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91. 发明公开

EP1289440A4 SELECTIVE PHOTOCOAGULATION 有权
标题翻译：选择性激光光凝
公开(公告)号：EP1289440A4
公开(公告)日：2005-07-27
申请号：EP01941803
申请日：2001-06-01
申请人： GEN HOSPITAL CORP
发明人： LIN CHARLES P
IPC分类号： A61B17/00 , A61B18/00 , A61B18/20 , A61F9/008
CPC分类号： A61B18/20 , A61B2017/00057 , A61B2018/00636 , A61B2018/00642 , A61F9/008 , A61F9/00821 , A61F2009/00844 , A61F2009/00855 , A61F2009/00863 , A61F2009/00897
摘要： Selective photocoagulation of particular cells, tissue or portion of tissue can be aided by monitoring microcavitation within the material exposed to electromagnetic radiation (12). The information gained by the detection of microcavitation events can be used to modulate the intensity of the radiation (12) to prevent significant thermal energy transmission and mechanical damage to cells, tissues or portions of tissues which are not directly exposed, but prone to thermal damage by such energy transmission. Detection of microcavitation also serves as a valuable therapeutic endpoint. The methods of the invention are applicable to laser eye surgery, since the target cells of several therapeutic photocoagulation methods, the retinal pigment epithelial (RPE) cells are proximate to photoreceptor cells. The inventive methods can help prevent the formation of blind spots that can be associated with laser eye surgery. Other fields of laser surgery can also be readily adapted to the methods described herein.

92. 发明公开

EP1210923A3 Control system for corneal laser surgery 有权
标题翻译：用于角膜激光手术控制系统
公开(公告)号：EP1210923A3
公开(公告)日：2003-08-27
申请号：EP01308220.1
申请日：2001-09-27
申请人： 20/10 Perfect Vision Optische Geraete GmbH
发明人： Bille, Josef
IPC分类号： A61F9/01 , A61F9/08 , A61B3/107
CPC分类号： A61B3/1015 , A61B2017/00017 , A61F9/00806 , A61F2009/00844 , A61F2009/00848 , A61F2009/00855 , A61F2009/00872 , A61F2009/0088
摘要： The present invention provides a closed-loop control system for superficial photoablation of tissue from an exposed stromal surface of an eye wherein the exposed surface introduces mechanically induced optical aberrations, said system comprising a source for generating an incising laser beam for photoablation of tissue from the exposed surface, a source for generating a diagnostic laser beam, a deformable mirror for directing said diagnostic laser beam through the exposed stromal surface to a focal spot on the retina of the eye, a detector for using light from said diagnostic beam reflected from the retina through the exposed stromal surface to generate an induced wavefront having characteristics of the mechanically induced optical aberrations, together with a distorted wavefront having actual real-time characteristics of the cornea, a compensator for altering a predetermined desired wavefront by incorporating said induced wavefront therewith to create a rectified wavefront, a comparator for comparing said rectified wavefront with said distorted wavefront to create an error signal, a means for reconfiguring said deformable mirror in accordance with said error signal to maintain a focal spot on the retina, and a means for ceasing generation of said incising laser beam when said error signal is a null. The present invention also provides a method for preparing a system for photoablation of a mechanically exposed stromal surface of an eye comprising providing the system with a distorted wavefront that has been determined by previous diagnosis of the eye and a desired wavefront.

93. 发明公开

EP1301154A2 LASER FLUENCE COMPENSATION OF A CURVED SURFACE 审中-公开
标题翻译：歪表面的激光流量补偿
公开(公告)号：EP1301154A2
公开(公告)日：2003-04-16
申请号：EP01901958.7
申请日：2001-01-11
申请人： LaserSight Technologies, Inc.
发明人： KLIEWER, Michael, L. , SMITH, Michael, J.
IPC分类号： A61F9/01
CPC分类号： B23K26/073 , A61F9/00806 , A61F9/00817 , A61F2009/00844 , A61F2009/00855 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882
摘要： A laser system and techniques which compensate for laser fluence drop off or losses of irradiation as an ablating laser beam is traversed on a curved surface (10) (e.g., on corneal tissue). The disclosed ablating laser system and techniques compensated for fluence differentials from pulse-to-pulse by adjusting an appropriate parameter of a laser beam. In the preferred embodiment, the number of pulses imparted in the periphery, the size or shape of the ablating laser beam is adjusted with, e.g., a variable aperture (30) placed in the beam delivery path, by changing a magnification of relay optics (40) in the beam delivery path, or by increasing a number of ablation spots in peripheral portions of an ablation zone as compared with the number of ablation spots in a central portion of the ablation zone.

94. 发明公开

EP1280469A1 NON-PENETRATING FILTRATION SURGERY 有权
标题翻译：不会渗透滤过手术
公开(公告)号：EP1280469A1
公开(公告)日：2003-02-05
申请号：EP00922836.2
申请日：2000-05-08
申请人： Optotech Ltd.
发明人： HAREL, Alex , ASSIA, Ehud , SHARGIL, Adi
IPC分类号： A61B18/18
CPC分类号： A61F9/00821 , A61B2017/00017 , A61F9/008 , A61F9/00802 , A61F2009/00855 , A61F2009/00865 , A61F2009/00872 , A61F2009/00891 , A61F2009/00897
摘要： This invention is an apparatus for ophthalmic surgery comprising a laser source (52) that generates a laser beam (54); a scanner (56) comprising an input for said laser beam, and an output of a spatially scanned laser beam (54); controlling circuitry that drives said scanner (56) to remove tissue in a desired pattern on the eye (40); a microscope (58) for viewing said tissue removal; and a beam combiner (70) comprising a first input for a line of sight of said microscope (58) and second input for said spatially scanned beam (54).

95. 发明公开

EP1210923A2 Control system for corneal laser surgery 有权
标题翻译： Hornhaut-Laser-Chirurgie的Steuerungssystemfürdie
公开(公告)号：EP1210923A2
公开(公告)日：2002-06-05
申请号：EP01308220.1
申请日：2001-09-27
申请人： 20/10 Perfect Vision Optische Geraete GmbH
发明人： Bille, Josef
IPC分类号： A61F9/01
CPC分类号： A61B3/1015 , A61B2017/00017 , A61F9/00806 , A61F2009/00844 , A61F2009/00848 , A61F2009/00855 , A61F2009/00872 , A61F2009/0088
摘要： The present invention provides a closed-loop control system for superficial photoablation of tissue from an exposed stromal surface of an eye wherein the exposed surface introduces mechanically induced optical aberrations, said system comprising a source for generating an incising laser beam for photoablation of tissue from the exposed surface, a source for generating a diagnostic laser beam, a deformable mirror for directing said diagnostic laser beam through the exposed stromal surface to a focal spot on the retina of the eye, a detector for using light from said diagnostic beam reflected from the retina through the exposed stromal surface to generate an induced wavefront having characteristics of the mechanically induced optical aberrations, together with a distorted wavefront having actual real-time characteristics of the cornea, a compensator for altering a predetermined desired wavefront by incorporating said induced wavefront therewith to create a rectified wavefront, a comparator for comparing said rectified wavefront with said distorted wavefront to create an error signal, a means for reconfiguring said deformable mirror in accordance with said error signal to maintain a focal spot on the retina, and a means for ceasing generation of said incising laser beam when said error signal is a null.
The present invention also provides a method for preparing a system for photoablation of a mechanically exposed stromal surface of an eye comprising providing the system with a distorted wavefront that has been determined by previous diagnosis of the eye and a desired wavefront.
摘要翻译：本发明提供了一种闭环控制系统，用于从眼睛的暴露的基质表面的组织表面光消融，其中暴露表面引入机械感应的光学像差，所述系统包括用于产生切割激光束的源，用于从暴露表面，用于产生诊断激光束的源，用于将所述诊断激光束通过暴露的基质表面引导到眼睛的视网膜上的焦斑的可变形反射镜，用于使用来自视网膜反射的所述诊断光的光的检测器通过暴露的基质表面产生具有机械感应的光学像差的特征的感应波阵面，以及具有角膜的实际实时特性的失真波阵面，用于通过将所述感应波前并入而改变预定的所需波前的补偿器，以产生一个纠正的波前，一个比较或用于将所述经整流的波前与所述畸变波阵面进行比较以产生误差信号;根据所述误差信号重新配置所述可变形反射镜以在视网膜上保持焦点的装置，以及用于停止产生所述切割激光束的装置，所述错误信号为空。本发明还提供了一种用于制备眼睛的机械暴露的基质表面的光消融的系统的方法，包括向所述系统提供由先前的眼睛诊断和期望的波前确定的失真的波前。

96. 发明授权

EP0681724B1 LASER CALIBRATION DEVICE 失效转让
标题翻译： DEVICE FOR校准激光
公开(公告)号：EP0681724B1
公开(公告)日：1999-08-04
申请号：EP94904501.7
申请日：1993-12-20
申请人： Novartis AG , Novartis-Erfindungen Verwaltungsgesellschaft m.b.H.
发明人： HALL, Deborah, K. , RENCS, Erik
IPC分类号： G09B23/28 , A61F9/00 , G09B23/30
CPC分类号： A61F9/008 , A61B2017/00707 , A61B2017/00725 , A61F9/00804 , A61F9/00814 , A61F2009/00855 , A61F2009/00872 , G09B23/30

97. 发明公开

EP0921764A1 CONOSCOPIC SYSTEM FOR REAL-TIME CORNEAL TOPOGRAPHY 失效
标题翻译：锥光拍摄装置用于实时角膜地形图
公开(公告)号：EP0921764A1
公开(公告)日：1999-06-16
申请号：EP97926482.0
申请日：1997-05-09
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY
发明人： MOSER, Christophe , BARBASTATHIS, Georgios , PSALTIS, Demetri
IPC分类号： A61B3 , A61F9 , G01B11 , A61B18
CPC分类号： G01B11/255 , A61B3/107 , A61B18/20 , A61B2018/00636 , A61F9/00804 , A61F2009/00844 , A61F2009/00855 , A61F2009/00872 , A61F2009/00882 , A61F2009/00897 , G03H1/0493
摘要： The invention is a corneal topographer (240) based on cornea-scope holography with partially coherent illumination. Corneal topographic measurements can be accomplished at a processing rate higher than the standard video rate of 30 Hz. The corneo-scope measurements can be used in an optic electronic servo (220) to control photo-refractive keratectomy system (200) in real time for an improved accuracy in laser ablation of a corneal surface of the eye (230).

98. 发明公开

EP0790807A1 LASER SCULPTING METHOD AND SYSTEM 失效
标题翻译： LASER雕塑的方法和系统
公开(公告)号：EP0790807A1
公开(公告)日：1997-08-27
申请号：EP95916976.0
申请日：1995-04-18
申请人： AUTONOMOUS TECHNOLOGIES CORPORATION
发明人： FREY, Rudolph, W. , BURKHALTER, James, H. , GRAY, Gary, P.
IPC分类号： A61B , B23K , B44B , H01S , A61B19 , A61F7 , A61F9 , A61N5
CPC分类号： A61F9/008 , A61F9/00804 , A61F2009/00855 , A61F2009/00872 , A61F2009/00897
摘要： A method and system are provided for eroding or ablating a shaped volume of an eye's corneal tissue (10) in accordance with the treatment of a specified eye condition. To determine the laser beam shot pattern, a plurality of laser beam shots of uniform intensity are first selected to form a uniform shot pattern of uniform shot density. The laser beam shots applied in accordance with the uniform shot pattern of uniform shot density would be capable of eroding a volume of the corneal tissue (10) of uniform height. The volume of uniform height is approximately equivalent to that of the shaped volume. The laser beam shots are applied to the corneal tissue in a spatially distributed pattern spread over an area approximately equivalent to the surface area of the shaped volume to be eroded. The spatially distributed pattern extends the uniform shot pattern in fixed angles from a reference position on the shaped volume representative of the shaped volume's axis of symmetry. Shot density for the laser beam shots changes in correspondence with distance from the reference position.

99. 发明公开

EP3377010A1 METHOD FOR TESTING A LASER DEVICE 有权转让
公开(公告)号：EP3377010A1
公开(公告)日：2018-09-26
申请号：EP16763590.3
申请日：2016-08-26
申请人： NOVARTIS AG
发明人： ABRAHAM, Mario , RIEDEL, Peter
IPC分类号： A61F9/008
CPC分类号： A61F9/00802 , A61F9/00825 , A61F2009/00846 , A61F2009/00855 , A61F2009/00859 , A61F2009/00872 , G01N21/84 , G01N2201/06113
摘要： A method for testing a laser device configured to emit pulsed, focused laser radiation includes providing an artificial eye body with a pattern that simulates a pupil and/or an iris structure. An irradiation test object is arranged above the pattern. The irradiation test object is separate from the eye body and is made of a material that is modifiable by the laser radiation. The laser radiation is applied to the irradiation test object according to a predefined application profile, so that a material modification that corresponds to the application profile is generated in the irradiation test object.

100. 发明授权

EP2709576B1 VERFAHREN ZUR KALIBRIERUNG EINES SYSTEMS ZUR CHIRURGISCHEN BEHANDLUNG EINES AUGES 有权转让
标题翻译：一种校正眼睛手术治疗系统的方法
公开(公告)号：EP2709576B1
公开(公告)日：2018-04-11
申请号：EP11720390.1
申请日：2011-05-16
申请人： WaveLight GmbH
发明人： WELLHOEFER, Armin , DONITZKY, Christof
IPC分类号： A61F9/008
CPC分类号： A61F9/00802 , A61F2009/00844 , A61F2009/00855

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