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1. 发明公开

EP1898221A2 Analyzer with automatically actuated movable closure of pipetting openings 审中-公开
标题翻译：分析自动化最佳化学计算方法VerschlussfürPipettenöffnungen
公开(公告)号：EP1898221A2
公开(公告)日：2008-03-12
申请号：EP07014568.5
申请日：2007-07-25
申请人： F.HOFFMANN-LA ROCHE AG , Roche Diagnostics GmbH
发明人： Schacher, Gottlieb , Gut, Raphael
IPC分类号： G01N35/02
CPC分类号： G01N35/025 , B01L3/0217 , B01L2200/142 , B01L2200/16 , B01L2300/045 , B01L2300/049 , G01N35/1002 , G01N35/1083 , G01N2035/00287
摘要： A clinical chemistry analytical apparatus for automatically analyzing a plurality of samples of biological fluids, wherein aliquots of said samples are mixed with aliquots of selected reagent liquids in reaction cuvettes for forming sample-reagent-mixtures contained in a plurality of reaction cuvettes. The apparatus comprises: (a) an array of reagent containers and an array of reaction cuvettes , each of the reagent containers and each of the reaction cuvettes having an open upper end, (b) an automatic pipetting unit (12) having a pipetting needle (13) for taking an aliquot of reagent from one of said reagent containers and for delivering said aliquot into one of said reaction cuvettes, the automatic pipetting (12) unit having a transport device (31) for moving the pipetting needle (13) to at least one pipetting position, (c) a movable cover (14) covering a chamber (18) in which the reagent containers are stored, the cover (14) having at least one pipetting opening (15, 16) which allows insertion of the pipetting needle (13) therethrough, (d) a closure mechanism (17) which in a first state closes the pipetting opening (15, 16) and in a second state leaves it open, (e) transport means for automatically transporting each of the reagent containers to a pipetting position, at which the opening at the upper end of the reagent container is aligned with the pipetting opening (15, 16) of the cover (14), and (f) means for automatically actuating the closure mechanism (17) to bring it into its second state before introducing the pipetting needle (13) through the pipetting opening (15, 16) and for automatically actuating the closure mechanism (17) to bring it into its first state after withdrawal of the pipetting needle (13) from the pipetting opening (15, 16). The means for automatically actuating said closure mechanism (17) are adapted for being actuated by a displacement of said transport device (31) associated with the motion thereof that moves the pipetting needle (13) to the at least one pipetting position, respectively away from the at least one pipetting position.
摘要翻译：一种用于自动分析多个生物流体样本的临床化学分析装置，其中所述样品的等分试样与反应比色杯中的等分试样液一起混合，用于形成多个反应试管中包含的样品 - 试剂混合物。该装置包括：（a）一组试剂容器和一组反应池，每个试剂容器和每个反应试管具有开放的上端，（b）具有移液针的自动移液装置（12）（13），用于从所述试剂容器之一中取出试剂的等分试样并将所述等分试样输送到所述反应试液中的一个中，所述自动移液装置（12）具有用于将移液针（13）移动到至少一个移液位置，（c）覆盖其中存储有试剂容器的室（18）的可移动盖（14），所述盖（14）具有至少一个移液孔（15,16）（d）一个闭合机构（17），其在第一状态下关闭吸液开口（15,16），并且在第二状态下将其打开，（e）运输装置，用于自动运送每个试剂容器移至移液位置，在试剂容器的上端的起搏与盖（14）的吸液孔（15,16）对准，（f）用于在引入之前自动致动闭合机构（17）使其处于其第二状态的装置所述移液针通过所述移液开口（15,16）并且用于在从所述移液开口（15,16）中取出所述移液针（13）之后自动致动所述关闭机构（17）使其进入其第一状态，。用于自动启动所述闭合机构（17）的装置适于由与所述移动装置（31）相关联的所述运送装置（31）的移动而致动，所述移动装置将所述移液针（13）移动到所述至少一个移液位置，至少一个移液位置。

2. 发明公开

EP1898221A3 Analyzer with automatically actuated movable closure of pipetting openings 审中-公开
标题翻译： Analyzer与吸管口自动确认移动封闭
公开(公告)号：EP1898221A3
公开(公告)日：2008-10-29
申请号：EP07014568.5
申请日：2007-07-25
申请人： F.HOFFMANN-LA ROCHE AG , Roche Diagnostics GmbH
发明人： Schacher, Gottlieb , Gut, Raphael
IPC分类号： G01N35/02
CPC分类号： G01N35/025 , B01L3/0217 , B01L2200/142 , B01L2200/16 , B01L2300/045 , B01L2300/049 , G01N35/1002 , G01N35/1083 , G01N2035/00287
摘要： A clinical chemistry analytical apparatus for automatically analyzing a plurality of samples of biological fluids, wherein aliquots of said samples are mixed with aliquots of selected reagent liquids in reaction cuvettes for forming sample-reagent-mixtures contained in a plurality of reaction cuvettes. The apparatus comprises: (a) an array of reagent containers and an array of reaction cuvettes , each of the reagent containers and each of the reaction cuvettes having an open upper end, (b) an automatic pipetting unit (12) having a pipetting needle (13) for taking an aliquot of reagent from one of said reagent containers and for delivering said aliquot into one of said reaction cuvettes, the automatic pipetting (12) unit having a transport device (31) for moving the pipetting needle (13) to at least one pipetting position, (c) a movable cover (14) covering a chamber (18) in which the reagent containers are stored, the cover (14) having at least one pipetting opening (15, 16) which allows insertion of the pipetting needle (13) therethrough, (d) a closure mechanism (17) which in a first state closes the pipetting opening (15, 16) and in a second state leaves it open, (e) transport means for automatically transporting each of the reagent containers to a pipetting position, at which the opening at the upper end of the reagent container is aligned with the pipetting opening (15, 16) of the cover (14), and (f) means for automatically actuating the closure mechanism (17) to bring it into its second state before introducing the pipetting needle (13) through the pipetting opening (15, 16) and for automatically actuating the closure mechanism (17) to bring it into its first state after withdrawal of the pipetting needle (13) from the pipetting opening (15, 16). The means for automatically actuating said closure mechanism (17) are adapted for being actuated by a displacement of said transport device (31) associated with the motion thereof that moves the pipetting needle (13) to the at least one pipetting position, respectively away from the at least one pipetting position.

3. 发明公开

EP1898220A1 Analyzer with automatically actuated movable closure of pipetting openings 审中-公开
标题翻译：装置用于通过自动操作的可动封闭件用于移液开口分析
公开(公告)号：EP1898220A1
公开(公告)日：2008-03-12
申请号：EP06018932.1
申请日：2006-09-11
申请人： F.HOFFMANN-LA ROCHE AG , Roche Diagnostics GmbH
发明人： Schacher, Gottlieb , Gut, Raphael
IPC分类号： G01N35/02
CPC分类号： G01N35/025 , B01L3/0217 , B01L2200/142 , B01L2200/16 , B01L2300/045 , B01L2300/049 , G01N35/1002 , G01N2035/00287
摘要： A clinical chemistry analytical apparatus for automatically analyzing a plurality of samples of biological fluids, wherein aliquots of said samples are mixed with aliquots of selected reagent liquids in reaction cuvettes for forming sample-reagent-mixtures contained in a plurality of reaction cuvettes. The apparatus comprises: (a) a housing (11) in the interior of which reagent containers and reaction cuvettes are arranged which have open upper ends, (b) an automatic pipetting unit (12) having a pipetting needle (13) for taking an aliquot of reagent from one of said reagent containers and for delivering said aliquot into one of said reaction cuvettes, the automatic pipetting (12) unit having a transport device (31) for moving the pipetting needle (13) to at least one pipetting position, (c) a movable cover (14) covering a chamber (18) in the housing (11), the reagent containers being stored in the chamber (18), the cover (14) having a closed position at which it closes said chamber (18), the cover (14) having at least one pipetting opening (15, 16) which allows insertion of the pipetting needle (13) therethrough, (d) a closure mechanism (17) which in a first state closes the pipetting opening (15, 16) and in a second state leaves it open, (e) transport means for automatically transporting each of the reagent containers to a pipetting position, at which the opening at the upper end of the reagent container is aligned with the pipetting opening (15, 16) of the cover (14), and (f) means for automatically actuating the closure mechanism (17) to bring it into its second state before introducing the pipetting needle (13) through the pipetting opening (15, 16) and for automatically actuating the closure mechanism (17) to bring it into its first state after withdrawal of the pipetting needle (13) from the pipetting opening (15, 16).
摘要翻译：用于自动分析生物流体的样品的复数，worin说样品的等分试样的临床化学分析仪器与在反应试管中选择试剂液体用于形成包含在反应试管的多个采样-试剂混合物的等分试样混合。该装置包括：（a），其中的试剂容器和反应试管的内部的壳体（11）布置有具有开放的上端，（b）至自动移液单元（12），具有移液针（13），用于拍摄上从所述试剂容器中的一个和用于输送所述等分试样到所述反应试管中的一个，具有用于移液针（13）移动到至少一个移液位置的传输设备（31）的自动移液（12）单元的试剂的等分试样，（c）中的可动罩（14），其覆盖在所述壳体（11）的腔室（18），所述试剂容器被存储在所述腔室（18）中，具有在其关闭所述腔室（闭合位置的盖（14） 18），具有盖（14）的至少一个移液开口（15，16），其通过允许该移液针（13的插入）有，（D）的封闭机构（17）（在第一状态下关闭该移液开口 15，16）和在第二状态中离开它打开，（e）中的输送装置，用于自动TRANSPO rting每个试剂容器吸移位置，在该在试剂容器的上端开口与盖（14）的移液开口（15，16）对准，和（f）用于自动促动闭合机构（17），使之进入其第二状态通过移液开口引入所述移液针（13）（15，16）之前和用于自动地致动闭合机构（17），使之进入其第一状态撤出后从移液开口（15，16）的移液针（13）。

4. 发明公开

EP2527037A1 Apparatus and process for opening/closing fluid containers 有权
标题翻译： Vorrichtung und verfahren zumöffnen/ schliessen vonfluidbehältern
公开(公告)号：EP2527037A1
公开(公告)日：2012-11-28
申请号：EP11167523.7
申请日：2011-05-25
申请人： F. Hoffmann-La Roche AG , Roche Diagnostics GmbH
发明人： Gut, Raphael , Schacher, Gottlieb
IPC分类号： B01L3/14 , B65D41/00 , B67B7/00 , B67B7/18 , G01N35/10
CPC分类号： B01L3/50825 , B01L2300/042 , B01L2300/046 , B67B7/00 , G01N35/0099 , G01N2035/0405
摘要： The present invention pertains to an apparatus for the automated opening/closing one or more fluid containers, each of which being provided with container comprising an opening and a cap for closing said container opening, wherein said cap is pivotable with respect to said container body so as to open or close said container opening, comprising: a mount, a carriage supported by the mount by means of a translating mechanism, adapted to bidirectionally translate said carriage with respect to said mount; a carriage comprising a base portion and a pivoting portion supported by said base portion by means of a pivoting mechanism, adapted to bidirectionally pivot said pivoting portion with respect to said base portion, wherein said pivoting portion is provided with at least one contact member, adapted to contact at least one projecting portion of said cap of each of said one or more fluid containers while pivoting said pivoting portion so as to open and optionally close said container opening; a drive coupled to said carriage for translating said base portion and pivoting said pivoting portion.
摘要翻译：本发明涉及一种用于自动打开/关闭一个或多个流体容器的装置，每个流体容器设置有容器，该容器包括用于封闭所述容器开口的开口和盖，其中所述盖可相对于所述容器主体枢转，因此为了打开或关闭所述容器开口，包括：安装件，通过平移机构由所述安装座支撑的滑架，适于相对于所述底座双向平移所述托架; 托架，其包括基部和枢转部分，所述枢转部分通过枢转机构由所述基部支撑，适于相对于所述基部部分双向枢转所述枢转部分，其中所述枢转部分设置有至少一个接触构件，在枢转所述枢转部分的同时接触所述一个或多个流体容器中的每一个的所述盖的至少一个突出部分，以便打开并任选地关闭所述容器开口; 耦合到所述托架的驱动器，用于平移所述基部并枢转所述枢转部分。

5. 发明公开

EP2535712A1 Analytical system for the preparation of biological material 审中-公开
标题翻译：分析系统zur Herstellung eines biologischen材料
公开(公告)号：EP2535712A1
公开(公告)日：2012-12-19
申请号：EP11169994.8
申请日：2011-06-15
申请人： F. Hoffmann-La Roche AG , Roche Diagnostics GmbH
发明人： Zuppiger, Adelrich , Burghardt, Géza , Meyberg, Michael , D'Amore, Alessandro , Gut, Raphael
IPC分类号： G01N33/543 , G01N35/10
CPC分类号： G01N35/10 , G01N2035/1053 , G01N2035/1062
摘要： The present invention relates to a system for the isolation of biological material, using binding particles for the separation and/or isolation of such material.
More precisely, the present invention relates to a system for the isolation of biological material comprised in a fluid sample, said system comprising
• a separation station (1) constructed and arranged to separate and purify said biological material from said fluid sample, said separation station comprising at least one receiving vessel (2)
• a reservoir (3) containing a suspension of binding particles (4) for the isolation of said biological material
• a pipetting device (5) comprising a pipettor (6) for transferring said suspension of binding particles
• a measuring device (7) for determining the relative or absolute quantity of said binding
particles or a portion thereof within said pipettor.

The present invention further provides a method for the isolation of biological material comprised in a fluid sample.
摘要翻译：本发明涉及一种用于分离生物材料的系统，其使用用于分离和/或分离这种材料的结合颗粒。更准确地说，本发明涉及用于分离包含在流体样品中的生物材料的系统，所述系统包括分离站（1），其被构造和布置成从所述流体样品中分离和净化所述生物材料，所述分离包括至少一个接收容器（2）的储存器（3），其包含用于分离所述生物材料的结合颗粒（4）的悬浮液，移液装置（5）包括移液器（6），用于将所述用于确定所述粘合颗粒的相对或绝对量或所述移液器内的一部分的测量装置（7）的粘合颗粒悬浮液。本发明还提供了用于分离包含在流体样品中的生物材料的方法。

6. 发明授权

EP2410343B1 Wash station and process for washing reusable fluid manipulators 有权
标题翻译：清洗站和方法，用于清洗可重复使用的流体操纵器
公开(公告)号：EP2410343B1
公开(公告)日：2013-10-02
申请号：EP11174789.5
申请日：2011-07-21
申请人： F. Hoffmann-La Roche AG , Roche Diagnostics GmbH
发明人： Gut, Raphael
IPC分类号： G01N35/10 , B08B3/02 , B05B1/26 , B01L99/00
CPC分类号： G01N35/1004 , B01L9/52 , B05B1/267 , B08B3/02

7. 发明公开

EP2410343A1 Wash station and process for washing reusable fluid manipulators 有权
标题翻译： Waschstation und Verfahren zum Waschen wiederwendbarer Fluidmanipulatoren
公开(公告)号：EP2410343A1
公开(公告)日：2012-01-25
申请号：EP11174789.5
申请日：2011-07-21
申请人： F. Hoffmann-La Roche AG , Roche Diagnostics GmbH
发明人： Gut, Raphael
IPC分类号： G01N35/10 , B08B3/02 , B01L99/00
CPC分类号： G01N35/1004 , B01L9/52 , B05B1/267 , B08B3/02
摘要： The present invention pertains to a wash element for washing one or more reusable fluid manipulators comprising at least one nozzle for connection to a fluid pump to generate a fluid jet and at least one deflector surface positioned to deflect the fluid jet towards a washing zone for receiving at least a portion of the fluid manipulator. The deflector surface is being shaped to broaden the fluid jet. The invention further relates to a wash station having a cavity provided with one or more wash elements. The invention yet further relates to an automated system for manipulating fluids comprising at least one wash station and a controller set up to control washing the fluid manipulator. In a process for washing the reusable fluid manipulator at least a portion of the fluid manipulator is moved in a washing zone, a fluid jet of washing fluid is generated and directed onto a deflector surface shaped to broaden and deflect the fluid jet towards the washing zone.
摘要翻译：本发明涉及一种用于洗涤一个或多个可重复使用的流体操纵器的洗涤元件，其包括用于连接到流体泵的至少一个喷嘴以产生流体射流和至少一个偏转器表面，所述至少一个偏转器表面定位成将流体射流偏转到用于接收的洗涤区至少一部分流体操纵器。导流板表面被成形以扩大流体射流。本发明还涉及具有设置有一个或多个洗涤元件的空腔的洗涤台。本发明进一步涉及一种用于操纵流体的自动化系统，包括至少一个洗涤站和控制器，其设置为控制洗涤流体操纵器。在用于清洗可重复使用的流体操纵器的过程中，流体操纵器的至少一部分在洗涤区域中移动，产生洗涤流体的流体射流并被引导到偏转器表面上，该偏转器表面成形以使流体射流朝向洗涤区域变宽。

8. 发明公开

EP4184176A1 METHOD FOR DETECTION OF A BOTTOM OF AT LEAST ONE WELL 审中-实审
公开(公告)号：EP4184176A1
公开(公告)日：2023-05-24
申请号：EP21208700.1
申请日：2021-11-17
申请人： Roche Diagnostics GmbH , F. Hoffmann-La Roche AG
发明人： Birckner, Patrick , Durrer, Simon , Ettel, Christian , Gut, Raphael , Hermann, Pius , Meier, Alexander , Spescha, Roger , Wang, Pengfei
IPC分类号： G01N35/10
摘要： A method for detection of a bottom (118) of at least one well (120) of a multiwell plate (122) for a pipetting device (112) is disclosed. The pipetting device (112) comprises at least one pipetting head (114) configured for being coupled to a plurality of pipetting tips (116). The method comprises using at least one force sensor (124) configured for measuring a resistance force (150) depending on a force on a pipetting tip (116) exerted by the bottom (118). The method comprises the following steps:
a) measuring the resistance force (150) during movement of one of the pipetting tips (116) from a start position (154) downstream towards the bottom (118) of the well (120) and stopping the movement at a bottom position (156), wherein the bottom position (156) is a position where a predefined resistance force (158) is reached;
b) storing the bottom position (156) together with a corresponding logical position of the well (120) in the multiwell plate (122) in at least one database (130).
Further disclosed is a pipetting device (112), a laboratory instrument (110) for processing and/or analyzing a sample and a computer program and a computer-readable storage medium for performing the method.

9. 发明授权

EP2527037B1 Apparatus and process for opening/closing fluid containers 有权
标题翻译：流体容器的设备和方法，用于打开/关闭
公开(公告)号：EP2527037B1
公开(公告)日：2015-03-25
申请号：EP11167523.7
申请日：2011-05-25
申请人： F. Hoffmann-La Roche AG , Roche Diagnostics GmbH
发明人： Gut, Raphael , Schacher, Gottlieb
IPC分类号： G01N35/04 , B01L3/00 , G01N35/00 , B67B7/00
CPC分类号： B01L3/50825 , B01L2300/042 , B01L2300/046 , B67B7/00 , G01N35/0099 , G01N2035/0405

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