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1. 发明授权

EP2070535B1 Drugs for relieving carbonyl stress and peritoneal dialysates 有权
标题翻译：用于缓解羰基应激和腹膜透析的药物
公开(公告)号：EP2070535B1
公开(公告)日：2015-07-08
申请号：EP09002868.9
申请日：1999-08-23
申请人： Kurokawa, Kiyoshi , Miyata, Toshio , TOKAI UNIVERSITY EDUCATIONAL SYSTEM
发明人： Toshio, Miyata
IPC分类号： A61K31/4415 , A61P7/08
CPC分类号： A61K31/203 , A61K31/155 , A61K31/4965 , A61K33/00 , A61M1/287 , Y10S514/832 , Y10S514/866 , A61K2300/00

2. 发明授权

EP1339279B2 EVALUATION AND PRESERVATION SOLUTION 有权
标题翻译：解评价与保护
公开(公告)号：EP1339279B2
公开(公告)日：2010-11-17
申请号：EP01982986.0
申请日：2001-11-05
申请人： XVIVO Perfusion AB
发明人： STEEN, Stig
IPC分类号： A01N1/02
CPC分类号： A01N1/0226 , A01N1/02 , Y10S514/832
摘要： An evaluation and preservation solution for human and animal organs, tissues and parts thereof is described, wherein it comprises serum albumin at a concentration of 55-105 g/L, a scavenger and coating compound, preferably dextran compounds and derivatives thereof having essentially the same structure at a concentration of 1-55 g/L weight, and a physiological serum concentration of salts and nutrients in a physiologically acceptable medium.

3. 发明授权

EP1490097B2 USE OF BOTULINUM TOXIN FOR TREATING CARDIOVASCULAR DISEASES 有权
标题翻译：肉毒杆菌毒素用于治疗心脏和电路疾病中的应用
公开(公告)号：EP1490097B2
公开(公告)日：2010-08-18
申请号：EP03716821.8
申请日：2003-03-24
申请人： ALLERGAN, INC.
发明人： BROOKS, Gregory, F. , DONOVAN, Stephen
IPC分类号： A61K38/48 , A61K38/16 , C07K14/33 , A61L31/16 , A61P9/08
CPC分类号： A61L31/047 , A61K38/4893 , A61K45/06 , Y02A50/469 , Y10S514/814 , Y10S514/832
摘要： The present invention provides for methods of treating cardiovascular diseases in a mammal. The methods include a step of administering an effective amount of a botulinum toxin directly to a blood vessel of a mammal thereby treating a cardiovascular disease.

4. 发明公开

EP2070535A1 Drugs for relieving carbonyl stress and peritoneal dialysates 有权
标题翻译：用于缓解羰基应激和腹膜透析的药物
公开(公告)号：EP2070535A1
公开(公告)日：2009-06-17
申请号：EP09002868.9
申请日：1999-08-23
申请人： Kurokawa, Kiyoshi , Miyata, Toshio , TOKAI UNIVERSITY EDUCATIONAL SYSTEM
发明人： Toshio, Miyata
IPC分类号： A61K31/4415 , A61P7/08
CPC分类号： A61K31/203 , A61K31/155 , A61K31/4965 , A61K33/00 , A61M1/287 , Y10S514/832 , Y10S514/866 , A61K2300/00
摘要： Drugs for relieving carbonyl stress in the peritoneal cavity to be used in peritoneal dialysates which contain carbonyl compound-trapping agents as the active ingredient. Carbonyl compounds formed and accumulated during peritoneal dialysis are inactivated or eliminated by carbonyl compound-trapping agents such as aminoguanidine. Carbonyl compounds formed during the sterilization and storage of peritoneal dialysates are eliminated by preliminarily bringing into contact with the trapping agents. Further, addition of the trapping agents to peritoneal dialysates or circulation of the trapping agents by using a cartridge for trapping carbonyl compounds makes it possible to eliminate carbonyl compounds originating in the blood of the patients which flow into the peritoneal cavity as the dialysis proceeds. Thus, modification of proteins in the peritoneal cavity can be inhibited and peritoneal damage in association with peritoneal dialysis can be relieved.
摘要翻译：用于缓解腹膜腔内羰基应激的药物用于含有羰基化合物捕获剂作为活性成分的腹膜透析液。在腹膜透析过程中形成并积累的羰基化合物被羰基化合物捕获剂如氨基胍灭活或消除。通过预先与捕获剂接触来消除在腹膜透析液的灭菌和储存过程中形成的羰基化合物。此外，通过使用用于捕获羰基化合物的盒向腹膜透析液中添加捕获剂或使捕获剂循环，可以随着透析的进行而消除源自流入腹膜腔的患者的血液中的羰基化合物。因此，可以抑制腹膜腔内蛋白质的改变，并且可以缓解与腹膜透析相关的腹膜损伤。

5. 发明授权

EP1545757B1 PERFLUOROCARBON EMULSIONS WITH NON-FLUORINATED SURFACTANTS 有权
标题翻译：与非氟化表面活性剂PERFLUORKOHLENWASSERSTOFFEMULSIONEN
公开(公告)号：EP1545757B1
公开(公告)日：2007-02-21
申请号：EP03798735.1
申请日：2003-09-23
申请人： Therox, Inc.
发明人： HSU, Li-Chien , CREECH, Jeffrey , ZALESKY, Paul , KIVINSKI, Margaret
IPC分类号： B01F17/00
CPC分类号： A61K31/03 , A61K8/06 , A61K8/70 , A61K9/0014 , A61K9/107 , A61K2800/22 , A61Q19/00 , B01F3/0807 , B01F7/00633 , B01F7/16 , B01F13/1027 , B01F17/0028 , B01F17/0064 , B01F17/0085 , B01F17/0092 , Y10S514/832 , Y10S514/937
摘要： A stable fluorocarbon (FC) emulsion is described. The FC emulsion of the present invention comprises a continuous FC immiscible hydrophilic liquid phase and a dispersed phase comprising FC suspended as droplets within the continuous phase. The emulsion further comprises an emulsifying agent and a stabilizing agent. The stabilizing agent of the present invention reduces the ability of the FC droplets to move within the continuous phase. The present invention also provides a method of making a FC emulsion. The method comprises mixing an FC immiscible hydrophilic liquid and a solid emulsifying agent by agitation at a temperature elevated above the phase transition temperature of the emulsifying agent and below the boiling temperature of the FC immiscible hydrophilic liquid, and adding FC to the mixture of step (a) and agitating at the elevated temperature to disperse droplets of FC in the FC immiscible hydrophilic liquid to form the FC emulsion. The invention also provides another method of making an FC emulsion, which does not require a solid emulsifying agent. The method comprises mixing an FC immiscible hydrophilic liquid and an emulsifying agent to form a first mixture; mixing a stabilizing agent with the first mixture to form a second mixture; and mixing FC with the second mixture to form a third mixture to disperse droplets of FC in the FC immiscible hydrophilic liquid and to form the FC emulsion, wherein the stabilizing agent reduces ability of the droplets to move within a continuous phase of the FC emulsion.

6. 发明授权

EP1339279B1 EVALUATION AND PRESERVATION SOLUTION 有权
标题翻译：解评价与保护
公开(公告)号：EP1339279B1
公开(公告)日：2006-06-21
申请号：EP01982986.0
申请日：2001-11-05
申请人： Vitrolife AB
发明人： STEEN, Stig
IPC分类号： A01N1/02
CPC分类号： A01N1/0226 , A01N1/02 , Y10S514/832

7. 发明公开

EP1011710A4 METHODS AND COMPOSITIONS FOR OPTIMIZATION OF OXYGEN TRANSPORT BY CELL-FREE SYSTEMS 失效
标题翻译： ZERAMMENSETZUNGEN ZURFREIEN SYSTEMEN的VERFAHREN SUUR OPTIMIERUNG DES SAUERSTOFFTRANSPORTES
公开(公告)号：EP1011710A4
公开(公告)日：2004-03-31
申请号：EP98911428
申请日：1998-02-27
申请人： UNIV CALIFORNIA
发明人： WINSLOW ROBERT M , INTAGLIETTA MARCOS
IPC分类号： A61K45/00 , A61K31/715 , A61K35/14 , A61K38/16 , A61K38/42 , A61P7/08 , A61K47/36 , A61K47/48
CPC分类号： A61K38/42 , Y10S514/832 , Y10S514/833 , Y10S530/813 , Y10S530/815 , Y10S530/829 , A61K2300/00
摘要： Compositions, and methods of use thereof, for use as blood substitute products comprise aqueous mixtures of oxygen-carrying and non-oxygen carrying plasma expanders and methods for the use thereof. The oxygen-carrying component may consist of any hemoglobin-based oxygen carrier, while the non-oxygen carrying plasma expander may consist of any suitable diluent.
摘要翻译：用作血液替代品的组合物及其使用方法包括含氧和非氧气等离子体扩展器的含水混合物及其使用方法。载氧组分可以由任何基于血红蛋白的氧载体组成，而非携氧血浆扩张剂我由任何合适的稀释剂组成。

8. 发明授权

EP0857733B1 Mit Schutzliganden der Sauerstoffbindungsstellen versehene Hämoglobine als künstliche Sauerstoffträger zur direkten biologisch-medizinischen Anwendung und Verfahren zu ihrer Herstellung 失效
标题翻译：随着氧的保护结合的配体提供的网站血红蛋白作为人造氧载体直接生物学和医学的应用和它们的制备方法
公开(公告)号：EP0857733B1
公开(公告)日：2003-07-09
申请号：EP97121124.8
申请日：1997-12-02
申请人： Sangui BioTech AG , Pötzschke, Harald, Dr.
发明人： Barnikol, Wolfgang, Prof.Dr.Dr. , Pötzschke, Harald
IPC分类号： A61K38/42
CPC分类号： A61K38/42 , Y10S514/832

9. 发明公开

EP0857733A3 Mit Schutzliganden der Sauerstoffbindungsstellen versehene Hämoglobine als künstliche Sauerstoffträger zur direkten biologisch-medizinischen Anwendung und Verfahren zu ihrer Herstellung 失效
标题翻译：随着氧的保护结合的配体提供的网站血红蛋白作为人造氧载体直接生物学和医学的应用和它们的制备方法
公开(公告)号：EP0857733A3
公开(公告)日：1999-07-07
申请号：EP97121124.8
申请日：1997-12-02
申请人： SanguiBioTech AG , Pötzschke, Harald, Dr.
发明人： Barnikol, Wolfgang, Prof.Dr.Dr. , Pötzschke, Harald
IPC分类号： C07K14/805
CPC分类号： A61K38/42 , Y10S514/832
摘要： Künstliche Sauerstoffträger aus nativem oder modifizierten Hämoglobinen zur direkten biologisch-medizinischen Anwendung, bei denen die Sauerstoffbindungsstelle des Hämoglobins mit einem Schutzliganden. vorzugsweise Kohlenmonoxid, versehen ist, der vor der Anwendung nicht abgetrennt werden muß.

10. 发明公开

EP0923733A1 METHOD FOR ANALYSING ABSORPTION, DISTRIBUTION, METABOLISM, EXCRETION (ADME) AND PHARMACOKINETICS PROPERTIES OF COMPOUND MIXTURES 失效
标题翻译：法分析的吸收，分布，代谢，排泄的药代动力学特性和多个连接的混合物
公开(公告)号：EP0923733A1
公开(公告)日：1999-06-23
申请号：EP97941390.0
申请日：1997-08-28
申请人： CHIRON CORPORATION
发明人： DIETZ, Corine, M. , GIBBONS, Jacqueline, A. , TAYLOR, Eric, W.
IPC分类号： G01N33 , A61K9
CPC分类号： A61K9/0026 , G01N33/5088 , G01N33/557 , Y10S514/832 , Y10T436/19
摘要： A method for analyzing the ADME/PK properties of a mixture of compounds is (1) perfusing an animal or organ with a perfluorocarbon emulsion blood substitute, (2) administering the mixture of test compounds, (3) withdrawing an aliquot of the perfusate, (4) disrupting the emulsion, and (5) analyzing the aqueous phase of the perfusate for the concentration of test compounds.

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