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91. 发明公开

EP1210120A1 NERVE CELL GROWTH MODULATORS (AMPHIBODIES) 审中-公开
标题翻译：神经细胞生长调节剂（AMPHIKÖRPER）
公开(公告)号：EP1210120A1
公开(公告)日：2002-06-05
申请号：EP00928054.6
申请日：2000-04-20
申请人： Fraidakis, Matt
发明人： OLSON, Lars
IPC分类号： A61K47/48 , A61K38/18 , A61K39/395
CPC分类号： C07K14/475 , A61K38/00 , A61K47/6425 , C07K16/18 , C07K2317/55 , C07K2319/00 , C07K2319/75 , C12N15/62
摘要： The present invention relates to a nerve cell growth modulator denoted an amphibody. The amphibody according to the invention is comprised of at least two components, wherein a first component is capable of binding to a target and suppressing, or essentially neutralising, a nerve cell growth inhibitor effect thereof; and a second component is capable of stimulating nerve cell growth and/or regeneration. In the most preferred embodiment, the present amphibody is a neuromodulator comprised of the above disclosed two components connected by a linker element. Amphibodies according to the invention are a useful means of molecular disguise of a non-permissive environment into a permissive, and outgrowth promotive and favorable one. The present invention also relates to genetic and chemical methods of preparation of an amphibody according to the invention as well as to various advantageous uses thereof.

92. 发明公开

EP1173284A1 HOMOGENISING OF SMALL-VOLUME MIXTURES BY CENTRIFUGATION AND HEATING 有权
标题翻译：均匀化了小共混物通过热和离心
公开(公告)号：EP1173284A1
公开(公告)日：2002-01-23
申请号：EP00921255.6
申请日：2000-03-24
申请人： Alphahelix AB
发明人： MALMQUIST, Mats
IPC分类号： B04B15/02 , B01F3/08 , B04B5/02 , G01N1/38
CPC分类号： B01L7/5255 , B01F9/0003 , B01L7/52 , B04B5/0407 , B04B15/02 , G01N1/44 , G01N2035/00495 , Y10T436/25375
摘要： The efficient temperation of a sample is achieved when the sample is subjected to centrifugation simultaneously with heating and optionally also cooling. This is achieved in a device comprising at least a rotor (1) for holding reaction vessels (2), a motor (3), connected to said rotor, means such as a processor (4) for controlling the speed of the rotor, and means (5 and 6) for heating and cooling the contents of the reaction vessels, wherein the means (6) for heating cover the apices of the reaction vessels for at least part of the rotational path of said vessels and that the means for heating operate at a temperature significantly higher than the melting temperature of the reaction vessels. The invention further relates to a method for performing chemical reactions and in particular a method for performing biochemical reactions involving thermocycling, for example PCR-reactions.

93. 发明公开

EP1169044A1 USE OF FUCOSYLATED SIALYLATED N-ACETYL LACTOSAMINE CARBOHYDRATE STRUCTURES FOR INHIBITION OF BACTERIAL ADHERENCE 有权
标题翻译： FUCOSILIERTEN SIALILIERTEN N-乙酰基 - 乳糖胺的糖结构用于抑制细菌粘附USE
公开(公告)号：EP1169044A1
公开(公告)日：2002-01-09
申请号：EP00921217.6
申请日：2000-03-16
申请人： Borén, Thomas
发明人： BOR N, Thomas , HAMMARSTRÖM, Lennart , KARLSSON, Karl-Anders , TENEBERG, Susann
IPC分类号： A61K31/702 , A61K31/715 , A61P1/04
CPC分类号： A61K31/702 , A61K31/715 , A61K31/726 , A61K39/395
摘要： A fucosylated sialylated N-acetyl lactosamine structure such as a sialyl-Lewis antigen carbohydrate structure, for example sialyl-Lewis x and in particular dimeric or repetitive sialyl-Lewis x can be used for the preparation of a pharmaceutical composition for the treatment or prophylaxis in humans of conditions involving infection by Helicobacter pylori and related pathogens of the human gastrointestinal mucosa. Further, said conditions can be treated through the administration of a fucosylated sialylated lactosamine structure, such as a sialyl-Lewis antigen carbohydrate structure or corresponding antibodies to patients in need thereof.

94. 发明公开

EP1167383A1 Novel conjugates of opioids and endogenous carriers 有权
标题翻译：阿片样物质内分泌素trägerproteinen
公开(公告)号：EP1167383A1
公开(公告)日：2002-01-02
申请号：EP01121557.1
申请日：1998-11-06
申请人： Conjuchem, Inc.
发明人： Ezrin, Alan M. , Bridon, Dominique P. , Holmes, Darren L. , Milner, Peter
IPC分类号： C07K14/665 , C07K14/70 , A61K47/48
CPC分类号： A61K49/0056 , A61K38/00 , A61K47/643 , A61K47/6901 , C07K14/665
摘要： Conjugates are prepared from antinociceptive agents, particularly opioids or opioid analogs, more particularly dynorphins, endorphins, deltorphins, enkephalins or analogs thereof, by combining said antinociceptive agent with a material providing a functionally reactive group capable of reacting with a blood component (preferably a blood cell or protein). Said conjugates permit extension of the therapeutic life of the antinociceptive agent. They may be administered to patients to alleviate pain, produce analgesic effects, or assist in cases of narcotics withdrawal, and may also be used as probes for receptor activity. The administration to the patient may be made either in vivo or ex vivo and may be performed by either introducing the derivative including the reactive functional group into the patient's vascular system or preparing such a conjugate externally (or in vitro ) and introducing that conjugate to the patient's vascular system.
摘要翻译：通过将所述抗伤害感受剂与提供能够与血液成分（优选血液）反应的功能反应性基团的材料组合，由抗感受伤害剂，特别是阿片样物质或阿片样物质类似物，更特别是强啡肽，内啡肽，去角质素，脑啡肽或其类似物制备缀合物细胞或蛋白质）。所述缀合物允许延长抗伤害感受剂的治疗寿命。可以向患者施用以缓解疼痛，产生镇痛作用或辅助戒毒的情况，并且也可以用作受体活性的探针。对患者的施用可以在体内或体外制备，并且可以通过将包含反应性官能团的衍生物引入患者的血管系统中或者从外部（或体外）引入该缀合物并将该缀合物引入到病人的血管系统。

95. 发明公开

EP1159756A2 COMPOUNDS FOR THE TREATMENT OF CANCER 有权
标题翻译： LINKS用于癌症治疗
公开(公告)号：EP1159756A2
公开(公告)日：2001-12-05
申请号：EP99958453.5
申请日：1999-12-28
申请人： Ardenia Investments Ltd.
发明人： STRELCHENOK, Oleg
IPC分类号： H01L21/00
CPC分类号： C07H15/252
摘要： It is shown that the potency of anti-cancer drugs, here exemplified by doxorubicin, can be increased by the use of polyunsaturated fatty acid amides and in particular specific combinations of such compounds, forming complexes with doxorubicin. Further, a modified form of doxorubicin is presented.

96. 发明公开

EP1140108A1 METHOD AND COMPOSITION FOR TREATMENT OF FEMALE SEXUAL DYSFUNCTION 有权
标题翻译：方法和组合性功能障碍的女性的治疗
公开(公告)号：EP1140108A1
公开(公告)日：2001-10-10
申请号：EP00901353.3
申请日：2000-01-04
申请人： Synphora AB
发明人： STJERNSCHANTZ, Johan , RESUL, Bahram
IPC分类号： A61K31/557
CPC分类号： A61K31/557
摘要： The present invention makes available a composition for the treatment of female sexual dysfunction, said composition comprising a selective EP2 or EP4 prostanoid receptor agonist and in particular one of 19-hydroxy-PGE2, 19R-hydroxy-PGE2, 18-hydroxy-PGE2, 20-hydroxy-PGE2, or salts or esters thereof. The invention further discloses a method of treatment of female sexual dysfunction, wherein the above composition is applied topically in the form of a cream, gel, ointment or solids.

97. 发明公开

EP1137301A1 Method for location of mobile stations in a mobile network 审中-公开
标题翻译： Verfahren zur Erfassung der Position einesMobilfunkendgerätesin einem mobilfunknetz
公开(公告)号：EP1137301A1
公开(公告)日：2001-09-26
申请号：EP00850053.0
申请日：2000-03-23
申请人： TELEFONAKTIEBOLAGET L M ERICSSON (publ)
发明人： Cedervall, Mats , Kangas, Ari , Jober, Johan
IPC分类号： H04Q7/38
CPC分类号： H04W64/00 , G01S5/10
摘要： The invention is concerned with a method for location of mobile stations within a mobile network including at least two mobile stations and at least three base stations, by means of signal measurements performed at the mobile stations and/or the base stations. In the method of the invention two or more mobile stations are loctaed simultaneously by minimizing a cost-function, which is achieved by means of a sufficient number of equations, whereby in each equation the location of a mobile station is a function of the location of a base station in the network and performed signal measurements.
摘要翻译：本发明涉及通过在移动站和/或基站处执行的信号测量来确定移动站内的至少两个移动站和至少三个基站的移动站的位置的方法。在本发明的方法中，通过最小化成本函数同时获得两个或多个移动站，该成本函数是通过足够数量的方程来实现的，由此在每个等式中，移动站的位置是网络中的基站并执行信号测量。

98. 发明公开

EP1135152A1 A PHARMACEUTICAL COMPOSITION COMPRISING CYCLOSPORIN IN A LIPID CARRIER 审中-公开
标题翻译：在环孢菌素脂肪的载体的药物组合物含有
公开(公告)号：EP1135152A1
公开(公告)日：2001-09-26
申请号：EP99963798.6
申请日：1999-12-03
申请人： Lipocore Holding AB
发明人： HERSLÖF, Bengt , KAUFMANN, Peter , KROON, Carl-Gunnar
IPC分类号： A61K38/13 , A61K9/107
CPC分类号： A61K9/1274 , A61K38/13
摘要： A pharmaceutical composition comprising a cyclosporin as an active substance in a lipid carrier, which carrier comprises membrane lipids in combination with monoglycerides and optionally non-polar lipids, which composition is characterized in being liquid at room temperature and containing 0.5-25 % cyclosporin, 10-45 % membrane lipids, 10-55 % monoglycerides and 0-45 % non-polar lipids. A composition of the invention is bioequivalent to a commercial drug containing in addition to cyclosporin and additives also toxic emulsifiers and ethanol.

99. 发明公开

EP1126835A1 METHOD FOR PREVENTING INCREASED IRIDIAL PIGMENTATION DURING PROSTAGLANDIN TREATMENT 审中-公开
标题翻译：程序为IRIS的色素沉着增加过程中前列腺素的预防
公开(公告)号：EP1126835A1
公开(公告)日：2001-08-29
申请号：EP99971315.9
申请日：1999-11-04
申请人： Synphora AB
发明人： STJERNSCHANTZ, Johan , RESUL, Bahram
IPC分类号： A61K31/18 , A61K31/40 , A61K31/12 , A61K31/557 , A61K45/00 , A61P27/06
CPC分类号： A61K31/573 , A61K31/00 , A61K31/405
摘要： Anti-inflammatory agents are used to prevent iridial pigmentation during prostaglandin treatment and to manufacture pharmaceuticals for this purpose. A method for preventing iridial pigmentation as well as a method for treating glaucoma is based on the concomitant or simultaneous administration of a prostaglandin or prostaglandin analogue and an anti-inflammatory agent. Both non-steroid and steroid anti-inflammatory agents can be employed according to the invention.

100. 发明公开

EP1121596A1 MICROARRAY SYSTEM AND PROCESS FOR PERFORMING BIOCHEMICAL REACTIONS 审中-公开
标题翻译：微阵列系统AND METHOD FOR PERFORMING生化反应
公开(公告)号：EP1121596A1
公开(公告)日：2001-08-08
申请号：EP99970472.9
申请日：1999-10-12
申请人： Picron Microarray AB
发明人： MALMQUIST, Mats
IPC分类号： G01N33/543
CPC分类号： G01N33/54306 , B01J2219/00164 , B01J2219/005 , B01J2219/00648 , B01J2219/00659 , B01J2219/00664
摘要： A particulate or dynamic microarray system is produced by immobilising reactant molecules on particles, arranged in at least three distinct groups corresponding to the number of reactants used. Preferably, the groups are separated by intervening groups without immobilised reactant molecules or with specific signal molecules. Further, the particles are suspended in a medium which can be solidified subsequent to the reaction or reactions between analytes and immobilised reagents. The inventive system offers better kinetic properties than presently used spatially static microarrays, where reactant molecules are immobilised e.g. on gels or chips.

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