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91. 发明公开

EP1886672A2 Solid dosage form comprising solid dispersion and method for producing the same 有权
标题翻译：固体剂型，其包含固体分散体，以及制造其的方法
公开(公告)号：EP1886672A2
公开(公告)日：2008-02-13
申请号：EP07015395.2
申请日：2007-08-06
申请人： Shin-Etsu Chemical Co., Ltd.
发明人： Kusaki, Fumie , Hoshino, Takafumi , Maruyama, Naosuke , Nishiyama, Yuichi , Fukui, Ikuo , Umezawa, Hiroshi
IPC分类号： A61K9/20 , A61K47/38 , A61K31/44
CPC分类号： A61K9/2054 , A61K31/44
摘要： Provided are a solid dosage form comprising a solid dispersion that allows a drug in the preparation to be rapidly dissolved without compromising the solubility of the solid dispersion, and a method for producing the same. More specifically, provided is a solid dosage form comprising a solid dispersion, the dispersion comprising: a poorly soluble drug, a water-soluble polymer and a disintegrant, wherein the disintegrant is low-substituted hydroxypropylcellulose having an average particle size of 10 to 100 µ m and a specific surface area measured by BET method of at least 1.0 m 2 /g. Moreover, provided is a method for producing a solid dosage form comprising a solid dispersion, the method comprising steps of: spraying a water-soluble polymer solution in which a poorly soluble drug has been dispersed or dissolved, on a powder of low-substituted hydroxypropylcellulose having an average particle size of 10 to 100 µm and a specific surface area measured by BET method of at least 1.0 m 2 /g and serving as a disintegrant and granulating the resultant; and drying.
摘要翻译：本发明提供一种固体剂型，其包含做了固体分散体允许在制备药物而不损害固体分散体中的溶解度迅速溶解，和用于生产其的方法。更具体地，提供了一种固体剂型，其包含固体分散体，所述分散体包括：难溶性药物，水溶性聚合物和崩解剂，worin所述崩解剂是具有在10平均颗粒尺寸为100μ低substituiertem羟丙基纤维素 m和至少1.0米2 /克的BET法测定的比表面积。更完了，提供的是用于制备固体剂型，其包含固体分散体的方法，该方法包括以下步骤：喷雾在其中溶解性差的药物已被分散或溶解于其中的水溶性聚合物溶液，在低substituiertem羟丙基的粉末具有在10至100微米的平均粒径和比表面积通过至少为1.0米2 /克和作为崩解剂和造粒得到的BET法测定; 和干燥。

92. 发明公开

EP1869053A1 SUBSTITUIERTE 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDIN-VERBINDUNGEN UND DEREN VERWENDUNG ZUR HERSTELLUNG VON ARZNEIMITTELN 有权
标题翻译：取代的4,5,6,7- TETRA HYDRO异恶唑并[4,5-c]吡啶化合物及其USE IN药品生产
公开(公告)号：EP1869053A1
公开(公告)日：2007-12-26
申请号：EP06724034.1
申请日：2006-04-05
申请人： Grünenthal GmbH
发明人： SUNDERMANN, Corinna , SUNDERMANN, Bernd , HOLENZ, Jörg , HENNIES, Hagen-Heinrich
IPC分类号： C07D498/04 , A61K31/4353 , A61P29/02
CPC分类号： C07D498/04
摘要： The invention relates to substituted 4, 5, 6, 7-tetrahydro-isoxazolo [4, 5-c] pyridine compounds of formula (I), to a method for their production, to medicaments containing said compounds and to the use of said compounds for producing medicaments. It has been found that substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c] pyridine compounds of general formula (I) are suitable for noradrenaline receptor regulation, in particular for inhibiting the noradrenaline (NA) uptake, for 5-HT receptor regulation, in particular for inhibiting the 5-hydroxy-tryptophan (5-HT) uptake and/or for batrachotoxin (BTX) receptor regulation and can thus be used in particular as pharmaceutical active ingredients in medicaments for the prophylaxis and/or treatment of disorders or diseased that are associated with said receptors or processes.

93. 发明公开

EP1863754A1 METHOD FOR PREPARING VALIENAMINE 审中-公开
标题翻译： VERFAHREN ZUR HERSTELLUNG VON VALIENAMIN
公开(公告)号：EP1863754A1
公开(公告)日：2007-12-12
申请号：EP05821418.0
申请日：2005-12-02
申请人： Chemtech Research Incorporation
发明人： BYUN, Il Suk, 614-903, Hyojachon Apt. , KIM, Joo Sung, 102-1006, Shinbanpo Suwon Apt. , SHIN, Sung Hye, 308-104, Maehwamaeul Jugong Apt. , KIM, Wan Joo, 328-404, Olympic Apt.
IPC分类号： C07C213/08
CPC分类号： C07C213/08 , C07C2601/16 , C07C215/44
摘要： The present invention provides a method for preparing valienamine from acarbose or acarbose derivatives by using a base. The present invention provides an improved method for preparing valienamine compared to conventional preparation methods of valienamine by simplifying the reaction steps and diminishing byproducts.
摘要翻译：本发明提供了通过使用碱从阿卡波糖或阿卡波糖衍生物制备valienamine的方法。本发明提供了一种通过简化反应步骤和副产物减少来制备valienamine与通过噻吩胺的制备方法相比的改进方法。

94. 发明公开

EP1838934A1 A COMPOSITE MASONRY BUILDING BLOCK 审中-公开
标题翻译：复合墙石
公开(公告)号：EP1838934A1
公开(公告)日：2007-10-03
申请号：EP06700038.0
申请日：2006-01-04
申请人： Benex Technologies Pty Ltd
发明人： Bennett, Kerry, Robert
IPC分类号： E04C1/40
CPC分类号： E04C1/40 , E04B2002/0215 , E04B2002/0221
摘要： A composite masonry building block (1) that has an inner core (20) of lighter density than an outer face and includes upper most protrusions (4, 73) and matching lowermost cavities (5, 76) to have an interlocking arrangement with other like blocks. Also disclosed is an inner lighter density material which includes an expanded plastic such as polystyrene with a cement binder. The upper (2) surface of the block (1) may include a plurality of protrusions and lower (3) may have a plurality of cavities (5). The arrangement of the protrusions (4) in relation to the upper surface (2) and the arrangement of cavities (5) in relation to lower surface (3) are such that the protrusions (4) will locate within and interlock with the consistently aligned and placed cavities of the adjacent block.

95. 发明公开

EP1833913A1 HOCH KATIONISCHE POLYMERDISPERSIONEN, VERFAHREN ZU DEREN HERSTELLUNG UND DEREN VERWENDUNG 有权转让
标题翻译：高阳离子聚合物分散体，方法生产及其用途
公开(公告)号：EP1833913A1
公开(公告)日：2007-09-19
申请号：EP05815497.2
申请日：2005-11-30
申请人： Ashland Licensing and Intellectual Property LLC
发明人： BELLMANN, Susanne , STEINER, Norbert , ISSBERNER, Jörg , BOEKELO, Christian , WOEBEL, Wolfgang
IPC分类号： C08L33/26 , C08F220/60 , D21H17/43
CPC分类号： C09D133/02 , C08F220/60 , C08L33/02 , C08L33/24 , C09D133/24 , D21H17/375 , D21H17/43 , D21H21/10 , C08L2666/04
摘要： The invention relates to a water-in-oil polymer dispersion which comprises a polymer A having a cationic monomer content of at least 55 % by weight and at least one polymer dispersant B based on cationized dialkylaminoalkyl(meth)acrylamides having an average molecular weight of more than 350.000 to 1 million g/mol. The invention also relates to a method for producing said dispersion and to the use thereof.

96. 发明公开

EP1789064A1 IMPROVED ANTICANCER TREATMENT 审中-公开
标题翻译：改进癌症治疗
公开(公告)号：EP1789064A1
公开(公告)日：2007-05-30
申请号：EP05771774.6
申请日：2005-08-17
申请人： Purdue Research Foundation , Archibald, David
发明人： ARCHIBALD, David , MORR , Dorothy , MORR , D. James
IPC分类号： A61K36/18 , A61P35/00
CPC分类号： A61K36/31 , A61K36/81
摘要： A method of inhibiting tNOX in a living entity which includes administering to the entity, wherein the entity has cancer cells that express tNOX, a therapeutically active amount of a combination of botanicals selected from the groups consisting of cruciferous vegetables and Capsicum plants.

97. 发明公开

EP1756105A1 SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AND DRUGS CONTAINING SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE COMPOUNDS 审中-公开
标题翻译：取代的咪唑并[1,2-a]吡啶和取代的咪唑并[1,2-a]吡啶化合物含药物
公开(公告)号：EP1756105A1
公开(公告)日：2007-02-28
申请号：EP05744808.6
申请日：2005-04-28
申请人： Grünenthal GmbH
发明人： SUNDERMANN, Bernd , SUNDERMANN, Corinna , HENNIES, Hagen-Heinrich , JOSTOCK, Ruth , MERLA, Beatrix , RATH, Jean-Philippe
IPC分类号： C07D471/04 , A61K31/4188 , A61P25/00
CPC分类号： C07D471/04
摘要： The invention relates to the substituted imidazo[1,2-a]pyridine compounds of general formula (I), to methods for producing the same, to drugs containing said compounds as well as to the use of substituted imidazo[1,2-a]pyridine compounds in the production of drugs.

98. 发明授权

EP1663101B1 DARREICHUNGSFORM ZUR ORALEN VERABREICHUNG VON WIRKSTOFFEN, VITAMINEN UND/ODER NÄHRSTOFFEN, KIT UND VERWENDUNG 有权
标题翻译：药物剂型，口服活性物质，维生素和/或营养试剂盒与用途
公开(公告)号：EP1663101B1
公开(公告)日：2007-01-17
申请号：EP04765071.8
申请日：2004-09-10
申请人： Grünenthal GmbH
发明人： STERNBERGER, Elke , SEDAGHAT KERDAR, Rasoul , BARTHOLOMÄUS, Johannes
IPC分类号： A61J7/00 , A47G21/18
CPC分类号： A61J7/0038 , A47G21/183
摘要： The invention relates to an administration form for the oral administration of active substances, vitamins and/or nutrients, comprising a drinking straw (1) provided with a closing device (3) which is impermeable to the active substance formulation, vitamin formulation and/or nutrient formulation (2) and which is permeable to air and to a conveying liquid. The closing device has a standardised thickness and a hydrophobic finish.

99. 发明公开

EP1738189A1 SYSTEM AND METHOD FOR MONITORING A VEHICLE BATTERY 审中-公开
标题翻译：系统和方法用于监控车辆电池
公开(公告)号：EP1738189A1
公开(公告)日：2007-01-03
申请号：EP05712056.0
申请日：2005-01-26
申请人： Johnson Controls Technology Company
发明人： DOUGHERTY, Thomas, J. , WRUCK, William, J. , CHEN, Deeyu, C. , MILES, Ronald, C. , THOMPSON, Michael, L.
IPC分类号： G01R31/36
CPC分类号： G01R31/36 , G01R31/3679
摘要： A method for monitoring a battery installed in a vehicle includes utilizing a system provided within the vehicle to determine that a test of the battery should be performed when a first condition is satisfied. The method also includes electrically coupling at least one vehicle load to the battery and utilizing the system to analyze the response of the battery to the at least one vehicle load coupled to the battery. The system may be utilized to determine the state of health of the battery.

100. 发明公开

EP1730343A1 A PORTABLE CLOTHES STAND 审中-公开
标题翻译：便携式衣架
公开(公告)号：EP1730343A1
公开(公告)日：2006-12-13
申请号：EP05714218.4
申请日：2005-03-11
申请人： Roberts, Patricia Alida
发明人： Roberts, Patricia Alida
IPC分类号： D06F57/00 , D06F57/06 , D06F57/08
CPC分类号： D06F57/08
摘要： A clothes line with a central frame member (8). Outwardly extending end members (4) and (6) supporting clothes line therebetween, and legs (10) and (12) at each end of the member (8) which are supported to be foldable, between a position where they lie alongside the member (8) to a position providing support for the member (8). And there are means between the legs (10) and (12) and the member (8) which provides a locking strut effect.

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