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91. 发明公开

EP2460810A1 NOVEL FLAVANONE DERIVATIVE 有权
标题翻译：新的黄酮衍生物
公开(公告)号：EP2460810A1
公开(公告)日：2012-06-06
申请号：EP10804481.9
申请日：2010-07-29
申请人： National University Corporation Okayama University
发明人： SASAKI, Kenji , TSUCHIYA, Tomofusa , ABUGAFAR Md. Lokman Hossion , OHTSUKA, Nao , ZAMAMI, Yoshito , KUROSAKI, Yuji
IPC分类号： C07H17/07 , A61K31/7048 , A61P31/04
CPC分类号： C07H17/07
摘要： Provided is a novel antimicrobial agent. More specifically, provided is a novel antimicrobial agent capable of effectively acting on various resistant bacteria such as VSSA, MRSA, VISA, VRE, and VRSA. A novel flavanone derivative having a six-membered monosaccharide derivative, specifically, a glucose derivative or a galactose derivative is capable of effectively acting on the bacteria. More specifically, a compound represented by the general formula (I) is capable of effectively acting on the bacteria.

(In the formula: X represents a six-membered monosaccharide derivative; and Y is substituted by a hydroxyl group.)
摘要翻译：提供了一种新型抗菌剂。更具体而言，提供了能够有效作用于各种耐药细菌如VSSA，MRSA，VISA，VRE和VRSA的新型抗微生物剂。具有六元单糖衍生物，特别是葡萄糖衍生物或半乳糖衍生物的新型黄烷酮衍生物能够有效地作用于细菌。更具体地说，由通式（I）表示的化合物能够有效地作用于细菌。（式中，X表示6元单糖衍生物，Y表示羟基。）

92. 发明公开

EP2402440A1 -GLUCAN-DEFICIENT GENE IN BARLEY, SYNTHETIC GENE, AND USE OF SAME 审中-公开
标题翻译： - 葡萄糖基因，合成基因组
公开(公告)号：EP2402440A1
公开(公告)日：2012-01-04
申请号：EP10746257.4
申请日：2010-02-25
申请人： Incorporated Administrative Agency National Agriculture and Food Research Organization , National University Corporation Okayama University
发明人： TONOOKA Takuji , YOSHIOKA Toji , AOKI Emiko , TAKETA Shin
IPC分类号： C12N15/09 , A01H1/00 , A23K1/14 , A23L1/30 , C12C11/00 , C12G3/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10
CPC分类号： A01H5/10 , A23K10/30 , A23L7/104 , A23L7/25 , A23L33/10 , C07K14/415 , C12C1/18 , C12C2200/01 , C12G3/12 , C12N15/8245 , C12N15/8246
摘要： A Genomic DNA and a cDNA of a β-glucan-deficient gene in a barley and of a β-glucan synthesis gene in a barley, a barley having the genomic DNA of a β-glucan-deficient gene and a method for breeding the same, a method for producing an alcohol or a fermented food using barley kernels decreasing or deficient in β-glucan, and an animal feed composition are provided. A Genomic DNA of a β-glucan-deficient gene consisting of a base sequence having 90% or more homology to the base sequence of SEQ ID NO: 1 and producing a protein lacking a β-glucan synthesis activity when transcribed and translated, and a breeding method comprising a step of selecting a barley by determining the barley as having a β-glucan-deficient gene when the base corresponding to position 4,275, or corresponding to position 2,385, of the gene consisting of the base sequence of SEQ ID NO: 4 located near the centromere of chromosome 7H of the barley is mutated from G to A.
摘要翻译： A大麦中的β-葡聚糖缺乏基因和大麦中的β-葡聚糖合成基因的基因组DNA和cDNA，具有β-葡聚糖缺乏基因的基因组DNA的大麦及其育种方法提供了使用大麦籽粒减少或不足的β-葡聚糖的醇或发酵食品的制造方法和动物饲料组合物。一种由β-葡聚糖缺失基因组成的基因组DNA，其由与SEQ ID NO：1的碱基序列具有90％或更高同源性的碱基序列组成，并在转录和翻译时产生缺少β-葡聚糖合成活性的蛋白质，以及育种方法包括当对应于由SEQ ID NO：4的碱基序列组成的基因的位置4,275或对应于位置2,385的碱基时，通过测定大麦具有β-葡聚糖缺陷基因来选择大麦的步骤位于大麦染色体7H的着丝点附近的G从G突变为A.

93. 发明公开

EP2363147A1 COMPOSITION FOR LOCAL ANESTHESIA 有权
标题翻译： ZUSAMMENSETZUNGFÜRDIELOKALANÄSTHESIE
公开(公告)号：EP2363147A1
公开(公告)日：2011-09-07
申请号：EP09823324.0
申请日：2009-10-29
申请人： National University Corporation Okayama University
发明人： MIYAWAKI, Takuya , YOSHITOMI, Tatsushi
IPC分类号： A61K45/00 , A61K31/137 , A61K31/167 , A61K31/4164 , A61P23/00 , A61P43/00 , C07D233/58
CPC分类号： C07D233/58 , A61K31/137 , A61K31/167 , A61K31/4164 , A61K45/06 , A61K2300/00
摘要： An object of the present invention is to provide a composition for local anesthesia to be added to a local anesthetic drug, the composition showing a sustained local anesthetic effect and having high safety. The object is achieved by a composition for local anesthesia including a drug antagonistic to a systemic action of adrenaline, i.e., an α2 receptor agonist. The α2 receptor agonist can be added to a local anesthetic agent together with adrenaline or a salt thereof to reduce the amount of adrenaline to be added as compared to that of adrenaline or a salt thereof alone. As a result, a sustained local anesthetic effect is obtained and local anesthesia can be performed with high safety.
摘要翻译：本发明的目的是提供一种用于局部麻醉的组合物，其被添加到局部麻醉药物中，该组合物显示出持续的局部麻醉作用并具有高安全性。该目的通过用于局部麻醉的组合物来实现，该组合物包括拮抗肾上腺素的全身作用的药物即±2受体激动剂。与肾上腺素或其盐单独相比，可将±2受体激动剂与肾上腺素或其盐一起加入到局部麻醉剂中以减少添加的肾上腺素的量。结果，获得持续的局部麻醉效果，并且可以以高安全性进行局部麻醉。

94. 发明公开

EP2340829A1 NOVEL ANTISCHISTOSOMAL AGENT 有权
标题翻译：消除反病毒MITTEL
公开(公告)号：EP2340829A1
公开(公告)日：2011-07-06
申请号：EP09773402.4
申请日：2009-06-26
申请人： National University Corporation Okayama University
发明人： WATAYA,Yusuke , KIM, Hye-Sook , HIRAMOTO,Akiko , SATO,Akira , OTA,Nobuo , KUMAGAI,Takashi , SHIMOGAWARA, Rieko , TANIGUCHI,Toshie
IPC分类号： A61K31/357 , A61P33/12 , C07D323/00
CPC分类号： C07D323/00 , A61K31/357 , C07D325/00 , Y02A50/423
摘要： An object of the present invention is to provide a novel antischistosomal agent, and more specifically, to provide a novel drug capable of inhibiting a growth of schistosomes in vivo to prevent development of liver dysfunction due to eggs of the schistosomes in the case of infection with the schistosomes. The novel antischistosomal agent includes as an active ingredient a peroxide derivative. Specifically, the novel antischistosomal agent includes as an active ingredient a peroxide derivative represented by the general formula (I):

where C represents an alicyclic hydrocarbon ring group which may be substituted, and n represents an integer of 1 to 6.
摘要翻译：本发明的目的是提供一种新的抗血吸虫药，更具体地说，提供一种能够在体内抑制血吸虫生长的新型药物，以防止在感染情况下由血吸虫卵产生的肝功能障碍的发展血吸虫新型抗血吸虫药包括作为活性成分的过氧化物衍生物。具体地说，新型抗血吸虫药包括作为活性成分的通式（I）表示的过氧化物衍生物：其中C表示可被取代的脂环族烃环基，n表示1〜6的整数。

95. 发明公开

EP2216767A1 PAIRING COMPUTATION DEVICE, PAIRING COMPUTATION METHOD, AND RECORDING MEDIUM WHERE PAIRING COMPUTATION PROGRAM IS RECORDED 审中-公开
标题翻译：记录配对计算装置，配对计算和记录介质，其中配对计算程序
公开(公告)号：EP2216767A1
公开(公告)日：2010-08-11
申请号：EP08843368.5
申请日：2008-10-29
申请人： National University Corporation Okayama University
发明人： AKANE, Masataka , NOGAMI, Yasuyuki , MORIKAWA, Yoshitaka
IPC分类号： G09C1/00
CPC分类号： H04L9/3073 , G06F7/725 , H04L9/3255 , H04L2209/046
摘要： There is provided a pairing computation device, a pairing computation method and a recording medium recording a pairing computation program all enabling a pairing computation at high speed. In the case where the Ate pairing e(Q,P) is defined as in equation (1) and k is any one of even, a multiple of 3, a multiple of 4, and a multiple of 6, arithmetic operations of a rational function which is required to derive the Miller function f s,Q (P) are performed on the proper subfield specified by a twist curve using a quadratic and cubic non-residue v which becomes 1 when an exponentiation of this f s,Q (P) to the power of (q k - 1)/r is performed.
摘要翻译：提供了一种配对计算装置，配对计算方法以及记录介质中记录配对计算程序的所有可高速配对计算。另外，在吃了配对e（Q，P）被定义为在式（1）和k的情况下，即使任何一种，3的倍数，4的倍数和6的倍数，一个合理的算术运算这是需要导出米勒函数fs的所有功能，Q（P）进行上使用平方和立方非剩余v当这样的一个幂FS，Q（P），以成为1通过扭转曲线所指定的适当的子场的功率（q的k - 1）/执行河

96. 发明公开

EP2149382A1 DENTINOGENESIS PROMOTER AND DENTINOGENIC PULP-CAPPING MATERIAL 有权
标题翻译： MITTEL ZURFÖRDERUNGDER DENTINOGENESE UND MATERIAL ZUR BEDECKUNG VON DENTINOGENER PULPA
公开(公告)号：EP2149382A1
公开(公告)日：2010-02-03
申请号：EP08739206.4
申请日：2008-03-28
申请人： National University Corporation Okayama University
发明人： KUBOKI, Takuo , ONO, Mitsuaki , SONOYAMA, Wataru , FUJISAWA, Takuo , SHIMONO, Kengo , OSHIMA, Masamitsu , OKAMOTO, Yosuke
IPC分类号： A61K45/00 , A61K6/00 , A61K8/49 , A61K31/366 , A61K35/32 , A61P1/02 , A61P43/00 , A61Q11/00 , C12N5/06 , A61L27/00
CPC分类号： A61K31/47 , A61K8/365 , A61K8/4913 , A61K8/492 , A61K8/494 , A61K8/4953 , A61K8/498 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/505 , A61L27/3804 , A61L27/3865 , A61L27/54 , A61L2300/434 , A61Q11/00 , C07D309/22 , C07D401/12 , C12N5/0654 , C12N2501/70
摘要： The present invention provides a dentinogenesis inducer and dentinogenesis pulp-capping material, which are effectively used for formation (regeneration) of dentin. The present invention also provides a method of producing odontoblasts useful for dental regenerative therapy and the application of the obtained odontoblasts. The dentinogenesis inducer and the dentinogenesis pulp-capping material of the present invention are both characterized by the use of an HMG-CoA reductase inhibitor as an active ingredient. Additionally, odontoblasts can be produced by culturing cells capable of differentiating into odontoblasts in the presence of the HMG-CoA reductase inhibitor.
摘要翻译：本发明提供牙本质发生诱导剂和牙本质发生纸浆覆盖材料，其有效用于牙本质的形成（再生）。本发明还提供了可用于牙科再生治疗的成牙质细胞的生产方法和所获得的成牙质细胞的应用。本发明的牙本质发生诱导剂和牙本质发生纸浆覆盖材料的特征在于使用HMG-CoA还原酶抑制剂作为活性成分。另外，通过在HMG-CoA还原酶抑制剂的存在下培养能够分化成成牙质细胞的细胞可以产生成牙本质细胞。

97. 发明公开

EP2140876A1 THERAPEUTIC AGENT COMPRISING VASOHIBIN 审中-公开
标题翻译：治疗MITTEL MIT VASOHIBIN
公开(公告)号：EP2140876A1
公开(公告)日：2010-01-06
申请号：EP08738932.6
申请日：2008-03-26
申请人： National University Corporation Okayama University , Shionogi & Co., Ltd.
发明人： SATO, Yasufumi , MAESHIMA, Yohei , NASU, Tatsuyo , TANABE, Katsuyuki , MAKINO, Hirofumi
IPC分类号： A61K38/19 , A61K48/00 , A61P13/12 , A61P43/00 , C07K14/435 , C12N15/12
CPC分类号： C07K14/47 , A61K38/00 , A61K38/1709 , A61K48/00
摘要： A therapeutic agent containing Vasohibin for diabetic nephropathy, and a therapeutic agent containing Vasohibin for peritoneal sclerosis. Since the therapeutic agent containing Vasohibin of the present invention is a substance in which Vasohibin inhibits angiogenesis in an autocrine manner, the therapeutic agent is effective for inhibiting the progression of diabetic nephropathy and peritoneal sclerosis in which the inhibition in the angiogenesis or the production of cytokine is important, so that the therapeutic agent is suitably used in, for example, the treatment of a disease requiring an action for inhibiting the progression of diabetic nephropathy, and a disease requiring an inhibitory action for peritoneal sclerosis, or the like.
摘要翻译：含有Vasohibin用于糖尿病肾病的治疗剂和含有Vasohibin用于腹膜硬化的治疗剂。由于含有本发明的血管抑制素的治疗剂是以自分泌方式抑制血管生成的物质，所以治疗剂对于抑制血管发生抑制或细胞因子产生的糖尿病性肾病和腹膜硬化的发展是有效的是重要的，因此治疗剂适合用于例如需要抑制糖尿病性肾病进展的疾病的疾病的治疗，以及需要腹膜硬化症的抑制作用的疾病等。

98. 发明公开

EP1857173A1 FLOW ADJUSTING DEVICE, MICRO-REACTOR AND USE THEREOF 审中-公开
标题翻译：维多利亚时代的维多利亚时代
公开(公告)号：EP1857173A1
公开(公告)日：2007-11-21
申请号：EP06713944.4
申请日：2006-02-17
申请人： National University Corporation Okayama University
发明人： SAKATA, Yusaku, c/o Grad. School Nat. Science , MUTO, Akinori, c/o Grad. School Nat. Science , THALLADA, Bhaskar, c/o Grad. School Nat. Science
IPC分类号： B01J19/00 , B81B5/00 , F16K13/10 , G01N35/08 , G01N37/00
CPC分类号： B01J19/0093 , B01J2219/00783 , B01J2219/00822 , B01J2219/00824 , B01J2219/00826 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/00837 , B01J2219/0086 , B01J2219/00889 , B01J2219/00891 , B01J2219/00905 , B01J2219/0093 , B01J2219/00959 , B01L3/502738 , B01L3/502746 , B01L3/502761 , B01L3/502784 , B01L2200/0647 , B01L2200/0673 , B01L2300/0864 , B01L2400/084 , F16K99/0001 , F16K99/0023 , F16K2099/0084 , G01N2035/00514 , Y10T137/2185 , Y10T137/2191
摘要： A microreactor containing a plurality of introduction channels 21 and 22 for introducing a plurality of liquids, a merging section 23 for merging the plurality of introduction channels 21 and 22, and a reaction channel 41 located on a downstream side of the merging section 23, characterized in that a flow control section 80 is located on a downstream side of the merging section 23 and an upstream side of the reaction channel 41, and the flow control section 80 contains in a channel 81 thereof a movable particle 82. According to the constitution, such a microreactor can be provided that the flow state in the reaction channel 41 is controlled to realize a flow state with good reproducibility.
摘要翻译：包含多个用于引入多个液体的引入通道21和22的微反应器，用于合并多个引入通道21和22的合流部23和位于合流部23的下游侧的反应通道41，其特征在于，流量控制部80位于合流部23的下游侧和反应通道41的上游侧，流路控制部80在通道81中包含可动粒子82.根据该结构，可以提供这样的微反应器，即反应通道41中的流动状态被控制以实现具有良好再现性的流动状态。

99. 发明公开

EP1731118A1 BRAIN COOLING APPARATUS AND FLUID INFUSION DEVICE FOR USE THEREIN 有权
标题翻译： GEHIRNKÜHLGERÄT
公开(公告)号：EP1731118A1
公开(公告)日：2006-12-13
申请号：EP05719940.8
申请日：2005-03-03
申请人： National University Corporation Okayama University
发明人： TAKEDA, Yoshimasa , MORITA, Kiyoshi
IPC分类号： A61F7/12 , A61M16/04
CPC分类号： A61F7/12 , A61F2007/0002 , A61F2007/0056 , A61M16/04 , A61M16/0409 , A61M16/0438 , A61M16/0461
摘要： This brain cooling apparatus, including: a tube body 2 which can maintain an airway in the respiratory tract of a living body; a pharyngeal cuff 5 which is provided in the peripheral part of this tube body 2 and can store a cooled fluid; and an injection and discharge portion 6 which can inject and discharge a fluid into and from this pharyngeal cuff 5, in which the pharyngeal cuff 5 is-' flexible enough to inflate and deflate when a fluid is injected and discharged, and when a fluid is injected in a state where an airway in the respiratory tract of a living body is maintained by the tube body 2, the inflated pharyngeal cuff adheres closely to the pharyngeal part T of the living body.
摘要翻译：该脑冷却装置包括：管体2，其能够维持生物体的呼吸道中的气道; 咽管套5，其设置在该管体2的周边部分中，并且可以存储冷却的流体; 以及能够将流体从该咽部袖带5注入和排出的注射和排出部分6，其中，咽部袖带5在流体被注入和排出时具有足够的柔性以使其膨胀和放气，并且当流体为在管体2保持生物体的呼吸道中的气道的状态下注入，充气的咽囊紧贴于生物体的咽部T。

100. 发明公开

EP1491651A1 NITRIDED Mo ALLOY WORKED MATERIAL HAVING HIGH CORROSION RESISTANCE, HIGH STRENGTH AND HIGH TOUGHNESS AND METHOD FOR PRODUCTION THEREOF 有权
标题翻译：氮化钼合金材料，具有高耐腐蚀性能，用于生产高和高韧性和强度过程
公开(公告)号：EP1491651A1
公开(公告)日：2004-12-29
申请号：EP03745433.7
申请日：2003-03-27
申请人： Japan Science and Technology Agency , National University Corporation Okayama University , A.L.M.T. CORP.
发明人： Takada, Jun , Nagae, Masahiro , Nakanishi, Makoto , Takida, Tomohiro
IPC分类号： C23C8/24 , C22C27/04
CPC分类号： C22C27/04 , C23C8/02 , C23C8/24 , C23C26/00
摘要： The present invention provides an innovative material which has properties which cannot be achieved with conventional materials, i.e., having satisfactory high corrosion resistance and high strength in very severe corrosive conditions, for example, a 75% sulfuric acid (H 2 SO 4 ) aqueous solution (180°C) in addition to high strength at high temperatures and high toughness at low temperatures, and provides a method for effectively manufacturing the innovative material.
A worked molybdenum-alloy material, subjected to nitriding, which has high corrosion resistance, high strength, and high toughness, includes fine nitride particles formed by subjecting a nitride-forming-metal element dissolved to form a solid solution in an untreated worked molybdenum-alloy material to internal nitriding, the fine nitride particles being dispersed inside the worked molybdenum-alloy material subjected to nitriding; and a molybdenum nitride layer formed by subjecting a worked structure or a recovered structure at the surface of the untreated worked molybdenum-alloy material to external nitriding, the molybdenum nitride layer being provided at the surface of the worked molybdenum-alloy material subjected to nitriding. A method for manufacturing a worked molybdenum-alloy material subjected to nitriding includes the steps of subjecting an untreated worked alloy material in which at least any one of titanium, zirconium, hafnium, vanadium, niobium, and tantalum is dissolved to form a solid solution to multi-step internal nitriding treatment including a stepwise increase of the treatment temperature, and then subjecting the worked alloy material to external nitriding treatment.
摘要翻译：氮化钼合金加工材料（1）包括基钼合金制作在表面上形成材料和氮化钼层（4）。所述基材含有工作通过氮化的金属元素存在内部的材料加工形成的微细的氮化物粒子（2）。氮化物层是由氮化加工组织或回收的结构形成。

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