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1. 发明公开

EP1215215A1 Platelet aggregation inhibitors containing c-terminal aminergic side chain amino acid residues 失效
标题翻译：死亡细胞死亡C末端氨基末端Seitenketten焓
公开(公告)号：EP1215215A1
公开(公告)日：2002-06-19
申请号：EP02002913.8
申请日：1996-03-22
申请人： G.D. SEARLE & CO.
发明人： Abood, Norman A. , Bovy, Philippe R. , Flynn, Daniel L. , Rico, Joseph G. , Rogers, Thomas E.
IPC分类号： C07K14/75 , C07K5/06 , A61K38/05
CPC分类号： C07K5/021 , A61K38/00 , C07K5/0202 , C07K5/06113
摘要： This invention relates to compounds having the following formula:
or pharmaceutically acceptable salt thereof which are useful in the inhibition of platelet aggregation, to pharmaceutical compositions containing such compounds, and to a method of inhibiting platelet aggregation in mammals by administering such compounds and compositions.
摘要翻译：本发明涉及具有下式的化合物：其可用于抑制血小板聚集的或其药学上可接受的盐，含有这些化合物的药物组合物，以及通过施用这些化合物和成分。

2. 发明授权

EP1122245B1 2-Amino-benzoxazinones for the treatment of viral infections 失效
标题翻译： 2-氨基 - 苯并嗪酮用于病毒感染的治疗
公开(公告)号：EP1122245B1
公开(公告)日：2004-07-07
申请号：EP01110048.4
申请日：1996-05-23
申请人： G.D. Searle & Co.
发明人： Abood, Norman , Flynn, Daniel L. , Becker, Daniel P. , Bax, Brian M. , Li, Hui , Nosal, Roger A. , Schretzman, Lori A. , Villamil, Clara I.. , Bennett, Michael J. , Bedell, John L. , Williams, Kenneth
IPC分类号： C07D265/24 , C07D413/12 , A61K31/536 , A61P31/12
CPC分类号： C07D265/24 , C07D413/04 , C07D413/12 , C07D417/12

3. 发明公开

EP1122245A3 2-Amino-benzoxazinones for the treatment of viral infections 失效
标题翻译： 2-氨基 - 苯并嗪酮用于病毒感染的治疗
公开(公告)号：EP1122245A3
公开(公告)日：2001-08-22
申请号：EP01110048.4
申请日：1996-05-23
申请人： G.D. Searle & Co.
发明人： Abood, Norman , Flynn, Daniel L. , Becker, Daniel P. , Bax, Brian M. , Li, Hui , Nosal, Roger A. , Schretzman, Lori A. , Villamil, Clara I.. , Bennett, Michael J. , Bedell, John L. , Williams, Kenneth
IPC分类号： C07D265/24 , C07D413/12 , A61K31/536 , A61P31/12
CPC分类号： C07D265/24 , C07D413/04 , C07D413/12 , C07D417/12
摘要： A class of compounds for the treatment of viral infections. Compounds of particular interest are defined by Formula I or a pharmaceutically-acceptable salt thereof.

4. 发明公开

EP1122245A2 2-Amino-benzoxazinones for the treatment of viral infections 失效
标题翻译： 2-氨基苯并恶嗪酮用于治疗病毒感染
公开(公告)号：EP1122245A2
公开(公告)日：2001-08-08
申请号：EP01110048.4
申请日：1996-05-23
申请人： G.D. Searle & Co.
发明人： Abood, Norman , Flynn, Daniel L. , Becker, Daniel P. , Bax, Brian M. , Li, Hui , Nosal, Roger A. , Schretzman, Lori A. , Villamil, Clara I.. , Bennett, Michael J. , Bedell, John L. , Williams, Kenneth
IPC分类号： C07D265/24 , C07D413/12 , A61K31/536 , A61P31/12
CPC分类号： C07D265/24 , C07D413/04 , C07D413/12 , C07D417/12
摘要： A class of compounds for the treatment of viral infections. Compounds of particular interest are defined by Formula I
wherein R - R 4 are as defined herein, or a pharmaceutically-acceptable salt thereof.
摘要翻译：一类用于治疗病毒感染的化合物。特别感兴趣的化合物由式I定义，其中R 1 -R 4如本文所定义，或其药学上可接受的盐。

5. 发明公开

EP0504680A1 New meso-azacyclic aromatic acid amides and esters as novel serotonergic agents 失效
标题翻译：咔唑che che che che che che。。。。。。。。。。。。。。。。
公开(公告)号：EP0504680A1
公开(公告)日：1992-09-23
申请号：EP92103863.4
申请日：1992-03-06
申请人： G.D. Searle & Co.
发明人： Becker, Daniel P. , Flynn, Daniel L. , Moormann, Alan Edward , Nosal, Roger , Villamil, Clara I.
IPC分类号： C07D487/04 , C07D487/08 , C07D471/08 , A61K31/40 , A61K31/435 , A61K31/55 , A61K31/53 , A61K31/505 , A61K31/415
CPC分类号： C07D471/08 , C07D487/04 , C07D487/08
摘要： The meso-azacyclic aromatic acid amides and esters of formula

where Ar represents a radical of the formula:

X is NH od O; and Z represents a radical of the formula:

are useful in the treatment of the central nervous system and gastrointestinal motility disorders such as gastroesophageal reflux, non-ulcer dyspepsia, delayed gastric emptying, ileus, irritable bowel syndrom, and the like. Additionally, the compounds of the present invention find utility as antagonists of serotonin 5-HT₃ receptors. As such they are useful for the treatment of humans and animals wherein antagonism of 5-HT₃ reseptors is beneficial. Therapy is indicated for, but not limited to, the treatment of anxiety, psychoses, depression (especially depression accompanied by anxiety), cognitive disorders, substance abuse dependence and/or withdrawal, irritable bowel syndrome, emesis caused by chemotherapeutic agents, and visceral pain. Additionally, the compounds of the present invention may find utility as enhancers of nasal absorption of bioactive compounds.
摘要翻译：内消旋 - 氮杂环芳香酰胺和式的酯，其中Ar表示下式的基团：其中X是O， Z表示下式的基团：可用于治疗中枢神经系统和胃肠动力障碍，例如胃食管反流，非溃疡性消化不良，胃排空迟缓，肠梗阻，肠易激综合征等。此外，本发明的化合物可用作5-羟色胺5-HT 3受体的拮抗剂。因此，它们可用于治疗其中5-HT 3受体拮抗剂的拮抗作用有益的人和动物。治疗指示但不限于治疗焦虑，精神病，抑郁症（特别是伴有焦虑症的抑郁症），认知障碍，药物滥用依赖和/或戒断，肠易激综合征，化疗药物引起的呕吐和内脏痛。此外，本发明的化合物可用作生物活性化合物的鼻吸收增强剂。

6. 发明公开

EP0504679A1 New imidazopyridines as serotonergic 5-HT3 antagonists 失效
标题翻译：咪唑并吡啶al-serotonergische 5-HT3拮抗剂。
公开(公告)号：EP0504679A1
公开(公告)日：1992-09-23
申请号：EP92103862.6
申请日：1992-03-06
申请人： G.D. Searle & Co.
发明人： Becker, Daniel P. , Flynn, Daniel L. , Moormann, Alan Edward , Nosal, Roger , Villamil, Clara I.
IPC分类号： C07D519/00 , C07D471/04 , A61K31/435
CPC分类号： C07D471/04
摘要： The imidazopyridines of formula
wherein Ar represents a radical of the formula

Z represents a radical of the formula

The compounds are seterotonergic 5-HT₃ antagonists. As such they are useful for the treatment of humans and animals wherein antagonism of 5-HT₃ receptors is beneficial. Therapy is indicated for, but not limited to, the treatment of anxiety, psychoses, depression (especially depression accompanied by anxiety), cognitive disorders, substance abuse dependence and withdrawal, gastrointestinal motility disturbancies (including esophageal reflux, dyspepsia, gastric stasis, irritable bowel syndrome), emesis caused by chemotherapeutic agents, and visceral pain. Additionally, the compounds of the present invention may find utillity as enhancers of nasal absoption of bioactive compounds.
摘要翻译：下式的咪唑并吡啶其中Ar表示式CHEM> Z的基团表示下式的基团。化合物是稳定性能的5-HT 3拮抗剂。因此，它们可用于治疗其中5-HT 3受体拮抗作用有益的人和动物。治疗指示但不限于治疗焦虑，精神病，抑郁症（特别是伴有焦虑症的抑郁症），认知障碍，药物滥用依赖和戒断，胃肠蠕动窒息（包括食管反流，消化不良，胃潴留，肠易激惹）综合征），化疗引起的呕吐和内脏痛。此外，本发明的化合物可以发现作为生物活性化合物鼻吸收的增强剂。

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