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171. 发明公开

EP1884059A2 SECRET SHARING TECHNIQUE WITH LOW OVERHEAD INFORMATION CONTENT 审中-公开
标题翻译：具有低开销信息的内容秘密共享技术
公开(公告)号：EP1884059A2
公开(公告)日：2008-02-06
申请号：EP06752138.5
申请日：2006-05-03
申请人： Temple University of the Commonwealth System of Higher Education
发明人： BAI, Li
IPC分类号： H04L9/00
CPC分类号： H04L9/085 , H04L2209/60
摘要： An apparatus and method for sharing a secret comprising the steps of generating a first random matrix, generating a first projection matrix from the first random matrix, and determining a first remainder matrix from the first projection matrix and the first secret matrix. The first secret matrix may be determined using the remainder matrix and a plurality of distributed vector shares.

172. 发明公开

EP1802238A2 APPARATUS AND METHOD OF ENDOSCOPIC SUTURING 审中-公开
标题翻译：内窥镜切割设备和方法
公开(公告)号：EP1802238A2
公开(公告)日：2007-07-04
申请号：EP05812927.1
申请日：2005-10-18
申请人： Temple University of the Commonwealth System of Higher Education
发明人： MILLER, Larry, S.
IPC分类号： A61B17/04
CPC分类号： A61B17/0401 , A61B17/0469 , A61B17/0487 , A61B2017/0409 , A61B2017/0417 , A61B2017/0445 , A61B2017/0458 , A61B2017/0461 , A61B2017/0464 , A61B2017/0488 , A61B2017/06052
摘要： An adjustable suture assembly is provided that may be employed in various surgical procedures to draw and/or hold tissue and/or muscle together. The suture assembly may include a suture lock or tensioner that is adjustably securable to two or more lengths of suture to provide a surgeon with an ability to maintain tissue or muscle in one secured position and subsequently readjust the suture assembly to maintain the tissue or muscle in a different secured position. The suture assembly may include two or more sutures having an anchor attached to an end of each suture for anchoring the suture to desired tissue or muscle. An endoscopic suturing device is provided to deliver and place two or more sutures in tissue or muscle during a surgical procedure. The suturing device may be configured to carry a plurlaity of sutures so that multiple sutures can be placed in tissue or muscle during a single intubation of the device. The suture assembly and suturing device may be employed with an endoscope to facilitate surgical treatment of obesity which involves narrowing and/or disabling the pyloric sphincter to reduce the rate of gastric emptying.
摘要翻译：提供可调整的缝合线组件，其可以用于各种外科手术中以将组织和/或肌肉牵引和/或保持在一起。缝合线组件可以包括可调节地固定到两段或更多段缝合线的缝合线锁或张紧器，以使外科医生能够将组织或肌肉保持在一个固定位置，并且随后重新调整缝合线组件以将组织或肌肉保持在一个不同的安全位置。缝合线组件可以包括两根或更多根缝合线，该两根或更多根缝合线具有连接到每根缝合线的端部的锚固件，用于将缝合线锚定到期望的组织或肌肉。提供内窥镜缝合装置以在手术过程中递送两根或更多根缝合线并将其放置在组织或肌肉中。缝合装置可以被构造成携带多重缝合线，使得在装置的单次插管期间可以将多根缝合线放置在组织或肌肉中。缝合线组件和缝合装置可以与内窥镜一起使用以促进对肥胖症的手术治疗，其涉及使幽门括约肌变窄和/或使其失能以降低胃排空速率。

173. 发明授权

EP1173160B1 (E)-STYRYL SULFONE ANTICANCER AGENTS 有权
标题翻译：（E） - 苯乙烯磺酸钠抗癌剂
公开(公告)号：EP1173160B1
公开(公告)日：2005-06-22
申请号：EP00921553.4
申请日：2000-03-31
申请人： Temple University of the Commonwealth System of Higher Education
发明人： REDDY, E., Premkumar , REDDY, M., V., Ramana
IPC分类号： A61K31/10 , C07C317/10 , C07C321/20 , C07C317/44
CPC分类号： C07C317/18 , C07C317/10 , C07C317/44
摘要： (E)-styryl benzylsulfones of formula (I) are useful as anticancer agents wherein R1, R2, R3, and R4 are independently selected from the group consisting of hydrogen, fluoro, chloro, iodo, bromo, C1-C6 alkyl, C1-C4 alkoxy, nitro, cyano and trifluoromethyl, with the proviso that (a) R1, R2, and R3 not all hydrogen when R4 is 2-chloro or 4-chloro; (b) when R1 and R3 are hydrogen and R2 is 4-bromo or 4-chloro, then R4 may not be 4-chloro, 4-fluoro or 4-bromo; (c) when R1 and R3 are hydrogen and R2 is 4-fluoro, then R4 may not be 4-fluoro or 4-bromo; (d) when R1 is hydrogen, and R4 is 2-fluoro, the R2 and R3 may not be 4-fluoro; and (e) when R1 is hydrogen and R3 is 4-hydrogen, 4-chloro, 4-bromo, 4-methyl or 4-methoxy, and R4 is 2-hydrogen, 2-chloro, or 2-fluoro; then R2 may not be 4-hydrogen, 4-chloro, 4-fluoro, or 4-bromo.
摘要翻译：（E） - 苯乙烯基苄基砜可用作抗癌剂，其中R 1，R 2，R 3和R 4独立地选自氢，氟，氯，碘，溴，C 1 -C 6烷基，C 1 -C 6烷基， C4烷氧基，硝基，氰基和三氟甲基，条件是（a）当R4是2-氯或4-氯时，R1，R2和R3不全是氢; （b）当R 1和R 3是氢并且R 2是4-溴或4-氯时，则R 4可以不是4-氯，4-氟或4-溴; （c）当R 1和R 3是氢并且R 2是4-氟时，则R 4可以不是4-氟或4-溴; （d）当R 1为氢且R 4为2-氟时，R 2和R 3可以不是4-氟; 和（e）当R 1为氢且R 3为4-氢，4-氯，4-溴，4-甲基或4-甲氧基，且R 4为2-氢，2-氯或2-氟时; 那么R2可能不是4-氢，4-氯，4-氟或4-溴。

174. 发明授权

EP0934429B1 CHRONIC FATIGUE SYNDROME DIAGNOSIS 失效
标题翻译：诊断慢性疲劳综合症
公开(公告)号：EP0934429B1
公开(公告)日：2004-05-19
申请号：EP97945254.7
申请日：1997-09-19
申请人： Temple University of the Commonwealth System of Higher Education
发明人： SUHADOLNIK, Robert, J.
IPC分类号： C12Q1/34 , C12Q1/68 , G01N33/53 , G01N33/68 , G01N33/569
CPC分类号： C12Q1/34 , G01N33/573 , G01N2333/922
摘要： Chronic fatigue syndrome is diagnosed through detection of an about 30 kDa RNase L molecule under native conditions in cellular extracts of RNase L-containing cells such as peripheral blood mononuclear cells. Proteins are fractionated according to molecular weight under nondenaturing conditions. The fractionated proteins are assayed for the presence of the about 30 kDa protein having 2-5A-dependent RNase L enzyme activity. The severity of the affliction may be determined by testing for the presence of RNase L molecules having approximate molecular weights of 30 and 80 kDa. The presence of the about 30 kDa RNase L, and the absence of the about 80 kDa RNase L molecule, correlates with severe chronic fatigue syndrome. The presence of both RNase L molecules indicates a less severe chronic fatigue syndrome affliction. Under denaturing conditions, and in the presence of protease inhibitors, chronic fatigue syndeome may be diagnosed through the detection of an about 37 kDa 2-5A binding protein.

175. 发明授权

EP0810820B1 PRODUCTION OF COMPOSITIONS CONTAINING AGGREGATION PHEROMONES 失效
标题翻译：聚集的生产费洛蒙组合物
公开(公告)号：EP0810820B1
公开(公告)日：2003-04-09
申请号：EP96904229.0
申请日：1996-01-19
申请人： TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
发明人： GEHRET, Michael, J. , CHANG, Frank, N.
IPC分类号： A01M1/20 , A01N25/10 , A01N61/00
CPC分类号： A01N63/02 , A01M1/2011 , A01M2200/011 , A01N25/006
摘要： An insecticidal product comprises a solid substrate with sterile cockroach aggregation pheromones, a sterile insecticidal composition comprises a solvent extract of the product, and an insect attractant product comprises a solid substrate having the composition partially or fully coated thereon. The product and composition of the invention may be utilized in the manufacture of insect traps (1) provided with a hollow receptacle and an opening, and optionally, a cover. An insect trap (1) comprises a hollow receptacle (7) with a slippery internal surface to prevent the exit of the insects, and an opening (8), and optionally a cover (6). The present products are particularly suitable for trapping insects, such as cockroaches.

176. 发明授权

EP0821582B1 CONTROLLED RELEASE TABLET 失效
标题翻译：与控释片
公开(公告)号：EP0821582B1
公开(公告)日：2002-12-04
申请号：EP96908487.0
申请日：1996-02-28
申请人： Temple University of the Commonwealth System of Higher Education
发明人： KIM, Cherng-Ju
IPC分类号： A61K9/22
CPC分类号： A61K9/2072 , A61K9/2031 , A61K9/2054

177. 发明授权

EP0630249B1 DUAL ACTION 2',5'-OLIGOADENYLATE ANTIVIRAL DERIVATIVES AND USES THEREOF 失效
标题翻译： DUAL ACTION 2'，5'-OLIGOADYYLATE ANTIVIRAL DERIVATIVES AND USES THEREOF
公开(公告)号：EP0630249B1
公开(公告)日：2002-09-18
申请号：EP93906054.7
申请日：1993-02-18
申请人： Temple University of the Commonwealth System of Higher Education
发明人： SUHADOLNIK, Robert J. , PFLEIDERER, Wolfgang
IPC分类号： A61K31/70 , A61K31/74 , C07H21/00
CPC分类号： A61K31/70 , A61K47/549 , A61K47/551 , A61K47/554 , A61K47/557 , C07H21/00 , C07J43/003 , C07J51/00
摘要： Viral infection is inhibited in mammals by administration of metabolically stable, non-toxic 2',5'-oligoadenylate (2-5A) derivatives that have a dual therapeutic effect. The compounds activate the intracellular latent 2-5A dependent endoribonuclease RNase L and also inhibit the action of viral DNA polymerases. Conjugates of the 2-5A derivatives for therapeutic delivery are also described.
摘要翻译：通过施用具有双重治疗效果的代谢稳定的，无毒的2'，5'-寡聚腺苷酸（2-5A）衍生物，病毒感染在哺乳动物中受到抑制。这些化合物激活细胞内潜伏的2-5A依赖性内切核糖核酸酶RNase L，并且还抑制病毒DNA聚合酶的作用。还描述了用于治疗递送的2-5A衍生物的缀合物。

178. 发明授权

EP0716856B1 Therapeutic uses of 2',5'-oligoadenylate derivatives 失效
标题翻译： 2”的治疗用途，5'-寡聚腺苷酸衍生物
公开(公告)号：EP0716856B1
公开(公告)日：2001-08-29
申请号：EP96101815.7
申请日：1989-05-24
申请人： Temple University of the Commonwealth System of Higher Education
发明人： Suhadolnik, Robert J. , Pfleiderer, Wolfgang
IPC分类号： A61K31/047 , C07H21/00
CPC分类号： A61K31/70 , A61K31/7088 , A61K31/7115 , A61K31/712 , A61K31/7125 , A61K47/554 , C07H21/00 , C07H23/00

179. 发明公开

EP0873752A2 Aqueous solvent based encapsulation of a bovine herpes virus type-1 subunit vaccine 失效
标题翻译： Verkapslung einer Untereinheit des Bovinen疱疹病毒Typ-1在wässrigenLösungsmittelnals Impfstoff。
公开(公告)号：EP0873752A2
公开(公告)日：1998-10-28
申请号：EP98302863.0
申请日：1998-04-14
申请人： PFIZER INC. , Temple University of the Commonwealth System of Higher Education , THE CHILDREN'S HOSPITAL OF PHILADELPHIA
发明人： Campos, Manuel , Frenchick, Patrick , Clark, Frederick , Offit, Paul , Moser, Charlotte , Speaker, Tully
IPC分类号： A61K9/50 , A61K39/12 , A61K39/295
CPC分类号： A61K39/245 , A61K9/5036 , A61K9/5047 , A61K39/12 , A61K2039/55555 , C12N2710/16734 , Y10S424/813
摘要： A microencapsulated subunit component from bovine herpes virus-1 (BHV-1) is disclosed. Vaccines, kits, and methods for using the same to vaccinate a member of a bovine species are also disclosed.
摘要翻译：公开了一种来自牛疱疹病毒-1（BHV-1）的微胶囊化亚单位成分。还公开了疫苗，试剂盒和使用该疫苗接种牛类成员的方法。

180. 发明公开

EP0810820A1 COMPOSITIONS CONTAINING AGGREGATION PHEROMONES, THEIR PRODUCTION AND USES 失效
标题翻译：聚集信息素成分，其生产和使用
公开(公告)号：EP0810820A1
公开(公告)日：1997-12-10
申请号：EP96904229.0
申请日：1996-01-19
申请人： TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
发明人： GEHRET, Michael, J. , CHANG, Frank, N.
IPC分类号： A01M1 , A01N25 , A01N63
CPC分类号： A01N63/02 , A01M1/2011 , A01M2200/011 , A01N25/006
摘要： An insecticidal product comprises a solid substrate with sterile cockroach aggregation pheromones, a sterile insecticidal composition comprises a solvent extract of the product, and an insect attractant product comprises a solid substrate having the composition partially or fully coated thereon. The product and composition of the invention may be utilized in the manufacture of insect traps (1) provided with a hollow receptacle and an opening, and optionally, a cover. An insect trap (1) comprises a hollow receptacle (7) with a slippery internal surface to prevent the exit of the insects, and an opening (8), and optionally a cover (6). The present products are particularly suitable for trapping insects, such as cockroaches.

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