专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

101. 发明公开

EP0360433A1 Protein derivatives and a process for their preparation 失效
标题翻译：蛋白衍生物和Verfahren zu ihrer Herstellung。
公开(公告)号：EP0360433A1
公开(公告)日：1990-03-28
申请号：EP89308680.1
申请日：1989-08-25
申请人： Offord, Robin Ewart
发明人： Offord, Robin Ewart , Rose, Keith
IPC分类号： C07K3/08 , A61K39/44 , A61K47/00 , G01N33/543
CPC分类号： G01N33/532 , A61K47/62 , A61K47/6889 , C07K1/1072
摘要： Protein derivatives of formula (1)
A-CO-N(R¹)CH₂-Z-R² (1)
wherein A-CO is the residue of a protein or peptide A-CO₂H (especially where -CO₂H is the C-terminal carboxyl group of the protein or peptide); R¹ is a hydrogen atom or an alkyl, aryl or aralkyl group; Z¹, which may be present or absent is a spacer group; R² is a group -C(OH)(R³)CH₂NHR⁴ or -C(R³)O (where R³ and R⁴ which may be the same or different, is each a hydrogen atom or an alkyl, aryl or aralkyl group); with the proviso that when A-CO is a residue of insulin, R¹ is other than a hydrogen atom; and the salts thereof. The compounds may be prepared by a condensation reaction,, especially in the presence of an enzyme capable of catalysing the formation of a peptide bond. The compounds may be used to form protein conjugates in which a group of interest such as another protein or peptide or an effector or reporter group is coupled to the protein through a -N(R¹)CH₂-Z¹-C(OH)(R³)CH₂N= or -N(R¹)CH₂Z¹-CH= group.
摘要翻译：式（1）的蛋白衍生物A-CO-N（R 1）CH 2 -ZR 2（1）其中A-CO是蛋白质或肽A-CO 2 H的残基（特别是其中-CO 2 H是C - 蛋白质或肽的末端羧基）; R 1是氢原子或烷基，芳基或芳烷基; 可能存在或不存在的Z 1是间隔基; R 2是基团-C（OH）（R 3）CH 2 NHR 4或-C（R 3）O（其中R 3和R 4可以相同或不同）各自为氢原子或烷基，芳基或芳烷基）; 条件是当A-CO是胰岛素的残基时，R 1不是氢原子; 及其盐。化合物可以通过缩合反应制备，特别是在能够催化形成肽键的酶的存在下。所述化合物可用于形成蛋白质缀合物，其中目标组如另一蛋白质或肽或效应物或报道基团通过-N（R 1）CH 2 -Z 1 -C （OH）（R 3）CH 2 N =或-N（R 1）CH 2 Z 1 -CH =基团。

102. 发明公开

EP0359428A1 Protein derivatives and a process for their preparation 失效转让
标题翻译：蛋白质衍生物及其制备方法
公开(公告)号：EP0359428A1
公开(公告)日：1990-03-21
申请号：EP89308681.9
申请日：1989-08-25
申请人： Offord, Robin Ewart , Rose, Keith
发明人： Offord, Robin Ewart , Rose, Keith
IPC分类号： C07K1/107 , A61K47/00 , G01N33/543
CPC分类号： G01N33/5748 , A61K47/62 , C07K1/1072 , G01N33/532
摘要： Protein derivatives of formula (1) A-CO-N(R 1 )N(R 2 )-Z 1 -
wherein A-CO is the residue of a protein or peptide A-CO 2 H (especially where -C0 2 H is the C-terminal carboxyl group of the protein or peptide); R 1 , R 2 , R 3 and R 4 , which may be the same or different, and which may be present or absent, is each a spacer group, X is an oxygen or sulphur atom; and the salts thereof. The compounds may be prepared by a condensation reaction, especially in the presence of an enzyme capable of catalysing the formation of a peptide bond. The compounds may be used to form protein conjugates in which a group of interest such as another protein or peptide or an effector or reporter group is coupled to the protein through a -N-(R 1 )N(R 2 )-Z 1 -C(=X)-Z 2 -N(R 3 )N= group.
摘要翻译：式（1）的蛋白质衍生物A-CO-N（R1）N（R2）-Z1-其中A-CO是蛋白质或肽A-CO2H的残基（尤其是其中-CO2H是C端羧基蛋白质或肽）; R 1，R 2，R 3和R 4可以相同或不同，并且可以存在或不存在，各自为间隔基团，X为氧或硫原子; 及其盐。化合物可以通过缩合反应来制备，特别是在能够催化形成肽键的酶的存在下。该化合物可用于形成蛋白质偶联物，其中一组目的基团如另一种蛋白质或肽或效应物或报道基团通过-N-（R 1）N（R 2）-Z 1 -C（= X）-Z 2 -N（R 3）N =基团。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式