
摘要： The present invention provides for the identification and cloning of functional plant centromeres in Arabidopsis. This will permit construction of stably inherited plant artificial chromosomes (PLACs) which can serve as vectors for the construction of transgenic plant and animal cells. In addition, information on the structure and function of these regions will prove valuable in isolating additional centromeric and centromere related genetic elements and polypeptides from other species.

16. 发明授权

EP0563278B1 CONTROL OF GENE EXPRESSION BY IONIZING RADIATION 失效
标题翻译：基因表达的电离辐射控制
公开(公告)号：EP0563278B1
公开(公告)日：2000-03-08
申请号：EP92903431.2
申请日：1991-12-19
申请人： ARCH DEVELOPMENT CORPORATION, The University of Chicago , DANA FARBER CANCER INSTITUTE
发明人： WEICHSELBAUM, Ralph, R. , HALLAHAN, Dennis, E. , SUKHATME, Vikas, P. , KUFE, Donald, W.
IPC分类号： C12N15/67 , C12N15/62 , C12N15/85 , A61K41/00
CPC分类号： A61K41/0023 , C07K14/52 , C07K14/525 , C12N15/63 , C12N15/67 , C12N15/85

17. 发明公开

EP0971710A1 USE OF CHELERYTHRINE AND RADIATION FOR TUMOR THERAPY 失效
标题翻译：白屈菜红和放疗在肿瘤治疗中的应用
公开(公告)号：EP0971710A1
公开(公告)日：2000-01-19
申请号：EP98914302.9
申请日：1998-03-25
申请人： ARCH DEVELOPMENT CORPORATION , DANA FARBER CANCER INSTITUTE
发明人： WEICHSELBAUM, Ralph, R. , QUINTANS, Jose , CHMURA, Steven, J. , KUFE, Donald, W.
IPC分类号： A61K31/435
CPC分类号： A61K31/4741 , A61K41/00
摘要： Combination of low doses of irradiation and chelerythrine results in increased apoptosis in tumor cells. The doses of either irradiation or chelerythrine alone are such that increased apoptosis or decreased tumor growth or proliferation would not be expected.

18. 发明公开

EP0941245A1 PROMOTER FOR SMOOTH MUSCLE CELL EXPRESSION 失效
标题翻译：表达的平滑肌启动子
公开(公告)号：EP0941245A1
公开(公告)日：1999-09-15
申请号：EP97942457.0
申请日：1997-08-29
申请人： Arch Development Corporation
发明人： PARMACEK, Michael, S. , SOLWAY, Julian
IPC分类号： C12N15 , A61F2 , A61K31 , A61K35 , A61K38 , A61K48 , A61P9 , A61P11 , A61P43 , C07K14 , C12N5
CPC分类号： C07K14/4716 , A01K2217/05 , A61K48/00 , C12N2799/022
摘要： Disclosed is a smooth muscle cell specific promoter, the SM22α gene promoter as well as the murine cDNA and genomic SM22α nucleic acid sequences. Also disclosed are methods of preventing restenosis following balloon angioplasty and methods of treating asthma based on inhibition of smooth muscle cell proliferation by expressing cell cycle control genes, or contraction inhibiting peptides in smooth muscle cells, under the control of the SM22α promoter.

19. 发明公开

EP0862445A1 METHODS AND COMPOSITIONS FOR VIRAL ENHANCEMENT OF CELL KILLING 失效
标题翻译：单纯疱疹病毒联合化疗治疗癌症
公开(公告)号：EP0862445A1
公开(公告)日：1998-09-09
申请号：EP96934086.0
申请日：1996-10-07
申请人： ARCH DEVELOPMENT CORPORATION , DANA-FARBER CANCER INSTITUTE
发明人： HALLAHAN, Dennis, E. , WEICHSELBAUM, Ralph, R. , KUFE, Donald , SIBLEY, Gregory, S. , ROIZMAN, Bernard
IPC分类号： A61K51 , A61K31 , A61K35 , A61K45 , A61K48 , A61N5 , A61P35 , C12Q1
CPC分类号： A61K48/00 , A61K35/761 , A61K35/763 , A61K38/191 , A61K45/06 , A61N2005/1098 , C12N2710/10032 , C12N2710/10332 , A61K2300/00
摘要： The present invention is directed to novel methods of enhancing the effectiveness of DNA damaging agents by exposing cells to viruses prior to or during exposure to the damaging agent. In certain embodiments of the invention, the DNA damaging agent is ionizing radiation, the virus is an adenovirus, and the increase in cell killing is synergistic when compared to radiation alone.

20. 发明公开

EP0827401A2 METHODS AND COMPOSITIONS FOR INHIBITING ALPHA-REDUCTASE ACTIVITY 失效
标题翻译：方法和装置，用来抑制5α还原酶活性
公开(公告)号：EP0827401A2
公开(公告)日：1998-03-11
申请号：EP96916487.0
申请日：1996-05-16
申请人： ARCH DEVELOPMENT CORPORATION
发明人： LIAO, Shutsung , LIANG, Theming
IPC分类号： C07D311 , A61K8 , A61K31 , A61K36 , A61K45 , A61P3 , A61P13 , A61P15 , A61P17 , A61P35 , A61P43 , A61Q7 , A61Q19 , C07C53 , C07C57 , C07C61 , C07C69
CPC分类号： A61K8/361 , A61K8/37 , A61K8/498 , A61K8/67 , A61K31/216 , A61K31/353 , A61K31/565 , A61K45/06 , A61K2800/782 , A61Q7/00 , A61Q19/00 , A61Q19/06 , C07C53/21 , C07C57/52 , C07C57/56 , C07C61/16 , C07C61/40 , C07C69/88 , A61K31/35 , A61K31/235 , A61K31/20 , A61K31/19 , A61K2300/00
摘要： Disclosed are novel classes of antiandrogenic compounds including saturated and unsaturated fatty acids, catechin gallates, their derivatives, and synthetic analogs, and their use in treating disorders associated with androgenic activities. Also disclosed is the use of compositions not previously known for their antiandrogenic activity in treating disorders related to androgenic activities and cancers. Methods are disclosed for the treatment of breast cancer, prostate cancer, and other tumors using compositions comprising testosterone compositions in combination with 5α-reductase inhibitors such as fatty acids and catechin compositions. Compositions and methods are also disclosed for use in reducing lipid production in an animal, reducing organ and body weight, treating hair loss, benign prostatic hyperplasia, reducing sebum production, and other related disorders.

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