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    • 119. 发明公开
    • TREATMENT OF SKIN AND SOFT TISSUE INFECTION WITH NITRIC OXIDE
    • BEHANDLUNG VON INFEKTIONEN DER HAUT UND WEICHTEILE MIT STICKOXID
    • EP2897586A1
    • 2015-07-29
    • EP13771686.6
    • 2013-09-18
    • Transdermal Biotechnology, Inc.
    • PERRICONE, Nicholas, V.
    • A61K9/00A61K9/10A61K9/127A61P17/10A61P31/00
    • A61K33/00A61J1/1412A61J1/1468A61K9/0014A61K9/06A61K9/10A61K9/127A61K47/24A61K47/544
    • The present invention generally relates to compositions and methods for treatment of skin and/or other soft tissues that are infected with bacteria such as Staphylococcus aureus, and/or other infectious organisms. In some cases, the composition may include nitric oxide. The nitric oxide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other vesicles containing nitric oxide. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin, e.g., onto a site of infection, or on another suitable portion of the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.
    • 本发明一般涉及用于治疗被细菌如金黄色葡萄球菌感染的皮肤和/或其它软组织的组合物和方法,和/或其他感染性生物体。 在一些情况下,组合物可以包括一氧化氮。 一氧化氮可以存在于包含卵磷脂(例如磷脂酰胆碱)的第一相内。 在某些实施方案中,卵磷脂存在于含有一氧化氮的脂质体,胶束或其它囊泡中。 组合物可以采取可以摩擦或喷到皮肤上的凝胶,霜剂,洗液,软膏,溶液,固体“棒”等的形式,例如到感染部位,或 在皮肤的另一适合部分上。 本发明的其它方面通常涉及制备或使用这种组合物的方法,促进这些组合物的方法,包括这种组合物的试剂盒等。