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101. 发明公开

EP0808244A2 MULTICOLOR ORGANIC LIGHT EMITTING DEVICES 失效
标题翻译：多色有机发光器件
公开(公告)号：EP0808244A2
公开(公告)日：1997-11-26
申请号：EP95943680.0
申请日：1995-12-06
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY
发明人： SAPOCHAK Linda , FORREST, Stephen R , BURROWS, Paul , McCARTY, Dennis , THOMPSON, Mark E
IPC分类号： H05B33 , C09K11 , G09G3 , H01L27 , H01L33 , H01L51
CPC分类号： H01L24/82 , C09K11/06 , H01L27/156 , H01L27/3209 , H01L51/0034 , H01L51/0035 , H01L51/0036 , H01L51/0038 , H01L51/0042 , H01L51/005 , H01L51/0051 , H01L51/0059 , H01L51/0077 , H01L51/008 , H01L51/0081 , H01L51/0084 , H01L51/5012 , H01L51/5036 , H01L51/5048 , H01L51/5234 , H01L2251/5323 , H01L2924/12033 , H01L2924/12041 , H01L2924/12042 , H01L2924/12044 , Y10T428/26 , Y10T428/265 , Y10T428/31678 , H01L2924/00
摘要： An organic light emitting structure comprises, in sequence, a substrate, a first electrically conductive layer, a transparent organic light emitting layer structure, a transparent electrically conductive metal layer having a work function less than 4 eV, and a second electrically conductive layer of indium tin oxide. The structure can be incorporated in a multicolor organic light emitting device employing vertically stacked layers of double heterostructure devices which are fabricated from organic compounds. The vertical stacked structure is formed on a glass base having a transparent coating of ITO or similar metal to provide a substrate. Deposited on the substrate is the vertical stacked arrangement of three double heterostructure devices, each fabricated from a suitable organic material. Stacking is implemented such that the double heterostructure with the longest wavelength is on the top of the stack. This constitutes the device emitting red light on the top with the device having the shortest wavelength, namely, the device emitting blue light, on the bottom of the stack. Located between the red and blue device structures is the green device structure. The devices are configured as stacked to provide a staircase profile whereby each device is separated from the other by a thin transparent conductive contact layer to enable light emanating from each of the devices to pass through the semitransparent contacts and through the lower device structures while further enabling each of the devices to receive a selective bias.

102. 发明公开

EP0805416A2 Light normalization method for machine vision 失效
标题翻译： Verfahren zur LichtnormalisierungfürMaschinenvision
公开(公告)号：EP0805416A2
公开(公告)日：1997-11-05
申请号：EP97105616.3
申请日：1997-04-04
申请人： SIEMENS CORPORATE RESEARCH, INC. , THE TRUSTEES OF PRINCETON UNIVERSITY
发明人： Fang, Ming , Bang, Richard D.
IPC分类号： G06T5/40
CPC分类号： G06T5/009 , G06T5/40 , G06T2207/20016 , G06T2207/30201
摘要： A method for normalizing the lighting changes in an input image made up of an X and Y array of pixels having various illuminating intensities, wherein the lighting changes having an additive effect and a multiplicative effect on the input image. The method comprises the steps of estimating the additive effect from the input image to provide a background estimate; estimating the multiplicative effect from the input image to provide a gain estimate; subtracting the background estimate from the image; and normalizing the image with respect to the gain estimate. Also described is an apparatus for automatically determining the identity of an image. The apparatus comprises video camera for acquiring the image to be recognized and a light normalizer coupled to the video camera for normalizing lighting changes in the image and producing a normalized image which can be more accurately recognized. Also included in the apparatus is an image recognizer coupled to the light normalizer, for receiving the normalized image and determining the identity of the image.
摘要翻译：一种用于对由具有各种照明强度的像素的X和Y阵列构成的输入图像进行标准化的方法，其中照明改变具有对输入图像的加法效果和乘法效应。该方法包括以下步骤：从输入图像估计附加效应以提供背景估计; 估计来自输入图像的乘法效应以提供增益估计; 从图像中减去背景估计; 并且相对于增益估计来归一化图像。还描述了一种用于自动确定图像的身份的装置。该装置包括用于获取要识别的图像的摄像机和耦合到摄像机的光规范化器，用于归一化图像中的照明变化，并产生可以更准确地识别的标准化图像。装置中还包括耦合到光标准化器的图像识别器，用于接收归一化图像并确定图像的身份。

103. 发明公开

EP0686160A1 SOLUTION AND SOLID-PHASE FORMATION OF GLYCOSIDIC LINKAGES 失效
标题翻译：液相和固相教育糖苷键
公开(公告)号：EP0686160A1
公开(公告)日：1995-12-13
申请号：EP94908048.0
申请日：1994-02-23
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY
发明人： KAHNE, Daniel, E.
IPC分类号： C07H1 , B01J31 , C07H3 , C07H11 , C07H15 , C07H17 , C07H19 , C08B37 , C40B50
CPC分类号： C07H15/14 , B01J2219/00599 , C07B2200/11 , C07H3/04 , C07H3/06 , C07H11/00 , C07H15/18 , C07H15/203 , C07H17/04 , C07H19/04 , C40B50/08
摘要： The invention relates to methods that permit the rapid construction of oligosaccharides and other glycoconjugates. Methods for forming multiple glycosidic linkages in solution in a single step are disclosed. The invention takes advantage of the discovery that the relative reactivity of glycoside residues containing anomeric sulfoxides and nucleophilic functional groups can be controlled. In another aspect of the invention, the reactivity of activated anomeric sugar sulfoxides is utilized in a solid phase method for the formation of glycosidic linkages. The methods disclosed may be applied to the preparation of specific oligosaccharides and other glycoconjugates, as well as to the preparation of glycosidic libraries comprising mixtures of various oligosaccharides, including glycoconjugates, which can be screened for biological activity.

104. 发明授权

EP0327190B1 Pyrido(2,3-d)pyrimidine derivatives 失效
标题翻译：吡啶并[2,3-D] pyrimidinderivate。
公开(公告)号：EP0327190B1
公开(公告)日：1993-12-08
申请号：EP89300046.3
申请日：1989-01-05
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY , ELI LILLY AND COMPANY
发明人： Taylor, Edward C. , Shih, Chuan
IPC分类号： C07D471/04 , A61K31/505
CPC分类号： C07D471/04

105. 发明公开

EP0549886A1 Process for the preparation of pyrrolo[2,3-d]pyrimidines 失效
标题翻译： Verfahren zur Herstellung von Pyrrolo（2,3-d）嘧啶酮。
公开(公告)号：EP0549886A1
公开(公告)日：1993-07-07
申请号：EP92120057.2
申请日：1992-11-25
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY
发明人： Taylor, Edward C. , Patel, Hemantkumar H.
IPC分类号： C07D487/04 , C07D307/68
CPC分类号： C07D487/04 , C07D307/68
摘要： 5-Substituted pyrrolo[2,3-d]pyrimidines are prepared from a nucleophile of the formula R²-C(=NH)NH₂ and a 2-amino-5-substituted-furan carrying a cyano or carboxy group in the 4-position. A typical example is the preparation of ethyl 4-{2-(2,4-diaminopyrrolo[2,3-d]pyrimidin-5-yl)ethyl}benzoate, an intermediate for the preparation of the known N-[4-(2-(2,4-diaminopyrrolo[2,3-d]pyrimidin-5-yl)ethyl}benzoyl]-L-glutamic acid, by allowing guanidine and ethyl 4-[2-(2-amino-3-cyanofur-4-yl)ethyl]benzoate to react under mild conditions.
摘要翻译： 5-取代的吡咯并[2,3-d]嘧啶由式R 2 -C（= NH）NH 2的亲核试剂和携带氰基或羧基的2-氨基-5-取代呋喃制备 4-位。典型的实例是制备4- {2-（2,4-二氨基吡咯并[2,3-d]嘧啶-5-基）乙基}苯甲酸乙酯，制备已知N- [4-（ 2-（2,4-二氨基吡咯并[2,3-d]嘧啶-5-基）乙基}苯甲酰基] -L-谷氨酸酰胺，通过使胍和4- [2-（2-氨基-3-氰基） -4-基）乙基]苯甲酸甲酯，在温和条件下反应。

106. 发明公开

EP0527896A1 SUBSTRATES AND INHIBITORS FOR PRENYL CYSTEINE METHYLTRANSFERASE ENZYMES 失效
标题翻译：底物和抑制剂用于PRENYLCYSTEIN甲基转移酶。
公开(公告)号：EP0527896A1
公开(公告)日：1993-02-24
申请号：EP91909734.0
申请日：1991-05-03
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY
发明人： STOCK, Jeffry, B.
IPC分类号： C07C323 , C12Q1
CPC分类号： C12Q1/48 , C07C323/59
摘要： Composés de la formule (I), dans laquelle: R1 représente alkyle contenant 1 à 3 atomes de carbone; R2 représente -COX, dans lequel X représente hydroxy, méthyle, amino, thio, HN-(alkyle contenant 1 à 3 atomes de carbone), N-(alkyle contenant 1 à 3 atomes de carbone)2 ou halogène; R3 représente un alkyle à chaîne droite ou ramifiée contenant 10 à 25 atomes de carbone, ou un alcène à chaîne droite ou ramifiée, ou un alcène à chaîne droite ou ramifiée comprenant des alcènes poly-insaturés contenant 10 à 25 atomes de carbone; et le métal alcalin, le métal alcalino-terreux, l'ammonium, et ses sels d'ammonium substitués constituent spécifiquement, lorsque R2 représente -COOH, des substrats et/ou des inhibiteurs d'enzymes de méthyltransférase de cystéine de prényle, lesquelles catalysent le transfert de méthyle de S-adénosylméthionine aux C-terminaisons de protéines et de peptides présentant des résidus de cystéine prénylée au niveau de leurs C-terminaisons. Les composés, en tant que substrats, sont particulièrement adaptés à une utilisation dans des analyses permettant de détecter qualitativement ou quantitativement les enzymes de méthyltransférase de cystéine de farnésyle.

107. 发明公开

EP0452660A3 L-glutamic acid derivatives 失效
标题翻译： L-谷氨酸衍生物
公开(公告)号：EP0452660A3
公开(公告)日：1992-01-29
申请号：EP91103482.5
申请日：1991-03-07
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY
发明人： Taylor, Edward C. , Schrader, Thomas H. , Walensky, Loren W.
IPC分类号： C07D239/49 , A61K31/505
CPC分类号： C07D239/48
摘要： Substituted pyrimidin-5-yl derivatives of L-glutamic acid are anti-neoplastic agents. A typical embodiment is N-{4-[6-(2,6-diamino-4-hydroxypyrimidin-5-yl)hex-1-en-3-yl]benzoyl}-L-glutamic acid.

108. 发明授权

EP0255228B1 4(3H)-Oxo-5,6,7,8,-Tetrahydropyrido-(2,3-d)Pyrimidine derivatives 失效
标题翻译： 4（3H）-OXO-5,6,7,8-羟基吡啶-2-基（2,3-D）吡嗪衍生物
公开(公告)号：EP0255228B1
公开(公告)日：1991-05-02
申请号：EP87305636.0
申请日：1987-06-24
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY
发明人： Taylor, Edward C. , Beardsley, George Peter , Shih, Chuan , Hamby, James M.
IPC分类号： C07D471/04 , A61K31/435
CPC分类号： C07D471/04 , Y02P20/55

109. 发明公开

EP0415510A2 L-glutamic acid derivatives 失效
标题翻译： L-Glutaminsäure衍。
公开(公告)号：EP0415510A2
公开(公告)日：1991-03-06
申请号：EP90301169.0
申请日：1990-02-05
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY
发明人： Taylor, Edward C. , Shih, Chuan , Harrington, Philip M.
IPC分类号： C07D409/06 , A61K31/505
CPC分类号： C07D409/06
摘要： Pyrimidin-5-yl derivatives of L-glutamic acid are anti-neoplastic agents. A typical embodiment is N-(4-[5-(2,6-diamino-4-hydroxypyrimidin-5-yl)-butyl]thien-2-ylcarboxy)-L-glutamic acid.
摘要翻译： L-谷氨酸的嘧啶-5-基衍生物是抗肿瘤剂。典型的实施方案是N-（4- [5-（2,6-二氨基-4-羟基嘧啶-5-基） - 丁基]噻吩-2-基羧基）-L-谷氨酸。

110. 发明公开

EP0325343A3 L-glutamic acid derivatives 失效
标题翻译： L-谷氨酸衍生物
公开(公告)号：EP0325343A3
公开(公告)日：1990-09-05
申请号：EP89300045.5
申请日：1989-01-05
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY , ELI LILLY AND COMPANY
发明人： Taylor, Edward C. , Harrington, Philip M. , Shih, Chuan
IPC分类号： C07D239/50 , C07D239/48 , C07D239/54 , A61K31/505
CPC分类号： C07D239/48 , C07D239/50 , C07D239/545
摘要： Pyrimidin-5-yl derivatives of L-glutamic acid are anti-neoplastic agents. A typical embodiment is N-(4-[4-(2,4-diamino-6-hydroxypyrimidin-5-yl)-butyl]-benzoyl)-L-glutamic acid.

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