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1. 发明专利

AU2002252967B2 Degradble elastomers for chewing gum base 未知
公开(公告)号：AU2002252967B2
公开(公告)日：2005-11-03
申请号：AU2002252967
申请日：2002-03-25
申请人： GUMLINK AS
发明人： ANDERSEN LONE , STOREY ROBSON , WITTORFF HELLE , ISAKSEN ANETTE
IPC分类号： A23G4/00 , A23G4/06 , A23G4/08 , C08G63/08 , C08G63/64 , C08G64/02 , A23G003/30 , C08G063/02 , C08G063/08

2. 发明专利

AU2002252967B8 Degradable elastomers for chewing gum base 未知
公开(公告)号：AU2002252967B8
公开(公告)日：2005-11-17
申请号：AU2002252967
申请日：2002-03-25
申请人： GUMLINK AS
发明人： ANDERSEN LONE , STOREY ROBSON , WITTORFF HELLE , ISAKSEN ANETTE
IPC分类号： A23G4/00 , A23G4/06 , A23G4/08 , C08G63/08 , C08G63/64 , C08G64/02 , A23G003/30 , C08G063/08 , C08G063/02
摘要： There is provided a novel degradable gum base comprising low molecular weight elastomer replacement compounds which are generally applicable for chewing gum formulations. In particular there is provided a gum base and a chewing gum comprising a polyester polymer obtainable by the polymerisation of two or more different cyclic ester monomers, wherein the cyclic ester monomers have a low glass transition temperature (Tg) and the polyester polymer has a glass transition temperature (Tg) in the range from (-20 DEG C) to (-80 DEG C).

3. 发明专利

AU2002353551B2 pH responsive biodegradable polylactic acid derivatives forming polymeric micelles and uses thereof for poorly water soluble drug delivery 未知
公开(公告)号：AU2002353551B2
公开(公告)日：2005-09-08
申请号：AU2002353551
申请日：2002-10-17
申请人： SAMYANG BIOPHARMACEUTICALS
发明人： SEO MIN-HYO , KIM BONG-OH , CHOI IN-JA , SHIM MYUNG-SEOB
IPC分类号： A61K9/10 , A61K9/51 , A61K47/34 , C08F2/00 , C08G63/06 , C08G63/08 , C08G63/78 , C08L101/16 , C08L067/04 , C08G063/08 , A61K009/10 , A61K047/34
摘要： Polylactic acid derivatives capable of forming micelles in an aqueous solution with a pH of 4 or above, having one terminal carboxyl group. The polylactic acid derivatives may be applied as a drug delivery system in various forms since poorly water soluble drugs can be entrapped inside the micelles.

4. 发明申请

US20030153724A1 Lactic acid polymer and process for producing the same 有权
标题翻译：乳酸聚合物及其制备方法
公开(公告)号：US20030153724A1
公开(公告)日：2003-08-14
申请号：US10344131
申请日：2003-04-03
发明人： Kohei Yamamoto , Tsutomu Tani , Takashi Aoki , Yoshio Hata
IPC分类号： C08G063/08
CPC分类号： A61K38/09 , A61K9/1647 , A61K9/5031 , A61K47/34 , C08G63/08 , C08G63/88 , C08G63/912 , Y10S514/963 , Y10S514/965
摘要： A process for producing a lactic acid polymer of 15,000 to 50,000 in weight-average molecular weight, the content of polymeric materials having not more than about 5,000 in weight-average molecular weight therein being not more than about 5% by weight, characterized by hydrolyzing a high molecular weight lactic acid polymer, placing the resultant solution comprising the hydrolyzed product under a condition capable of precipitating the objective lactic acid polymer, separating the precipitated lactic acid polymer and collecting them. The lactic acid polymer is useful as a matrix for sustained-release preparations. The sustained-release microcapsule preparation encapsulating a physiologically active substance can fully prevent the initial excessive release of the physiologically active substance from the microcapsules and keep a stable release rate over a long period of time.
摘要翻译：一种生产重均分子量为15,000至50,000的乳酸聚合物的方法，其中重均分子量不超过约5,000的聚合物材料的含量不超过约5重量％，其特征在于水解高分子量乳酸聚合物，将包含水解产物的所得溶液置于能够沉淀目标乳酸聚合物的条件下，分离沉淀的乳酸聚合物并收集它们。乳酸聚合物可用作缓释制剂的基质。包封生理活性物质的缓释微胶囊制剂可以充分地防止生物活性物质从微胶囊的初始过度释放，并在长时间内保持稳定的释放速率。

5. 发明申请

US20030125509A1 Hydrogel-forming system with hydrophobic and hydrophilic components 失效
标题翻译：具有疏水和亲水组分的水凝胶形成体系
公开(公告)号：US20030125509A1
公开(公告)日：2003-07-03
申请号：US10369676
申请日：2003-02-21
发明人： Chee-Youb Won , Yeli Zhang , Chih-Chang Chu
IPC分类号： C08G063/08
CPC分类号： C08L5/02 , A61K9/205 , A61K47/36 , C08B37/0021 , C08G18/6484 , C08G18/8108 , C08G2210/00 , C08L67/07 , Y10S525/937 , C08L2666/02 , C08L2666/26
摘要： A hydrogel forming system which comprises a hydrophobic macromer with unsaturated group terminated ends and a hydrophilic polymer which is a polysaccharide containing hydroxyl groups which are reacted with unsaturated group introducing compound, is convertible by free radical polymerization to form a hydrogel containing a three dimensional crosslinked polymer network containing hydrophobic and hydrophilic components. Preferably, the hydrophobic polymer is prepared by reacting the hydroxyls of a diol obtained by converting hydroxy of terminal carboxylic acid group of poly(lactic acid) to aminoethanol group, with an unsaturated group introducing compound which is acryloyl chloride or isocyanate having an unsaturated group at one end of the molecules. Preferably, the hydrophilic polymer is dextran wherein one or more hydroxyls in a glucose unit of the dextran is (are) reacted with an unsaturated group introducing compound which is acryloyl chloride or isocyanate having an unsaturated group at one end of a molecule. Agent can be entrapped in the polymer network, e.g., drugs, water-soluble macromolecules or synthetic or natural polymers, for controlled release therefrom.
摘要翻译：包含具有不饱和基团末端的疏水性大分子单体和亲水性聚合物的水凝胶形成体系，其是含有与不饱和基团导入化合物反应的羟基的多糖，可通过自由基聚合反应形成含有三维交联聚合物的水凝胶网络含有疏水和亲水组分。优选地，疏水性聚合物通过将通过将聚（乳酸）的末端羧酸基团的羟基与氨基乙醇基团的羟基与不饱和基团引入化合物（其是丙烯酰氯或具有不饱和基团的异氰酸酯）分子的一端。优选地，亲水性聚合物是葡聚糖，其中葡聚糖的葡萄糖单元中的一个或多个羟基与不饱和基团引入化合物反应，该化合物是分子的一端具有不饱和基团的丙烯酰氯或异氰酸酯。药剂可以被包埋在聚合物网络中，例如药物，水溶性大分子或合成或天然聚合物，用于从其中控释。

6. 发明申请

US20020161169A1 Hydrogel-forming system with hydrophobic and hydrophilic components 失效
标题翻译：具有疏水和亲水组分的水凝胶形成体系
公开(公告)号：US20020161169A1
公开(公告)日：2002-10-31
申请号：US10096435
申请日：2002-03-13
发明人： Chee-Youb Won , Yeli Zhang , Chih-Chang Chu
IPC分类号： C08G063/08
CPC分类号： C08L5/02 , A61K9/205 , A61K47/36 , C08B37/0021 , C08G18/6484 , C08G18/8108 , C08G2210/00 , C08L67/07 , Y10S525/937 , C08L2666/02 , C08L2666/26
摘要： A hydrogel forming system which comprises a hydrophobic macromer with unsaturated group terminated ends and a hydrophilic polymer which is a polysaccharide (e.g., dextran) containing hydroxy groups which are reacted with unsaturated group introducing compound, is convertible by free radical polymerization to form a hydrogel containing a three dimensional crosslinked polymer network containing hydrophobic and hydrophilic components. Agent can be entrapped in the polymer network, e.g., drugs, macromolecules or synthetic or natural polymers, for controlled release therefrom.
摘要翻译：包含具有不饱和基团末端的疏水大分子单体和亲水性聚合物的水凝胶形成体系，其是含有与不饱和基团引入化合物反应的含羟基的多糖（例如，葡聚糖），可通过自由基聚合反应形成含有含有疏水和亲水组分的三维交联聚合物网络。药剂可以被捕获在聚合物网络中，例如药物，大分子或合成或天然聚合物，用于从其中控制释放。

7. 发明申请

US20040092699A1 Copolycarbonate diol and thermoplastic polyurethane obtained therefrom 有权
标题翻译：由其获得的共聚碳酸酯二醇和热塑性聚氨酯
公开(公告)号：US20040092699A1
公开(公告)日：2004-05-13
申请号：US10469297
申请日：2003-08-29
发明人： Eizaburou Ueno , Tetsuo Masubuchi
IPC分类号： C08G018/10 , C08G063/08
CPC分类号： C08G64/0208 , C08G18/0895 , C08G18/10 , C08G18/44 , C08G18/3206
摘要： A copolycarbonate diol comprising: (a) recurring units each represented by the following formula (1): 1 (b) recurring units each independently represented by the following formula (2): 2 wherein n is 4, 5 or 6; and (c) terminal hydroxyl groups, wherein the copolycarbonate diol has a number average molecular weight of from 300 to 20,000, and wherein the amount of the recurring units (a) is from 10 to 90% by mole, based on the total molar amount of the recurring units (a) and (b). A thermoplastic polyurethane obtained by copolymerizing the above-mentioned copolycarbonate diol with a polyisocyanate.
摘要翻译：一种共聚碳酸酯二醇，其包含：（a）各自由下式（1）表示的重复单元：（b）各自独立地由下式（2）表示的重复单元：其中n为4,5或6; 和（c）末端羟基，其中共聚碳酸酯二醇的数均分子量为300〜20,000，其中重复单元（a）的量为总摩尔量的10〜90摩尔％的重复单位（a）和（b）。通过将上述共聚碳酸酯二醇与多异氰酸酯共聚得到的热塑性聚氨酯。

8. 发明申请

US20030139567A1 Sequentially ordered biodegradable lactide (glycolide or lactide/glycolide)epsilon -caprolactone multi-block copolymer and process for the preparation thereof 失效
标题翻译：顺序排列的可生物降解丙交酯（乙交酯或丙交酯/乙交酯）ε-己内酯多嵌段共聚物及其制备方法
公开(公告)号：US20030139567A1
公开(公告)日：2003-07-24
申请号：US10298111
申请日：2002-11-14
发明人： Young Ha Kim , Soo Hyun Kim , Soo-Hong Lee , Oju Jeon
IPC分类号： C08G063/08
CPC分类号： C08G63/08
摘要： Disclosed is a sequentially ordered biodegradable lactide (or glycolide or lactide/glycolide)/null-caprolactone multi-block copolymers having proper degradation properties and enhanced mechanical properties such as flexibility and elasticity and a process for the preparation thereof.
摘要翻译：公开了具有适当的降解性能和增强的机械性能如柔韧性和弹性的顺序可生物降解的丙交酯（或乙交酯或丙交酯/乙交酯）/ε-己内酯多嵌段共聚物及其制备方法。

9. 发明申请

US20030125431A1 Crystalline polyglycolic acid, polyglycolic acid composition and production process thereof 有权
标题翻译：结晶聚乙醇酸，聚乙醇酸组合物及其制备方法
公开(公告)号：US20030125431A1
公开(公告)日：2003-07-03
申请号：US10132578
申请日：2002-04-25
发明人： Kazuyuki Yamane , Hiromitsu Miura , Toshihiko Ono , Junji Nakajima , Daisuke Itoh
IPC分类号： C08K005/49 , C08G063/08
CPC分类号： C08G63/08 , C08G63/80 , C08G63/88 , C08K5/527 , C08L67/04
摘要： Crystalline polyglycolic acid wherein a difference between the melting point Tm and the crystallization temperature Tc2 is not lower than 35null C., and a difference between the crystallization temperature Tc1 and the glass transition temperature Tg is not lower than 40null C. A production process of polyglycolic acid modified in crystallinity, comprising applying heat history to crystalline polyglycolic acid at a temperature of not lower than (the melting point Tm of the crystalline polyglycolic acidnull38null C.). A polyglycolic acid composition comprising crystalline polyglycolic acid and a heat stabilizer, wherein a difference (T2nullT1) between the temperature T2 at 3%-weight loss on heating of the polyglycolic acid composition and the temperature T1 at 3%-weight loss on heating of the crystalline polyglycolic acid is not lower than 5null C.
摘要翻译：其中熔点Tm和结晶温度Tc2之差不低于35℃的结晶聚乙醇酸，结晶温度Tc1与玻璃化转变温度Tg之差不低于40℃。制备方法在结晶性中改性的聚乙醇酸，包括在不低于（结晶聚乙醇酸+ 38℃的熔点Tm）的温度下对结晶聚乙醇酸施加热历史。一种包含结晶聚乙醇酸和热稳定剂的聚乙醇酸组合物，其中在加热聚乙醇酸组合物时3％重量损失温度T2与加热时3％重量损失温度T1之间的差值（T2-T1）的结晶聚乙醇酸不低于5℃

10. 发明申请

US20020091229A1 Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers 失效
标题翻译：可光聚合的可生物降解的水凝胶作为组织接触材料和控制释放载体
公开(公告)号：US20020091229A1
公开(公告)日：2002-07-11
申请号：US10021508
申请日：2001-10-22
申请人： Board of Regents, The University of Texas System Texas
发明人： Jeffrey A. Hubbell , Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Neil P. Desai , Jennifer L. Hill
IPC分类号： C08G063/08 , C08J003/28
CPC分类号： A61K9/0024 , A61K9/1635 , A61K9/1647 , A61K38/47 , A61K38/49 , A61K47/32 , A61K2035/128 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L26/0019 , A61L27/34 , A61L27/36 , A61L27/38 , A61L27/3839 , A61L27/52 , A61L29/085 , A61L31/10 , A61L31/145 , A61L31/148 , A61L31/16 , A61L2300/424 , A61L2300/602 , C08F290/00 , C08F290/06 , C08F291/00 , C09D153/00 , C09J153/00 , C12N5/0012 , C12N5/0677 , C12N11/04 , C12N2533/30 , C12N2533/32 , C12N2533/40 , C12N2533/74 , C12Y302/01017 , C12Y304/21068 , Y10T428/29 , Y10T428/2913 , Y10T428/2967 , Y10T428/31786 , C08L71/02
摘要： Hydrogels of polymerized and crosslinked macromers comprising hydrophilic oligomers having biodegradable monomeric or oligomeric extensions, which biodegradable extensions are terminated on free ends with end cap monomers or oligomers capable of polymerization and cross linking are described. The hydrophilic core itself may be degradable, thus combining the core and extension functions. Macromers are polymerized using free radical initiators under the influence of long wavelength ultraviolet light, visible light excitation or thermal energy. Biodegradation occurs at the linkages within the extension oligomers and results in fragments which are non-toxic and easily removed from the body. Preferred applications for the hydrogels include prevention of adhesion formation after surgical procedures, controlled release of drugs and other bioactive species, temporary protection or separation of tissue surfaces, adhering of sealing tissues together, and preventing the attachment of cells to tissue surfaces.
摘要翻译：描述了聚合和交联的大分子单体的水凝胶，其包含具有可生物降解的单体或低聚延伸的亲水性低聚物，其生物可降解的延伸部分在端基单体或能够聚合和交联的低聚物的自由端上终止。亲水核心本身可以是可降解的，因此结合核心和延伸功能。大分子单体在长波长紫外光，可见光激发或热能的影响下，使用自由基引发剂聚合。生物降解发生在延伸低聚物内的连接处，并导致无毒且容易从体内去除的碎片。水凝胶的优选应用包括防止外科手术后的粘连形成，药物和其他生物活性物质的控制释放，临时保护或组织表面分离，将密封组织粘附在一起，以及防止细胞附着到组织表面。

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