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111. 发明公开

EP2611876A1 ADHESIVE STRUCTURE WITH STIFF PROTRUSIONS ON ADHESIVE SURFACE 审中-公开
标题翻译：段刚性SURVEYS上的键合面粘合结构
公开(公告)号：EP2611876A1
公开(公告)日：2013-07-10
申请号：EP11773331.1
申请日：2011-08-22
申请人： ETHICON ENDO-SURGERY, INC. , Agency for Science, Technology and Research
发明人： NATARAJAN, Sriram , COOPER, Kevin , ELMOUELHI, Noha , VYAKARNAM, Murty, N. , YEE, Low, Hong , RODRIGUEZ, Isabel , TIONG, Lim, Chee , YEE, Audrey, Ho Yoke
IPC分类号： C09J7/00 , A61B17/08 , A61L31/04 , A61L31/06 , A61F2/00 , B29C33/52
CPC分类号： C09J7/00 , A61B2017/00871 , A61B2017/00938 , A61B2017/00942 , A61B2017/00951 , A61L24/0042 , A61L24/046 , A61L24/06 , A61L24/106 , B29C33/424 , B29C33/52 , C09J2201/626 , C09J2423/106 , C09J2467/006 , Y10T428/24008 , C08L67/04 , C08L23/12
摘要： An adhesive structure is provided comprising a surface from which extend substantially cylindrical protrusions comprising a stiff resin having a Young's modulus of greater than 17 MPa. The protrusions are of sufficiently low diameter to promote adhesion by physical attractive forces, e.g., Van der Waals attractive forces, as measured by shear adhesion between the adhesive structure and a target surface. A method for preparing the structure is provided as well as a combination of the adhesive structure and target surface.

112. 发明授权

EP2456479B1 IMPLANTABLE MEDICAL DEVICE COMPRISING COPOLYMER OF L-LACTIDE WITH IMPROVED FRACTURE TOUGHNESS 有权
标题翻译：与阻力增加假期的L-丙交酯共聚物植入式医疗设备
公开(公告)号：EP2456479B1
公开(公告)日：2013-05-15
申请号：EP10733128.2
申请日：2010-07-14
申请人： Abbott Cardiovascular Systems Inc.
发明人： WANG, Yunbing , OBERHAUSER, James , GADA, Manish , GLAUSER, Thierry , GUERIGUIAN, Vincent , STEICHEN, Bethany , KLEINER, Lothar , MA, Xiao
IPC分类号： A61L31/06 , A61L31/14
CPC分类号： A61L31/14 , A61L31/06 , C08L67/04

113. 发明公开

EP2586469A1 Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers 有权
标题翻译： Medizinische Vorrichtungen mit ausgerichteten Filmen aus Poly-4-hydroxybutyrat und Copolymeren
公开(公告)号：EP2586469A1
公开(公告)日：2013-05-01
申请号：EP12199776.1
申请日：2007-11-16
申请人： Tepha, Inc.
发明人： Rizk, Said , Martin, David P. , Ho, Kicherl , Williams, Simon F.
IPC分类号： A61L31/06 , A61L31/10 , A61L27/18 , A61L27/34 , B29C55/04 , B29C55/12 , C08J5/22
CPC分类号： A61L27/34 , A61L27/18 , A61L31/10 , B29C55/005 , B29C55/04 , B29C55/12 , B29K2067/00 , B29K2067/046 , B29K2995/006 , C08L67/04
摘要： Continuous processing methods for making absorbable polymeric films with one or more of the following properties: high toughness, low modulus, high tensile strength, and thickness less than 10 mm, more preferably less than 1 mm, and more preferably less than 100 µm, have been developed. In the preferred embodiment, the polymer is a polyhydroxyalkanoate, and in the most preferred embodiment, the polymer comprises 4-hydroxybutyrate. A particularly preferred embodiment is a film of poly-4-hydroxybutyrate or copolymer thereof, wherein the film has a tensile strength greater than 5.5 kgf/mm 2 , tensile modulus less than 181 kgf/mm 2 , and elongation at break from 10-500%, wherein the film is derived by a continuous process such as melt extrusion or solvent casting, followed by orientation to more than 25% of the film's original length in one or more directions. These can be used for a variety of purposes including fabrication of medical devices.
摘要翻译：用于制造具有以下性质中的一种或多种的可吸收聚合物膜的连续加工方法：高韧性，低模量，高拉伸强度和小于10mm，更优选小于1mm，更优选小于100μm的厚度具有已经开发在优选的实施方案中，聚合物是聚羟基链烷酸酯，并且在最优选的实施方案中，聚合物包含4-羟基丁酸酯。特别优选的实施方案是聚-4-羟基丁酸酯或其共聚物的膜，其中所述膜的拉伸强度大于5.5kgf / mm 2，拉伸模量小于181kgf / mm 2，断裂伸长率为10-500 ％，其中通过连续方法如熔融挤出或溶剂流延获得膜，然后在一个或多个方向上定向至超过膜的原始长度的25％。这些可以用于各种目的，包括制造医疗器械。

114. 发明授权

EP2237810B1 BIODEGRADABLE POLYMERS 有权
标题翻译：生物降解聚合物
公开(公告)号：EP2237810B1
公开(公告)日：2013-05-01
申请号：EP08869926.9
申请日：2008-12-31
申请人： Boston Scientific Scimed, Inc.
发明人： BENCO, John , BODEN, Mark
IPC分类号： A61L31/06 , A61L31/14
CPC分类号： A61L31/148 , A61L31/04 , A61L31/10

115. 发明公开

EP2019645A4 DELIVERY OF OPHTHALMOLOGIC AGENTS TO THE EXTERIOR OR INTERIOR OF THE EYE 审中-公开
标题翻译：眼部外或眼内的眼部活性物质的释放
公开(公告)号：EP2019645A4
公开(公告)日：2013-03-06
申请号：EP07776644
申请日：2007-05-01
申请人： MEDIVAS LLC
发明人： LANDIS GEOFFREY C , TURNELL WILLIAM D , YUMIN YUAN
IPC分类号： A61F2/00 , A61K9/00 , A61K47/34 , A61L31/06 , A61L31/14 , A61L31/16
CPC分类号： A61K31/047 , A61F9/0008 , A61K9/0048 , A61K9/0051 , A61K9/1075 , A61K9/5031 , A61K9/5073 , A61K9/5089 , A61K47/55 , A61K47/59 , A61K47/593 , A61K47/595

116. 发明公开

EP2483332A4 CROSSLINKED HYDROGELS AND RELATED METHOD OF PREPARATION 有权
标题翻译： VERNETZTE HYDROGELE UND HERSTELLUNGSVERFAHRENDAFÜR
公开(公告)号：EP2483332A4
公开(公告)日：2013-02-27
申请号：EP10819764
申请日：2010-09-29
申请人： OTTAWA HOSPITAL RES INST , UNIV OTTAWA
发明人： GRIFFITH MAY , LI FENGFU , AHN JAE-IL
IPC分类号： C08J3/24 , A61K9/107 , A61K31/522 , A61L27/14 , A61L31/06 , A61P27/02 , A61P31/22 , C08J3/075 , C08K5/42 , C08L89/06
CPC分类号： A61K9/06 , A61K9/0051 , A61K31/522 , A61K38/39 , A61K41/0042 , A61K47/42 , A61K49/0073 , A61L27/24 , A61L27/52 , A61L2430/16 , C08H1/06 , C08J3/075 , C08J3/24 , C08J2300/16 , C08J2389/06 , C08K5/0025 , C08K5/29 , C08L89/06
摘要： The present invention provides a method of manufacturing a hydrogel comprising the step of crosslinking a biopolymer using a carbodiimide crosslinker of Formula I wherein at least one of R1 and R2 is a functional group that is a bulky organic functional group. R1 and R2 can each independently be an optionally substituted saturated or unsaturated functional group selected from the group consisting of an alkyl, a cycloalkyl, a heterocyclic, and an aryl. The bulky organic functional group will slow down the crosslinking reaction of carbodiimide due to the steric effects and/or electronic effects, in comparison to a crosslinking reaction using EDC. Also provided are the hydrogels and ophthalmic devices prepared using the method of the invention and uses thereof.
摘要翻译：本发明提供一种制备水凝胶的方法，其包括使用式I的碳二亚胺交联剂交联生物聚合物的步骤，其中R 1和R 2中的至少一个是大体积有机官能团的官能团。 R 1和R 2可各自独立地为选自烷基，环烷基，杂环和芳基的任选取代的饱和或不饱和官能团。与使用EDC的交联反应相比，体积较大的有机官能团将由于空间效应和/或电子效应而减缓碳二亚胺的交联反应。还提供了使用本发明的方法制备的水凝胶和眼科装置及其用途。

117. 发明公开

EP2552504A1 METHOD TO MAKE POLY(L-LACTIDE) STENT WITH TUNABLE DEGRADATION RATE 失效
标题翻译： METHOD FOR PRODUCTION聚（L-丙交酯）支架调速开采的
公开(公告)号：EP2552504A1
公开(公告)日：2013-02-06
申请号：EP11707253.8
申请日：2011-02-16
申请人： Abbott Cardiovascular Systems Inc.
发明人： WANG, Yunbing , MA, Xiao
IPC分类号： A61L31/04 , A61L31/14 , A61L31/06
CPC分类号： A61L31/148 , A61F2/82 , A61F2/89 , A61F2/958 , A61F2002/30062 , A61F2210/0004 , A61K9/1647 , A61K9/204 , A61L31/06 , B29C47/0066 , B29K2067/046 , B29L2031/7534 , C08G63/08 , C08G63/90 , C08J2367/04 , C08L67/04 , C09D167/04 , C09J167/04
摘要： Methods of making a biodegradable polymeric stent made from poly(L-lactide) and a low concentration of L-lactide monomer is disclosed. The concentration of L-lactide is adjusted to provide a degradation behavior that is suitable for different treatment applications including coronary, peripheral, and nasal. Methods include making a poly(L-lactide) material for a stent with uniformly distributed L-lactide monomer through control of polymerization conditions during PLLA synthesis, control of post-processing conditions, or both.

118. 发明公开

EP2552503A1 MEDICAL DEVICE 审中-公开
标题翻译：医疗装置
公开(公告)号：EP2552503A1
公开(公告)日：2013-02-06
申请号：EP11712309.1
申请日：2011-03-23
申请人： Invibio Limited
发明人： JARMAN-SMITH, Marcus , MCDONOUGH, Gordon , SERENO, Nuno , WHITEHEAD, Tony
IPC分类号： A61L31/02 , A61L31/06 , A61L31/10
CPC分类号： A61B17/72 , A61B17/88 , A61L31/022 , A61L31/06 , C08L71/00
摘要： A titanium body (2) of a femoral nail incorporates an opening (3) leading into a hollow region (4) which defines a cavity in which electronics may be incorporated. A potting compound overlays the electronics, within the region (4). A 100 to 150µm thick cover (18) made from polyetheretherketone is arranged to overlay the opening (3) and close the hollow region (4). The cover (18) is made from flat polyetheretherketone film of suitable thickness which is heat shrunk onto a former and then machined to define the desired shape.
摘要翻译：股骨钉的钛体（2）包括通向中空区域（4）的开口（3），所述中空区域限定其中可以结合有电子器件的空腔。灌封化合物覆盖区域内的电子器件（4）。将由聚醚醚酮制成的100至150μm厚的覆盖物（18）布置成覆盖开口（3）并封闭中空区域（4）。盖（18）由合适厚度的扁平聚醚醚酮薄膜制成，热缩在成型器上，然后加工成规定的形状。

119. 发明公开

EP2505213A2 System and method for formation of biodegradable ultra-porous hollow fibers and use thereof 审中-公开
标题翻译：系统和方法，用于形成超生物可利用的多孔性中空纤维和它们的使用
公开(公告)号：EP2505213A2
公开(公告)日：2012-10-03
申请号：EP12162042.1
申请日：2012-03-29
申请人： Tyco Healthcare Group LP
发明人： Gleiman, Seth , Ostapoff, Roland
IPC分类号： A61L15/26 , A61L27/18 , A61L31/06
CPC分类号： A61L15/26 , A61L27/18 , A61L31/06 , D01D5/0038 , D01D5/0061 , D01D5/247 , D01F6/625
摘要： A system and method for forming biodegradable ultra-porous hollow fibers are disclosed. The fibers are formed by electrospinning a liquid polymer composition (e.g., solution) of a high molecular weight aliphatic polyester in a controlled environment.
摘要翻译：一种用于形成可生物降解的超多孔中空纤维系统和方法游离缺失光盘。纤维通过在受控环境中静电纺丝的高分子量脂肪族聚酯的液体聚合物组合物（E. G.，溶液）而形成。

120. 发明公开

EP2498835A1 BIODEGRADABLE THERMOPLASTIC ELASTOMERS 有权
标题翻译：可生物降解的热塑性弹性体
公开(公告)号：EP2498835A1
公开(公告)日：2012-09-19
申请号：EP10830295.1
申请日：2010-11-15
申请人： Nanyang Technological University
发明人： VENKATRAMAN, Subramanian , ABADIE, Marc , WIDJAJA, Leonardus, Kresna , LIPIK, Vitali
IPC分类号： A61L31/06 , A61L17/00 , A61L27/18 , A61L29/06 , C08G63/91 , C08G64/18 , C08G83/00
CPC分类号： C08G63/06 , A61L17/06 , A61L17/12 , A61L27/18 , A61L27/58 , C08G63/81 , C08G63/912 , C08G64/18 , C08G2261/126 , C08L67/04
摘要： The present invention relates to a biodegradable thermoplastic elastomer having the general formula A-B-A wherein each A is an amorphous polymer having a glass transition temperature (Tg) >40° C or a semi-crystalline polymer having a glass transition temperature (Tg) and/or melting temperature (Tm) >40° C; B is a copolymer of -caprolactone (CL) and at least one additional monomer selected from the group consisting of L-lactic acid (LLA), trimethyl carbonate (TMC), and glycolic acid (GA), or B is different to A and is lactic-co-glycolic acid (LGA); and wherein the molar ratio of CL to the at least one additional monomer in the copolymer B is in the range between about 1:0.09 to about 1:1.

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