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1. 发明公开

EP2226075A1 MATERIAL FOR PREVENTING TISSUE ADHESION AND MATERIAL FOR PREVENTING JOINT CONTRACTURE 审中-公开
标题翻译：材料关节挛缩的预防和材料组织粘连防止
公开(公告)号：EP2226075A1
公开(公告)日：2010-09-08
申请号：EP08852570.4
申请日：2008-11-14
申请人： The University of Tokyo , KAKEN PHARMACEUTICAL CO., LTD.
发明人： MORO, Toru , NAKAMURA, Kozo , KAWAGUCHI, Hiroshi , ISHIYAMA, Noriyuki , ISHIHARA, Kazuhiko , KONNO, Tomohiro , OHYAMA, Tadashi , YOSHIKAWA, Mizuna
IPC分类号： A61K31/80 , A61K31/715 , A61K31/765 , A61P41/00 , A61P43/00
CPC分类号： A61K31/715 , A61K31/765 , A61K31/80
摘要： The present invention provides a tissue adhesion prevention material preparable at an affected area at the time of surgical procedure by producing a three-dimensional polymeric structure having a flexible structure and high solute permeability in a medium comprising water as the main component under mild conditions appropriate for body tissue components (i.e., at ordinary temperature and pressure) without conducting a chemical reaction or employing a physical procedure such as heating or light or radiation irradiation. This makes it possible to provide a tissue adhesion prevention material and a joint contracture prevention materials, which can effectively prevent postoperative adhesion of a tissue in the affected area to the surrounding tissue and contracture of the movable part of a joint.
The tissue adhesion prevention material and/or the joint contracture prevention material of the present invention comprise, as the main component, a composition comprising a compound having a polyvalent hydroxyl group and a polymer containing phosphorylcholine groups and phenylboronic acid groups.
摘要翻译：本发明通过产生具有包含水作为适合在温和条件下的主要成分在培养基中的柔性结构和高溶质透过性的三维聚合物结构提供在受影响的区域中的组织粘连防止材料制备的在外科手术过程的时间体的组织成分（即，在普通的温度和压力）不进行化学反应或物理用人过程：如加热或光或放射线照射。这使得可以提供一种组织粘连防止材料和关节挛缩预防材料，可有效地防止在患处的关节的可动部的周围组织和挛缩的组织的术后粘连。的组织粘连防止材料和/或本发明的关节挛缩预防材料包括，作为主要成分，其包括具有多价羟基和聚合物含磷酸胆碱基团和苯基硼酸基团的化合物的组合物。

2. 发明公开

EP1258250A1 NERVE PROTECTIVE DRUGS 有权
标题翻译： NERVENSCHUTZMITTEL
公开(公告)号：EP1258250A1
公开(公告)日：2002-11-20
申请号：EP00987803.4
申请日：2000-12-28
申请人： Kaken Pharmaceutical Co., Ltd.
发明人： MURATA, Takahiko , OHYAMA, Tadashi , AMAKAWA, Masahiro , FUJITA, Keiko , UEO, Haruyoshi
IPC分类号： A61K45/00 , A61K38/25 , A61K38/08 , A61K38/05 , A61K38/06 , A61K31/395 , A61K31/505 , C07D225/08 , C07D239/91 , A61P25/00 , A61P9/10 , A61P25/28
CPC分类号： C07D233/64 , A61K31/00 , A61K31/395 , A61K31/438 , A61K31/505 , A61K31/517 , A61K38/04 , A61K38/08 , A61K38/25 , C07D207/16 , C07D211/60 , C07D225/08 , C07D239/91 , C07D471/04 , C07D471/10 , Y10S930/12
摘要： An agent for prevention or treatment of diseases involving degeneration or death of nerve cells, characterized by containing a growth hormone secretion promoting substance as an active ingredient, is provided.
摘要翻译：提供了一种用于预防或治疗涉及神经细胞变性或死亡的疾病的药剂，其特征在于含有生长激素分泌促进物质作为活性成分。

3. 发明公开

EP3009426A1 4-ALKYNYL IMIDAZOLE DERIVATIVE AND MEDICINE COMPRISING SAME AS ACTIVE INGREDIENT 有权
标题翻译： 4-ALKYNYL-IMIDAZOL-DERIVAT UND ARZNEIMITTEL DAMIT ALS WIRKSTOFF
公开(公告)号：EP3009426A1
公开(公告)日：2016-04-20
申请号：EP14811154.5
申请日：2014-06-12
申请人： Kaken Pharmaceutical Co., Ltd.
发明人： IKEGAMI, Satoru , WATANABE, Atsushi , HIRANO, Kimio , OHYAMA, Tadashi
IPC分类号： C07D233/90 , A61K31/4164 , A61K31/4174 , A61K31/4178 , A61K31/4245 , A61K31/4439 , A61P19/00 , A61P19/02 , A61P21/00 , A61P25/04 , A61P29/00 , A61P43/00 , C07D401/06 , C07D401/12 , C07D403/12 , C07D413/12
CPC分类号： A61K31/4439 , A61K31/4164 , A61K31/4174 , A61K31/4178 , A61K31/4245 , C07D233/90 , C07D401/06 , C07D401/12 , C07D403/12 , C07D413/12
摘要： There are provided 4-alkynylimidazole derivatives represented by the following general formula (I) or phamaceutically acceptable salts thereof; the derivatives have a superior EP4 receptor antagonistic action and are useful as pharmaceuticals for the treatment of diseases associated with the EP4 receptor, for example, as anti-inflammatory and/or analgesic drugs for inflammatory diseases and diseases that involve various kinds of pains, and further as pharmaceuticals for the treatment of immune diseases that result from inflammations as evoked by tissue destruction due to the activation of Th1 cells and/or Th17 cells:
摘要翻译：提供由以下通式（I）表示的4-炔基咪唑衍生物或其药学上可接受的盐; 该衍生物具有优异的EP4受体拮抗作用，可用作治疗与EP4受体有关的疾病的药物，例如作为炎性疾病的抗炎和/或止痛药物以及涉及各种疼痛的疾病，以及进一步作为用于治疗由于Th1细胞和/或Th17细胞的激活而被组织破坏引起的炎症引起的免疫疾病的药物：

4. 发明授权

EP3009426B1 4-ALKYNYL IMIDAZOLE DERIVATIVE AND MEDICINE COMPRISING SAME AS ACTIVE INGREDIENT 有权
标题翻译： 4-炔丙基咪唑衍生物和包含其作为活性成分的药物
公开(公告)号：EP3009426B1
公开(公告)日：2018-05-02
申请号：EP14811154.5
申请日：2014-06-12
申请人： Kaken Pharmaceutical Co., Ltd.
发明人： IKEGAMI, Satoru , WATANABE, Atsushi , HIRANO, Kimio , OHYAMA, Tadashi
IPC分类号： C07D233/90 , A61K31/4164 , A61K31/4174 , A61K31/4178 , A61K31/4245 , A61K31/4439 , A61P19/00 , A61P19/02 , A61P21/00 , A61P25/04 , A61P29/00 , A61P43/00 , C07D401/06 , C07D401/12 , C07D403/12 , C07D413/12
CPC分类号： A61K31/4439 , A61K31/4164 , A61K31/4174 , A61K31/4178 , A61K31/4245 , C07D233/90 , C07D401/06 , C07D401/12 , C07D403/12 , C07D413/12
摘要： There are provided 4-alkynylimidazole derivatives represented by the following general formula (I) or phamaceutically acceptable salts thereof; the derivatives have a superior EP4 receptor antagonistic action and are useful as pharmaceuticals for the treatment of diseases associated with the EP4 receptor, for example, as anti-inflammatory and/or analgesic drugs for inflammatory diseases and diseases that involve various kinds of pains, and further as pharmaceuticals for the treatment of immune diseases that result from inflammations as evoked by tissue destruction due to the activation of Th1 cells and/or Th17 cells:

5. 发明授权

EP1258250B1 NERVE PROTECTIVE DRUGS 有权
标题翻译：神经保护产品
公开(公告)号：EP1258250B1
公开(公告)日：2005-09-14
申请号：EP00987803.4
申请日：2000-12-28
申请人： KAKEN PHARMACEUTICAL CO., LTD.
发明人： MURATA, Takahiko , OHYAMA, Tadashi , AMAKAWA, Masahiro , FUJITA, Keiko , UEO, Haruyoshi
IPC分类号： A61K45/00 , A61K38/25 , A61K38/08 , A61K38/05 , A61K38/06 , A61K31/395 , A61K31/505 , C07D225/08 , C07D239/91 , A61P25/00 , A61P9/10 , A61P25/28
CPC分类号： C07D233/64 , A61K31/00 , A61K31/395 , A61K31/438 , A61K31/505 , A61K31/517 , A61K38/04 , A61K38/08 , A61K38/25 , C07D207/16 , C07D211/60 , C07D225/08 , C07D239/91 , C07D471/04 , C07D471/10 , Y10S930/12

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