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1. 发明公开

EP4435081A1 PERMEABLE MEMBRANE SUPPORT 审中-公开
公开(公告)号：EP4435081A1
公开(公告)日：2024-09-25
申请号：EP24163241.3
申请日：2024-03-13
申请人： ST1 CO., LTD.
发明人： YOON, Yong Jun , KO, Byung Jun
IPC分类号： C12M1/00 , C12M3/00 , C12M1/12
CPC分类号： C12M25/04 , C12M23/38 , C12M23/46
摘要： A permeable membrane support having a removable permeable membrane is disclosed The permeable membrane support includes a lower support having a hollow cylinder shape with an outer diameter smaller than an inner diameter of a plate well so to be accommodated in the plate well, wherein the lower support includes: an upper end having a first opening and a lower end having a second opening; an inner wall extending between the upper and lower ends and having an open channel defined therein and extending therebetween and communicating with the first and the second openings; a support surface portion extending inwardly from an inner surface of a lower end of the inner wall and having a central opening defined therein constituting the open channel; an upper support including: a cylindrical lower member constructed to be partially accommodated in the lower support; a pair of opposing wings constructed to be supported on a top of the plate well; and a deformable beam portion extending upwardly from an upper circumferential end of the cylindrical lower member to the two opposing wings so as to connect the two opposing wings and the cylindrical lower member to each other; and a permeable membrane disposed between the support surface portion of the lower support and a bottom surface of the cylindrical lower member of the upper support, wherein the permeable membrane includes a porous thin-film and a sealing pattern bonded to a circumference of the porous thin-film, wherein the inner wall of the lower support and the deformable beam portion of the upper support include a hook and a groove, respectively, or include a groove and a hook, respectively, for snap-fit coupling between the lower and upper supports.

2. 发明公开

EP4433571A1 CASSETTE FOR PRESERVATION OF NATURAL AND BIOENGINEERED TISSUES 审中-实审
公开(公告)号：EP4433571A1
公开(公告)日：2024-09-25
申请号：EP22840372.1
申请日：2022-11-15
申请人： Tissue Testing Technologies LLC
发明人： CAMPBELL, Lia H. , WRIGHT, Gregory J. , GREENE, Elizabeth , BROCKBANK, Kelvin G.M.
IPC分类号： C12M1/32 , C12M3/00 , C12M1/12
CPC分类号： C12M25/04 , C12M23/12 , C12M23/46

3. 发明公开

EP4392545A1 VORRICHTUNG UND VERFAHREN ZUR ERZEUGUNG VON ORGANOIDEN SOWIE ZELLKULTUR 审中-实审
公开(公告)号：EP4392545A1
公开(公告)日：2024-07-03
申请号：EP22737425.3
申请日：2022-06-20
申请人： Technische Universität Ilmenau
发明人： SCHOBER, Andreas , HAMPL, Jörg , BRAUER, Dana , MAI, Patrick , KAYSAN, Leon , NGUEN, Lan Vi , SCHRÖDER, Insa
IPC分类号： C12N5/00 , C12M3/06 , C12M1/12 , C12N5/0797
CPC分类号： C12N5/0062 , C12M25/10 , C12M25/18 , C12M23/16 , C12N5/0623 , C12M25/04 , C12N2533/9020130101 , C12N2533/4020130101 , C12N2535/0020130101

4. 发明公开

EP4392542A1 FLUID FLOW PLATE 审中-实审
公开(公告)号：EP4392542A1
公开(公告)日：2024-07-03
申请号：EP22768903.1
申请日：2022-08-22
申请人： Newcells Biotech Limited
发明人： BROWN, Colin Douglas Archibald , PISAPIA, Francesca , O'BRIEN, Donovan Benjamin
IPC分类号： C12M3/06 , C12M1/12 , C12M1/34
CPC分类号： C12M27/16 , C12M41/00 , C12M25/04

5. 发明授权

EP1893738B1 CULTURE INSERT CARRIER, CULTURE INSERT AND CULTURE INSERT SYSTEM 有权
公开(公告)号：EP1893738B1
公开(公告)日：2018-12-05
申请号：EP06742457.2
申请日：2006-06-09
申请人： NUNC A/S
发明人： ESSER, Peter , STIGBORG, Frank, T. , PEDERSEN, Klaus , ISKOV, Stefan
IPC分类号： C12M1/12
CPC分类号： C12M23/12 , C12M25/04
摘要： The present invention relates to a culture insert carrier, a culture insert and a culture system for culturing and testing of different kinds of cells, such as for example skin models. A culture insert carrier for supporting at least one culture insert in a culture tray having at least one well, wherein the culture insert carrier comprises a plane member with at least one opening for insertion of the at least one culture insert in such a way that the culture insert carrier supports the at least one culture insert in a position in the culture tray is provided. Further, a culture insert comprising a plurality of suspension elements including a first set of suspension elements and a second set of suspension elements, the suspension elements being adapted to suspend the culture insert in a plurality of vertical positions, including a first vertical position and a second vertical position, in relation to a frame is provided.

6. 发明公开

EP3294861A1 WELL INSERTS WITH BRITTLE MEMBRANES 审中-公开
公开(公告)号：EP3294861A1
公开(公告)日：2018-03-21
申请号：EP16723322
申请日：2016-05-10
申请人： SIMPLINEXT SA
发明人： ANGELONI SUTER SILVIA , SUTER KASPAR , MARGUET ERIC , BERGERAT SYLVAIN , VOUTAT CHARLOTTE
IPC分类号： C12M1/12 , C12M1/00
CPC分类号： C12M25/04 , C12M23/00
摘要： The present invention relates to a well insert (10) for cell culture, comprising: - a membrane support (10a) having an upper end and a lower end, said upper end being adapted to engage a well of a microplate so as to suspend the well insert (10) therein; - a permeable membrane (1) for supporting a tissue culture, the permeable membrane (1) being attached at said lower end of the membrane support (10a) and sealed thereto, the permeable membrane (1) being of brittle material. According to the invention, the membrane support (10a) is overmoulded or fastened on to the permeable membrane (1) so as be sealed thereto.

7. 发明公开

EP3212759A1 CELL CULTURE INSERT 审中-公开
标题翻译：细胞培养插页
公开(公告)号：EP3212759A1
公开(公告)日：2017-09-06
申请号：EP15791189.2
申请日：2015-10-29
申请人： Corning Incorporated
发明人： MARTIN, Gregory Roger , TANNER, Allison Jean
IPC分类号： C12M1/12 , C12M3/00
CPC分类号： C12M25/04 , C12M21/08
摘要： A cell culture insert for use in culturing cells to promote the formation of spheroids and methods of using these spheroid-promoting cell culture inserts. The cell culture insert includes a porous membrane and one or more sidewalls that are non-adherent to cells and cause the cells in the insert to associate with each other and form spheroids.
摘要翻译：用于培养细胞以促进球体形成的细胞培养插入物和使用这些球状体促进细胞培养插入物的方法。细胞培养插入物包括多孔膜和一个或多个不与细胞粘附的侧壁，并使插入物中的细胞相互缔合并形成球状体。

8. 发明授权

EP1910512B1 MULTILAYERED CELL CULTURE APPARATUS 有权
标题翻译：附加层细胞培养装置
公开(公告)号：EP1910512B1
公开(公告)日：2016-10-05
申请号：EP06787388.5
申请日：2006-07-13
申请人： Corning Incorporated
发明人： MARTIN, Gregory R , TANNER, Allison J
IPC分类号： C12M3/06 , B01L3/08 , C12M1/24
CPC分类号： C12M23/08 , C12M23/04 , C12M23/24 , C12M23/34 , C12M23/38 , C12M23/58 , C12M25/02 , C12M25/04 , C12M25/06 , C12M29/04 , C12N5/0602
摘要： A multilayered cell culture apparatus for the culturing of cells is disclosed. The cell culture apparatus is defined as an integral structure having a plurality of cell culture chambers in combination with tracheal space(s). The body of the apparatus has imparted therein gas permeable membranes in combination with tracheal spaces that will allow the free flow of gases between the cell culture chambers and the external environment. The flask body also includes an aperture that will allow access to the cell growth chambers by means of a needle or cannula. The size of the apparatus, and location of an optional neck and cap section, allows for its manipulation by standard automated assay equipment, further making the apparatus ideal for high throughput applications.

9. 发明公开

EP3030646A1 METHODS, APPARATUSES, AND SYSTEMS FOR CELL AND TISSUE CULTURE 无效
标题翻译： VERFAHREN，VORRICHTUNGEN UND SYSTEMEFÜRZELL- UND GEWEBEKULTUR
公开(公告)号：EP3030646A1
公开(公告)日：2016-06-15
申请号：EP14833661.3
申请日：2014-08-07
申请人： Agency for Science, Technology and Research , Carnegie Mellon University
发明人： ZENG, Yukai , LEDUC, Philip R. , CHIAM, Keng-Hwee
IPC分类号： C12M3/00 , C12M1/14
CPC分类号： C12M23/20 , C12M23/12 , C12M23/44 , C12M25/04 , C12M25/06 , C12M35/04
摘要： This invention provides an apparatus and method for culturing cells to probe the influence that the properties of a surface onto which the cells are bonded has on the properties of the cell.
摘要翻译：本发明提供一种用于培养细胞以探测细胞结合的表面的性质对细胞特性的影响的装置和方法。

10. 发明授权

EP2548943B1 Clamping insert for cell culture 有权
标题翻译：细胞培养夹紧嵌入
公开(公告)号：EP2548943B1
公开(公告)日：2016-05-11
申请号：EP11174937.0
申请日：2011-07-21
申请人： CSEM Centre Suisse d'Electronique et de Microtechnique SA - Recherche et Développement
发明人： Angeloni Suter, Silvia , Liley, Martha
IPC分类号： C12M1/00 , C12M1/12
CPC分类号： C12M25/04 , C12M23/00 , C12M23/48 , C12M25/08 , C12M41/46 , Y10T29/49998
摘要： The invention concerns a clamping insert for cell culture comprising: - a lower support (12) comprising: i. a hollow member (14) sized to be engaged in a well of a microplate, said hollow member (14) being open at both its ends and comprising a support surface (16) at one of its ends, ii. first tightening means, - an inner holder (22) sized to be fitted inside the hollow member (14), and comprising second tightening means arranged to cooperate with said first tightening means of the hollow member (14) to tighten reversibly between the inner holder (22) and the support surface (16) of the lower support (12) a porous substrate, said inner holder (22) comprising an opened channel keeping free the porous substrate; - retaining means (18) intended to cooperate with the well of the microplate to allow the clamping insert to be suspended in the well of the microplate, - sealing means (26) to hermetically seal the contact area between the clamping insert and said porous substrate.

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