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    • 4. 发明授权
    • 大环化合物及其用途
    • CN111566113B
    • 2024-01-09
    • CN201880085912.X
    • 2018-11-15
    • 哈佛大学的校长及成员们卫材研究发展管理有限公司
    • Y.岸吉良和信伊藤宪
    • C07D493/22A61P35/00A61K31/357
    • 本发明提供了具有肿瘤血管重塑作用和/或抗CAF(癌症相关成纤维细胞)活性的新颖化合物(例如式(I)、(II)、(III)、(IV)化合物)或其药学上可接受的盐及其医疗用途,所述化合物或盐任选在药学上可接受的载体中。(56)对比文件Zheng, Wanjun.Macrocyclic ketoneanalogues of halichondrin B.Bioorganic &Medicinal Chemistry Letters.2004,第14卷5551-5554.Pettit, George R..Antineoplasticagents. 219. Isolation and structure ofthe cell growth inhibitory constituentsfrom the western Pacific marine spongeAxinella sp.Journal of MedicinalChemistry.1991,第34卷3339-3340.Litaudon, Marc.Isohomohalichondrin B,a new antitumor polyether macrolide fromthe New Zealand deep-water spongeLissodendoryx sp.TetrahedronLetters.1994,第35卷9435-9438.Fang, Francis G..Synthetic studiestowards halichondrins: synthesis of theleft halves of norhalichondrins andhomohalichondrins《.Tetrahedron Letters》.1992,第33卷(第12期),1557-1560.Hickford, Sarah J. H..Antitumourpolyether macrolides: Four newhalichondrins from the New Zealand deep-water marine sponge Lissodendoryx sp..《Bioorganic & Medicinal Chemistry》.2009,第17卷(第6期),2199-2203.Yahata, Kenzo.Unified, Efficient, andScalable Synthesis of Halichondrins:Zirconium/Nickel-Mediated One-Pot KetoneSynthesis as the Final Coupling Reaction.《Angewandte Chemie InternationalEdition》.2017,第56卷(第36期),10796-10800.Ueda, Atsushi.Total Synthesis ofHalichondrin A, the Missing Member in theHalichondrin Class of Natural Products.《Journal of the American ChemicalSociety》.2014,第136卷(第13期),5171-5176.Jackson, Katrina L..The Halichondrinsand E7389《.Chemical Reviews》.2009,第109卷(第7期),3044-3079.Jackson, Katrina L..A total synthesisof norhalichondrin B《.Angewandte ChemieInternational Edition》.2009,第48卷(第13期),2346-2350.Henderson, James A..Highlyfunctionalized pyranopyrans from furans:a synthesis of the C27-C38 and C44-C53subunits of norhalichondrin B《.OrganicLetters》.2007,第9卷(第25期),5299-5302.Litaudon, Marc.Antitumor polyethermacrolides: new and hemisynthetichalichondrins from the New Zealand deep-water sponge Lissodendoryx sp..《Journalof Organic Chemistry》.1997,第62卷(第6期),1868-1871.