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101. 发明公开

EP2563791A1 A PROCESS OF A QUATERNARY AMMONIUM SALT USING PHOSPHATE 有权转让
标题翻译： FOR季铵盐方法，其中使用磷酸盐
公开(公告)号：EP2563791A1
公开(公告)日：2013-03-06
申请号：EP11775165.1
申请日：2011-04-25
申请人： Dainippon Sumitomo Pharma Co., Ltd.
发明人： AE, Nobuyuki , FUJIWARA, Yuji
IPC分类号： C07D471/10 , C07D487/10
CPC分类号： C07D417/14 , C07D487/10
摘要： The present invention relates to a novel process for preparing quaternary ammonium salt derivatives.

102. 发明授权

EP2058300B1 SUCCINIC ACID DIESTER DERIVATIVE, PROCESS FOR PRODUCTION THEREOF, AND USE OF THE DERIVATIVE IN THE PRODUCTION OF PHARMACEUTICAL PREPARATION 有权
标题翻译：琥珀酸二酯，生产和衍生品的使用制备药物制备方法
公开(公告)号：EP2058300B1
公开(公告)日：2013-01-09
申请号：EP07806339.3
申请日：2007-08-30
申请人： Dainippon Sumitomo Pharma Co., Ltd. , Katayama Seiyakusyo Co. Ltd.
发明人： INAGAKI, Takashi , YAMAKAWA, Yoshikazu
IPC分类号： C07C271/22 , C07C269/06 , C07D207/416 , C07B61/00
CPC分类号： C07D207/416 , C07B53/00 , C07C269/06 , C07C271/22 , C07C2601/14

103. 发明公开

EP2500345A1 8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXAMIDE DERIVATIVE 有权
标题翻译： 8-氮杂二环〔3.2。 - ]辛-8- CARBOXAMIDDERIVAT
公开(公告)号：EP2500345A1
公开(公告)日：2012-09-19
申请号：EP10829980.1
申请日：2010-11-11
申请人： Dainippon Sumitomo Pharma Co., Ltd.
发明人： HORIUCHI, Yoshihiro , SAWAMURA, Kiyoto , FUJIWARA, Hiroaki
IPC分类号： C07D451/02 , A61K31/46 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61P1/14 , A61P1/16 , A61P3/02 , A61P3/04 , A61P3/06 , A61P3/08 , A61P3/10 , A61P5/14 , A61P5/18 , A61P5/50 , A61P7/04 , A61P9/00 , A61P9/10 , A61P9/12
CPC分类号： C07D451/06
摘要： Disclosed is a compound represented by formula (1) or a pharmacologically acceptable salt thereof. (In the formula, A represents a group that is represented by formula (A-1); R 1a and R 1b may be the same or different and each independently represents a C 1-6 alkyl group which may be substituted by one to three halogen atoms; m and n each independently represents an integer of 0-5; X 1 represents a hydroxyl group or an aminocarbonyl group; Z 1 represents a single bond or the like; and R 2 represents an optionally substituted C 1-6 alkyl group, an optionally substituted C 6-10 aryl group or the like.)
摘要翻译：公开了由式（1）表示的化合物或其药理学上可接受的盐。（式中，A表示由式（A-1）表示的基团; R 1a和R 1b可以相同或不同，各自独立地表示可被1〜3个取代的C 1-6烷基卤素原子; m和n各自独立地表示0-5的整数; X 1表示羟基或氨基羰基; Z 1表示单键等; R 2表示任选取代的C 1-6烷基，任选取代的C 6-10芳基等）

104. 发明授权

EP1891956B1 SOLUBILIZATION PREPARATION 有权
标题翻译：备增溶
公开(公告)号：EP1891956B1
公开(公告)日：2012-08-29
申请号：EP06766601.6
申请日：2006-06-12
申请人： Dainippon Sumitomo Pharma Co., Ltd.
发明人： OTODA, Kazuya , NAKAMURA, Mayumi , ARIYAMA, Teruko , NAKAGAWA, Takashi
IPC分类号： A61K9/08 , A61K31/496 , A61K47/10 , A61K47/12 , A61K47/16 , A61P25/18 , A61P25/28
CPC分类号： A61K31/496 , A61K9/0019 , A61K9/0095 , A61K9/08 , A61K47/10 , A61K47/12 , A61K47/18

105. 发明公开

EP2463286A1 BENZYL PIPERIDINE COMPOUND 审中-公开
标题翻译： BENZYL PIPERIDINE化合物
公开(公告)号：EP2463286A1
公开(公告)日：2012-06-13
申请号：EP10806467.6
申请日：2010-08-04
申请人： Dainippon Sumitomo Pharma Co., Ltd.
发明人： TOYODA, Tomohiro , NISHIDA, Tomoaki , YOSHINAGA Hidefumi
IPC分类号： C07D405/06 , A61K31/453 , A61P25/22 , A61P25/24 , A61P43/00
CPC分类号： C07D405/06
摘要： Provided is a new serotonin-reuptake inhibitor that exhibits affinity for serotonin-1A receptors. Said serotonin-reuptake inhibitor is a compound represented by formula (1) or a pharmacologically acceptable salt thereof. In the formula, R 1 represents a hydrogen atom, a 2-hydroxyethyl group, or a 2-methoxyethyl group. R 2 represents one of the following bonded to a methylene group which is bonded to a piperidine ring: a chlorine atom bonded in a p-position; a bromine atom bonded in a p-position; a methyl group bonded in a p-position; a chlorine atom bonded in an m-position; or a bromine atom bonded in an m-position. Either Y 1 represents a hydrogen atom and Y 2 represents a hydrogen atom or a hydroxyl group, or Y 1 and Y 2 together represent an oxo group. Z represents a group represented by one of the following formulas: formula (3-1-1), formula (3-1-2), formula (3-2-1), formula (3-2-2), formula (3-3-1), formula (3-3-2), formula (3-4-1), or formula (3-4-2). However, if R 1 represents a 2-hydroxyethyl group or a 2-methoxyethyl group and Y 1 and Y 2 both simultaneously represent hydrogen atoms, then Z represents a group represented by one of the following formulas: formula (3-1-2), formula (3-2-1), formula (3-2-2), formula (3-3-1), formula (3-3-2), formula (3-4-1), or formula (3-4-2).
摘要翻译：提供了对血清素-1A受体表现出亲和力的新的5-羟色胺再摄取抑制剂。所述血清素再摄取抑制剂是由式（1）表示的化合物或其药理学上可接受的盐。式中，R 1表示氢原子，2-羟乙基或2-甲氧基乙基。 R2表示键合至与哌啶环键合的亚甲基的以下之一：键合于对位的氯原子; 键合在对位上的溴原子; 在对位键合的甲基; 键合在m位的氯原子; 或键合在间位的溴原子。 Y1表示氢原子，Y2表示氢原子或羟基，或者Y1和Y2一起表示氧代基。 Z表示由下式之一表示的基团：式（3-1-1），式（3-1-2），式（3-2-1），式（3-2-2），式 3-3-1），式（3-3-2），式（3-4-1）或式（3-4-2）。但是，如果R1表示2-羟乙基或2-甲氧基乙基，并且Y1和Y2两者同时表示氢原子，则Z表示由下式之一表示的基团：式（3-1-2），式（3-2-1），式（3-2-2），式（3-3-1），式（3-3-2），式（3-4-1）或式（3-4- 2）。

106. 发明公开

EP2256114A4 AMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME 有权转让
标题翻译：包含此酰胺衍生物和药物组合物
公开(公告)号：EP2256114A4
公开(公告)日：2012-05-09
申请号：EP09711609
申请日：2009-02-20
申请人： DAINIPPON SUMITOMO PHARMA CO
发明人： KATO SHIRO , HARADA HIROSHI , YAMAZAKI HIROSHI , KAN YOKO , HIROKAWA YOSHIMI , NAKAMURA TAKANORI
IPC分类号： C07D413/06 , A61K31/5377 , A61K31/553 , A61P1/00 , A61P1/04 , A61P1/06 , A61P1/08 , A61P1/10 , A61P13/02 , A61P13/08 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P43/00 , C07D413/14
CPC分类号： C07D413/06 , C07D413/14

107. 发明公开

EP2447264A1 N-SUBSTITUTED-CYCLIC AMINO DERIVATIVE 审中-公开
标题翻译： N-取代 - 环状氨基衍生物
公开(公告)号：EP2447264A1
公开(公告)日：2012-05-02
申请号：EP10792158.7
申请日：2010-06-24
申请人： Dainippon Sumitomo Pharma Co., Ltd.
发明人： SUETSUGU, Satoshi , FUKUDA, Nobuhisa , NAKAI, Yoshio , TAKADA, Takashi , IKUMA, Yohei , NAKAHIRA, Hiroyuki
IPC分类号： C07D401/12 , A61K31/4709 , A61K31/538 , A61K31/5383 , A61K31/5415 , A61P9/10 , A61P9/12 , A61P13/12 , A61P25/06 , A61P25/28 , A61P27/02 , A61P43/00 , C07D413/12 , C07D413/14 , C07D417/12 , C07D498/10
CPC分类号： A61K31/4709 , A61K31/538 , A61K31/5383 , A61K31/5415 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The present invention provides a compound of formula (I):

wherein R 1a is optionally substituted C 1-6 alkyl, etc.; R 1m is hydrogen atom, etc.; G 1 , G 2 , G 3 and G 4 are (i), etc. ((i) G 1 is -N(R 1b )-, G 2 is -CO-, G 3 is -C(R 1c )(R 1d )-, and G 4 is oxygen, etc.); R 1b is optionally substituted C 1-6 alkyl, etc.; R 1c and R 1d are each independently optionally substituted C 1-6 alkyl, etc.; R 2 is optionally substituted C 1-6 alkyl, etc.; R 3a , R 3b , R 3c , and R 3d are each independently a group: -A-B (A is a single bond, etc., B is hydrogen atom, etc.), etc.; n is 1, etc.; R 5 is C 1-4 alkoxycarbonyl, etc., or a pharmaceutically acceptable salt thereof, which is useful as a renin inhibitor.
摘要翻译：本发明提供了式（I）的化合物：其中R 1a是任选取代的C 1-6烷基等; R1m是氢原子等; （i）G1为-N（R1b） - ，G2为-CO-，G3为-C（R1c）（R1d） - ，且G4为氧，则G 1，G 2，G 3和G 4为等等。）; R1b是任选取代的C1-6烷基等; R1c和R1d各自独立地为任选取代的C1-6烷基等; R2是任选取代的C1-6烷基等; R 3a，R 3b，R 3c和R 3d各自独立地为-A-B（A为单键等，B为氢原子等）等。 n是1等; R5为C1-4烷氧基羰基等，或其药学上可接受的盐，其可用作肾素抑制剂。

108. 发明授权

EP1662007B9 PREVENTIVE OR REMEDY FOR INFLAMMATORY BOWEL DISEASES CONTAINING ANTI-CD81 ANTIBODY AS THE ACTIVE INGREDIENT 有权
标题翻译：手段预防和愈合炎症性肠病有抗CD81抗体作为活性成分
公开(公告)号：EP1662007B9
公开(公告)日：2012-02-29
申请号：EP04772572.6
申请日：2004-08-25
申请人： Dainippon Sumitomo Pharma Co., Ltd.
发明人： WATANABE, Takamasa , KIKUCHI, Kaoru
IPC分类号： A61K39/395 , A61P1/04
CPC分类号： C12Q1/6883 , A61K2039/505 , C07K16/2896 , C07K2317/70 , C12Q2600/136 , C12Q2600/158 , G01N33/6893 , G01N2800/065
摘要： It is possible to use a CD81 gene expression inhibitor and a screening system using the inhibition of CD81 expression or the inhibition of its function (activity) as an indication in searching for a drug for preventing, ameliorating or treating IBD. Also, anti-CD81 antibody is highly efficacious as the active ingredient of a drug for preventing, ameliorating or treating IBD. Further, it is possible to use a polynucleotide having at least 15 consecutive bases in the base sequence of CD81 gene and/or a polynucleotide complementary to the above polynucleotide as a disease marker for IBD.

109. 发明公开

EP2414340A1 COMPOUNDS FOR TREATING DISORDERS MEDIATED BY METABOTROPIC GLUTAMATE RECEPTOR 5, AND METHODS OF USE THEREOF 审中-公开
标题翻译：用于治疗化合物，通过代谢型谷氨酸受体5介导的疾病和申请流程。
公开(公告)号：EP2414340A1
公开(公告)日：2012-02-08
申请号：EP10712266.5
申请日：2010-04-01
申请人： Dainippon Sumitomo Pharma Co., Ltd.
发明人： BURDI, Douglas , SPEAR, Kerry, L. , HARDY, Larry, Wendell
IPC分类号： C07D263/56 , C07D498/04 , A61K31/423 , A61K31/424
CPC分类号： C07D498/04 , A61K31/423 , A61K31/424 , C07D263/56
摘要： Provided herein are compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, psychiatric disorders, neuromuscular disorders, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds provided herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

110. 发明授权

EP1652848B1 PROCESS FOR PRODUCING IMIDE COMPOUND 有权转让
标题翻译：一种用于生产酰亚胺
公开(公告)号：EP1652848B1
公开(公告)日：2012-02-01
申请号：EP04748182.5
申请日：2004-07-27
申请人： Dainippon Sumitomo Pharma Co., Ltd.
发明人： KAKIYA, Yuzo, Dainippon Sumitomo Pharma Co., Ltd. , ODA, Mayumi, Dainippon Sumitomo Pharma Co., Ltd.
IPC分类号： C07D417/12 , A61K31/496 , A61P25/28
CPC分类号： C07D401/14 , C07D295/00 , C07D417/12
摘要： A process for producing an imide compound hydrochloride. It is an excellent industrial process. The process, which is for producing either the imide compound hydrochloride represented by the formula (2): or enantiomers thereof, is characterized by treating either the compound represented by the formula (1): or enantiomers thereof with an aqueous hydrochloric acid solution in a hydrophilic medium and crystallizing the resultant hydrochloride.

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