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161. 发明公开

EP2809173A1 CHOCOLATE PRODUCTION METHOD AND APPARATUS 有权
标题翻译：方法和设备巧克力生产
公开(公告)号：EP2809173A1
公开(公告)日：2014-12-10
申请号：EP13743146.6
申请日：2013-01-31
申请人： Temple University - Of The Commonwealth System of Higher Education
发明人： TAO, Rongjia , TANG, Hong
IPC分类号： A23G1/04 , A23G1/50
CPC分类号： A23G1/0006 , A23G1/0046 , A23G1/18 , A23V2002/00
摘要： The present invention relates to a method and an apparatus for producing a chocolate product. The method includes delivering liquid chocolate having a viscosity through a pipe along a delivery path to a production station for producing the chocolate product. The liquid chocolate includes solid particles suspended within the liquid chocolate. The method changes the viscosity of the liquid chocolate by applying an electric field to the liquid chocolate in a direction along the delivery path of a strength and duration determined to aggregate the suspended solid particles into streamlined shapes extending along the direction of the delivery path.

162. 发明公开

EP2600719A1 2-SUBSTITUTED-8-ALKYL-7-OXO-7,8-DIHYDROPYRIDO[2,3-D]PYRIMIDINE-6-CARBONITRILES AND USES THEREOF 有权
标题翻译： 2-取代的8-烷基-7-氧代-7,8-二氢吡啶并[2,3-d]嘧啶-6-甲腈及其用途
公开(公告)号：EP2600719A1
公开(公告)日：2013-06-12
申请号：EP11815012.7
申请日：2011-07-21
申请人： Temple University - Of The Commonwealth System of Higher Education
发明人： REDDY, E., Premkumar , REDDY, M. V., Ramana
IPC分类号： A01N43/90 , A61K31/505 , A61K31/519
CPC分类号： C07D471/04
摘要： Compounds according to Formula (I), as well salts thereof: wherein R1 and R2 are as defined herein, are useful as antiproliferative agents and kinase inhibitors. Synthetic methods for preparing the compounds of Formula (I) are also provided.

163. 发明授权

EP1143873B1 SELECTIVE DENTIN CARIES EXCAVATOR 有权
标题翻译：选择性龋挖掘机
公开(公告)号：EP1143873B1
公开(公告)日：2012-05-02
申请号：EP99960601.5
申请日：1999-11-29
申请人： Temple University - Of The Commonwealth System of Higher Education
发明人： BOSTON, Daniel, W.
IPC分类号： A61C3/02
CPC分类号： A61C3/02
摘要： A dental bur (210) has a working surface including cutting elements (220) which deflect or abrade upon encountering material at or above the preselected hardness corresponding to the lower limit of hardness of non-carious dentin. The dental bur is constructed of metal, ceramic, or plastic.

164. 发明授权

EP1773310B1 ALPHA, BETA-UNSATURATED SULFONES, SULFOXIDES, SULFONIMIDES, SULFINIMIDES, ACYLSULFONAMIDES AND ACYLSULFINAMIDES AND THERAPEUTIC USES THEREOF 有权
标题翻译： α，β-不饱和砜SULFONOXIDE，磺酰亚胺SULFINIMIDE，酰基磺酰胺和ACYLSULFINAMIDE和治疗使用了
公开(公告)号：EP1773310B1
公开(公告)日：2011-10-19
申请号：EP05812220.1
申请日：2005-06-23
申请人： Temple University - Of The Commonwealth System of Higher Education
发明人： REDDY, Premkumar, E. , REDDY, Ramana, M. V.
IPC分类号： A61K31/18 , A61K31/4439 , C07C317/10 , C07D333/18 , C07D333/22
CPC分类号： A61K31/18 , A61K31/4439 , C07C317/18 , C07C317/24 , C07C317/28 , C07C317/46 , C07D333/18 , C07D333/22
摘要： α,β-Unsaturated sulfones, sulfoxides, sulfonimides, sulfinimides, acylsulfonamides and acylsulfinamides of Formula I: wherein R1 R2, M1 M2, L, E1, E2, Q1, Q2 and n are as defined herein, are useful as anti-angiogenesis agents, as agents for treatment of age related senile dementia, and as antiproliferative agents including, for example, as anticancer agents.

165. 发明授权

EP1487428B1 AMINO-SUBSTITUTED (E)-2,6-DIALKOXYSTYRYL 4-SUBSTITUTED BENZYLSULFONES FOR TREATING PROLIFERATIVE DISORDERS 有权转让
标题翻译：氨基 - 取代的（E）-2,6-二DIALKOXYSTYRYL 4-取代BENZYLSULFONE用于治疗增殖性疾病
公开(公告)号：EP1487428B1
公开(公告)日：2011-09-21
申请号：EP03711347.9
申请日：2003-02-28
申请人： Temple University - Of The Commonwealth System of Higher Education , Onconova Therapeutics, Inc.
发明人： REDDY, Premkumar, E. , REDDY, Ramana, M., V. , BELL, Stanley, C.
IPC分类号： A61K31/136 , C07C217/54 , C07C251/08 , C07C251/24
CPC分类号： C07D295/155 , C07C317/28 , C07D295/15
摘要： Compounds useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula (I); wherein: X, X1, X2, Ra, R1, R2, R3, R4, R5, R6, R7, g, M, y, a, b, d, e, V, W, Z and Q are as defined herein.

166. 发明授权

EP1534284B1 AMINO-SUBSTITUTED SULFONANILIDES AND DERIVATIVES THEREOF FOR TREATING PROLIFERATIVE DISORDERS 有权
标题翻译：氨基SULPHONANILIDE及其衍生物对增生性疾病的治疗
公开(公告)号：EP1534284B1
公开(公告)日：2011-07-27
申请号：EP03711348.7
申请日：2003-02-28
申请人： Temple University - Of The Commonwealth System of Higher Education , Onconova Therapeutics, Inc.
发明人： REDDY, Premkumar, E. , REDDY, Ramana, M., V. , BELL, Stanley, C.
IPC分类号： A61K31/497 , A61K31/225 , A61K31/17 , A61K31/18 , C07C311/29 , C07C303/38 , C07C303/40 , C07C57/34 , C07C69/157 , C07C275/40 , C07D241/04
CPC分类号： C07C311/27 , C07C311/44
摘要： Compounds useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula (I): wherein:Ar, X, X1, g, R and R3 are as defined herein.

167. 发明公开

EP2252314A2 LEPTIN AGONIST AND METHODS OF USE 有权
标题翻译：瘦素受体激动剂和应用过程
公开(公告)号：EP2252314A2
公开(公告)日：2010-11-24
申请号：EP09714654.2
申请日：2009-02-27
申请人： Temple University - Of The Commonwealth System of Higher Education
发明人： SURMACZ, Eva , OTVOS, Laszlo, Jr.
IPC分类号： A61K38/04 , G01N33/53 , C07K2/00
CPC分类号： C07K14/5759 , A61K38/00 , C07K7/06
摘要： Peptides are provided having leptin receptor agonist activity. The peptides are useful for treating obesity, insulin resistance, lipodystrophy and hypothalamic amenorrhea, anorexia-related infertility, among other diseases and conditions related to leptin deficiency and/or leptin resistance.

168. 发明公开

EP2176432A1 METHOD FOR DETECTING DISEASE MARKERS 有权
标题翻译：通过膜电泳的手段疾病和癌症分类的诊断
公开(公告)号：EP2176432A1
公开(公告)日：2010-04-21
申请号：EP08724520.5
申请日：2008-01-15
申请人： Temple University - Of The Commonwealth System of Higher Education
发明人： CHANG, Frank, N. , DUONG, Phu, T. , TUSZYNSKI, George, P.
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： G01N33/57415 , G01N33/5743 , G01N33/57438 , G01N33/57488 , G01N33/6893 , G01N33/6896 , G01N2500/00 , G01N2800/2807 , G01N2800/2821 , G01N2800/2835 , G01N2800/285 , G01N2800/32 , G01N2800/56 , G01N2800/60 , Y02A50/57
摘要： Disease specific markers, in particular cancer markers, can be detected by electrophoretically separating proteins and protein complexes from a biological sample on a protein binding polymeric membrane in a low conductivity, water-miscible organic solvent buffer. Electrophoretic separation profiles representing different diseases can be produced, and used in the diagnosis or prognosis of these diseases.

169. 发明授权

EP1223923B1 UNSATURATED ARYL SULFONES FOR PROTECTING NORMAL CELLS FROM CYTOTOXICITY OF CHEMOTHERAPEUTIC AGENTS 有权
标题翻译：不饱和芳基砜对于正常细胞对细胞毒性作用化疗药物的保护
公开(公告)号：EP1223923B1
公开(公告)日：2010-03-31
申请号：EP00973486.4
申请日：2000-10-11
申请人： Temple University - Of The Commonwealth System of Higher Education
发明人： COSENZA, Stephen, C. , REDDY, M., V., Ramana , REDDY, E., Premkumar
IPC分类号： A61K31/10 , A61K31/12 , A61K31/192 , A61K45/06 , C07C317/10 , A61P35/00
CPC分类号： A61K45/06 , A61K31/10 , A61K31/12 , A61K31/192 , C07C317/10 , C07C317/14 , C07C317/18 , C07C317/44 , C07C2603/24 , A61K2300/00

170. 发明授权

EP1328511B1 SUBSTITUTED (E)-STYRYL BENZYLSULFONES FOR TREATING PROLIFERATIVE DISORDERS 有权
标题翻译： SUBSTITUIERTE（E）-STYRYLBENZYLSULFONE ZUR BEHANDLUNG PROLIFERATIVER ERKRANKUNGEN
公开(公告)号：EP1328511B1
公开(公告)日：2010-03-24
申请号：EP01977567.5
申请日：2001-10-05
申请人： Temple University - Of The Commonwealth System of Higher Education
发明人： REDDY, E., Premkumar , REDDY, M., V., Ramana
IPC分类号： C07C317/00 , C07C317/02 , A61K31/10
CPC分类号： C07C317/18 , A61K31/10 , C07C317/10 , C07C317/28
摘要： (E)-Styryl benzylsulfones useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula I: wherein: R1 is selected from the group consisting of halogen, C1-C6 alkoxy, nitro, phosphonato, amino, sulfamyl, carboxy, acetoxy and dimethylamino (C2-C6 alkoxy); and R2 and R3 are independently selected from the group consisting of halogen, C1-C6 alkoxy, C1-C6 alkyl, nitro, cyano, hydroxy, phosphonato, amino, sulfamyl, carboxy, acetoxy, and dimethylamino (C2-C6 alkoxy); provided: R1 may not be halogen when R2 and R3 are both halogen; R2 may not be 2-halogen when R3 is 4-halogen; or a pharmaceutically acceptable salt thereof; or formula II: whrein: R4 is selected from the group consisting of C1-C6 alkoxy, phosphonato, amino, sulfamyl, carboxy, acetoxy and dimethylamino (C2-C6 alkoxy); R6 is selected from the group consisting of nitro, hydrogen, phosphonato, amino, sulfamyl, carboxy, acetoxy and dimethylamino (C2-C6 alkoxy); and R7 is selected from the group consisting of halogen, C1-C6 alkoxy, C1-C6 alkyl, nitro, cyano, hydroxy, phosphonato, amino, sulfamyl, carboxy, acetoxy, dimethylamino (C2-C6 alkoxy) and trifluoromethyl; provided R5 and R6 may not be hydrogen in the same compound; or a pharmaceutically acceptable salt thereof.
摘要翻译：（E）可用作抗增殖剂的酪氨酸苄基砜，包括例如抗癌剂，根据式I提供：其中：R 1选自卤素，C 1 -C 6烷氧基，硝基，膦酰基，氨基，氨基磺酰基，羧基，乙酰氧基和二甲基氨基（C 2 -C 6烷氧基）; R 2和R 3独立地选自卤素，C 1 -C 6烷氧基，C 1 -C 6烷基，硝基，氰基，羟基，膦酸根，氨基，氨基磺酰基，羧基，乙酰氧基和二甲基氨基（C 2 -C 6烷氧基）; 条件是：当R 2和R 3都是卤素时，R 1可以不是卤素; 当R 3为4-卤素时，R 2可以不为2-卤素; 或其药学上可接受的盐; 或式II化合物：其中：R 4选自C 1 -C 6烷氧基，膦酰基，氨基，氨基磺酰基，羧基，乙酰氧基和二甲基氨基（C 2 -C 6烷氧基）; R 6选自硝基，氢，膦酰基，氨基，氨基磺酰基，羧基，乙酰氧基和二甲基氨基（C 2 -C 6烷氧基）; 和R 7选自卤素，C 1 -C 6烷氧基，C 1 -C 6烷基，硝基，氰基，羟基，膦酰基，氨基，氨基磺酰基，羧基，乙酰氧基，二甲基氨基（C 2 -C 6 烷氧基）和三氟甲基; 提供的R 5和R 6可以不是同一化合物中的氢; 或其药学上可接受的盐。

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