专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

91. 发明公开

EP1496834A2 HIGH AFFINITY INTEGRIN POLYPEPTIDES AND USES THEREOF 审中-公开
标题翻译：具有高亲和力的整合素及其用途多肽
公开(公告)号：EP1496834A2
公开(公告)日：2005-01-19
申请号：EP02723441.8
申请日：2002-03-13
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： ARNAOUT, M., Amin , LI, Rui , XIONG, Jian-Ping
IPC分类号： A61K6/00
CPC分类号： C07K16/2845 , A61K38/00 , C07K14/70553
摘要： Polypeptides comprising all or part of a variant integrin alpha subunit A domain or a variant integrin beta subunit A-like domain are described. In solution or in membrane-associated form, the A domain or the A-like domain of the polypeptides of the invention exists predominantly in a high affinity conformation. In the polypeptides of the invention, referred to as variant integrin polypeptides, a crucial isoleucine residue (described in greater detail below) is absent. The isoleucine can be either deleted or replaced with different amino acids residue, preferably a smaller or less hydrophobic amino acid residue, e.g., alanine or glycine. Because the variant integrin polypeptides of the invention exist in solution or in membrane-associated form predominantly in a high affinity conformation, they are useful in screening assays for the identification of molecules that bind to (and/or mediate the activity of) an integrin. They are also useful for generating antibodies, e.g., monoclonal antibodies, which bind to the high affinity form of an integrin. Some such antibodies recognize an epitope that is either not present or not accessible on an integrin that is in a lower affinity conformation. The variant integrin polypeptides of the invention can be derived from any integrin alpha subunit or any integrin beta subunit and could be used therapeutically. The variant integrin polypeptides preferably include a ligand-binding portion of an A-domain or an A-like domain.

92. 发明授权

EP1053027B1 BIBAPCITIDE-BASED PHARMACEUTICAL COMPOSITIONS FOR IMAGING AND TREATING THROMBI 有权
标题翻译： ON BIBAPCITIDE BASED Pharmaceutische组合物用于成像和治疗血栓
公开(公告)号：EP1053027B1
公开(公告)日：2004-10-13
申请号：EP99906771.3
申请日：1999-02-05
申请人： Diatide, Inc.
发明人： DEAN, Richard, T. , LISTER-JAMES, John
IPC分类号： A61K51/08 , A61K38/16 , A61P7/02
CPC分类号： C07K14/705 , A61K51/08 , A61K2123/00
摘要： The invention provides novel precursor reagents used in production of imaging agents derived from apcitide. Imaging agents made using the precursor reagents of the invention are useful for in vivo detection and diagnosis of thrombi. The precursor reagents of the invention may also be used in production of antithrombotic agents derived from apcitide. The presence of the free carboxylate groups affords the precursor reagents greater solubility than bibapcitide in aqueous media.

93. 发明公开

EP1461039A1 PHARMACEUTICAL COMPOSITIONS COMPRISING A MULTIFUNCTIONAL PHOSPHODIESTERASE INHIBITOR AND AN ADENOSINE UPTAKE INHIBITOR 有权
标题翻译：药物制剂含西洛他唑并创下腺苷抑制剂
公开(公告)号：EP1461039A1
公开(公告)日：2004-09-29
申请号：EP02796079.8
申请日：2002-12-26
申请人： OTSUKA PHARMACEUTICAL CO., LTD.
发明人： LIU, Yongge , SUN, Bing , YOSHITAKE, Masuhiro , KAMBAYASHI, Jun-Ichi
IPC分类号： A61K31/4709 , A61K31/519 , A61P7/02 , A61P9/08
CPC分类号： A61K31/4745 , A61K31/4709 , A61K31/519 , A61K31/522 , A61K45/06 , A61K2300/00
摘要： The present invention relates to pharmaceutical compositions comprising at least one multifunctional phosphodiesterase inhibitor (MPDEI) and at least one adenosine uptake inhibitor. The present invention also relates to compositions comprising cilostazol and dipyridamole and their use.

94. 发明公开

EP1453540A2 MODULATION OF LIR FUNCTION TO TREAT RHEUMATOID ARTHRITIS 审中-公开
标题翻译： LIR功能的调节对治疗类风湿性关节炎的
公开(公告)号：EP1453540A2
公开(公告)日：2004-09-08
申请号：EP02795627.5
申请日：2002-11-12
申请人： Immunex Corporation , Arm, Jonathan P. , Tedla, Nicodemus , Borges, Luis G.
发明人： ARM, Jonathan P.,c/o Brigham and Women's Hospital , TEDLA, Nicodemus , BORGES, Luis, G.
IPC分类号： A61K45/00 , A61K39/395 , C07K16/28
CPC分类号： C07K16/2803 , A61K2039/505
摘要： This invention relates to methods for treating rheumatoid arthritis (RA) by administering one or more agents that specifically target LIR-2, LIR-3 and LIR-7. Results disclosed herein indicate that these three LIRs may participate in regulating the activation of leukocytes that infiltrate synovial tissue. Thus, inflammation in the joints of RA patients can be ameliorated by administering agents that modulate expression or function of LIR-2 and/or LIR-3 and/or LIR-7 to reduce or eliminate the activation of monocytes or macrophages present in inflamed joints, or to reduce their recruitment to the site of inflammation. This can be accomplished by modulating LIR-7, which transmits a stimulatory signal, and/or by modulating LIR-2 and/or LIR-3, which when triggered exert an inhibitory effect, or by concurrently modulating two or all three of these LIRs.

95. 发明公开

EP1451333A2 UL16 BINDING PROTEIN 4 有权
标题翻译： UL16-结合蛋白4
公开(公告)号：EP1451333A2
公开(公告)日：2004-09-01
申请号：EP02778459.4
申请日：2002-10-04
申请人： Immunex CorporatioN
发明人： COSMAN, David, J.
IPC分类号： C12P1/00 , C12P21/06 , C12N1/20 , C12N5/00 , C12N15/00 , G01N33/00 , C07K1/00 , C07K14/00 , C07K17/00 , C07H21/04
CPC分类号： C07K14/705
摘要： ULBP4, a novel member of the ULBP family has been isolated and characterized. ULBP4 is a useful activator of immune effector cells, particularly of NK cells.

96. 发明授权

EP0964889B1 POLYPROPYLENE COPOLYMER ALLOY, PROCESS FOR ITS PRODUCTION AND USES OF THE ALLOY 无效
标题翻译：聚丙烯共聚物合金，工艺用于生产和用途合金
公开(公告)号：EP0964889B1
公开(公告)日：2004-07-14
申请号：EP98908959.4
申请日：1998-03-04
申请人： ExxonMobil Chemical Patents Inc.
发明人： GEORGELLIS, George, Byron , CHENG, Chia, Yung , CHIEN, William, Moa-Tseng
IPC分类号： C08L23/14
CPC分类号： D01F6/46 , B01J8/0035 , B01J8/006 , B01J8/24 , B01J19/18 , B01J2208/00212 , B01J2208/00274 , B01J2208/00575 , C08F10/06 , C08F210/16 , C08L23/14 , C08L23/142 , C08L2205/02 , C08F2/001 , C08L2666/06 , C08F210/06 , C08F2500/12 , C08F210/08
摘要： The present invention relates to polypropylene alloys which are especially suited for soft fiber and fabric applications. An embodiment of these alloys comprises an ethylene-propylene random copolymer having an ethylene content of from 1.0 to 5.0 % by weight, in an amount of from 40 to 90 % by weight of the alloy; and an ethylene-propylene bipolymer having an ethylene content of from 10 to 30 % by weight, in an amount of from 10 to 60 % by weight of the alloy. The present invention further relates to a hybrid process for making these alloys.

97. 发明公开

EP1420831A1 LIPID CONSTRUCTS AS THERAPEUTIC AND IMAGING AGENTS 审中-公开
标题翻译：脂类构造物，作为治疗剂和成像剂
公开(公告)号：EP1420831A1
公开(公告)日：2004-05-26
申请号：EP02756736.1
申请日：2002-07-26
申请人： Targesome, Inc.
发明人： WARTCHOW, Charles, Aaron , DECHENE, Neal, Edward , PEASE, John, S.
IPC分类号： A61K51/12 , A61K9/127
CPC分类号： A61K51/1234
摘要： Lipid constructs containing a chelator, a targeting entity, a detectable entity, and/or a therapeutic entity are provided, as well as methods relating to their use. The therapeutic or treatment entity may be associated with the lipid construct by covalent or non-covalent means. In some cases, the therapeutic or treatment entity is a radioisotope.

98. 发明公开

EP1404831A2 TYPE 2 CYTOKINE RECEPTOR AND NUCLEIC ACIDS ENCODING SAME 审中-公开
标题翻译： TYP-2 ZYTOKINREZEPTOR UNDDAFÜRKODIERENDENUKLEINSÄUREN
公开(公告)号：EP1404831A2
公开(公告)日：2004-04-07
申请号：EP02718833.3
申请日：2002-01-14
申请人： Genetics Institute, LLC
发明人： FOUSER, Lynette , LIU, Wei , DENG, Bijia
IPC分类号： C12N15/12 , C07K14/715 , C12N5/10 , C12N15/62 , C12Q1/68 , C07K16/18 , A61K38/17 , A61K39/00 , A61K48/00 , G01N33/50 , G01N33/53
CPC分类号： C07K14/715 , A61K38/00 , A61K2039/505 , A61K2039/53 , C07K2319/00
摘要： The present invention provides novel isolated CRF2-12 polynucleotides and polypeptides encoded by the CRF2-12 polynucleotides. Also provided are the antibodies that immunospecifically bind to a CRF2-12 polypeptide or any derivative (including fusion derivative), variant, mutant or fragment of the CRF2-12 polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the CRF2-12 polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.
摘要翻译：本发明提供新的分离的CRF2-12多核苷酸和由CRF2-12多核苷酸编码的多肽。还提供了免疫特异性结合CRF2-12多肽或CRF2-12多肽，多核苷酸或抗体的任何衍生物（包括融合衍生物），变体，突变体或片段的抗体。本发明还提供了CRF2-12多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态以及其它用途的方法。

99. 发明公开

EP1179348A3 Use of IL-12 and IL-12 antagonists in the treatment of autoimmune diseases 失效
标题翻译： IL-12和IL-12拮抗剂用于治疗自身免疫性疾病的用途
公开(公告)号：EP1179348A3
公开(公告)日：2003-12-03
申请号：EP01117762.3
申请日：1995-03-07
申请人： Genetics Institute, LLC
发明人： Leonard, John P. , Goldman, Samuel , O'Hara, Richard Jr.
IPC分类号： A61K38/20 , A61K39/395 , A61P37/00
CPC分类号： A61K38/208 , A61K2039/505 , C07K16/244
摘要： Method of treating autoimmune conditions are disclosed comprising administering to a mammalian subject IL-12 or an IL-12 antagonist. In certain preferred embodiments the autoimmune condition is one which is promoted by an increase in levels of IFN-γ or TNF-α. Suitable conditions for treatment include multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, autoimmune pulmonary inflammation, Guillain-Barre syndrome, autoimmune thyroiditis, insulin dependent diabetes melitis and autoimmune inflammatory eye disease.

100. 发明公开

EP1364212A2 THREE HYBRID ASSAY SYSTEM 有权
标题翻译：三杂交检测系统
公开(公告)号：EP1364212A2
公开(公告)日：2003-11-26
申请号：EP02723332.9
申请日：2002-03-04
申请人： GPC Biotech AG , GPC Biotech Inc.
发明人： BECKER, Frank , COME, Jon, H. , KLEY, Nikolai A. , REICHEL, Christoph
IPC分类号： G01N33/566 , A61K31/01 , C07K14/00
CPC分类号： C40B30/04 , C07D231/54 , C07D487/04 , C07F9/65583 , C07F9/6561 , G01N33/6845 , G01N2500/10
摘要： The invention provides compositions and methods for isolating ligand binding polypeptides for a user-specified ligand, and for isolating small molecule ligands for a user-specified target polypeptide using an improved class of hybrid ligand compounds.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式