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91. 发明公开

EP3098326A1 ISOTHERMAL AMPLIFICATION ASSAY FOR RAPID AND ACCURATE DETECTION OF HEMORRHAGIC FEVER VIRUSES IN CLINICAL SAMPLES 审中-公开
标题翻译：等温扩增程序出血蝗VIREN快速，准确的检测在临床试验
公开(公告)号：EP3098326A1
公开(公告)日：2016-11-30
申请号：EP15305798.9
申请日：2015-05-27
申请人： INSTITUT PASTEUR
发明人： Manuguerra, Jean-Claude , Escadafal, Camille , Kwasiborski, Aurélia , Vanhomwegen, Jessica
IPC分类号： C12Q1/70
CPC分类号： C12Q1/701
摘要： The invention relates to a method for diagnosing a Viral Hemorrhagic Fever by isothermal amplification of a target sequence of a Hemorrhagic Fever virus nucleic acid located within a gene which codes for a protein of the viral ribonucleocapsid. The invention relates also to a kit for performing the method.
摘要翻译：本发明涉及一种用于通过位于基因，其编码病毒核壳体的蛋白质内的出血热病毒核酸的靶序列的等温扩增诊断病毒性出血热的方法。本发明涉及这样一种试剂盒，用于执行该方法。

92. 发明公开

EP3074512A1 TAL EFFECTOR MEANS USEFUL FOR PARTIAL OR FULL DELETION OF DNA TANDEM REPEATS 审中-公开
标题翻译： TAL-EFFEKTORMITTEL ZUR PARTIELLEN ODERVOLLSTÄNDIGEN删除VON DNA-TANDEM-REPEATS
公开(公告)号：EP3074512A1
公开(公告)日：2016-10-05
申请号：EP14838781.4
申请日：2014-11-26
申请人： Institut Pasteur
发明人： RICHARD, Guy-Franck , MOSBACH, Valentine , VITERBO, David
IPC分类号： C12N9/22 , C12N15/10 , C12N15/62 , A61P25/00 , A61P21/00 , A61P19/00 , A61K38/16 , A61K48/00
CPC分类号： C12N9/22 , A61K48/005 , C07K2319/80 , C12N15/62 , C12N15/907 , C12Y301/21004
摘要： The application relates to means, which derive from TAL effectors and TALENs. The structure of the means of the application is especially adapted for partial or full deletion of at least one DNA tandem repeat, more particularly for partial or full deletion of at least one DNA tandem repeat in a double-stranded DNA, more particularly for partial or full deletion of at least one DNA tandem repeat, which is contained in a double-stranded DNA and, which forms a complex secondary structure, such as a hairpin, a triple helix or a tetraplex secondary structure. The means of the application are notably useful in the treatment and/or prevention and/or palliation of a disease or disorder involving at least one DNA tandem repeat, such as DM1, SCA8, SCA12, HDL2, SBMA, HD, DRPLA, SCA1, SCA2, SCA3, SCA6, SCA7, SCA17, PSACH, DM2, SCA10, SPD1, OPMD, CCD, HPE5, HFG syndrome, BPES, EIRE1, FRAXA, FXTAS and FRAXE.
摘要翻译：本申请涉及从TAL效应器和TALEN得到的方法。所述应用手段的结构特别适用于部分或完全缺失至少一个DNA串联重复，更特别地适用于双链DNA中至少一个DNA串联重复的部分或完全缺失，更特别是部分或全部至少一个DNA串联重复的完全缺失，其包含在双链DNA中，并形成复合二级结构，例如发夹，三螺旋或四倍体二级结构。本申请的方法在治疗和/或预防和/或缓解涉及至少一种DNA串联重复的疾病或病症中非常有用，例如DM1，SCA8，SCA12，HDL2，SBMA，HD，DRPLA，SCA1， SCA2，SCA3，SCA6，SCA7，SCA17，PSACH，DM2，SCA10，SPD1，OPMD，CCD，HPE5，HFG综合征，BPES，EIRE1，FRAXA，FXTAS和FRAXE。

93. 发明授权

EP2059609B1 GENOMIC MORSE CODE 有权
标题翻译：基因组莫尔斯电码
公开(公告)号：EP2059609B1
公开(公告)日：2016-08-31
申请号：EP07803261.2
申请日：2007-09-05
申请人： Institut Pasteur , Genomic Vision
发明人： LEBOFSKY, Ronald , BENSIMON, Aaron , WALRAFEN, Pierre
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6841 , Y10T436/143333

94. 发明公开

EP3013357A1 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF ACUTE EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE 审中-公开
标题翻译：用于治疗慢性阻塞性肺病急性加重的方法和药物组合物
公开(公告)号：EP3013357A1
公开(公告)日：2016-05-04
申请号：EP14735542.4
申请日：2014-06-27
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Institut Pasteur De Lille , Centre National pour la Recherche Scientifique (CNRS) , Université de Lille 1 Sciences et Technologies , Université de Droit et de la Santé de Lille 2
发明人： GOSSET, Philippe , PICHAVANT, Muriel , SHARAN, Riti
IPC分类号： A61K38/20 , A61P11/00
CPC分类号： A61K38/20 , A61K9/007 , A61K39/092 , A61K45/06 , A61K48/00 , A61K2039/521 , Y02A50/473 , Y02A50/478
摘要： The present invention relates to methods and pharmaceutical compositions for the treatment of acute exacerbation of chronic obstructive pulmonary disease. In particular, the invention relates to relates to a polypeptide selected from the group consisting of IL-22 polypeptides or IL-17 polypeptides for use in a method for the treatment of acute exacerbation of chronic obstructive pulmonary disease in a subject in need thereof.
摘要翻译：本发明涉及用于治疗慢性阻塞性肺病急性加重的方法和药物组合物。具体而言，本发明涉及用于在有需要的受试者中治疗慢性阻塞性肺病急性恶化的方法中使用的选自IL-22多肽或IL-17多肽的多肽。

95. 发明公开

EP3009142A1 OPIORPHIN FOR USE AS ANALGESIC AGENT 审中-公开
标题翻译： OPIORPHIN ZUR VERWENDUNG ALS ANALGETIKUM
公开(公告)号：EP3009142A1
公开(公告)日：2016-04-20
申请号：EP15188991.2
申请日：2009-05-26
申请人： Institut Pasteur
发明人： ROUGEOT, Catherine
IPC分类号： A61K38/08 , A61K38/55 , A61P25/04
CPC分类号： C07K14/47 , A61K38/08 , A61K38/1709
摘要： The present invention relates to peptides derived from human Basic Proline-rich Lacrimal Protein (BPLP), notably opiorphin, for use as analgesic agents for chronic treatment of pain
摘要翻译：本发明涉及衍生自人类基础脯氨酸丰富的泪液蛋白（BPLP）的肽，特别是opiorphin，用作慢性疼痛的镇痛剂

96. 发明公开

EP2904396A1 USE OF LEPTOSPIRA FAINEI SEROVAR HURSTBRIDGE BACTERIA FOR DIAGNOSING!LEPTOSPIROSIS 有权
标题翻译： VERWENDUNG VON LEPTOSPIRA FAINEI SERVV HURSTBRIDGE-BAKTERIEN ZUR DIAGNOSE VON LEPTOSPIROSE
公开(公告)号：EP2904396A1
公开(公告)日：2015-08-12
申请号：EP13771520.7
申请日：2013-10-04
申请人： Institut Pasteur
发明人： BOURHY, Pascale , CHANTEAU, Suzanne , GOARANT, Cyrille , PICARDEAU, Mathieu , NATO, Faradibano , DARTEVELLE, Sylvie
IPC分类号： G01N33/569 , G01N33/68
摘要： The present invention discloses an in vitro method for diagnosing a Leptospira infection in a biological sample of a subject, comprising a step of contacting said sample with bacterial cells of a serovar of the Leptospira fainei species, preferably bacterial cells of the Leptospira fainei serovar Hurstbridge, or an antigenic fraction of said bacterial cells. In a preferred embodiment, said Leptospira infection is not due to bacteria belonging to the serovar of the Leptospira fainei species used in the diagnostic method.
摘要翻译：本发明公开了一种用于诊断受试者生物样品中的钩端螺旋体感染的体外方法，其包括将所述样品与钩端螺旋体属（Leptospira fainei）的血清型细菌细胞接触的步骤，优选为钩端螺旋体钩端螺旋体梭菌Hurstbridge的细菌细胞，或所述细菌细胞的抗原级分。在优选的实施方案中，所述钩端螺旋体感染不是由于诊断方法中使用的属于钩端螺旋体属（Leptospira fainei）的血清型的细菌。

97. 发明公开

EP2903634A1 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE PROPHYLACTIC TREATMENT OF BACTERIAL SUPERINFECTIONS POST-INFLUENZA 审中-公开
标题翻译：方法和药物组合物，细菌PROPHELAKTISCHEN二重感染由流感诊疗
公开(公告)号：EP2903634A1
公开(公告)日：2015-08-12
申请号：EP13771149.5
申请日：2013-10-01
申请人： INSERM - Institut National de la Santé et de la Recherche Médicale , INSTITUT PASTEUR DE LILLE , Université de Lille 1 Sciences et Technologies , Centre National de la Recherche Scientifique (CNRS) , Université du Droit et de la Santé de Lille 2
发明人： TROTTEIN, François , FAVEEUW, Christelle. , IVANOV, Stoyan. , FOUNTAINE, Josette.
IPC分类号： A61K38/20 , A61P31/04 , G01N33/68
CPC分类号： A61K38/20 , A61K38/2066 , A61K45/06 , C12Q1/6883 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158 , G01N33/6869 , G01N2800/26 , G01N2800/50 , A61K2300/00
摘要： The present invention relates to methods and pharmaceutical compositions for the prophylactic treatment of bacterial superinfections post-influenza. In particular, the present invention relates to an interleukin 22 (IL-22) polypeptide for use in the prophylactic treatment of bacterial superinfections post-influenza in a subject in need thereof.

98. 发明公开

EP2873728A1 A subunit vaccine platform based on multimeric ribonucleoproteins comprising nucleoproteins of a non-segmented negative-strand RNA virus as carriers of heterologous polypeptides 审中-公开
标题翻译：亚单位疫苗平台基于与非节段负链RNA病毒核蛋白的多聚核糖异源多肽的载体
公开(公告)号：EP2873728A1
公开(公告)日：2015-05-20
申请号：EP13306577.1
申请日：2013-11-18
申请人： INSTITUT PASTEUR , Centre National de la Recherche Scientifique
发明人： Sala, Monica , Jacob, Daria , Tangy, Frédéric
IPC分类号： C12N7/00 , C12N15/81
CPC分类号： A61K39/165 , A61K39/015 , A61K39/125 , A61K2039/521 , A61K2039/523 , A61K2039/542 , A61K2039/545 , A61K2039/57 , A61K2039/575 , A61K2039/6031 , A61K2039/6075 , A61K2039/70 , C07K14/005 , C07K14/445 , C07K2319/85 , C12N7/00 , C12N15/815 , C12N2760/18422 , C12N2760/18434 , C12N2760/18451 , C12N2760/18471 , C12N2770/32322 , C12N2770/32334 , C12N2770/32351 , Y02A50/412
摘要： The present invention relates to a subunit vaccine platform based on multimeric ribonucleoproteins (RNPs) comprising nucleoproteins of a non-segmented negative-strand ribonucleic acid (RNA) virus as carriers of heterologous polypeptides. The present invention also relates to multimeric RNPs resulting from the assembly of at least 200 fusion proteins with a cellular RNA, or to recombinant yeasts or yeast lysates expressing these multimeric RNPs. It also concerns a process for the preparation of these multimeric RNPs or recombinant yeasts or yeast lysates. In particular, the present invention relates to their use as active ingredient for the in vitro production of an immunogenic composition or in eliciting a protective prophylactic or a therapeutic immune response against said heterologous polypeptide in a host in need thereof. Recombinant yeasts or yeast lysates of the invention can also be used as expression and vector systems for delivery to a host.
摘要翻译：本发明涉及一种亚单位疫苗平台基于多聚核糖核蛋白（RNP），其包含非节段负海滩核糖核酸（RNA）病毒作为异源多肽的载体的核蛋白。因此，本发明涉及一种多聚体RNP从至少200融合蛋白与细胞RNA的组装得到的，或与表达论文多聚RNP重组酵母或酵母裂解物。因此，它涉及一种用于合成多聚体RNP或重组酵母或酵母裂解物的制备方法。特别地，本发明涉及它们作为用于免疫原性组合物的体外生产或在引发保护性预防或抵抗在需要其的宿主所述异源多肽的治疗性免疫应答的活性成分使用。重组酵母或本发明的酵母溶胞产物可以因此被用作表达和载体系统用于输送到主机。

99. 发明公开

EP2873680A1 Oligopeptide and methods for producing conjugates thereof 审中-公开
标题翻译： Oligopeptid和Verfahren zur Herstellung von Konjugaten davon
公开(公告)号：EP2873680A1
公开(公告)日：2015-05-20
申请号：EP13306554.0
申请日：2013-11-13
申请人： F.Hoffmann-La Roche AG , INSTITUT PASTEUR
发明人： Lafaye, Pierre , Bay, Sylvie , Delatour, Benoît , Dhenain, Marc , Duyckaerts, Charles , Li, Tengfei , Vandesquille, Matthias , Czech, Christian , Grueninger, Fiona
IPC分类号： C07K16/18 , A61K47/48 , G01N33/00
CPC分类号： C07K16/18 , A61K49/0032 , A61K49/0058 , A61K49/085 , A61K49/16 , A61K51/1093 , C07K2317/22 , C07K2317/34 , C07K2317/565 , C07K2317/569 , C07K2317/92 , C07K2319/00 , G01N33/6854 , G01N2333/4709
摘要： The present invention relates to an oligopeptide and conjugates thereof. The present invention also relates to the use of these oligopeptide conjugates for treating or diagnosing disorders mediated by amyloid β deposits. Finally, the present invention also relates to a coupling method for obtaining oligopeptide coupled with a substance of interest (functional conjugates).
摘要翻译：本发明涉及寡肽及其缀合物。本发明还涉及这些寡肽缀合物用于治疗或诊断由淀粉样蛋白²沉积物介导的病症的用途。最后，本发明还涉及用于获得与感兴趣物质（功能性共轭物）偶联的寡肽的偶联方法。

100. 发明授权

EP2233567B1 Nucleotide sequence encoding the enzyme I-SceI and the uses thereof 失效
标题翻译：核苷酸序列编码酶I-SceI的及其用途
公开(公告)号：EP2233567B1
公开(公告)日：2015-03-18
申请号：EP09175319.4
申请日：1995-11-06
申请人： INSTITUT PASTEUR , Université Pierre et Marie Curie (Paris 6)
发明人： Choulika, André , Perrin, Arnaud , Dujon, Bernard , Nicolas, Jean-François
IPC分类号： C12N9/22 , C12N15/66 , C12Q1/68
CPC分类号： C12Q1/683 , A01K2217/05 , C12N9/22 , C12N15/66 , C12Q1/6841 , Y10S530/824

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