专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

111. 发明公开

EP2623498A1 SODIUM SALT OF 6-FLUORO-3-HYDROXY-2-PYRAZINE CARBOXAMIDE 有权
标题翻译： NATRIUMSALZ AUS 6-氟-3-羟基-2-吡嗪羧酰胺
公开(公告)号：EP2623498A1
公开(公告)日：2013-08-07
申请号：EP11829253.1
申请日：2011-09-29
申请人： Toyama Chemical Co., Ltd.
发明人： TAKAKURA, Keiko , NAKAMATSU, Namika , TAKESHIMA, Sakiko , UEHARA, Sayuri
IPC分类号： C07D241/24 , A61K9/08 , A61K9/19 , A61K31/4965 , A61P31/12 , A61P31/16
CPC分类号： C07D241/24 , A61K9/19 , C07B2200/13
摘要： A preparation replete with crystals of a sodium salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide has superior solubility, and is useful as a preparation for injection.
摘要翻译：含有6-氟-3-羟基-2-吡嗪甲酰胺的钠盐晶体的制剂具有优异的溶解性，可用作注射剂。

112. 发明公开

EP2623497A1 MEGLUMINE SALT OF 6-FLUORO-3-HYDROXY-2-PYRAZINE CARBOXAMIDE 有权转让
标题翻译： MEGLUMINSALZ VON 6-氟-3-羟基-2-吡啶羧酸
公开(公告)号：EP2623497A1
公开(公告)日：2013-08-07
申请号：EP11829249.9
申请日：2011-09-29
申请人： Toyama Chemical Co., Ltd.
发明人： TAKAKURA, Keiko , NAKAMATSU, Namika , TAKESHIMA, Sakiko , NAKASHIMA, Takayoshi
IPC分类号： C07D241/24 , A61K9/08 , A61K9/19 , A61K31/4965 , A61P31/12 , A61P31/16
CPC分类号： C07D241/24 , A61K9/0019 , A61K9/08 , A61K9/19 , A61K31/4965 , A61K31/497 , A61K47/18 , A61K47/183 , A61K47/22 , A61K47/26 , C07C215/10
摘要： A preparation replete with a meglumine salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide has superior solubility, and is useful as a preparation for injection.
摘要翻译：富含6-氟-3-羟基-2-吡嗪甲酰胺的葡甲胺盐的制剂具有优异的溶解性，可用作注射剂。

113. 发明授权

EP2221309B1 NAPHTHYRIDINE DERIVATIVE MONOHYDRATE AND METHOD FOR PRODUCING THE SAME 有权
标题翻译：萘并吡啶衍生物一水合物及其制备方法
公开(公告)号：EP2221309B1
公开(公告)日：2013-07-24
申请号：EP08855286.4
申请日：2008-11-25
申请人： Toyama Chemical Co., Ltd. , Taisho Pharmaceutical Co., Ltd.
发明人： KIYOTO, Taro , TAKEBAYASHI, Masahiro , BABA, Yasutaka , SYOJI, Muneo , NOGUCHI, Toshiya , USHIYAMA, Fumihito , URABE, Hiroki , HORIKIRI, Hiromasa
IPC分类号： C07D519/00 , A61K31/4545 , A61P31/04 , C07D309/40 , C07D491/056 , C07D491/04
CPC分类号： C07D519/00 , C07D309/40 , C07D491/04

114. 发明公开

EP2527343A1 HETEROCYCLIC COMPOUND HAVING AZOLE GROUP 审中-公开
标题翻译：含有偶氮基团的杂环化合物
公开(公告)号：EP2527343A1
公开(公告)日：2012-11-28
申请号：EP11734701.3
申请日：2011-01-20
申请人： Toyama Chemical Co., Ltd.
发明人： OONISHI, Yuji , AWASAGUCHI, Kenichiro , NOMURA, Nobuhiko , TOHDO, Keisuke , KAWAI, Hyouei , WAKATSUKI, Tomomi
IPC分类号： C07D413/04 , A61K31/4375 , A61K31/4709 , A61P31/18 , C07D471/04
CPC分类号： C07D413/04 , A61K31/4375 , A61K31/4709 , C07D471/04
摘要： A heterocyclic compound represented by general formula (I)

[wherein R 1 represents an optionally protected amino group, or an optionally substituted C 1-6 alkyl group; R 2 and R 3 independently represent a C 1-2 alkyl group; X represents a hydrogen atom, or a halogen atom; Z 1 represents C-R 4 (wherein R 4 represents a hydrogen atom, a halogen atom, an optionally protected amino group, or a C 1-6 alkylsulfonyl group), or N; Z 2 represents C-R 5 (wherein, R 5 represents a hydrogen atom, a hydrogen atom, a halogen atom, an optionally protected amino group, or a C 1-6 alkylsulfonyl group), or N; Z 3 represents C-R 6 (wherein R 6 represents a hydrogen atom, a hydrogen atom, a halogen atom, an optionally protected amino group, or a C 1-6 alkylsulfonyl group ), or N; Z 4 represents C-R 7 (wherein, R 7 represents a hydrogen atom, a hydrogen atom, a halogen atom, an optionally protected amino group, or a C 1-6 alkylsulfonyl group), or N; Z represents CH or N; and A represents a methylene group, or a bond] or a salt thereof, which has an excellent anti-HIV activity and is thereof useful as an anti-HIV agent.
摘要翻译：由通式（I）表示的杂环化合物[其中R1表示任选被保护的氨基或任选被取代的C1-6烷基; R2和R3独立地表示C1-2烷基; X代表氢原子或卤素原子; Z 1表示C-R 4（其中R 4表示氢原子，卤素原子，任选保护的氨基或C 1-6烷基磺酰基）或N; Z 2表示C-R 5（其中，R 5表示氢原子，氢原子，卤原子，任选保护的氨基或C 1-6烷基磺酰基）或N; Z 3表示C-R 6（其中R 6表示氢原子，氢原子，卤素原子，任选保护的氨基或C 1-6烷基磺酰基）或N; Z4表示C-R7（其中，R7表示氢原子，氢原子，卤原子，任选保护的氨基或C1-6烷基磺酰基）或N; Z代表CH或N; A代表亚甲基或键]或其盐，其具有优异的抗HIV活性并且可用作抗HIV剂。

115. 发明公开

EP2407166A4 TABLET AND GRANULATED POWDER CONTAINING 6-FLUORO-3-HYDROXY-2-PYRAZINECARBOXAMIDE 有权转让
标题翻译：片剂和颗粒与6-氟-3-羟基-2-吡嗪羧酰胺
公开(公告)号：EP2407166A4
公开(公告)日：2012-07-18
申请号：EP10750921
申请日：2010-03-12
申请人： TOYAMA CHEMICAL CO LTD
发明人： KAKUDA SAHOE , NISHIMURA SETSUKO , HIROTA TAKAFUMI
IPC分类号： A61K31/4965 , A61K9/14 , A61K9/20 , A61K47/02 , A61K47/14 , A61K47/32 , A61K47/36 , A61K47/38
CPC分类号： A61K31/4965 , A61K9/2027 , A61K9/2054

116. 发明公开

EP2468743A1 Nitrogen-containing bicyclic compounds useful as antibacterial agents 审中-公开
标题翻译： el el el el el el el el el el el el el el el el el el el
公开(公告)号：EP2468743A1
公开(公告)日：2012-06-27
申请号：EP12000147.4
申请日：2006-06-22
申请人： Toyama Chemical Co., Ltd. , Taisho Pharmaceutical Co., Ltd.
发明人： Kiyoto, Taro , Tanaka, Tadashi , Tsutsui, Yasuhiro , Ando, Junichi , Motono, Mai , Kawaguchi, Yasuko , Noguchi, Toshiya , Ushiki, Yasunobu , Ushiyama, Fumihito , Urabe, Hiroki
IPC分类号： C07D401/06 , A61K31/4709 , A61K31/496 , A61P31/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D491/056
CPC分类号： C07D405/14 , C07D215/227 , C07D401/06 , C07D401/14 , C07D405/12 , C07D409/14 , C07D413/14 , C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04 , C07D519/00
摘要： A nitrogen-containing heterocyclic compound represented by the general formula: wherein the dashed line represents a single bond or a double bond; R 1 , R 2 , R 3 , R 4 and R 5 independently represent a hydrogen atom, halogen atom, a lower alkyl, aryl, lower alkoxy or monocyclic heterocyclic group which may be substituted or the like; R 6 represents a lower alkyl, aryl, monocyclic heterocyclic, bicyclic heterocyclic or tricyclic heterocyclic group which may be substituted; X 1 represents a lower alkylene group or the like; X 2 represents a lower alkylene, lower alkenylene or lower alkynylene group which may be substituted; X 3 represents an oxygen atom, sulfur atom, a sulfinyl group, sulfonyl group or the like; Y 1 represents a bivalent cyclic group, containing a nitrogen, which may be substituted or the like; and Z 1 represents a nitrogen atom, a carbon atom which may be substituted or the like, or a salt thereof. The compound or salt has a potent antibacterial activity and a high safety, and is therefore useful as an excellent antibacterial agent.
摘要翻译：一种由以下通式表示的含氮杂环化合物：其中虚线表示单键或双键; R 1，R 2，R 3，R 4和R 5独立地表示可以被取代的氢原子，卤素原子，低级烷基，芳基，低级烷氧基或单环杂环基等。 R 6表示可以被取代的低级烷基，芳基，单环杂环，双环杂环或三环杂环基; X 1表示低级亚烷基等; X 2表示可以被取代的低级亚烷基，低级亚烯基或低级亚烷基; X 3表示氧原子，硫原子，亚磺酰基，磺酰基等; Y 1表示可以被取代的氮的二价环状基团， Z 1表示氮原子，可被取代的碳原子等，或其盐。该化合物或盐具有有效的抗菌活性和高安全性，因此可用作优异的抗菌剂。

117. 发明公开

EP1988085A4 PROCESS FOR PRODUCTION OF 3-[5-[4-(CYCLOPENTYLOXY)-2-HYDROXYBENZOYL]-2-[(3-HYDROXY-1,2-BEZISOXAZOL-6-YL)METHOXY]PHENYL]PROPIONATE ESTER AND INTERMEDIATE FOR THE PROCESS 有权
标题翻译：工艺用于制备3- [5- [4-（环戊氧基）-2-羟基苯甲酰基] -2 - [（3-羟基-1,2-苯并异恶唑-6-基）甲氧基]苯基]该方法的丙酸酯和中间体
公开(公告)号：EP1988085A4
公开(公告)日：2012-05-30
申请号：EP07714479
申请日：2007-02-19
申请人： TOYAMA CHEMICAL CO LTD
发明人： YONEZAWA KENJI , TAKAMATSU TAMOTSU , AOKI NAOKATU , HASHIMOTO TOMOHIRO , TAKEBAYASHI MASAHIRO , SUZUKI YOSHIAKI , OONISHI YUJI
IPC分类号： C07D261/20 , C07B61/00 , C07C67/303 , C07C69/738 , C07D311/14
CPC分类号： C07D261/20 , C07C67/03 , C07C67/303 , C07C69/738 , C07C2601/08 , C07D311/14

118. 发明授权

EP2248809B1 Alkyl-3-[2-(benzo[b]thiophen-5-yl)-ethoxy]-propanoates as intermediates in the production of Azetidin-3-ol derivatives 有权
标题翻译：烷基-3- [2-（苯并[b]噻吩-5-基） - 乙氧基] - 丙酸甲酯在氮杂环丁烷-3-醇衍生物的制备中间体
公开(公告)号：EP2248809B1
公开(公告)日：2012-05-09
申请号：EP10007872.4
申请日：2006-03-27
申请人： TOYAMA CHEMICAL CO., LTD.
发明人： Saitoh, Akihito , Suzuki, Yoshiaki , Yonezawa, Kenji , Kawamura, Mitsuhide , Kusanagi, Takahiko , Nakai, Takashi
IPC分类号： C07D409/12 , C07D333/54 , C07D333/64
CPC分类号： C07D333/54 , C07D333/64 , C07D409/12

119. 发明授权

EP2070536B1 PHARMACEUTICAL COMPOSITION COMPRISING PHENYLAMIDINE DERIVATIVE AND METHOD OF USING THE PHARMACEUTICAL COMPOSITION IN COMBINATION WITH ANTIFUNGAL AGENT 有权
标题翻译： WITH A苯基脒衍生物和使用该药物组合物组合地方法WITH A抗真菌剂的药物组合物
公开(公告)号：EP2070536B1
公开(公告)日：2011-12-28
申请号：EP07829080.6
申请日：2007-10-03
申请人： Toyama Chemical Co., Ltd.
发明人： NISHIKAWA, Hiroshi
IPC分类号： A61K31/445 , A61K31/4196 , A61K31/7048 , A61K45/00 , A61K31/10 , A61K45/06 , A61P31/10
CPC分类号： A61K31/4196 , A61K31/445 , A61K31/7048 , A61K45/06 , A61K2300/00
摘要： Disclosed is a pharmaceutical composition comprising a phenylamidine derivative represented by the general formula: [wherein R1 and R2 independently represent a C3-4 alkyl group which may be substituted] or a salt thereof and at least one substance selected from an azole-type antifungal agent, a polyene-type antifungal agent, a candin-type antifungal agent and a fluoropyrimidine-type antifungal agent. Also disclosed is a method of using a combination of the phenylamidine derivative or the salt thereof and the substance. The pharmaceutical composition and the method are useful for the treatment of a fungal infectioninduced by a fungal pathogen.

120. 发明公开

EP2389937A1 Medicinal composition for improving brain function 有权
标题翻译： Medizinische Zusammensetzungen zur Verbesserung der Hirnfunktion
公开(公告)号：EP2389937A1
公开(公告)日：2011-11-30
申请号：EP11006318.7
申请日：2003-04-03
申请人： TOYAMA CHEMICAL CO., LTD.
发明人： Nakada, Yasushi , Nakagawa, Masaya , Ono, Satoshi
IPC分类号： A61K31/381 , A61K31/122 , A61K31/21 , A61K31/397 , A61K31/445 , A61K31/473 , A61K31/55 , A61K45/00 , A61P25/28 , A61P43/00
CPC分类号： A61K45/06 , A61K31/122 , A61K31/21 , A61K31/381 , A61K31/397 , A61K31/445 , A61K31/473 , A61K31/55 , A61K2300/00
摘要： Use of a following ingredients in combination for use in the treatment or prevention of dysfunction of cerebral acetylcholine neurons in the sequela of cerebrovascular dementia, senile dementia, Alzheimer's disease, ischemic cerebral lesion and cerebral apoplexy or the memory impairment caused by selective neuronal death:
Ingredient (A):
an alkyl ether derivative represented by the following formula:

wherein either
(R 1 represents a benzothienyl group;
R 2 represents a hydrogen atom;
R 3 and R 4 , each represents a C 1-6 alkyl group which is optionally substituted with a hydroxyl group;
R 3 and R 4 , taken conjointly with the nitrogen atom to which R 3 and R 4 are linked, form an azetidine ring which is optionally substituted with a hydroxyl group;
m represents an integer of 1; and
n represents an integer of 3);
or a salt thereof,

Ingredient (B) :
Tacrine or
Donepezil
for the manufacture of a pharmaceutical composition.
摘要翻译：使用以下成分组合用于治疗或预防脑血管性痴呆，老年痴呆，阿尔茨海默氏病，缺血性脑损伤和脑中风后遗症或由选择性神经元死亡引起的记忆障碍中脑乙酰胆碱神经元功能障碍的成分：成分（A）：由下式表示的烷基醚衍生物：其中（R 1表示苯并噻吩基; R 2表示氢原子; R 3和R 4各自表示任选取代的C 1-6烷基具有羟基; R 3和R 4与R 3和R 4连接的氮原子并用，形成任选被羟基取代的氮杂环丁烷环; m表示1的整数; n表示整数3）; 或其盐，成分（B）：用于制造药物组合物的他克林或多奈哌齐。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式