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1. 发明授权

EP1001970B1 DIPEPTIDE DERIVATIVES AS GROWTH HORMONE SECRETAGOGUES 失效
标题翻译：二肽衍生物促进生长激素分泌的
公开(公告)号：EP1001970B1
公开(公告)日：2007-03-07
申请号：EP98921680.9
申请日：1998-06-05
申请人： PFIZER INC.
发明人： CARPINO, Philip, Albert , GRIFFITH, David, Andrew , LEFKER, Bruce, Allen
IPC分类号： C07K5/023 , A61K38/06 , C07D471/04 , C07D498/04 , A61K31/495
CPC分类号： C07D487/04 , A61K38/00 , C07D471/04 , C07D491/04 , C07D513/04 , C07K5/0202 , C07K5/0205 , C07K5/0207 , C07K5/021 , C07K5/06026
摘要： This invention is directed to compounds of formula (I), and the pharmaceutically-acceptable salts thereof, where the substituents are as defined in the Specification, which are growth hormone secretogogues and which increase the level of endogenous growth hormone. The compounds of this invention are useful for the treatment and prevention of osteoporosis and/or frailty, congestive heart failure, frailty associated with aging, obesity; accelerating bone fracture repair, attenuating protein catabolic response after a major operation, reducing cachexia and protein loss due to chronic illness, accelerating wound healing, or accelerating the recovery of burn patients or patients having undergone major surgery; improving muscle strength, mobility, maintenance of skin thickness, metabolic homeostasis or renal homeostasis. The compounds of the present invention are also useful in treating osteoporosis and/or frailty when used in combination with: a bisphosphonate compound such as alendronate; estrogen, premarin, and optionally progesterone; an estrogen agonist or antagonist; or calcitonin, and pharmaceutical compositions useful therefor. Further, the present invention is directed to pharmaceutical compositions useful for increasing the endogenous production or release of growth hormone in a human or other animal which comprises an effective amount of a compound of the present invention and a growth hormone secretagogue selected from GHRP-6, Hexarelin, GHRP-1, growth hormone releasing factor (GRF), IGF-1, IGF-2 or B-HT920. The invention is also directed to intermediates useful in the preparation of compounds of Formula (I).

2. 发明公开

EP1488903A3 Method of manufacturing molded product of foamed resin and apparatus for molding foamed resin. 有权
标题翻译：一种生产发泡的塑料体和装置的过程用于模制泡沫塑料体
公开(公告)号：EP1488903A3
公开(公告)日：2007-01-10
申请号：EP04290078.7
申请日：2004-01-12
申请人： Ono Sangyo Co., Ltd.
发明人： Sakamoto, Kazuo, c/o Ono Sangyo Co. Ltd. , Uno, Taiko, c/o Ono Sangyo Co. Ltd.
IPC分类号： B29C44/34 , B29C44/60
CPC分类号： B29C44/3419 , B29C44/348 , B29C44/60
摘要： While steam is supplied to flow channels to heat inner cavity surfaces to a temperature equal to or higher than the heat distortion temperature of a molding resin, the resin mixed with a supercritical fluid is injected from an injection molding machine into a mold cavity. When the injection of a predetermined quantity of the resin is completed, the supply of the steam in the flow channels is stopped, and cooling water starts to be supplied to the flow channels. The inner cavity surfaces are thus quickly switched from a heated state to a cooled state, cooling and solidifying the resin into a molded product of good appearance which is free of broken cell marks on its surface.

3. 发明授权

EP1301534B1 PF-4 MUTE, SES FRAGMENTS ET PEPTIDES DE FUSION MUTES, LEURS ANALOGUES, LES SEQUENCES D'ADN, ADNc ET ARNm CORRESPONDANTES, ET LEUR UTILISATION DANS L'INHIBITION DE L'ANGIOGENESE 有权
标题翻译：突变PF4，及其突变体片段和融合肽，它们的类似物，相应的DNA，cDNA和mRNA序列和它们用于抑制血管生成
公开(公告)号：EP1301534B1
公开(公告)日：2007-01-10
申请号：EP01955438.5
申请日：2001-07-18
申请人： UNIVERSITE DE BORDEAUX I , INSTITUT DES VAISSEAUX ET DU SANG
发明人： BIKFALVI, Andreas , ALEMANY, Monica
IPC分类号： C07K14/52 , A61K38/19 , A61P35/00 , C12N15/11
CPC分类号： C07K14/49 , A61K38/00
摘要： The invention concerns a peptide selected among the group consisting of PF-4, fragments and fusion peptides derived from PF-4, and their analogues, having an angiogenesis-inhibiting activity, wherein the glutamine in position 56 in the native PF-4 is replaced by an arginine, a lysine or a histidine, preferably an arginine. The inventive peptide has an I50 less than the I50 of the same peptide not having a mutation in 56. The invention also concerns DNA or cDNA sequences coding for said peptides and the use of said sequences and/or said peptides for preparing a medicine inhibiting angiogenesis and/or proliferation of cells.

4. 发明公开

EP1581499A1 MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN INHIBITORS 审中-公开
标题翻译：微粒体甘油三酯转运蛋白的抑制剂
公开(公告)号：EP1581499A1
公开(公告)日：2005-10-05
申请号：EP03777091.4
申请日：2003-12-10
申请人： Pfizer Products Inc.
发明人： BERTINATO, PeterPfizer Global Res.and Development , MADDUX, Todd,M.Pfizer Global Research&Development
IPC分类号： C07D213/75 , C07C237/52 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , A61K31/444 , A61K31/4439 , A61K31/443 , A61K31/4436 , A61K31/166 , A61K31/167
CPC分类号： C07D213/75 , C07C237/22 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention provides inhibitors of microsomal triglyceride transfer protein (MTP) and/or apolipoprotein B (Apo B) secretion having Formula (I) which are useful for the treatment of obesity and related diseases, as well as prevention and treatment of atherosclerosis and its clinical sequelae, for lowering serum lipids, and in the prevention and treatment of related diseases. The invention further relates to pharmaceutical compositions comprising the compounds of the present invention and to methods of treating obesity, atherosclerosis, and related diseases and/or conditions with the compounds of the present invention, either alone or in combination with other pharmaceutical agents, including lipid-lowering agents.

5. 发明公开

EP1460189A1 Dispositif hygiénique à diffusion progressive pour sanitaires 有权
标题翻译： Sanitäreinrichtungen的Vorrichtung zur Abgabe von Duft- und Reinigungswirkstoffen
公开(公告)号：EP1460189A1
公开(公告)日：2004-09-22
申请号：EP04290655.2
申请日：2004-03-10
申请人： Bolton Manitoba SpA
发明人： Luciani, Alain , Oliva, Marco , Stefanelli, Claudio , Ferri, Michele , Petrillo, Franco
IPC分类号： E03D9/03 , A61L9/05 , A61L9/04 , A61L9/12
CPC分类号： E03D9/032 , A61L9/05 , A61L9/12 , E03D9/007 , E03D9/02
摘要： L'invention a pour objet un dispositif hygiénique pour sanitaires, comprenant (i) un récipient éventuellement amovible (14) comprenant des composés chimiques actifs nettoyants susceptibles d'entrer en contact avec l'eau de la chasse d'eau, (ii) une matrice servant de support à des substances volatiles parfumées et/ou désodorisantes qui ne sont pas susceptibles d'entrer en contact avec l'eau de la chasse d'eau; (iii) un moyen (12) pour suspendre ledit dispositif à l'intérieur des toilettes sur le bord (11) de la cuvette des toilettes; (iv) un élément distributeur (13) pour relâcher dans le flux de la chasse d'eau une quantité de composés chimiques actifs nettoyants ; (v) un moyen (15) pour libérer en continu dans l'air les substances volatiles, ledit moyen (15) étant éventuellement recouvert d'un élément de protection amovible (18).
摘要翻译：具有用于将其附接到马桶轮圈内部的钩形夹子（12）的分配器（10）由用于液体或凝胶形式的化学活性物质的容器（14）组成，其用于清洁和消毒与冲洗水混合的碗和连接到其上的保持器（15），其将香料连续地释放到空气中。香料是挥发性物质的形式，其包含在基质中并通过与保护层（18）共挤出的半透膜（23）释放。

6. 发明公开

EP1453788A1 SUBSTITUTED HYDROXYETHYLAMINES 审中-公开
标题翻译：替代羟基乙酰胺
公开(公告)号：EP1453788A1
公开(公告)日：2004-09-08
申请号：EP02795769.5
申请日：2002-12-06
申请人： Elan Pharmaceuticals, Inc. , Pharmacia & Upjohn Company
发明人： TENBRINK, Ruth , MAILLARD, Michel , WARPEHOSKI, Martha
IPC分类号： C07C215/18 , C07C215/10 , C07C217/58 , C07C233/36 , C07C233/78 , C07C271/20 , C07C323/42 , C07C323/38 , C07C309/74 , C07D263/30 , C07D303/36
CPC分类号： C07C233/36 , C07C217/64 , C07C233/40 , C07C233/66 , C07C233/78 , C07C271/16 , C07C271/20 , C07C271/28 , C07C309/74 , C07C311/09 , C07C323/42 , C07C2601/02 , C07C2601/14 , C07D263/32 , C07D263/48 , C07D303/36
摘要： Disclosed are compounds of the formula (I) and the pharmaceutically acceptable salts thereof wherein the variables G, L, A, W, E, R2, R3, R4, R5, RN, and RC are defined herein. These compounds interact with and inhibit the activity of the enzyme beta- secretase. These compounds are therefore useful in treating Alzheimer's disease and other similar diseases. Pharmaceutical compositions and methods of treatment of these diseases are also disclosed.
摘要翻译：公开了下式的化合物及其可药用盐，其中变量G，L，A，W，E，R2，R3，R4，R5，R N和R / SUB>。这些化合物与β-分泌酶的活性相互作用并抑制其活性。因此，这些化合物可用于治疗阿尔茨海默病和其他类似疾病。还公开了治疗这些疾病的药物组合物和方法。

7. 发明授权

EP1265645B1 PREPARATION PARFUMEE SOLIDE SOUS FORME DE MICROBILLES ET SON UTILISATION 有权
标题翻译：固体香水组合物中，微球和它们的使用形式
公开(公告)号：EP1265645B1
公开(公告)日：2004-08-18
申请号：EP01917168.5
申请日：2001-03-16
申请人： V.Mane Fils
发明人： MANE, Jean , BLEUEZ, Loic , DELPECH, Guy , HOC, Nathalie , HANNETEL, Jean-Michel , DAILLAND, Pascal
IPC分类号： A61L9/012
CPC分类号： A61L9/012 , Y10T436/12
摘要： The invention concerns a solid perfumed preparation with high persistency in the form of microbeads and comprising a volatile aromatic raw material, or a mixture of volatile aromatic raw materials, and one or several fusible excipients. Said preparation can further comprise one of the following constituents: one or more polymers dispersible in the melted mass formed by the constituents of the preparation, one or more mineral additives, one or more surfactants, one or more antioxidants, one or more colouring agents. The invention can be used in cosmetics and in household product industries.

8. 发明公开

EP1438280A1 NOUVEAUX DERIVES DU NORBORNANE ET DU NORBORNENE, LEUR UTILISATION ET PRODUITS PARFUMES LES CONTENANT 有权
标题翻译：降冰片烯降冰片烯及其用途和含有香水产品
公开(公告)号：EP1438280A1
公开(公告)日：2004-07-21
申请号：EP02796823.9
申请日：2002-10-23
申请人： V. Mane Fils S.A.
发明人： MANE, Jean , CHANOT, Jean-Jacques , LE BORGNE, Fabrice , SCHROEDER, Martin
IPC分类号： C07C43/13 , C07C49/323 , C07C69/14 , C07C69/24 , C07D317/12 , C07C13/40 , C07C49/21 , C11B9/00
CPC分类号： C11B9/0015 , C07C13/39 , C07C31/137 , C07C33/14 , C07C41/03 , C07C41/28 , C07C43/13 , C07C43/1781 , C07C45/455 , C07C45/62 , C07C45/69 , C07C47/225 , C07C49/21 , C07C49/323 , C07C69/003 , C07C69/007 , C07C2602/42 , C11B9/0007 , Y02P20/582 , C07C49/553
摘要： The invention concerns a novel compounds of formula (I), wherein the dotted line bond is present or not, and wherein R1 represents: when the dotted line bond is present -CHCH3OH or -CHCH3 OCOR or -CHCH3XCH2CHOHR' or -CHCH3OCHR'CH2OH or formula (II) when the dotted line bond is absent -CHCH3OH or -CHCH3OCOR or -COCH3 or formula (II) or -CHCH3XCH2 CHOHR' or -CH2CH2XCH2CHOHR' or -CHCH3OCHR'CH2OH or -CHCHCOR' or -CH2CH2CHR'OH or -CH2CH2CHR'OCOR or CHCHCHOHR' or -CHCHCHR'OCOR, wherein R represents H, Me, Et, Pr, isoPr, But, isoBut, CH3CH2)4, (CH3)2CHCH2, CH2CH, (CH3)2CCH, and R' represents H, Me or Et, and X represents O, N or S, and their preparation method. Because of their fragrance, said compounds are highly interesting for the perfume industry, for cosmetic and care products

9. 发明授权

EP1138661B1 Mannitol pulvérulent et son procédé de préparation 有权
标题翻译：粉状甘露醇和它们的制备方法
公开(公告)号：EP1138661B1
公开(公告)日：2004-04-28
申请号：EP01400772.8
申请日：2001-03-26
申请人： Roquette Frères
发明人： Labergerie, Erik , Lefevre, Philippe , Lis, José
IPC分类号： C07C31/26 , A61K47/10 , A61K9/14
CPC分类号： A61K47/26 , A61K9/2018 , A61K9/4858 , C07C31/26

10. 发明公开

EP1311635A1 SOLVENT-BASED NON-FLUORESCENT INKS FOR WRITING INSTRUMENTS BASED UPON PIGMENT DISPERSIONS IN NON-AQUEOUS SOLVENTS 有权
标题翻译：溶剂型非荧光油墨基于在非水溶剂颜料分散体书写工具
公开(公告)号：EP1311635A1
公开(公告)日：2003-05-21
申请号：EP01964207.3
申请日：2001-08-20
申请人： BIC CORPORATION
发明人： NOWAK, Michael, T. , CHEN, Qingping
IPC分类号： C09D11/16 , C09D11/18 , C08L67/00 , C08L67/08
CPC分类号： C09D11/17
摘要： A non-aqueous non-fluorescent ink composition suitable for use in writing instruments is described comprising a non-fluorescent pigment dispersion, a stabilizer and a high boiling point organic solvent. The ink composition may also include resins, plasticizers, antiskinning agents and lubricants.

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