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1. 发明公开

EP3348303A2 FLÜSSIGPFLASTER, AUFTRAGEVORRICHTUNG UND DEREN VERWENDUNG 审中-公开
公开(公告)号：EP3348303A2
公开(公告)日：2018-07-18
申请号：EP17204715.1
申请日：2017-11-30
申请人： Elixmann, Madeleine
发明人： Elixmann, Madeleine
IPC分类号： A61M35/00 , A61L26/00
CPC分类号： A61M35/003 , A61L26/00 , A61L26/0014 , A61L26/0019 , A61M35/00 , C08L23/06 , C08L83/04
摘要： Auftragevorrichtung (1) und Flüssigpflaster (2) umfassend eine oder mehreren Komponenten, wobei das Flüssigpflaster nach Auftragen auf eine Hautstelle eines Anwenders durch passive oder aktive Aushärtung einen geschlossenen Film bildet und in seinen rheologischen Eigenschaften auf die Auftragevorrichtung abgestimmt ist, die Auftragevorrichtung umfassend ein Reservoir (3) mit Flüssigpflaster (2) aus festem, durch keine der Inhaltsstoffe des Flüssigpflasters angreifbarem Material, insbesondere Glas oder Kunststoff, wobei das Reservoir als ein Hohlkörper mit einer Öffnung (31) ausgebildet ist, wobei auf der Öffnung (31) des Reservoirs (3) dem ein Auftragemittel (4) mit Auftragespitze (42) befestigt ist, welches dazu geeignet ist, das Flüssigpflaster (2) gleichmäßig auf die Hautstelle des Anwenders aufzutragen und zu verteilen.

2. 发明授权

EP2825216B1 DRY HAEMOSTATIC COMPOSITION 有权
标题翻译：枯血母乳喂养成分
公开(公告)号：EP2825216B1
公开(公告)日：2015-08-19
申请号：EP13732818.3
申请日：2013-06-12
申请人： Ferrosan Medical Devices A/S
发明人： LARSEN, Kristian
IPC分类号： A61L24/10 , A61L24/00
CPC分类号： A61L26/0047 , A61K9/1658 , A61K31/047 , A61K31/70 , A61K38/014 , A61L2/04 , A61L2/07 , A61L2/081 , A61L2/082 , A61L2/087 , A61L2/10 , A61L2/202 , A61L2/204 , A61L2/206 , A61L2/208 , A61L24/0015 , A61L24/0036 , A61L24/104 , A61L26/00 , A61L26/0038 , A61L26/0066 , A61L2300/254 , A61L2300/418 , A61L2300/802 , A61L2400/04 , A61L2400/06 , B65B1/04 , B65D81/32
摘要： The present invention relates to a dry composition, which upon addition of an aqueous medium forms a substantially homogenous paste suitable for use in haemostasis procedures. The paste forms spontaneously upon addition of the liquid, hence no mechanical mixing is required for said paste to form. The invention further relates to methods of preparing said dry composition, a paste made from said dry composition and use of said paste for medical and surgical purposes.

3. 发明公开

EP2054030A1 ANTIMICROBIALS 有权
标题翻译：抗微生物剂
公开(公告)号：EP2054030A1
公开(公告)日：2009-05-06
申请号：EP07789107.5
申请日：2007-08-03
申请人： UCL Business PLC
发明人： WILSON, Michael , PARKIN, Ivan P. , NAIR, Sean , GIL-TOMAS, Jesus
IPC分类号： A61K9/00 , A61K9/10 , A61K31/28 , A61K41/00 , A61L15/00 , A61L26/00
CPC分类号： A61K31/5415 , A01N59/16 , A61K9/0014 , A61K9/0031 , A61K9/0034 , A61K9/0043 , A61K9/0046 , A61K9/0053 , A61K9/10 , A61K9/14 , A61K31/28 , A61K33/24 , A61K41/0038 , A61K41/0057 , A61L15/00 , A61L26/00 , C01P2004/64 , C10M2219/108 , Y10S977/777 , A01N2300/00 , A01N25/02 , A01N25/34 , A01N43/84
摘要： The present invention relates to mixtures comprising charge-stabilized metallic nanoparticles and a photosensitiser, and their use as light activated antimicrobials. The present invention also relates to metallic nanoparticle-ligand-photosensitiser conjugates and their use as light activated antimicrobials.

4. 发明授权

EP0946736B1 METHOD FOR EXPRESSION OF HETEROLOGOUS PROTEINS IN YEAST 失效
标题翻译：方法表达在HEFE异源蛋白
公开(公告)号：EP0946736B1
公开(公告)日：2003-10-29
申请号：EP97954073.9
申请日：1997-12-12
申请人： CHIRON CORPORATION
发明人： TEKAMP-OLSON, Patricia , MERRYWEATHER, James, P.
IPC分类号： C12N15/81 , C07K14/49 , C07K14/65 , C12N1/19
CPC分类号： A61K38/1858 , A61K9/0014 , A61K9/06 , A61L26/00 , C07K14/49 , C07K14/65 , C07K2319/02 , C12N15/81
摘要： Vectors are provided for expression of heterologous mammalian proteins. Vectors of the invention comprise nucleotide sequences encoding a signal peptide sequence for a yeast secreted protein, an optional leader peptide sequence for a yeast secreted protein, a native propeptide leader sequence for a mature protein of interest, and a sequence for the mature protein of interest, all operably linked to a yeast promoter. Each of these elements is associated with a processing site recognized in vivo by a yeast proteolytic enzyme. Any or all of these processing sites may be a preferred processing site that has been modified or synthetically derived for more efficient cleavage in vivo. The vectors are useful in methods for expression of heterologous mammalian proteins and their secretion in the biologically active mature form. Particularly, vectors comprising these nucleotides coding sequences can be used to transform a yeast host cell, which can then be cultured and screened for secretion of the biologically active mature protein of interest.

5. 发明公开

EP0946736A1 METHOD FOR EXPRESSION OF HETEROLOGOUS PROTEINS IN YEAST 失效
标题翻译：方法表达在HEFE异源蛋白
公开(公告)号：EP0946736A1
公开(公告)日：1999-10-06
申请号：EP97954073.0
申请日：1997-12-12
申请人： CHIRON CORPORATION
发明人： TEKAMP-OLSON, Patricia , MERRYWEATHER, James, P.
IPC分类号： A61K38 , A61P17 , C07K1 , C07K14 , C07K19 , C12N1 , C12N15
CPC分类号： A61K38/1858 , A61K9/0014 , A61K9/06 , A61L26/00 , C07K14/49 , C07K14/65 , C07K2319/02 , C12N15/81
摘要： Vectors are provided for expression of heterologous mammalian proteins. Vectors of the invention comprise nucleotide sequences encoding a signal peptide sequence for a yeast secreted protein, an optional leader peptide sequence for a yeast secreted protein, a native propeptide leader sequence for a mature protein of interest, and a sequence for the mature protein of interest, all operably linked to a yeast promoter. Each of these elements is associated with a processing site recognized in vivo by a yeast proteolytic enzyme. Any or all of these processing sites may be a preferred processing site that has been modified or synthetically derived for more efficient cleavage in vivo. The vectors are useful in methods for expression of heterologous mammalian proteins and their secretion in the biologically active mature form. Particularly, vectors comprising these nucleotides coding sequences can be used to transform a yeast host cell, which can then be cultured and screened for secretion of the biologically active mature protein of interest.

6. 发明公开

EP0560014A1 Biodegradable film dressing and method for its formation 失效
标题翻译： Biologisch abbaubarer Wundferband in Form einesSprühfilmsund Verfahren zu seiner Herstellung。
公开(公告)号：EP0560014A1
公开(公告)日：1993-09-15
申请号：EP93100358.6
申请日：1993-01-13
申请人： ATRIX LABORATORIES, INC.
发明人： Tipton, Arthur J. , Fujita, Shawn M. , Dunn, Richard L.
IPC分类号： A61L25/00
CPC分类号： A61L15/44 , A61K9/7015 , A61L24/0042 , A61L26/00 , A61L26/0066 , A61L26/0076 , A61L26/0085 , A61L26/009 , A61L2300/252 , A61L2300/604
摘要： The invention is directed to a biodegradable film dressing with or without additional therapeutic agents, an apparatus for spray delivery and a method for formation of the film dressing on a human or animal tissue. The film dressing is formed from a liquid composition of at least one biodegradable/bioerodible thermoplastic polymer in a pharmaceutically acceptable solvent. The spray apparatus includes a vessel containing the liquid composition with a dispensing means. The film is formed by dispensing, preferably by spraying, the liquid composition onto a tissue site and contacting the liquid composition with an aqueous based fluid to coagulate or solidify the film onto the human or animal tissue. The biodegradable film can be used to protect and to promote healing of injured tissue and/or to deliver biologically active agents.
摘要翻译：本发明涉及具有或不具有其他治疗剂的生物降解性膜敷料，用于喷雾递送的装置和在人或动物组织上形成膜敷料的方法。薄膜敷料由药学上可接受的溶剂中的至少一种生物可降解/生物可侵蚀的热塑性聚合物的液体组合物形成。喷雾装置包括容纳具有分配装置的液体组合物的容器。通过优选通过将液体组合物分配到组织部位上并且使液体组合物与基于水的液体接触使凝胶或固化到人体或动物组织上而形成膜。可生物降解的膜可用于保护和促进损伤组织的愈合和/或递送生物活性剂。

7. 发明授权

EP0225367B1 FILM FORMING COMPOSITION FOR TOPICAL USE 失效
标题翻译：用于局部使用的成膜组合物
公开(公告)号：EP0225367B1
公开(公告)日：1992-05-20
申请号：EP86903520.4
申请日：1986-06-11
申请人： Topical Systems Limited
发明人： IMRIE, Frazer, Keith, Elliott 44 Alexandra Road , JAMES, Ken 4 Colne Close
IPC分类号： A61K7/48 , A61K47/00 , A61K31/70
CPC分类号： A61K8/60 , A61K8/375 , A61K9/7015 , A61K47/26 , A61L26/00 , A61Q19/00 , Y10S514/844 , Y10S514/859 , Y10S514/871 , Y10S514/943
摘要： A composition for application to human and animal tissue surfaces, said composition comprising an aqueous medium and a film-forming component at least partially soluble or dispersible in said aqueous medium, said film-forming component comprising an ester or mixture of esters, at least one being an ester of a polyol.

8. 发明公开

EP0220934A2 Aluminium carboxylates 失效
标题翻译： Aluminiumcarboxylate。
公开(公告)号：EP0220934A2
公开(公告)日：1987-05-06
申请号：EP86308214.5
申请日：1986-10-22
申请人： STEPAN COMPANY
发明人： Bernhardt, Randal J. , Loeb, Melvin L. , Kay, James W.
IPC分类号： C07F5/06 , A61K7/44 , C08G79/10
CPC分类号： A61K8/26 , A61K8/58 , A61K47/24 , A61L26/00 , A61Q17/04 , C07F5/069 , C07F7/003 , C07F7/006 , C07F9/11 , G03C1/7614 , G03C1/815 , G03C1/85 , G03F7/004 , G03F7/029
摘要： The present invention relates to a method of providing on a surface an active and/or hydrophobic coating which comprises applying to said surface a coating of an organoaluminium compound of the formula
wherein R represents an amido carboxyl moiety selected from the group consisting of:
or
wherein R l and R 2 may be the same or different and are selected from the group consisting of hydrogen, an alkyl radical of rom 1 to about 20 carbon atoms, an aryl or aralkyl radical of from 6 to about 20 carbon atoms, and an alkenyl radical of from 3 to about 20 carbon atoms; R 3 is a hydrocarbyl radical of from 1 to about 6 carbon atoms; and the sum of the carbon atoms in R' and R 2 is in the range of from 0 to about 40, and the sum of the carbon atoms in R 1 , R 2 and R 3 is at least 2; R" is a modifier moiety selected from the group consisting of hydroxyl, an alkoxy radical of from 1 to about 6 carbon atoms, or carboxyl radical of from 1 to about 6 carbon atoms; R' comprises either a group as defined for R, which may be the same or different from R, or an active moiety, said active moiety being bonded to the aluminium by a carboxylate, sulphonate, phosphate, phosphite, oxa or thia linkage.
摘要翻译：本发明涉及一种在表面上提供活性和/或疏水涂层的方法，其包括向所述表面施涂下式的有机铝化合物的涂层...其中R表示选自下组的酰氨基羧基部分包括：... ...或... 其中R 1和R 2可以相同或不同，并且选自氢，1至约20个碳的烷基原子，6至约20个碳原子的芳基或芳烷基和3至约20个碳原子的烯基; R 3是1至约6个碳原子的烃基; 并且R 1和R 2中的碳原子之和在0至约40的范围内，R 1，R 2和R 3中的碳原子之和，至少2; ... R sec是选自羟基，1至约6个碳原子的烷氧基或1至约6个碳原子的羧基的修饰剂部分; R min包括 R定义的基团，其可以与R相同或不同，或活性部分，所述活性部分通过羧酸酯，磺酸酯，磷酸酯，亚磷酸酯，氧杂或硫键连接在铝上。

9. 发明公开

EP3391897A1 HEMOSTATIC COMPOSITION AND HEMOSTATIC METHOD USING HEMOSTATIC COMPOSITION 有权
公开(公告)号：EP3391897A1
公开(公告)日：2018-10-24
申请号：EP16875700.3
申请日：2016-12-14
申请人： 3-D Matrix Ltd.
发明人： NAGANO, Keiji , KOBAYASHI, Satoru
IPC分类号： A61K38/00 , A61K9/12 , A61L26/00 , A61P7/04 , A61P17/02 , A61P43/00 , C07K7/00
CPC分类号： A61K38/04 , A61K9/12 , A61K38/00 , A61L26/00 , A61P7/04 , A61P17/02 , C07K7/00
摘要： [Problem to be Solved]
It is intended to provide a composition for hemostasis which can be uniformly applied to a bleeding site and exerts a high hemostatic effect.
[Solution]
The present invention provides a composition to be applied as a spray to a subject, the spray being used for hemostasis, and the composition comprising a self-assembling peptide, wherein the self-assembling peptide self-assembles and thereby gels when the composition is applied to a bleeding site of the subject, and the self-assembling peptide is contained in the composition at a concentration at which the composition has an improved hemostatic ability as compared with that when directly applied.

10. 发明公开

EP3370785A1 HEMOSTATIC COMPOSITION 有权
公开(公告)号：EP3370785A1
公开(公告)日：2018-09-12
申请号：EP16805220.7
申请日：2016-11-08
申请人： Omrix Biopharmaceuticals Ltd. , Ethicon, Inc.
发明人： ILAN, Erez , FAINGOLD, Omri , FREIZUS, Nataly , EAVRI, Ronen , LOONEY, Dwayne , DHANARAJ, Sridevi , GALLOWAY, James , DANKER, Walter
IPC分类号： A61L24/00 , A61L24/04
CPC分类号： A61L26/0023 , A61L24/001 , A61L24/0015 , A61L24/02 , A61L24/043 , A61L24/06 , A61L24/08 , A61L26/00 , A61L26/0004 , A61L2300/106 , A61L2300/232 , A61L2300/25 , A61L2300/418 , A61L2300/802 , A61L2400/04 , C08L1/04
摘要： The invention relates to a hemostatic composition comprising a mixture of cellulose-based short and long fibers, preparation and use thereof.

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