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1. 发明授权

EP2974730B1 DRUG FOR RESPIRATORY DISEASES 有权
标题翻译：药物治疗呼吸道疾病
公开(公告)号：EP2974730B1
公开(公告)日：2018-01-31
申请号：EP14763747.4
申请日：2014-03-13
申请人： Daiichi Sankyo Company, Limited
发明人： TAKAHASHI, Sakiko , DOMON, Yuki , KITANO, Yutaka , SHINOZUKA, Tsuyoshi
IPC分类号： A61K31/506 , A61P11/00 , A61P11/06 , A61P11/08 , A61P11/14
CPC分类号： A61K31/506 , A61K31/433 , A61K31/496
摘要： It is intended to provide a therapeutic agent and/or a preventive agent for a respiratory disease or a therapeutic agent and/or a preventive agent for a sodium channel associated disease. The present invention provides a pharmaceutical comprising a compound represented by the following formula (I) or a pharmacologically acceptable salt thereof as an active ingredient: Ar 1 and Ar 2 : a heteroaryl group or an aryl group; R 1 , R 2 and R 3 : a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a halogenated C1-C6 alkyl group, a hydroxy C1-C6 alkyl group, a C1-C6 alkoxy C1-C6 alkyl group or a C3-C7 cycloalkyl group or a cyano group; R 4 and R 5 : a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a halogenated C1-C6 alkyl group, a hydroxyl group, a hydroxy C1-C6 alkyl group, a C1-C6 alkoxy C1-C6 alkyl group, a C3-C7 cycloalkyl group or a C1-C6 alkoxy group; n: an integer of 1 to 3; and the heteroaryl or aryl group optionally has one or two groups independently selected from a halogen atom, a C1-C6 alkyl group, a halogenated C1-C6 alkyl group, a hydroxyl group, a hydroxy C1-C6 alkyl group, a C1-C6 alkoxy C1-C6 alkyl group, a C3-C7 cycloalkyl group, a carboxyl group, a cyano group, an amino group, a C1-C3 alkylamino group and a di-C1-C3 alkylamino group, and when the heteroaryl or aryl group has two such groups, the two groups are the same as or different from each other.

2. 发明公开

EP2974730A1 DRUG FOR RESPIRATORY DISEASES 有权
标题翻译：药物治疗呼吸道疾病
公开(公告)号：EP2974730A1
公开(公告)日：2016-01-20
申请号：EP14763747.4
申请日：2014-03-13
申请人： Daiichi Sankyo Company, Limited
发明人： TAKAHASHI, Sakiko , DOMON, Yuki , KITANO, Yutaka , SHINOZUKA, Tsuyoshi
IPC分类号： A61K31/506 , A61P11/00 , A61P11/06 , A61P11/08 , A61P11/14
CPC分类号： A61K31/506 , A61K31/433 , A61K31/496
摘要： It is intended to provide a therapeutic agent and/or a preventive agent for a respiratory disease or a therapeutic agent and/or a preventive agent for a sodium channel associated disease. The present invention provides a pharmaceutical comprising a compound represented by the following formula (I) or a pharmacologically acceptable salt thereof as an active ingredient:

Ar 1 and Ar 2 : a heteroaryl group or an aryl group; R 1 , R 2 and R 3 : a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a halogenated C1-C6 alkyl group, a hydroxy C1-C6 alkyl group, a C1-C6 alkoxy C1-C6 alkyl group or a C3-C7 cycloalkyl group or a cyano group; R 4 and R 5 : a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a halogenated C1-C6 alkyl group, a hydroxyl group, a hydroxy C1-C6 alkyl group, a C1-C6 alkoxy C1-C6 alkyl group, a C3-C7 cycloalkyl group or a C1-C6 alkoxy group;
n: an integer of 1 to 3; and
the heteroaryl or aryl group optionally has one or two groups independently selected from a halogen atom, a C1-C6 alkyl group, a halogenated C1-C6 alkyl group, a hydroxyl group, a hydroxy C1-C6 alkyl group, a C1-C6 alkoxy C1-C6 alkyl group, a C3-C7 cycloalkyl group, a carboxyl group, a cyano group, an amino group, a C1-C3 alkylamino group and a di-C1-C3 alkylamino group, and when the heteroaryl or aryl group has two such groups, the two groups are the same as or different from each other.
摘要翻译：旨在提供用于呼吸系统疾病或钠通道相关疾病的治疗剂和/或预防剂的治疗剂和/或预防剂。本发明提供药物，其含有下式（I）所示的化合物或其药理学上可接受的盐作为有效成分：Ar 1和Ar 2：杂芳基或芳基; R 1，R 2和R 3：氢原子，卤素原子，C 1 -C 6烷基，卤代C 1 -C 6烷基，羟基C 1 -C 6烷基，C 1 -C 6烷氧基C 1 -C 6烷基或C 3 -C7环烷基或氰基; R 4和R 5：氢原子，卤素原子，C 1 -C 6烷基，卤代C 1 -C 6烷基，羟基，羟基C 1 -C 6烷基，C 1 -C 6烷氧基C 1 -C 6烷基， C3-C7环烷基或C1-C6烷氧基; n：1〜3的整数; 并且杂芳基或芳基任选具有一个或两个独立地选自卤素原子，C1-C6烷基，卤代C1-C6烷基，羟基，羟基C1-C6烷基，C1-C6烷基烷氧基C 1 -C 6烷基，C 3 -C 7环烷基，羧基，氰基，氨基，C 1 -C 3烷基氨基和二-C 1 -C 3烷基氨基，并且当杂芳基或芳基具有两个这样的组，两组彼此相同或不同。

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