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1. 发明公开

EP3283623A1 BIOSYNTHESIS OF ACETYLATED 13R-MO AND RELATED COMPOUNDS 审中-公开
标题翻译：乙酰化13R-MO及相关化合物的生物合成
公开(公告)号：EP3283623A1
公开(公告)日：2018-02-21
申请号：EP16717341.8
申请日：2016-04-14
申请人： Evolva SA , University of Copenhagen
发明人： HAMBERGER, Björn , ANDERSEN-RANBERG, Johan , JENSEN, Niels Bjerg , PATERAKI, Eirini , MØLLER, Birger Lindberg
IPC分类号： C12N9/10 , C12N9/16 , C12N15/52 , C12P5/00
CPC分类号： C12P17/06 , C12N9/1029 , C12P5/007
摘要： The invention relates to recombinant microorganisms and methods for producing acetylated diterpenes, including oxidized and/or acetylated oxidized diterpenes such as forskolin.

2. 发明公开

EP3099802A1 BIOSYNTHESIS OF FORSKOLIN AND RELATED COMPOUNDS 审中-公开
标题翻译：生物合成福司柯林和相关链接
公开(公告)号：EP3099802A1
公开(公告)日：2016-12-07
申请号：EP15706364.5
申请日：2015-01-30
申请人： The University of Copenhagen , Danmarks Tekniske Universitet , Evolva SA
发明人： HAMBERGER, Björn , MØLLER, Birger Lindberg , PATERAKI, Eirini , ANDERSEN-RANBERG, Johan , JENSEN, Niels Bjerg
IPC分类号： C12P5/00 , C12P17/06 , C12N9/02
CPC分类号： C12P17/06 , C12N9/0071 , C12P5/007 , C12Y114/14001
摘要： The invention described materials and methods for producing oxidised 13R-MO, such as forskolin. In particular, the invention describes P450s involved in oxidation of 13R- MO including CYP76AH8, CYP76AH11, CYP76AH15, CYP76AH17, CYP71D381 and CYP76AH9. Host organisms expressing one or more of these P450s are useful in the production of oxidized 13R-MO.

3. 发明授权

EP3083975B1 STEREO-SPECIFIC SYNTHESIS OF (13R)-MANOYL OXIDE 有权
公开(公告)号：EP3083975B1
公开(公告)日：2018-11-14
申请号：EP14816252.2
申请日：2014-12-19
申请人： Technical University of Denmark , University of Copenhagen
发明人： HAMBERGER, Björn , PATERAKI, Eirini , MØLLER, Birger Lindberg , NØRHOLM, Morten , NIELSEN, Morten Thrane , ANDERSEN-RANBERG, Johan , BOHLMANN, Carl Jörg , ZERBE, Philipp
IPC分类号： C12P17/02 , C07D311/00 , C12N9/16 , C12N15/52
CPC分类号： C07D311/92 , C07B2200/07 , C12N9/88 , C12N9/90 , C12N15/8243 , C12P17/06 , C12Y402/03 , C12Y505/01
摘要： The present invention relates to a method for manufacturing enantiomerically pure (13R)-manoyl oxide, said method comprising the steps of contacting geranylgeranyl diphosphate (GGPP) with a class II diterpene synthase to obtain labd-13-en-8,15-diol diphosphate (LPP), and then contacting the LPP with a class I diterpene synthase to obtain (13R)-manoyl oxide. The invention further relates to (13R)-manoyl oxide obtained by the method of the invention.

4. 发明公开

EP3215626A1 BIOSYNTHESIS OF OXIDISED 13R-MO AND RELATED COMPOUNDS 审中-公开
标题翻译：氧化13R-MO和相关化合物的生物合成
公开(公告)号：EP3215626A1
公开(公告)日：2017-09-13
申请号：EP15804062.6
申请日：2015-11-05
申请人： University of Copenhagen
发明人： ANDERSEN-RANBERG, Johan , PATERAKI, Eirini
IPC分类号： C12P17/06
CPC分类号： C12P17/06
摘要： The invention discloses novel methods for biosynthesis of forskolin and other oxidised 13R-MOs. Oxidised 13R-MO may be valuable on its own account or as precursors for production of forskolin. In particular, the invention provides methods of producing an oxidised 13R-manoyl oxide (13R-MO) comprising the steps of providing a host organism comprising a heterologous nucleic acid encoding an enzyme capable of catalysing hydroxylation of 13R-MO and/or oxidised 13R-MO at the 9 position, wherein said oxidised 13R-MO carries a –H at the 9-position and incubating said host organism in the presence of 13R-MO under conditions allowing growth of said host organism. The invention also discloses materials for use in said methods, in particular the invention provides the enzyme CYP76AH16.
摘要翻译：本发明公开了用于福斯高林和其他氧化的13R-MO的生物合成的新方法。氧化的13R-MO本身可能是有价值的，或作为用于生产毛喉素的前体。具体而言，本发明提供了生产氧化的13R-甘露糖基氧化物（13R-MO）的方法，包括以下步骤：提供包含编码能够催化13R-MO和/或氧化的13R-MO的羟基化的酶的异源核酸的宿主生物体，其中所述氧化的13R-MO在9位携带-H，并在存在13R-MO的情况下在允许所述宿主生物生长的条件下孵育所述宿主生物体。本发明还公开了用于所述方法的材料，特别是本发明提供了酶CYP76AH16。

5. 发明公开

EP3083975A1 STEREO-SPECIFIC SYNTHESIS OF (13R)-MANOYL OXIDE 审中-公开
标题翻译： STEREOSPEZIFISCHE SYNTHESE VON（13R）-MANOYLOXID
公开(公告)号：EP3083975A1
公开(公告)日：2016-10-26
申请号：EP14816252.2
申请日：2014-12-19
申请人： Technical University of Denmark , University of Copenhagen , The University of British Columbia
发明人： HAMBERGER, Björn , PATERAKI, Eirini , MØLLER, Birger Lindberg , NØRHOLM, Morten , NIELSEN, Morten Thrane , ANDERSEN-RANBERG, Johan , BOHLMANN, Carl Jörg , ZERBE, Philipp
IPC分类号： C12P17/02 , C07D311/00 , C12N9/16 , C12N15/52
CPC分类号： C07D311/92 , C07B2200/07 , C12N9/88 , C12N9/90 , C12N15/8243 , C12P17/06 , C12Y402/03 , C12Y505/01
摘要： The present invention relates to a method for manufacturing enantiomerically pure (13R)-manoyl oxide, said method comprising the steps of contacting geranylgeranyl diphosphate (GGPP) with a class II diterpene synthase to obtain labd-13-en-8,15-diol diphosphate (LPP), and then contacting the LPP with a class I diterpene synthase to obtain (13R)-manoyl oxide. The invention further relates to (13R)-manoyl oxide obtained by the method of the invention.
摘要翻译：本发明涉及一种制备对映异构纯的（13R） - 马来酰氧基氧化物的方法，所述方法包括以下步骤：将香叶基香叶基二磷酸酯（GGPP）与二级二萜合成酶接触，得到labd-13-en-8,15-二醇二磷酸酯（LPP），然后使LPP与I类二萜合酶接触，得到（13R） - 马来酰氧基。本发明还涉及通过本发明的方法获得的（13R） - 马来酰氧基氧化物。

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