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91. 发明公开

EP1494701A2 IMMUNOSUPPRESSANT COMPOUNDS, METHODS AND USES RELATED THERETO 审中-公开
标题翻译：免疫抑制化合物过程和相关的应用
公开(公告)号：EP1494701A2
公开(公告)日：2005-01-12
申请号：EP03714400.3
申请日：2003-03-24
申请人： GPC Biotech AG
发明人： NAGY, Zoltan , BRANDSTETTER, Tilmann
IPC分类号： A61K38/03 , A61K39/00 , A61K45/00 , C07K4/00
CPC分类号： C07K7/08 , A61K38/00 , C07K5/06078 , C07K5/0812 , C07K5/1016 , C07K7/02
摘要： The present invention relates to compositions and methods for suppressing an immune response, e.g, by inhibiting class II MHC- mediated activation of T cells. The subject compounds and methods may be used to treat or prevent disorders such as rheumatoid arthritis and/or multiple sclerosis.

92. 发明公开

EP1478776A2 VERFAHREN ZUR QUALITATIVEN UND QUANTITATIVEN BESTIMMUNG VON GENETISCHEM MATERIAL 有权
标题翻译：方法遗传物质的定性和定量测定
公开(公告)号：EP1478776A2
公开(公告)日：2004-11-24
申请号：EP03706577.8
申请日：2003-02-25
申请人： Bezirksverband Pfalz
发明人： HORMISCH, Diana , STRAUSS, Gerhard
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6813 , C12Q2545/101
摘要： The invention relates to a method for the qualitative and quantitative determination of genetic material that contains a known target sequence characteristic of the material and that can be present in addition to or mixed with another genetic material. According to the invention, a suspension that contains the genetic material with the target sequence and optionally other genetic material is (1) mixed with a molar excess of a first oligonucleotide probe whose nucleotide sequence is complementary to the target sequence, and optionally (2) mixed with a molar excess of a second oligonucleotide probe whose nucleotide sequence is complementary to a nucleotide sequence that is contained in all components of the entire genetic material to which the quantification shall apply. The entire genetic material, as far as double-stranded, is then converted to single strands, the first oligonucleotide probe is hybridized to the target sequence and optionally the second oligonucleotide probe is hybridized to the nucleotide sequence that is contained in all components of the genetic material. The concentration(s) of the non-hybridized first and optionally second oligonucleotide probe in the suspension is then determined and the share of genetic material having the target sequence in the entire genetic material to which the quantification shall be applied is determined from the concentration(s).

93. 发明公开

EP1465983A2 ENDOTHELIAL STEM CELLS, POPULATIONS, METHODS OF ISOLATION AND USE THEREOF 有权
标题翻译： ENDOTHELSTAMMZELLEN，人口，保温方法及用途
公开(公告)号：EP1465983A2
公开(公告)日：2004-10-13
申请号：EP02796023.6
申请日：2002-12-20
申请人： Immunex Corporation
发明人： FANSLOW III, William, C. , ROUSSEAU, Anne-Marie, C. , DANIEL, Thomas, O.
IPC分类号： C12N5/02 , A01N63/00
CPC分类号： C12N5/0691 , A61K35/12 , C12N5/0692
摘要： The present invention provides stem cells characterized as having the ability to renew and the ability to give rise to endothelial and/or endothelial-like cells, methods of isolating such stem cells and methods of use thereof. Also provided are progeny cells derived from the stem cells of the invention.

94. 发明授权

EP0676471B1 Effector proteins of rapamycin 失效
标题翻译：效应蛋白雷帕霉素
公开(公告)号：EP0676471B1
公开(公告)日：2004-09-29
申请号：EP95301475.0
申请日：1995-03-07
申请人： Wyeth , The Trustees of Columbia University in the City of New York
发明人： Molnar-Kimber, Katherine Lu , Failli, Amedeo Arturo , Caggiano, Thomas Joseph , Nakanishi, Koji , Chen, Yanqiu
IPC分类号： C12N15/12 , C07K14/705 , G01N33/68 , A61K31/70
CPC分类号： C12N9/1205 , A61K38/00 , C07K14/705 , G01N33/68

95. 发明公开

EP1441602A1 MOLECULAR PRESS DEHYDRATION METHOD FOR VEGETATIVE TISSUE USING THE SOLID PHASE OF WATER SOLUBLE POLYMER SUBSTANCES AS A DEHYDRATING AGENT 审中-公开
标题翻译：分子PRESS-排水法植物组织利用水的聚合物材料固相AS排出介质
公开(公告)号：EP1441602A1
公开(公告)日：2004-08-04
申请号：EP02802743.1
申请日：2002-09-02
申请人： YOO, Myung-Shik , SEO, Hyun-Chang
发明人： YOO, Myung-Shik , SEO, Hyun-Chang
IPC分类号： A23L3/40
CPC分类号： A61K8/02 , A01N3/00 , A23B7/02 , A23B7/0205 , A23B7/022 , A23B7/03 , A23B9/08 , A23L3/40 , A23L3/42 , A61K8/64 , A61K8/645 , A61K8/73 , A61K8/86 , A61K8/97 , A61K9/19 , A61K47/10 , A61K47/36 , A61K47/42 , A61Q19/00
摘要： The present method is related to a molecular press dehydration method of vegetative tissues using water-soluble polymers in solid-phase as dehydrating agents. The molecular press dehydration method of the present invention is characterized by that dehydration is done by induction of cytorrhysis to vegetative tissues mixed with water-soluble polymers such as PEG, gum arabic, arabinogalactan, egg albumin, milk protein, soybean protein, etc. in its solid-phase. Compared to the conventional dehydration methods, the present method enables to obtain much greater dehydration effects in the amount and the rate, even though a very small amount of polymer substance is used; and the method enables to obtain excellent quality of dehydrated tissues as well as dehydrated exudates; and is environmentally friendly under favor of reduced energy consumption. The dehydrated vegetative tissues are excellent in their storage stability, and flavor and texture after rehydration, and dehydrated exudates are excellent in the concentrated useful components, flavor, and preservation quality. Therefore, the dehydrated vegetative tissues and exudates obtained by using the dehydration method of the present invention may be usefully applied to various fields such as foods and beverages, feeds, cosmetics, medicines, flavorings, agricultural chemicals, coloring agents, etc. according to the characteristics of plants.

96. 发明公开

EP1437145A1 Enhanced scintigraphic imaging agents for imaging of infection and inflammation 审中-公开
标题翻译：改进的闪烁照相成像剂进行感染和炎症的制备
公开(公告)号：EP1437145A1
公开(公告)日：2004-07-14
申请号：EP03000204.2
申请日：2003-01-07
申请人： Schering AG
发明人： Manchanda, Rajesh , Krause, Sabine
IPC分类号： A61K51/08
CPC分类号： A61K31/70 , A61K51/08 , A61K51/088 , Y02A50/473
摘要： The invention describes enhanced scintigraphic imaging agents that can be used to localize infection and inflammation in a mammal. Specifically, the invention relates to radiolabeled, preferably technetium-99m labeled scintigraphic imaging agents that are compositions of a polysulfated glycan or mixture thereof and a compound comprising a polybasic peptide covalently linked to a radiolabel binding moiety. Methods and kits for making such compositions, and methods for using such compositions to image sites of infection and inflammation in a mammalian body are also provided. The enhanced imaging agents exhibit improved binding affinity to the polysulfated glycans, better biodistribution and infection uptake, thus providing improved imaging results.
摘要翻译：的试剂（R）包括多元化合物包含肽，其中肽包含至少四个精氨酸残基，和一个无线电标签 - 结合部分共价连接到多元化合物，其中所述试剂是能够在体内病理部位累积的，因此独立权利要求中包括了以下内容：（1）多聚试剂（MR），其包含（R）的至少两个多元化合物，其可以是相同的或不同的，至少一个无线电标签 - 结合部分共价连接到的所述一个多元化合物，和多价左部分共价连接到多元化合物中，无线标签结合部分或二者，其中所述多聚体多价试剂的分子量小于20000沓; （2）配合物（CO）由任一，使（R）与锝-99m在还原剂，优选连二亚硫酸盐离子，亚锡离子和亚铁离子，或标记（R）中选择的还原剂的存在下形成有锝 99米通过预还原的锝-99m配合物的配位体交换; （3）的组合物（C），其包含（R），其具有1000Da的，其中该组合物能够在哺乳动物体内的病理位点积累的分子量的多硫酸化聚糖; （4）闪烁照相成像剂（IA），其包含（C）和放射性同位素，其中所述放射性同位素是由它的无线电标签结合部分络合到所述试剂组合物内; （5）药物组合物（PC），其包含（R），（CO），（C），或（IA），并且还包括一个载体; （6）用于制备放射性药物制剂的试剂盒（K），所述试剂盒包含一个第一密封小瓶含有的（R）的预定量，和还原剂的足够量的标记试剂与放射性同位素，和第二密封小瓶包含预定（C）的一种多硫酸化多糖的量; 和（7）制备（M1），（R）通过体外化学合成。

97. 发明公开

EP1411058A1 Metallocene compositions 有权
标题翻译：双酚基金属配合物
公开(公告)号：EP1411058A1
公开(公告)日：2004-04-21
申请号：EP03027480.7
申请日：2001-05-21
申请人： ExxonMobil Chemical Patents Inc.
发明人： Kuchta, Matthew C. , Stehling, Udo M. , Li, Robert T. , Haygood, William T. , Burkhardt, Terry J.
IPC分类号： C07F17/00
CPC分类号： C07F17/00 , C08F4/65908 , C08F4/65912 , C08F4/65916 , C08F10/00 , C08F110/02 , C08F110/06 , C08F210/06 , C08F210/16 , C08F4/65927 , C08F2500/12 , C08F2500/03 , C08F2500/17 , C08F2500/15 , C08F2500/21
摘要： This invention relates to metallocene compositions and their use in the preparation of catalyst systems for olefin polymerization, particularly propylene polymerization. The metallocenes of the present invention may be represented by the formula:
wherein: M is a metal of Group 4, 5, or 6 of the Periodic Table;
R 1 and R 2 are identical or different, and are one of a hydrogen atom, a C 1 -C 10 alkyl group, a C 1 -C 10 alkoxy group, a C 6 -C 10 aryl group, a C 6 -C 10 aryloxy group, a C 2 -C 10 alkenyl group, a C 7 -C 40 arylalkyl group, a C 7 -C 40 alkylaryl group, a C 8 -C 40 arylalkenyl group, or a halogen atom, or are a conjugated diene which is optionally substituted with one or more hydrocarbyl, tri(hydrocarbyl)silyl groups or hydrocarbyl, tri(hydrocarbyl)silylhydrocarbyl groups, said diene having up to 30 atoms not counting hydrogen;
R 5 and R 6 are identical or different, are one of a hydrogen atom, a halogen atom, a C 1 -C 10 alkyl group, which may be halogenated, a C 6 -C 10 aryl group, which may be halogenated, a C 2 -C 10 alkenyl group, a C 7 -C 40 arylalkyl group, a C 7 -C 40 alkylaryl group, a C 8 -C 40 arylalkenyl group, a -NR 2 15 , -SR 15 , -OR 15 , -OSiR 3 15 or -PR 2 15 radical, wherein: R 15 is one of a halogen atom, a C 1 -C 10 alkyl group, or a C 6 -C 10 aryl group;
R 7 is
wherein:R 17 to R 24 are as defined for R 1 and R 2 , or two or more adjacent radicals R 17 to R 24 , including R 20 and R 21 , together with the atoms connecting them form one or more rings;
M 2 is carbon, silicon, germanium or tin;
the radicals R 3 , R 4 , and R 10 are identical or different and have the meanings stated for R 5 and R 6 ; or two adjacent R 10 radicals can be joined together to form a ring system.
摘要翻译：茂金属化合物是新的。新的茂金属化合物具有式（A）。 [图像] M：Ti，Zr，Hf，V，Nb，Ta，Cr，Mo或W; R 1>，R 2> H，1-10C烷基，1-10C烷氧基，6-10C芳基，6-10C芳氧基，2-10C烯基，2-4C烯基，7-40C芳基烷基，7-40C烷基芳基，8 -40C芳基烯基，OH或卤素原子; 或任选被烃基，三（烃基）甲硅烷基或三（烃基）甲硅烷基烃基取代的共轭二烯（具有多达30个不计算氢的原子） R，R 3，R 4，H，卤素，可以被卤化的1-10C烷基，可以被卤化的6-10C芳基，2-10C烯基，7-40C芳基烷基，7-40C烷基芳基，8-40C芳基烯基，-NR'2，-SR'，-OR'，-OSiR'3或-PR'2; R'：卤素，1-10C烷基或6-10C芳基; R 3>式（B）的化合物; R 1> 7> -R 2> 4> H，1-10C烷基，1-10C烷氧基，6-10C芳基，6-10C芳氧基，2-10C烯基，2-4C烯基，7-40C芳基烷基， 40 C烷基芳基，8-40 C芳基烯基，OH或卤素原子; M 2> C，Si，Ge，Sn包括R 2> 0>和R 2> 1的两个或多个相邻基团R 1> 7> -R 2>以及苯基的中间原子形成与苯基稠合的环。两个相邻的R基团与连接它们的原子连接形成环。还包括独立权利要求：（A）包含本发明金属茂化合物和助催化剂的反应产物的催化剂组合物; （B）载体催化剂体系，其包括载体材料，助催化剂和本发明金属茂化合物的产物; 和（C）聚合方法，包括在聚合条件下使单体和催化剂组合物接触。

99. 发明公开

EP1401818A2 TARGETED MULTIVALENT MACROMOLECULES 审中-公开
标题翻译：特异性结合的多价大分子
公开(公告)号：EP1401818A2
公开(公告)日：2004-03-31
申请号：EP02741784.9
申请日：2002-05-30
申请人： Targesome, Inc.
发明人： DANTHI, Narasimhan, S. , CHOI, Steven, H. , BEDNARSKI, Mark, David , WARTCHOW, Charles, Aaron , DECHENE, Neal, Edward , PEASE, John, S. , SHEN, Zhi, Min , ZHANG, Michael , TRULSON, Julie
IPC分类号： C07D237/02 , A61K31/33 , A61K51/00 , A61K49/00 , A61K49/04 , A61K9/127 , A61B8/00
CPC分类号： A61K51/1227 , A61K47/6907 , A61K47/6911 , A61K51/1234 , B82Y5/00
摘要： Targeted macromolecules comprising a linking carrier and more than one targeting entityare provided, as well as methods for their preparation and use. Targeted therapeutic agents, comprising a linking carrier, a therapeutic entity associated with the linking carrier, and at least one targeting entity are also provided, as well as methods for their preparation and use.

100. 发明授权

EP1294733B1 BRIDGED BIS(INDENYL)METALLOCENE COMPOUNDS 有权
标题翻译：桥联的双茚基取代的金属茂化合物
公开(公告)号：EP1294733B1
公开(公告)日：2004-02-25
申请号：EP01937633.4
申请日：2001-05-21
申请人： ExxonMobil Chemical Patents Inc.
发明人： KUCHTA, Matthew, C. , STEHLING, Udo, M. , LI, Robert, T. , HAYGOOD, William, T. , BURKHARDT, Terry, J.
IPC分类号： C07F17/00 , C08F4/642 , C08F10/00
CPC分类号： C07F17/00 , C08F4/65908 , C08F4/65912 , C08F4/65916 , C08F10/00 , C08F110/02 , C08F110/06 , C08F210/06 , C08F210/16 , C08F4/65927 , C08F2500/12 , C08F2500/03 , C08F2500/17 , C08F2500/15 , C08F2500/21
摘要： This invention relates to metallocene compositions and their use in the preparation of catalyst systems for olefin polymerization, particularly propylene polymerization. In one embodiment, the metallocenes of the present invention may be represented by the formula: wherein M is a metal of Group 4, 5, or 6 of the Periodic Table preferably, zirconium, hafnium and titanium, most preferably zirconium; R7 is wherein R?17 to R24¿ are as defined for R?1 and R2¿, or two or more adjacent radicals R?17 to R24¿, including R?20 and R21¿, together with the atoms connecting them form one or more rings; M2 is carbon, silicon, germanium or tin.

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