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    • 6. 发明公开
    • Method and apparatus for granulation and granulated product
    • 用于造粒和成粒产品的方法和装置
    • EP0237345A3
    • 1988-11-02
    • EP87302115
    • 1987-03-11
    • WASHINGTON UNIVERSITY TECHNOLOGY ASSOCIATES, INC.
    • Sparks,Robert EdwardMason,Norbert SimonCenter,Michael
    • B01J02/00
    • A61K9/1688B01J2/00B01J2/14B01J2/28
    • Method and apparatus for the formation of granules of a larger size or mass of a desired range from a feed stock (50) of smaller particles comprising feeding a meltable powdery material to be granulated, or a non-meltable powdery material with a meltable binder to the surface of a rotating spreader means (l0) in the form of a disk or bowl, at least a portion of which has been heated (l8) to a temperature above the melting point of the meltable compoent of the feed material wherein the rate of feeding, the energy input to the spreader means and the rotational speed of the spreader means are controlled so that there is sufficient time for at least a partial melting of the meltable component of the feed material substantially solely by contact with the heated surface of the spreader means, centrifugally spreading the material radially across the surface of the disk or bowl to form a layer of a liquid component (52) from the melted portion of the feed material on the surface of the spreader means, and dispersing the same from the edge thereof including droplets of the liquid component into an atomosphere cooler than the melting temperature to form the granulated product (54) in the cooler atmosphere. For certain materials only a part of the powdery feed material is melted forming a liquid film on the surface of the spreader means carrying a major portion of substantially unaffected or minimally affected feed material to produce a product comprising individual granules containing a core as the major part of each granule with the original powdery material essentially unchanged maintained in self-sustaining form by a matrix of melted and resolidified particles bonded to each other at their surface.
    • 9. 发明公开
    • Tablet coating apparatus
    • 片剂涂料装置
    • EP0030153A3
    • 1981-12-02
    • EP80304315
    • 1980-12-01
    • Lilly Industries Limited
    • Message, Stephen Roy
    • A61J03/06A61J03/00B01J02/00A23G03/26
    • B01J2/006A23G3/26
    • A tablet coating apparatus is described, which comprises a rotatable tablet receiving surface, rotary driving means coupled to the surface, an applicator for supply of coating fluid to the tablets (as hereinbefore defined), applicator shutdown means, an air conduit for supplying air to the tablets, air control means for regulating the supply of air, the arrangement of the air conduit and tablet receiving surface being such that in operation of the apparatus air passes from the air conduit through a bed of tablets on the tablet receiving surface, temperature sensing means in the path of the exhaust air and control means connected to the temperature sensing means, the rotary driving means, the air control means and the applicator shutdown means, for shutting off the supply of air to the rotatable tablet receiving surface, causing the rotary driving means to cease to rotate the tablet receiving surface and causing the applicator shutdown means to shut down the applicator whenever the temperature detected by the temperature sensing means exceeds a first predetermined value in operation of the apparatus and for causing the applicator shutdown means to shut down the applicator whenever the temperature detected by the temperature sensing means falls below a second predetermined value in operation of the apparatus.