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1. 发明授权

EP3237408B1 METHODS FOR PREPARING FUSED BICYCLIC 2, 4-DIAMINOPYRIMIDINE DERIVATIVES 有权
公开(公告)号：EP3237408B1
公开(公告)日：2018-10-31
申请号：EP15828406.7
申请日：2015-12-23
申请人： Cephalon, Inc.
发明人： ALLWEIN, Shawn, P. , BAKALE, Roger, P. , MOWREY, Dale, R. , PETRILLO, Daniel E. , KLUWER, Sander
IPC分类号： C07D403/12 , C07D295/135
CPC分类号： C07D241/04 , A61K31/495 , C07D295/135 , C07D403/12
摘要： The present disclosure is directed to improved methods useful for the preparation of, for example, 2-[[5-chloro-2-[[(6S)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-1-methoxy-6,7,8,9-tetrahydro-5Hbenzo[7]annulen-2-yl]amino]pyrimidin-4-yl]amino]-N-methyl-benzamide (CEP-37440).

2. 发明授权

EP3056494B1 FUSED BICYCLIC 2,4-DIAMINOPYRIMIDINE DERIVATIVE AS A DUAL ALK AND FAK INHIBITOR 有权
标题翻译：稠合双环2,4-二氨基嘧啶衍生物作为双酯和FAK抑制剂
公开(公告)号：EP3056494B1
公开(公告)日：2018-05-02
申请号：EP15202516.9
申请日：2013-03-06
申请人： CEPHALON, INC.
发明人： JACOBS, Martin J. , OTT, Gregory R. , COURVOISIER, Laurent , ALLWEIN, Shawn P.
IPC分类号： A61P35/00 , C07D403/04 , A61K31/506
CPC分类号： A61K31/506 , C07D403/04 , C07D403/12
摘要： The present invention provides a compound of formula (I) or a salt form thereof. The compound of formula (I) has ALK and FAK inhibitory activity, and may be used to treat proliferative disorders.

3. 发明授权

EP2346836B1 PROCESSES FOR THE PREPARATION OF BENDAMUSTINE 有权
标题翻译： BENDAMUSTINE的制备过程
公开(公告)号：EP2346836B1
公开(公告)日：2018-03-07
申请号：EP09793328.7
申请日：2009-10-07
申请人： Cephalon, Inc.
发明人： CHEN, Jian , PRZYUSKI, Katrin , ROEMMELE, Renee, Caroline
IPC分类号： C07D235/16 , C07D235/26 , C07C233/15
CPC分类号： C07D235/16 , C07C233/15 , C07D235/26
摘要： New methods for the preparation of bendamustine, and the pharmaceutical salts thereof, are described. Novel compounds useful for the preparation of bendamustine are also described.

4. 发明公开

EP3135276A1 NANOPARTICULATE AND MACROPARTICULATE FORMULATIONS 无效转让
标题翻译： NANOPARTIKEL- UND MAKROPARTIKELFORMULIERUNGEN
公开(公告)号：EP3135276A1
公开(公告)日：2017-03-01
申请号：EP16183869.3
申请日：2014-03-12
申请人： CEPHALON, INC.
发明人： BROWN, Peter D. , DRAGER, Anthony S.
IPC分类号： A61K9/14 , A61K47/50 , A61K31/5025 , A61K9/50
CPC分类号： A61K9/5146 , A61K9/145 , A61K9/5031 , A61K9/5089 , A61K31/4184 , A61K31/7088 , A61K38/02 , A61K47/60 , A61K47/6935 , C07D235/16
摘要： The present invention is directed to particles prepared via the polymerization of at least one surfactant and an isocyanate-containing compound. Pharmaceutical compositions prepared using these particles are also described.
摘要翻译：本发明涉及通过至少一种表面活性剂和含异氰酸酯的化合物的聚合制备的颗粒。还描述了使用这些颗粒制备的药物组合物。

5. 发明授权

EP2648728B1 JANUS KINASE 2 (JAK2) INHIBITOR FOR THE TREATMENT OF LUPUS 有权
标题翻译： Janus激酶2（JAK2）的抑制剂用于治疗狼疮
公开(公告)号：EP2648728B1
公开(公告)日：2016-04-27
申请号：EP11846725.7
申请日：2011-12-06
申请人： Cephalon, Inc.
发明人： DOBRZANSKI, Pawel T. , SEAVEY, Matthew M.
IPC分类号： A61K31/496 , A61P37/00 , A61P43/00
CPC分类号： A61K31/496

6. 发明授权

EP2822939B1 FUSED BICYCLIC 2,4-DIAMINOPYRIMIDINE DERIVATIVE AS A DUAL ALK AND FAK INHIBITOR 有权
标题翻译： AS ALK和FAK双2,4-二氨基嘧啶稠合双环衍生物抑制剂
公开(公告)号：EP2822939B1
公开(公告)日：2016-02-17
申请号：EP13710258.8
申请日：2013-03-06
申请人： Cephalon, Inc.
发明人： JACOBS, Martin J. , OTT, Gregory R. , COURVOISIER, Laurent , ALLWEIN, Shawn P.
IPC分类号： C07D403/04 , A61K31/506 , A61P9/00
CPC分类号： A61K31/506 , C07D403/04 , C07D403/12

7. 发明公开

EP2968072A1 CHILD RESISTANT COVER FOR ORAL DOSAGE FORMS 审中-公开
标题翻译： KINDERSICHERER DECKELFÜRORALE DARREICHUNGSFORMEN
公开(公告)号：EP2968072A1
公开(公告)日：2016-01-20
申请号：EP14716160.8
申请日：2014-03-13
申请人： Cephalon, Inc.
发明人： BRADWAY, Randy J. , FRANK, Gerald A.
IPC分类号： A61J7/00 , A61M31/00
CPC分类号： B65D83/0409 , A61J1/03 , A61J7/003 , A61J7/0053 , A61K31/4468 , A61K31/485 , A61M31/007
摘要： A child resistant safety device for an oral dosage form including a handle having a proximal end and a distal end to which an oral dosage form is mounted either directly or indirectly; a cover that moves with respect to the handle, or vice versa, for selectively shielding the oral dosage form; and a releasable locking mechanism that is moveable between a locked configuration and an unlocked configuration. In the locked configuration, the releasable locking mechanism is configured to prevent movement of the safety device to a deployed configuration in which the oral dosage form is exposed, and, in the unlocked configuration, the releasable locking mechanism is configured to permit movement of the safety device to the deployed configuration.
摘要翻译：一种用于口服剂型的耐儿童安全装置，包括具有直接或间接安装口服剂型的近端和远端的手柄; 相对于手柄移动的盖子，反之亦然，用于选择性地屏蔽口服剂型; 以及可在锁定配置和解锁配置之间移动的可释放锁定机构。在锁定构造中，可释放锁定机构构造成防止安全装置移动到其中暴露口服剂型的展开构型，并且在解锁构造中，可释放锁定机构被构造成允许安全设备到部署配置。

9. 发明公开

EP2782917A1 THIENOPYRIMIDINE INHIBITORS OF ATYPICAL PROTEIN KINASE C 有权转让
标题翻译：三苯甲酰氨基嘌呤抑制剂
公开(公告)号：EP2782917A1
公开(公告)日：2014-10-01
申请号：EP12795969.0
申请日：2012-11-19
申请人： Cancer Research Technology Limited , Cephalon, Inc.
发明人： DORSEY, Bruce D. , LEARN, Keith S. , MORRIS, Emma L. , OTT, Gregory R. , ROFFEY, Jonathan R. , SOUDY, Christelle N. , WAGNER, Jason C.
IPC分类号： C07D495/04 , C07D495/14 , A61K31/519 , A61P35/00
CPC分类号： C07D495/04 , C07D495/14 , C07D495/20 , C07D519/00 , C07F7/0812
摘要： The present invention provides a compound of formula (I) or a salt thereof, wherein R
1 , R
2 , R
3 , R
4 , R
5 , R
6 , A, G, M, Q and X are as defined herein. A compound of formula (I) and its salts have a PKC inhibitory activity, and may be used to treat proliferative disorders.
摘要翻译：本发明提供式（I）化合物或其盐，其中R 1，R 2，R 3，R 4，R 5，R 6，A，G，M，Q和X如本文所定义。式（I）化合物及其盐具有PKC抑制活性，可用于治疗增殖性疾病。

10. 发明公开

EP2723751A1 PROTEASOME INHIBITORS AND PROCESSES FOR THEIR PREPARATION, PURIFICATION AND USE 审中-公开
标题翻译：蛋白酶抑制剂和法来制造，清洗和使用
公开(公告)号：EP2723751A1
公开(公告)日：2014-04-30
申请号：EP12730349.3
申请日：2012-06-21
申请人： Cephalon, Inc.
发明人： BAKALE, Roger P. , MALLAMO, John P. , ROEMMELE, Renee Caroline
IPC分类号： C07F5/02 , A61K31/69
CPC分类号： C07F5/04 , C07F5/025
摘要： The invention provides boronic esters of Formula (I) wherein R is H or methyl, and methods for the preparation and purification thereof.

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