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1. 发明公开

EP3132022A1 SYNTHETIC METHANOTROPHIC AND METHYLOTROPHIC MICROORGANISMS 审中-公开
标题翻译：甲基化合物的合成甲基化
公开(公告)号：EP3132022A1
公开(公告)日：2017-02-22
申请号：EP15780357.8
申请日：2015-04-14
申请人： Industrial Microbes, Inc.
发明人： HELMAN, Noah , CLARKE, Elizabeth , GREENFIELD, Derek
IPC分类号： C12N1/00
CPC分类号： C12P7/46 , C12N9/0006 , C12N9/0008 , C12N9/0014 , C12N9/1022 , C12N9/88 , C12N9/90 , C12Y101/01001 , C12Y101/01224 , C12Y101/02007 , C12Y101/03013 , C12Y101/99037 , C12Y102/01002 , C12Y102/01046 , C12Y111/01006 , C12Y114/13025 , C12Y202/01003 , C12Y401/01043 , C12Y503/01027
摘要： Provided herein are non-naturally occurring microbial organisms comprising a methane-oxidizing metabolic pathway. The invention additionally comprises non-naturally occurring microbial organisms comprising pathways for the production of chemicals. The invention additionally provides methods for using said organisms for the production of chemicals.
摘要翻译：本文提供了包含甲烷氧化代谢途径的非天然存在的微生物生物。本发明还包含非天然存在的微生物生物体，其包含用于生产化学品的途径。本发明另外提供了使用所述生物体来生产化学品的方法。

2. 发明公开

EP2865750A3 Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them 审中-公开
标题翻译：转移酶和氧化还原酶，编码它们的核酸以及制备和使用它们的方法
公开(公告)号：EP2865750A3
公开(公告)日：2015-08-05
申请号：EP14194469.4
申请日：2008-12-31
申请人： BASF Enzymes LLC
发明人： Weiner, David , Luginbuhl, Peter , Bueno, Analia , Cuenca, Joslin , Marasco, Erin
IPC分类号： C12N9/10 , C12N9/02 , C12Q1/48 , C12Q1/26 , C07K14/38 , C07K16/40 , C07K9/00 , A61K38/44 , A61K38/45
CPC分类号： C12N9/1096 , A21D8/042 , A61K38/00 , C12N9/0004 , C12N9/0006 , C12N9/0014 , C12N9/10 , C12N15/1137 , C12N15/63 , C12N15/86 , C12P7/10 , C12Q1/6876 , C12Y206/01021 , D06L4/40 , D06M16/003 , G01N33/573 , Y02E50/16 , Y02P20/52 , Y02T50/678
摘要： This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having transferase activity, e.g., transaminase activity, e.g., d-amino-acid transferase activity, and/or oxidoreductase activity, e.g., dehydrogenase activity, e.g., damino-acid dehydrogenase activity, and/or catalyze the transfer of a chemical group, catalyze transamination, catalyze the reaction: D-alanine + 2-oxoglutarate pyruvate + D-glutamate, and/or catalyze an oxidation-reduction reaction, catalyze the removal of hydrogen atoms, and/or catalyze the reaction: D-amino acid + H 2 O + acceptor a 2-oxo acid + NH 3 + reduced acceptor. Thus, the invention provides enzymes, compositions, methods for production of pharmaceutical compositions, pharmaceutical intermediates, antibiotics, sweeteners, peptide enzymes, peptide hormones, fuel and fuel additive compositions, foods and food additives, beverage and beverage additives, feeds and feed additives, drugs and drug additives, dietary supplements, textiles, wood, paper, pulp, and detergents comprising the polypeptides or polynucleotides in accordance with the invention.
摘要翻译：本发明一般涉及酶，编码酶的多核苷酸，此类多核苷酸和多肽的用途，更具体地涉及具有转移酶活性例如转氨酶活性例如d-氨基酸转移酶活性和/或氧化还原酶活性的酶的用途，例如，脱氢酶活性，例如dam酸脱氢酶活性，和/或催化化学基团的转移，催化转氨基化，催化反应：D-丙氨酸+ 2-酮戊二酸<=>丙酮酸+ D-谷氨酸和/或催化氧化还原反应，催化去除氢原子和/或催化反应：D-氨基酸+ H 2 O +受体2-氧代酸+ NH 3 +还原受体。因此，本发明提供了用于生产药物组合物，药物中间体，抗生素，甜味剂，肽酶，肽激素，燃料和燃料添加剂组合物，食品和食品添加剂，饮料和饮料添加剂，饲料和饲料添加剂的酶，组合物，药物和药物添加剂，膳食补充剂，纺织品，木材，纸，纸浆和包含根据本发明的多肽或多核苷酸的去污剂。

3. 发明公开

EP2744897A2 BIOTECHNOLOGISCHES SYNTHESEVERFAHREN VON OMEGA-FUNKTIONALISIERTEN CARBONSÄUREN UND CARBONSÄURE-ESTERN AUS EINFACHEN KOHLENSTOFFQUELLEN 审中-公开
标题翻译：从简单的碳源OMEGA官能化的酸和羧酸酯的生物合成方法
公开(公告)号：EP2744897A2
公开(公告)日：2014-06-25
申请号：EP12745886.7
申请日：2012-08-15
申请人： Evonik Degussa GmbH
发明人： SCHAFFER, Steffen , DECKER, Nicole , GIELEN, Jasmin , HÄGER, Harald , HAAS, Thomas , PÖTTER, Markus , HENNEMANN, Hans-Georg , WESSEL, Mirja , VOLLAND, Michael
IPC分类号： C12N9/10 , C12N9/88 , C12P1/04 , C12N9/00
CPC分类号： C12P13/02 , C08G69/08 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0014 , C12N9/0077 , C12N9/1029 , C12N9/16 , C12N9/88 , C12N9/93 , C12N15/52 , C12P7/40 , C12P7/42 , C12P7/6409 , C12P7/6436 , C12P13/005 , Y02P20/52
摘要： The invention relates to a biotechnological process for the preparation of functionalized carbon acids and functionalized carbon acid esters from simple carbon sources.
摘要翻译：本发明的主题是一种用于生产ω-官能羧酸和从简单碳源ω官能羧酸酯的生物技术方法。

4. 发明公开

EP1839058A1 NOVEL USE OF FLUORESCENCE RESONANCE ENERGY TRANSFER 审中-公开
标题翻译：荧光共振能量转移的新用途
公开(公告)号：EP1839058A1
公开(公告)日：2007-10-03
申请号：EP05850394.7
申请日：2005-12-23
申请人： LEIDEN UNIVERSITY
发明人： Canters, Gerard W.,Leiden University , Aartsma, Thijs J., Leiden University
IPC分类号： G01N33/542 , C12Q1/26
CPC分类号： G01N33/542 , C12N9/0014 , C12Q1/26 , C12Q1/32 , C12Y104/99003
摘要： A novel use of Fluorescence Resonance Energy Transfer wherein a labelled protein comprising a Fluorescent energy donor label and at least one energy acceptor moiety capable of accepting energy from the donor label by Förster energy transfer is exposed to incident electromagnetic energy to excite the donor moiety and the fluorescence emission of the donor is measured. The or each energy acceptor moiety has a more and less active energy acceptor state and the level of quenching of donor fluorescence is indicative of this state. The energy acceptor moiety may be converted between its states by a redox reaction, optionally involving a partner redox protein. A novel system comprising the labelled protein, a redox partner protein, 'a light source for imposing incident light at the excitation wavelength for the fluorescent label and a light detector capable of detecting the fluorescence emitted by the label may be used in biosensors and/or to monitor enzymatic turnover.

6. 发明公开

EP2865750A2 Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them 审中-公开
标题翻译：转移酶，和氧化还原酶，编码它们的核酸，以及制备方法及其用途
公开(公告)号：EP2865750A2
公开(公告)日：2015-04-29
申请号：EP14194469.4
申请日：2008-12-31
申请人： BASF Enzymes LLC
发明人： WEINER, David , LUGINBUHL, Peter , BUENO, Analia , CUENCA, Joslin , MARASCO, Erin
IPC分类号： C12N9/10 , C12N9/02 , C12Q1/48 , C12Q1/26 , C07K14/38 , C07K16/40 , C07K9/00 , A61K38/44 , A61K38/45
CPC分类号： C12N9/1096 , A21D8/042 , A61K38/00 , C12N9/0004 , C12N9/0006 , C12N9/0014 , C12N9/10 , C12N15/1137 , C12N15/63 , C12N15/86 , C12P7/10 , C12Q1/6876 , C12Y206/01021 , D06L4/40 , D06M16/003 , G01N33/573 , Y02E50/16 , Y02P20/52 , Y02T50/678
摘要： This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having transferase activity, e.g., transaminase activity, e.g., d-amino-acid transferase activity, and/or oxidoreductase activity, e.g., dehydrogenase activity, e.g., damino-acid dehydrogenase activity, and/or catalyze the transfer of a chemical group, catalyze transamination, catalyze the reaction: D-alanine + 2-oxoglutarate pyruvate + D-glutamate, and/or catalyze an oxidation-reduction reaction, catalyze the removal of hydrogen atoms, and/or catalyze the reaction: D-amino acid + H 2 O + acceptor a 2-oxo acid + NH 3 + reduced acceptor. Thus, the invention provides enzymes, compositions, methods for production of pharmaceutical compositions, pharmaceutical intermediates, antibiotics, sweeteners, peptide enzymes, peptide hormones, fuel and fuel additive compositions, foods and food additives, beverage and beverage additives, feeds and feed additives, drugs and drug additives, dietary supplements, textiles, wood, paper, pulp, and detergents comprising the polypeptides or polynucleotides in accordance with the invention.
摘要翻译：本发明涉及基因的反弹到酶，多核苷酸更具体编码酶，使用搜索多核苷酸和多肽的，并具有转移酶活性，例如转氨酶活性，例如d-氨基酸酸转移酶活性，和/或氧化还原酶活性，例如酶脱氢酶活性，例如，Damino酸脱氢酶活性，和/或催化化学基团的转移，催化转氨基，催化反应：D-丙氨酸+ 2-酮戊二酸丙酮酸<=> + D-谷氨酸，和/或催化到氧化还原反应，催化除去氢原子的，和/或催化下列反应：D-氨基酸+ H 2 O +受体<=> 2-含氧酸+ NH 3 +还原的受体。因此，本发明提供的酶，组合物，方法用于制备药物组合物，医药中间体，抗生素，甜味剂，肽酶，肽类激素，燃料，燃料添加剂组合物，食品和食品添加剂，饮料和饮料添加剂，饲料和饲料添加剂，药物和药物添加剂，膳食补充剂，纺织品，木材，纸，纸浆，和洗涤剂包括以本发明在雅舞蹈的多肽或多核苷酸。

7. 发明公开

EP2510104A2 PROCESS FOR PRODUCING POLYAMINES COMPRISING THE ENZYMATIC OXIDATION OF AMINO ALCOHOLS 无效
标题翻译： PROCESS FOR与酶促氧化氨基醇的PRODUCING多胺
公开(公告)号：EP2510104A2
公开(公告)日：2012-10-17
申请号：EP10771455.2
申请日：2010-10-29
申请人： BASF SE
发明人： HAUER, Bernhard , ENGELMARK CASSIMJEE, David Karim , BERGLUND, Per
IPC分类号： C12P13/00 , C08G73/02
CPC分类号： C12P13/001 , A61K8/84 , A61K47/18 , A61Q19/00 , C08G73/0206 , C08G73/0213 , C12N9/0014 , D21C9/08 , D21H17/56 , D21H21/02
摘要： The present invention relates to a process for the production of a polyamine involving the use of enzymes; in particular to a process performed in aqueous environment; to the polyamines produced by said method; as well as the use of said polyamines for manufacturing paper, for immobilizing enzymes, or for preparing pharmaceutical or cosmetical compositions. The invention also relates to a novel method for
in situ regeneration of cofactors NAD(P)
+ .

8. 发明公开

EP2354240A1 Polypeptides and biosynthetic pathways 有权
标题翻译：多肽和生物合成Pfade
公开(公告)号：EP2354240A1
公开(公告)日：2011-08-10
申请号：EP10010240.9
申请日：2003-04-23
申请人： CARGILL, INCORPORATED
发明人： Abraham, Timothy W. , Cameron, Douglas C. , Dalluge, Joseph , Hicks, Paula M. , Hobson, Russell J. , McFarlan, Sara C. , Millis, Jim , Rosazza, Jack , Weiner, David P. , Zhao, Lishan
IPC分类号： C12P17/10 , C07D209/18 , C12N1/00 , C12N9/10 , C12N9/88 , C12N9/02 , C12N15/52 , C12N15/63
CPC分类号： C12N15/52 , C12N9/0006 , C12N9/0014 , C12N9/0016 , C12N9/1096 , C12P17/10
摘要： Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(iridol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing the indole-3-pyruvate and 2-hydroxy 2-(indol-3ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.
摘要翻译：提供可用于从葡萄糖，色氨酸，吲哚-3-乳酸，吲哚-3-丙酮酸和2-羟基2-（环烯醇-3-基甲基）-4-酮戊二酸制备莫纳甜的方法和组合物。还公开了制备吲哚-3-丙酮酸和2-羟基2-（吲哚基-3-甲基）-4-酮戊二酸中间体的方法。提供的组合物包括核酸分子，多肽，化学结构和细胞。方法包括体外和体内过程，体外方法包括化学反应。

9. 发明公开

EP1503985A4 POLYPEPTIDES AND BIOSYNTHETIC PATHWAYS 有权
标题翻译：多肽和生物合成PATHS
公开(公告)号：EP1503985A4
公开(公告)日：2006-11-02
申请号：EP03747304
申请日：2003-04-23
申请人： CARGILL INC
发明人： ABRAHAM TIMOTHY W , CAMERON DOUGLAS C , DALLUGE JOSEPH , HICKS PAULA M , HOBSON RUSSELL J , MCFARLAN SARA C , MILLIS JIM , ROSAZZA JOHN , WEINER DAVID P , ZHAO LISHAN
IPC分类号： C12N15/09 , C07D209/20 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02 , C12N9/10 , C12N9/88 , C12P13/04 , C12P17/10 , C07D209/18 , C12N1/00 , C12N15/52 , C12N15/63
CPC分类号： C12N15/52 , C12N9/0006 , C12N9/0014 , C12N9/0016 , C12N9/1096 , C12P17/10

10. 发明公开

EP1259254A1 METHOD OF TREATMENT OF ANORECTAL DISORDERS 审中-公开
标题翻译：治疗畸形疾病的方法
公开(公告)号：EP1259254A1
公开(公告)日：2002-11-27
申请号：EP01907234.7
申请日：2001-02-21
申请人： K King & Co Pty Limited
发明人： KING, Denis
IPC分类号： A61K38/44 , A61P1/00 , C12N15/53
CPC分类号： C12N9/0014 , A61K48/00 , C12Y114/13039
摘要： A method of treatment of an anal disease, said method including the step of increasing the level of at least one isoform of the enzyme nitric oxide synthase in the cells of the ano-rectal region of a subject in need of such treatment.
摘要翻译：一种治疗肛门疾病的方法，所述方法包括增加需要这种治疗的受试者的非直肠区域的细胞中酶一氧化氮合酶的至少一种同种型的水平的步骤。

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