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101. 发明授权

EP0060059B1 Method for determining the activity of cholinesterase and diagnostic solution for use therein 失效
标题翻译：确定胆碱酯酶活性的方法及其使用的诊断方法
公开(公告)号：EP0060059B1
公开(公告)日：1985-08-21
申请号：EP82300965.9
申请日：1982-02-25
申请人： FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC.
发明人： Kasahara, Yasushi , Ashihara, Yoshihiro , Sugiyama, Masami , Harada, Takahiro
IPC分类号： C12Q1/46
CPC分类号： C12Q1/46 , C12Q2334/00

102. 发明公开

EP0144176A2 Method of measuring a biological ligand 失效
标题翻译： Verfahren zur Messung eines biologischen Ligands。
公开(公告)号：EP0144176A2
公开(公告)日：1985-06-12
申请号：EP84307834.6
申请日：1984-11-13
申请人： FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC.
发明人： Ashihara, Yoshihiro , Kasahara, Yasushi
IPC分类号： G01N33/542 , G01N33/74 , G01N33/68 , G01N33/569 , G01N33/574 , G01N33/563 , G01N33/577
CPC分类号： G01N33/542 , G01N33/535 , G01N33/573 , G01N33/581 , G01N33/74 , Y10S435/963 , Y10S435/97 , Y10S436/813 , Y10S436/815
摘要： A method of determining a biological ligand which is highly sensitive and specific and which is suitable for use as a clinical test for the determination of physiological substances and trace components in humoral fluid comprises allowing there to coexist in an aqueous medium a system comprising (A) a ligand (1) to be measured, (8) either a combination (1) of an antibody against the ligand (1) and an enzyme capable of acting on a water-insoluble macromolecular substance or a combination (2) of a said enzyme and a ligand (2) having an antigenic determinant which is an antigenic determinant of said ligand (1), which combination (2) is present in the aqueous medium together with a said antibody, and (C) a said macromolecular substance, determining the residual activity of the enzyme after it has acted on said macromolecular substance and utilising the measurement thereby obtained as a measure of the biological ligand. The inventive method makes use of the steric hindrance of the combination (1) or (2) for the enzyme reaction which is carried out at the boundary between solid phase and liquid phase.
摘要翻译：确定高灵敏度和特异性的并且适用于测定体液中的生理物质和微量组分的临床试验的生物配体的方法包括允许在含水介质中共存包含（A）待测量的配体（1），（B）针对配体（1）的抗体的组合（1）和能够作用于水不溶性大分子物质的酶或所述酶的组合（2）和具有作为所述配体（1）的抗原决定簇的抗原决定簇的配体（2），所述组合（2）与所述抗体一起存在于水性介质中，和（C）所述大分子物质，酶在作用于所述大分子物质之后的残留活性，并利用由此获得的测量作为生物配体的量度。本发明的方法利用在固相和液相之间边界进行的酶反应的组合（1）或（2）的空间位阻。

103. 发明公开

EP0132292A2 Method of measuring biological ligands 失效
标题翻译： Verfahren zur Messung von biologischen Liganden。
公开(公告)号：EP0132292A2
公开(公告)日：1985-01-30
申请号：EP84304093.2
申请日：1984-06-18
申请人： FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC.
发明人： Ashihara, Yoshihiro , Kasahara, Yasushi
IPC分类号： G01N33/542 , G01N33/577 , G01N33/68 , G01N33/74 , G01N33/78 , G01N33/88 , G01N33/92 , G01N33/576 , G01N33/574
CPC分类号： G01N33/535 , G01N33/542 , G01N33/58
摘要： A highly sensitive and specific method of measuring a biological ligand which is suitable as a clinical test for determining physiological substances and trace components in humoral fluid comprises allowing there to coexist in an aqueous medium a system comprising (A) a ligand (1) to be measured, (B) a combination of a biotinyl enzyme inhibitor and a ligand (2) having an antigenic determinant which is also an antigenic determinant of ligand (1) and (C) an antibody capable of reacting with said antigenic determinant, contacting said system with a biotinyl enzyme, measuring the residual biotinyl enzyme activity and utilising the measurement thereby obtained as a measure of the biological ligand.
摘要翻译：测定生物配体的高灵敏度和特异性方法，其适合作为用于测定体液中的生理物质和痕量组分的临床试验，包括使其在水性介质中共存，所述体系包含（A）配体（1）测量，（B）生物素酶抑制剂和具有抗原决定簇的配体（2）的组合，所述配体也是配体（1）的抗原决定簇和（C）能够与所述抗原决定簇反应的抗体，用生物素酶测量剩余生物素酶活性，并利用由此获得的测量作为生物配体的量度。

104. 发明公开

EP0119767A2 Method of measuring ligands 失效
标题翻译： Verfahren zur Bestimmung von Liganden。
公开(公告)号：EP0119767A2
公开(公告)日：1984-09-26
申请号：EP84301154.5
申请日：1984-02-22
申请人： FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC.
发明人： Ashihara, Yoshihiro , Suzuki, Hiromasa , Kasahara, Yasushi
IPC分类号： G01N33/535 , G01N33/542
CPC分类号： G01N33/53 , G01N33/536 , G01N33/542 , Y10S435/969 , Y10S436/813 , Y10S436/817 , Y10S436/822 , Y10S530/861 , Y10S530/863
摘要： A method of measuring a ligand comprises bringing into contact with each other in aqueous solution ligand to be measured, an enzyme or a combination thereof with a macromolecular substance, and a combination of an antibody against the above ligand and an antibody against the above enzyme or a combination of the antibody combination with a macromolecular substance. The activity of the residual enzyme is then determined as a measure of the ligand. This method is highly sensitive and specific, and it is suitable as a clinical test for the determination of medicinal substances and trace constituents in body fluid.
摘要翻译：测定配体的方法包括在待测量的水溶液配体中，与大分子物质的酶或其组合以及针对上述配体的抗体与针对上述酶的抗体的组合相互接触，或抗体组合与大分子物质的组合。然后确定残留酶的活性作为配体的量度。该方法灵敏度高，具有特异性，适合作为体液中药物和微量成分测定的临床试验。

105. 发明公开

EP0092186A3 Method of preparing gamma globulin suitable for intravenous administration 失效
标题翻译：制备适用于静脉内给药的GAMMA GLOBULIN的方法
公开(公告)号：EP0092186A3
公开(公告)日：1984-07-18
申请号：EP83103635
申请日：1983-04-14
申请人： FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC.
发明人： Taniguchi, Nobuhiro , Endo, Tomohiro
IPC分类号： A61K39/395
CPC分类号： C07K16/065 , A61K38/00 , Y10S514/941
摘要： A method of preparing gamma globulin suitable for intravenous administration comprising a step of treating a gamma globulin composition containing aggregates of gamma globulin with polypropylene glycol (PPG) and dispersing agents for PPG under selected conditions.

106. 发明公开

EP0101166A1 Method of measuring infectious disease antibodies 失效
标题翻译：一种用于传染性抗体的测定方法。
公开(公告)号：EP0101166A1
公开(公告)日：1984-02-22
申请号：EP83303601.5
申请日：1983-06-22
申请人： FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC.
发明人： Sato, Takashi , Kubo, Emiko , Kayashima, Takako
IPC分类号： G01N33/571
CPC分类号： G01N33/569 , G01N33/54306 , G01N33/54313 , G01N33/54353 , G01N33/571 , G01N33/6854
摘要： A method of measuring an infectious disease antibody such as syphilis IgM comprises treating immunoglobulins of a sample with an anti immunoglobulin antibody able to react with the infectious disease antibody, sensitised on carrier particles and an antigen of the infectious disease sensitised on carrier particles. By operating according to the inventive method, the specific antibody of the specific infectious disease can be easily and exactly measured.

107. 发明公开

EP0091760A1 Anti immune complex antibody and preparation thereof 失效
标题翻译： Anti-Immunkomplex-Antikörperund Verfahren zur Herstellung desselben。
公开(公告)号：EP0091760A1
公开(公告)日：1983-10-19
申请号：EP83301845.0
申请日：1983-03-31
申请人： FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC.
发明人： Soma, Kazunori , Kasahara, Yasushi
IPC分类号： G01N33/564 , C07K15/14
CPC分类号： G01N33/563 , G01N33/564 , G01N2800/104 , Y10S435/961 , Y10S530/806 , Y10S530/866 , Y10S530/868
摘要： A novel antibody is obtained by using an antigen, a complex of an antigen and a F(ab') 2 fragment of the human antibody of this antigen or an aggregate of F(ab' 2 ) fragment of human immunoglobulin. This antibody reacts with an immune complex in serum of a patient subject to systemic lupus erythematosus and with an immune complex in serum of a patient subject to rheumatoid arthritis, but does not react with an aggregated IgG. The amount of immune complex in a blood serum is easily and exactly determined by using this antibody.
摘要翻译：通过使用抗原，抗原的复合物和该抗原的人抗体的F（ab min）2片段或人免疫球蛋白的F（ab min 2）片段的聚集体获得新的抗体。该抗体与患有系统性红斑狼疮的患者的血清中的免疫复合物和患有类风湿性关节炎的患者的血清中的免疫复合物反应，但不与聚集的IgG反应。通过使用该抗体容易且精确地测定血清中的免疫复合物的量。

108. 发明公开

EP0060059A1 Method for determining the activity of cholinesterase and diagnostic solution for use therein 失效
标题翻译：一种用于确定在相同的使用胆碱酯酶活性和诊断溶液法。
公开(公告)号：EP0060059A1
公开(公告)日：1982-09-15
申请号：EP82300965.9
申请日：1982-02-25
申请人： FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC.
发明人： Kasahara, Yasushi , Ashihara, Yoshihiro , Sugiyama, Masami , Harada, Takahiro
IPC分类号： C12Q1/46
CPC分类号： C12Q1/46 , C12Q2334/00
摘要： A method of simply and precisely determining the activity of cholinesterase comprises the steps of: mixing a diagnostic solution containing hydroxybenzoate hydroxylase, nicotinamide adenine dinucleotide phosphate reduced form (NADPH) and hydroxybenzoyl choline having the following formula:
with a liquid containing cholinesterase; and measuring the decrease in absorbance of light by NADPH, which corresponds to the consumption of NADPH and in turn the extent of production of hydroxybenzoic acid which is dependent on the activity of the cholinesterase-containing liquid.
摘要翻译：简单地且精确地确定采矿的方法胆碱酯酶的活性包括以下步骤：混合诊断溶液含羟基羟化酶，烟酰胺腺嘌呤二核苷酸磷酸还原形式（NADPH）和羟基苯甲酰胆碱具有下式：用含胆碱酯酶的液体; 和测量由NADPH在光的吸光度的降低，其对应于NADPH的生产羟基苯甲酸所有的其程度依赖于含胆碱酯酶液体的活性，进而消耗。

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