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131. 发明授权

EP1261623B1 NEW RETINOL DERIVATIVES, THE METHOD OF PREPARATIONS AND THE USES THEREOF 有权
标题翻译：视黄醇衍生物，它们的表示和使用的方法
公开(公告)号：EP1261623B1
公开(公告)日：2009-11-04
申请号：EP02729592.2
申请日：2002-01-10
申请人： Chebigen Inc.
发明人： SIN, Hong-Sig , PARK, Si-Ho , RHO, Young-Soy , UM, Soo-Jong , KWON, Youn-Ja , PARK, Myoung-Soon , HAN, Hye-Sook , JUNG, Min-Sook , KIM CHO, So-Mi , KIM, Dong-Myong , OH, Deok-Kun , PARK, Jong-Sup
IPC分类号： C07K5/00 , C07K5/06
CPC分类号： C07K5/06113 , C07K5/0613

132. 发明授权

EP0974272B1 SWEETENER COMPOSITION IMPROVED IN TASTE 无效
标题翻译：具有改进的风味甜味剂组成物
公开(公告)号：EP0974272B1
公开(公告)日：2007-08-01
申请号：EP97942214.4
申请日：1997-10-01
申请人： Ajinomoto Co., Inc.
发明人： ISHII, Shoichi, Food R&D Lab. Ajinomoto Co. Inc. , SHIMIZU, Tetsuji, Food R&D Lab. Ajinomoto Co. Inc.
IPC分类号： A23L1/236 , A23L1/22 , C07K5/06
CPC分类号： A23L2/60 , A23L27/32 , C07K5/0613
摘要： A sweetener composition which comprises N-[N-(3,3-dimethylbutyl)-L- alpha -aspartyl]-L-phenylalanine 1-methyl ester and either or b oth of aspartame and acesulfam K at a specific ratio and which exhibits high sweetness and well-balanced sweet characteristics approximate to those of sucrose.

133. 发明公开

EP1380570A4 PROCESS FOR PRODUCING N-FORMYLAMINO ACID AND UTILIZATION THEREOF 审中-公开
标题翻译：工艺生产N-FORMYLAMINOSÄURE及其用途
公开(公告)号：EP1380570A4
公开(公告)日：2006-09-27
申请号：EP02717163
申请日：2002-04-16
申请人： AJINOMOTO KK
发明人： KAWAHARA SHIGERU , TAKEMOTO TADASHI , FUJITA SHINJI , OHNO AYAKO
IPC分类号： C07C231/02 , C07C231/08 , C07C233/47 , C07K5/072 , C07K5/075 , C12P13/02 , C12P13/20 , C12P21/02 , C07K1/06 , C07K1/30
CPC分类号： C07K5/0613 , C07C231/02 , C07C231/08 , C12P13/02 , C12P13/20 , C12P21/02 , C07C233/47
摘要： A process for efficiently and industrially advantageously producing an N-formylamino acid by reacting an amino acid or its salt with formamide and/or methyl formate in the presence of a base. A process for efficiently and industrially advantageously producing N-formyl-α-aspartylphenylalanine methyl ester, which is a precursor of aspartame, by an enzymatic fusion reaction of N-formylaspartic acid with phenylalanine methyl ester wherein the concentration of N-formylaspartic acid is specified or the reaction is carried out in the presence of a trialkyl phosphate. A process for efficiently and industrially advantageously producing N-formyl-α-aspartylphenylalanine methyl ester having a high purity by adjusting the pH value of a phenylalanine methyl ester adduct of N-formyl-α-aspartylphenylalanine methyl ester.

134. 发明公开

EP1509300A1 PRODUCTION OF CRYSTALLINE MATERIALS BY USING HIGH INTENSITY ULTRASOUND 有权
标题翻译：晶体材料具有高功率超声生产
公开(公告)号：EP1509300A1
公开(公告)日：2005-03-02
申请号：EP03722816.0
申请日：2003-05-08
申请人： Accentus plc
发明人： McCausland, Linda Jane
IPC分类号： B01D9/00
CPC分类号： C07K5/0613 , B01D9/0013 , B01D9/0036 , B01D9/0063
摘要： A crystalline material sufficiently pure for use in pharmaceuticals may be made by forming a saturated solution of the material, changing the temperature of the solution so it becomes supersaturated, and briefly subjecting the solution to irradiation by high intensity ultrasound, before allowing the solution to cool gradually without further irradiation. The ultrasound may be applied using a vessel with an array of ultrasonic transducers attached to a wall, so each transducer radiates no more than 3 W/cm yet the power dissipation within the vessel is between 25 and 150 W/litre. This method can reduce the metastable zone width to less than 10 K. There is no erosion of the wall and consequently no formation of small particles of metal. It is applicable for example to aspartame, and to amino acids.

135. 发明公开

EP1449917A1 PROCESS FOR PRODUCING L−AMINO ACID USING ESCHERICHIA 有权
标题翻译：用ESCHERICHIA生产L-氨基酸的方法
公开(公告)号：EP1449917A1
公开(公告)日：2004-08-25
申请号：EP02788635.7
申请日：2002-11-21
申请人： Ajinomoto Co., Inc.
发明人： LIVSHITS, Vitaliy Arkadyevich , VITUSHKINA, Maria Viacheslavovna , GUSYATINER, Mikhail Markovich , ZIYATDINOV, Mikhail Kharisovich , AKHVERDIAN, Valery Zavenovich , SAVRASOVA, Ekaterina Alekseevna , DOROSHENKO, Vera Georgievna , MASHKO, Sergey Vladimirovich
IPC分类号： C12N15/09 , C12N1/21 , C07K14/245 , C12P13/04
CPC分类号： C07K14/245 , C07K5/0613 , C12P13/04 , C12P13/08 , C12P13/222
摘要： A method for producing an L-amino acid, such as L-phenylalanine, L-threonine is provided using bacterium belonging to the genus Escherichia wherein the L-amino acid productivity of said bacterium is enhanced by enhancing an activity of protein encoded by the yedA gene.
摘要翻译：使用属于埃希氏菌属的细菌提供了生产L-氨基酸如L-苯丙氨酸，L-苏氨酸的方法，其中通过增强由yedA编码的蛋白质的活性来增强所述细菌的L-氨基酸生产力基因。

136. 发明公开

EP1392841A2 ENZYMATIC COUPLING OF L-PHENYLALANINE METHYL ESTER AND N-BENZYLOXYCARBONYL-L-ASPARTIC ACID IN A CONTINUOUS OR FED-BATCH PROCESS 审中-公开
标题翻译： L-PHENYLALANINEMETHYLESTER和N-苯甲氧ASPARAGENSÄURE在连续或分批补料工艺酶促离合器
公开(公告)号：EP1392841A2
公开(公告)日：2004-03-03
申请号：EP02741519.9
申请日：2002-06-04
申请人： Holland Sweetener Company V.o.F.
发明人： TOKUDA, Akira , YAMAMOTO, Norihiro , NAKAMURA, Shiichiro , QUAEDFLIEG, Peter, Jan, Leonard, Mario
IPC分类号： C12P21/02 , C07K5/075
CPC分类号： C07K5/0613 , C12P21/02
摘要： The invention relates to a process for the preparation of N-benzyloxycarbonyl-α-L-aspartyl-L-phenylalanine methyl ester (Z-APM) by high-conversion enzymatic coupling of N-benzyloxycarbonyl-L-aspartic acid (Z-Asp) and L-phenylalanine methyl ester (L-PM) in a reaction mixture comprising an aqueous medium, a neutral protease as enzyme and an alkali metal salt, alkaline earth metal salt or ammonium salt, with formation of a precipitate. The enzymatic coupling of Z-Asp and L-PM is carried out in a continuous or fed-batch process at a pH of from 5.0 to 6.5 and an average charged molar ratio of Z-Asp and L-PM between 1:1 and 2:1 and wherein the actual molar ratio of Z-Asp and L-PM is higher than the average charge molar ratio. Preferably the alkali metal salt, alkaline earth metal salt or ammonium salt is present in an amount of from 3 to 25 %, calculated as % by weight based on the total reaction mixture.

137. 发明授权

EP0728196B1 MUTANTS OF A THERMOSTABLE NEUTRAL PROTEASE FROM BACILLUS 失效
标题翻译：突变体从THERMO-稳定的中性Protase芽孢
公开(公告)号：EP0728196B1
公开(公告)日：2003-05-02
申请号：EP95902309.4
申请日：1994-12-06
申请人： SAGAMI CHEMICAL RESEARCH CENTER , HOLLAND SWEETENER COMPANY V.O.F.
发明人： TANAKA, Yoshikazu , MIYAKE, Yoshio , HANZAWA, Satoshi , OHE, Seigou , KIDOKORO, Shunichi , MIKI, Yoichiro , ENDO, Kimiko , WADA, Akiyoshi
IPC分类号： C12N9/54 , C12P21/02 , C12P21/06
CPC分类号： C07K5/0613 , C12N9/54 , Y02P20/582
摘要： A modified protease is disclosed, which is a mutant of the thermostable neutral metallo-protease having the amino acid sequence of SEQ ID NO:1 wherein the 150th aspartic acid residue is replaced with tryptophan.

138. 发明公开

EP1261623A1 NEW RETINOL DERIVATIVES, THE METHOD OF PREPARATIONS AND THE USES THEREOF 有权
标题翻译：视黄醇衍生物，它们的表示和使用的方法
公开(公告)号：EP1261623A1
公开(公告)日：2002-12-04
申请号：EP02729592.2
申请日：2002-01-10
申请人： Chebigen Inc.
发明人： SIN, Hong-Sig , PARK, Si-Ho , RHO, Young-Soy , UM, Soo-Jong , KWON, Youn-Ja , PARK, Myoung-Soon , HAN, Hye-Sook , JUNG, Min-Sook , KIM CHO, So-Mi , KIM, Dong-Myong , OH, Deok-Kun , PARK, Jong-Sup
IPC分类号： C07K5/00
CPC分类号： C07K5/06113 , C07K5/0613
摘要： The present invention relates to novel retinol derivatives, the methods of preparation and the uses thereof. According to the present invention, retinol derivatives comprise carboester linkage between di-, tri-, polypeptide having functional group of COOH and retinol. Retinol derivatives in the present invention comprise carboester linkage between amino acid having functional group of di-COOH and retinol. Retinol derivatives comprise carboester linkage between retinol and the compounds having the function group of COOH and multiple double bonds on carbon chain. Retinol derivatives in the present invention comprise carboester linkage between retinol and the compounds having the functional group of di-COOH and one double bond. Retinol derivatives in the present invention comprise ether linkage between the compounds with OH functional group and retinol.

139. 发明公开

EP1252826A1 Non-caking aspartame fine grade 审中-公开
标题翻译： Nicht verbackendes煽动Aspartam
公开(公告)号：EP1252826A1
公开(公告)日：2002-10-30
申请号：EP01201533.5
申请日：2001-04-26
申请人： Holland Sweetener Company V.o.F.
发明人： Kuehn, Frank Thomas , Damen, Vera Henrica Johanna Thomas
IPC分类号： A23L1/236 , C07K5/06
CPC分类号： C07K5/0613 , A23L27/32
摘要： The invention relates to a method for producing an improved fine grade of α-L-aspartyl-L-phenylalanine methyl ester (aspartame; APM), having a particle size smaller than 100 µm, which has been produced by crystallisation under agitated conditions, granulation and subsequent mechanical size reduction, wherein the mechanical size reduction of the APM is carried out so as to obtain a first product of particles, smaller than 100 µm, from which in a further step the fraction of finest particles is removed to a large extent by dry classifying and APM is obtained having a d 10 value of at least 3 µm and a d 50 value in the range of from 15 to 65 µm, the d-values as determined by laser diffraction particle size measurement. In particular the invention relates to producing an improved fine grade of APM which may be handled easily and can suitably be used in powder mixes and other applications, such as chewing gum and tableting. The invention also relates to such improved novel fine grade products of APM having a d 10 value of at least 3 µm, a d 50 value in the range of from 15 to 65 µm, and a free bulk density of at least 270 kg/m 3 . The particle size distribution of such novel APM products, when represented graphically in a so-called Rosin-Rammler-Sperling-Bennett (RRSB) grid, shows a substantially steeper slope in the range between d 25 and d 90 than in the range between d 10 and d 20 .
摘要翻译：本发明涉及一种通过在搅拌条件下结晶产生的具有小于100μm的粒径的α-L-天冬氨酰基-L-苯丙氨酸甲酯（阿斯巴甜; APM）的改良精细级的方法，造粒和随后的机械尺寸减小，其中进行APM的机械尺寸减小以获得小于100μm的颗粒的第一产物，在另一步骤中，将最细颗粒的部分除去至大的颗粒通过干法分级得到的程度和获得具有至少3μm的d10值和15至65μm范围内的d50值的APM，通过激光衍射粒度测量确定的d值。特别地，本发明涉及生产改进的APM精细级别，其可以容易地处理，并且可以适当地用于粉末混合物和其它应用中，例如口香糖和压片。本发明还涉及具有d10值至少为3μm，d50值在15至65μm范围内的APM的这种改进的新型细级产品和至少270kg / m 2的自由堆积密度 <3>。当在所谓的Rosin-Rammler-Sperling-Bennett（RRSB）网格中以图形方式表示时，这种新型APM产品的粒度分布显示出在d25和d90之间的范围内比在d10和d20之间的范围内基本上更陡的斜率。

140. 发明授权

EP0654481B1 Process for producing alpha-L-aspartyl-L-phenylalanine methyl ester 失效
标题翻译：甲用于α-L-天冬氨酰-L-苯丙氨酸甲基酯的制备方法
公开(公告)号：EP0654481B1
公开(公告)日：2002-02-13
申请号：EP94118059.8
申请日：1994-11-15
申请人： Ajinomoto Co., Inc.
发明人： Hirano, Atsuhiko, Central Res. Lab. , Kataoka, Takehiko, Central Res. Lab. , Kishimoto, Shinichi, Central Res. Lab. , Yamahra, Satoshi, Tokai Plant
IPC分类号： C07K5/06 , A23L1/236 , F26B17/12
CPC分类号： C07K5/0613 , A23L27/32 , F26B21/06

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