专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

101. 发明授权

EP0066484B1 Procédé de préparation d'imides N-benzylsubstitués 有权
标题翻译：制备N-苄基取代的咪唑的方法
公开(公告)号：EP0066484B1
公开(公告)日：1984-08-08
申请号：EP82400805.6
申请日：1982-05-03
申请人： RHONE-POULENC SPECIALITES CHIMIQUES
发明人： Desbois, Michel , Reppelin, Michel
IPC分类号： C07D207/404 , C07D209/48 , C07D205/10 , C07D211/88
CPC分类号： C07D207/404 , C07D205/10 , C07D209/48 , C07D211/88

102. 发明公开

EP0104885A1 Leukotriene antagonists, their production, and compositions containing them 有权
标题翻译： Leukotrienantagonisten，deren Herstellung und diese enthaltende Zusammensetzungen。
公开(公告)号：EP0104885A1
公开(公告)日：1984-04-04
申请号：EP83305588.2
申请日：1983-09-21
申请人： MERCK FROSST CANADA INC.
发明人： Belanger, Patrice C. , Fortin, Rejean , Guindon, Yvan , Rokach, Joshua , Yoakim, Christiane
IPC分类号： C07C149/40 , C07C147/14 , C07C147/107 , C07D317/14 , C07D233/78 , C07D207/404 , C07D303/02 , C07C59/90 , A61K31/19 , C07C59/64 , C07C51/347
CPC分类号： C07D207/26 , C07C45/71 , C07C59/90 , C07C317/00 , C07C323/00 , C07D207/33 , C07D233/74 , C07D257/04 , C07D307/58 , C07D317/34 , C07C49/84
摘要： Compounds of the formulae:

and their pharmaceutically acceptable (including acid- addition) salts, which are novel, are antagonists of leukotrienes of C 4 , D 4 and E 4 , the slow reacting substance of anaphylaxis. They can be made into pharmaceutical compositions by incorporating them in a pharmaceutical carrier.
In the formulae, each R is H, OH, SH, C 1-8 alkyl, C 2-8 alkenyl, CF 3 , C 1-8 alkoxy, C 1-8 alkylthio, phenyl, phenyl having C 1-3 alkyl or halogen substitution, phen (C 2-4 alkyl), halogen, amino, N(R 4 ) 2 , COOR 4 or CH 2 OR 4 where R 4 is H or C 1-8 alkyl, formyl, CN, CF 3 S or NO 2 ;
each R' is R 4 ; OR 4 ; COOR 4 ; N(R 4 ) 2 ; SR 4 ; CH 2 OR 4 orCHO; , or together R' and R' are 0, CH 2 or
Y is oxyge, sulfur, sulfoxide, sulfone,
= NR 12 , = N - CO - R 13 or - N - CN, where R 11 is C 1-4 alkyl, R 12 is H or C 1-4 atkyl and R 13 is C 1-4 alkyl or C 1-4 alkoxy;

Y' is Y,
each R 1 is hydrogen or C 1-3 alkyl; each m is an integer from 0 to 6;
R 2 is
where Z is O. S, CH 2 , H and OH, C 1-4 alkenyl, or = N - R 14 , where R 14 is OH, CN, COOH, halogen, formyl, C 1-8 acyl, C 1-8 alkyl, C 1-8 alkoxy, C 1-8 halogenated alkyl, phenyl, or phenyl having C 1-3 alkyl or C 1-3 alkoxy substitution; each R e is H or C 1-4 alkyl; each R 7 is H, OH or C 1-4 alkyl; each R 8 is H or C 1-4 alkyl and is absent when the two indicated carbons are triply bonded;
R 5 is COOR 4 ; CH 2 OH; CHO; tetrazole; NHSO 2 R 14 ; CON-HSO 2 R 14 hydroxymethylketone; CN; CON(R 7 ) 2 ; a monocyclic or bicyclic heterocyclic ring containing an acidic hydroxyl group; or COOR 15 where R 15 is:
where each s is independently 0-3, R 6 is as defined above and R 16 is

(A) a monocyclic or bicyclic heterocyclic radical containing from 3 to 12 nuclear carbon atoms and 1 or 2 N heteroatoms or one N and one S heteratom, each ring in the heterocyclic radical being formed of 5 or 6 atoms, or
(B) W-R 17 where W is O, S or NH and R 17 contains up to 21 carbon atoms and is (1) a hydrocarbon radical or (2) an acyl radical or an organic acyclic or monocyclic carboxylic acid containing not more than 1 heteroatom in the ring;

each of r and q is 0-20 but r + q does not exceed 20; and
p is 0 or 1;
R 3 is C 1-6 alkyl or C 3-8 alkenyl;
R 9 is C 1-8 alkyl, C 1-8 alkoxy or (CH 2 ) r R 5 , where r and R s are as defined above: and
R 10 is H, C 1-8 alkyl; R 4 CO- or R 4 OCH 2 , where R 4 is as defined above.

The compounds are prepared by condensing together two compounds having appropriately substituted benzene rings, one of which contains a halogen atom in the chain containing Y and Y', which removes a hydrogen atom from the ring of the other compound.
摘要翻译：下列化合物：及其药学上可接受的（包括酸加成）盐，它们是C4，D4和E4的白三烯拮抗剂，其是过敏反应的缓慢反应物质。它们可以通过将其并入药物载体中而制成药物组合物。式中，R为H，OH，SH，C 1-6烷基，C 2-6烯基，CF 3，C 1-6烷氧基，C 1-6链炔基，苯基，具有C1-3烷基或卤素取代基的苯基，苯基（C2 -4烷基），卤素，氨基，N（R4）2，COOR4或CH2OR4，其中R4是H或C1-6烷基，甲酰基，CN，CF3S或NO2; 每个R 1是R 4; OR 4; COOR4; N（R 4）2; SR4; CH2OR4或CHO; 或R 1和R 2分别为O，CH 2或CH 2 Y，是氧，硫，亚砜，砜，= NR 11，= NR 12，= N-CO-R 13或-N-CN，其中R 11为C 1-4 烷基，R 12为H或C 1-4烷基，R 13为C 1-4烷基或C 1-4烷氧基; Y min为Y，-CH 2 - 或 - 每个R 1是氢或C 1-3烷基; 每个m是0至6的整数; 其中Z是O，S，CH2，H和OH，C1-4链烯基或= N-R14，其中R14是OH，CN，COOH，卤素，甲酰基，C1-6酰基，C1-6烷基， C 1-6烷氧基，C 1-6卤代烷基，苯基或具有C 1-3烷基或C 1-3烷氧基取代基的苯基; 每个R 6是H或C 1-4烷基; 每个R 7是H，OH或C 1-4烷基; 每个R 8为H或C 1-4烷基，当两个表示的碳原子键合时不存在; R5为COOR4; CH2OH; CHO; 四唑; NHSO2R14; CONHSO2R14羟甲基酮; CN; CON（R7）2; 含有酸性羟基的单环或双环杂环; 或COOR 15，其中R 15为：其中各s独立地为0-3，R 6如上所定义，R 16为（A）含有3至12个核碳原子和1或2个N杂原子的单环或双环杂环基，或一个N和一个S杂原子，杂环基中的每个环由5或6个原子形成，或（B）W-R 17，其中W是O，S或NH，R 17含有最多21个碳原子，并且是（1）a 烃基或（2）环中含有不超过1个杂原子的酰基或有机酰基或单环羧酸; r和q各自为0-20，但r + q不超过20; p为0或1; R3是C1-6烷基或C3-6烯基; R 9是C 1-6烷基，C 1-6烷氧基或（CH 2）r R 5，其中r和R 5如上所定义; R 10为H，C 1-6烷基; R4CO-或R4OCH2，其中R4如上所定义。通过将具有适当取代的苯边缘的两种化合物冷凝在一起制备化合物，其中一个在含有Y和Ymin的链中含有卤素原子，其从另一种化合物的环除去氢原子。

103. 发明公开

EP0066484A1 Procédé de préparation d'imides N-benzylsubstitués 有权
标题翻译：一种用于N-苄基酰亚胺的制备方法。
公开(公告)号：EP0066484A1
公开(公告)日：1982-12-08
申请号：EP82400805.6
申请日：1982-05-03
申请人： RHONE-POULENC SPECIALITES CHIMIQUES
发明人： Desbois, Michel , Reppelin, Michel
IPC分类号： C07D207/404 , C07D209/48 , C07D205/10 , C07D211/88
CPC分类号： C07D207/404 , C07D205/10 , C07D209/48 , C07D211/88
摘要： L'invention a pour objet un procédé de préparation d'imides N-benzyl substitués caractérisé en ce que l'on fait réagir, en présence d'acide fluorhydrique, un composé de formule:
dans laquelle Ar représente un radical benzénique avec un composé de formule:
dans laquelle R 1 représente un groupement hydrocarboné aliphatique ou aromatique ayant de 1 à 12 atomes de carbone.

104. 发明公开

EP4436954A1 DEUTERATED FUNCTIONALIZED DERIVATIVES OF ?-ALANINE, IN PARTICULAR FOR THE TREATMENT OF NEUROLOGICAL DISEASES 审中-公开
公开(公告)号：EP4436954A1
公开(公告)日：2024-10-02
申请号：EP22843893.3
申请日：2022-11-24
申请人： UNIWERSYTET JAGIELLONSKI
发明人： KAMINSKI, Krzysztof , ABRAM, Michal , KAMINSKI, Rafal , JAKUBIEC, Marcin
IPC分类号： C07D207/404 , A61P25/00 , A61K31/4015 , C07B59/00
CPC分类号： A61P25/00 , C07D207/404 , C07B59/002 , C07B2200/0520130101

105. 发明授权

EP3419963B1 USE OF BISPYRIDINES TO IMPROVE LABELING OF NUCLEOPHILES 有权转让
公开(公告)号：EP3419963B1
公开(公告)日：2022-08-10
申请号：EP17757298.9
申请日：2017-02-24
发明人： HAXO, Francis T. , KIMZEY, Michael J.
IPC分类号： G01N33/533 , C07D207/404 , C07D207/46

106. 发明公开

EP3999490A1 CANNABINOID DERIVATIVES 审中-实审
公开(公告)号：EP3999490A1
公开(公告)日：2022-05-25
申请号：EP20839588.9
申请日：2020-07-10
申请人： Canopy Growth Corporation
发明人： AHMAR, Siawash , GNANASEKARAN, Krishna Kumar , OMEARA, Jeffrey Alan , PARK, Ji Sung
IPC分类号： C07C311/29 , A61K31/18 , A61K31/185 , A61K31/335 , A61K31/4196 , A61K31/421 , A61K31/426 , A61K31/44 , A61K31/445 , A61K31/495 , A61K31/505 , A61K31/5375 , C07C309/42 , C07C317/22 , C07C317/24 , C07D205/06 , C07D205/12 , C07D207/404 , C07D211/54 , C07D213/61 , C07D213/71

108. 发明公开

EP3878840A1 CRYSTALLINE FORMS OF SALTS OF N1,N12-DI (ALL-TRANS-RETINOYL)SPERMINE, PROCESSES FOR THEIR PRODUCTION, AND PHARMACEUTICAL COMPOSITIONS THEREOF 审中-实审
公开(公告)号：EP3878840A1
公开(公告)日：2021-09-15
申请号：EP21386019.0
申请日：2021-03-05
申请人： University of Patras , Papaioannou, Dionysios , Drainas, Dionysios , Avgoustakis, Konstantinos
发明人： Papaioannou, Dionysios , Drainas, Dionysios , Avgoustakis, Konstantinos
IPC分类号： C07C403/20 , C07D207/404 , A61K31/164 , A61P17/00
摘要： The present invention provides crystalline forms of salts of N 1 ,N 12 - di (all-trans- retinoyl)spermine and specifically of the dihydroxysuccinimidyl and the hydrochloride-hydroxysuccinimide salts of N 1 , N 12 - di ( all-trans- retinoyl)spermine, as well as pharmaceutical formulations for topical, parenteral and oral administration of said crystalline forms. It also provides processes for the production of the crystalline forms of the dihydroxysuccinimidyl salt and the mixed hydrochloride-hydroxysuccinimide salt of the N 1 , N 12 -di (all-trans -retinoyl)spermine conjugate. Said crystalline forms are useful for the treatment of dermatological diseases such as psoriasis, inflammations and acne, as well as in cosmetics for example in anti-aging.

109. 发明授权

EP3270903B1 DISULFIDE-CONTAINING ALKYNE LINKING AGENTS 有权
公开(公告)号：EP3270903B1
公开(公告)日：2020-05-06
申请号：EP16765618.0
申请日：2016-03-16
申请人： Arrowhead Pharmaceuticals, Inc.
发明人： ALMEIDA, Aaron , BLOKHIN, Andrei, V. , WAKEFIELD, Darren, H. , BENSON, Jonathan, D. , ROZEMA, David, B.
IPC分类号： A61K47/54 , A61K31/105 , A61K31/40 , C07D207/404 , C12N15/11 , C12N15/113

110. 发明授权

EP2380567B1 MELANIN PRODUCTION INHIBITOR 有权
公开(公告)号：EP2380567B1
公开(公告)日：2019-01-16
申请号：EP09834853.5
申请日：2009-12-22
申请人： Pola Chemical Industries Inc.
发明人： YOKOYAMA, Kouji , KIMURA, Makoto , TAMAI, Masashi , SAITOH, Yuko , KATO, Tomomi , IKEDA, Yu
IPC分类号： A61K8/34 , A61K8/41 , A61K8/44 , A61K8/49 , A61Q19/02 , C07D233/58 , C07D401/06 , C07D207/12 , C07D207/404 , C07D295/03 , C07D295/096 , C07D213/30 , C07D213/38

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式