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1. 发明专利

AU2001259007B2 Novel composition 未知
公开(公告)号：AU2001259007B2
公开(公告)日：2005-11-17
申请号：AU2001259007
申请日：2001-05-17
申请人： ASTRAZENECA AB
发明人： NILSSON PER-GUNNAR , TROFAST EVA , THALBERG KYRRE , MALMQVIST-GRANLUND KARIN
IPC分类号： A61K47/26 , A61K9/00 , A61K9/14 , A61K9/72 , A61K31/135 , A61K31/16 , A61K31/165 , A61K31/167 , A61K31/205 , A61K31/57 , A61K31/58 , A61K31/7012 , A61L9/04 , A61P11/00 , A61P11/06 , A61P27/16 , A61K009/72 , A61K031/165 , A61P011/06 , A61K031/58
摘要： The invention relates to a process for preparing a novel pharmaceutical composition useful in the treatment of respiratory disorders such as asthma, rhinitis and chronic obstructive pulmonary disease (COPD).

2. 发明专利

AU2001283891B2 9.Alpha.-chloro-6.alpha.-fluoro-17.alpha.hydroxy-16-methyl-17-beta-methoxycarbonyl-androst-1,4-dienes esterified in position 17 .alpha. by a cyclic acyl group 未知
公开(公告)号：AU2001283891B2
公开(公告)日：2004-06-17
申请号：AU2001283891
申请日：2001-06-26
申请人： NOVARTIS AG
发明人： WATSON SIMON JAMES , CUENOUD BERNARD , SANDHAM DAVID ANDREW , PILGRIM GAYNOR ELIZABETH , KELLER THOMAS HUGO , BEATTIE DAVID
IPC分类号： A61K31/56 , A61P11/08 , A61P29/00 , A61P43/00 , C07C401/00 , C07J3/00 , C07J17/00 , C07J33/00 , C07J41/00 , C07J43/00 , C07J71/00 , C07J003/00 , A61K031/58 , A61K031/56 , C07J043/00 , C07J017/00 , C07J033/00
摘要： Compounds of formula (I), where R is a monovalent cyclic organic group having from 3 to 15 atoms in the ring system, useful as pharmaceuticals

3. 发明专利

AU2001276497B2 17.beta.-carbothioate 17.alpha.-arylcarbonyloxyloxy androstane derivative as anti-inflammatory agents 未知
公开(公告)号：AU2001276497B2
公开(公告)日：2005-04-07
申请号：AU2001276497
申请日：2001-08-03
申请人： GLAXO GROUP LTD
发明人： PAYNE JEREMY JOHN , JONES PAUL , BIGGADIKE KEITH
IPC分类号： A61K9/12 , A61K9/14 , A61K31/56 , A61K31/58 , A61K45/00 , A61K47/06 , A61K47/18 , A61K47/36 , A61P5/44 , A61P11/06 , A61P11/08 , A61P29/00 , A61P37/08 , A61P43/00 , C07J17/00 , C07J31/00 , C07J33/00 , C07J43/00 , C07J031/00 , A61K031/58 , A61P005/44 , C07J003/00 , C07J071/00 , C07J033/00
摘要： According to one aspect of the invention, there is provided a compound of formula (I) and solvates thereof. There are also provided compositions containing the compound, processes for preparing it, and its use in therapy.

4. 发明专利

AU2001275760B2 -11.beta.-hydroxy-16.alpha.-methyl-3-oxo-androst-1,4,-diene-17-carbothioic acid S-fluoromethyl ester as an anti-inflammatory agent 未知
公开(公告)号：AU2001275760B2
公开(公告)日：2005-03-17
申请号：AU2001275760
申请日：2001-08-03
申请人： GLAXO GROUP LTD
发明人： NICE ROSALYN KAY , COOTE STEVEN JOHN , BIGGADIKE KEITH
IPC分类号： A61K9/12 , A61K9/14 , A61K31/56 , A61K31/58 , A61K45/00 , A61K47/06 , A61K47/18 , A61K47/36 , A61P5/44 , A61P11/06 , A61P11/08 , A61P29/00 , A61P37/08 , A61P43/00 , C07J17/00 , C07J31/00 , C07J33/00 , C07J43/00 , C07J031/00 , A61P011/08 , A61P011/06 , A61P005/44 , A61K031/58 , C07J017/00
摘要： According to one aspect of the invention, there is provided a compound of formula (I) and solvates thereof. There are also provided compositions containing the compound, processes for preparing it, and its use in therapy.

5. 发明申请

US20040229853A1 Novel method and intermediates for preparing 19-norsteroid compounds 审中-公开
标题翻译：制备19-降胆固醇化合物的新方法和中间体
公开(公告)号：US20040229853A1
公开(公告)日：2004-11-18
申请号：US10834749
申请日：2004-04-29
申请人： Aventis Pharma S.A.
发明人： Denis Prat , Christian Moratille , Francoise Benedetti , Lahlou Nait-Bouda
IPC分类号： C07J043/00 , A61K031/58 , A61K031/56 , C07J001/00
CPC分类号： A61K31/566 , A61K31/58
摘要： The subject of the invention is a method for preparing compounds of general formula (I): 1 in which A, Z, R3 are as defined in the description, and the intermediate compounds for carrying out this method.
摘要翻译：本发明的主题是制备通式（I）的化合物的方法：其中A，Z，R 3如说明书中所定义，和用于实施该方法的中间体化合物。

6. 发明申请

US20040209853A1 Orally active 7.alpha.-alkyl androgens 审中-公开
标题翻译：口服活性的α-烷基雄激素
公开(公告)号：US20040209853A1
公开(公告)日：2004-10-21
申请号：US10837061
申请日：2004-04-29
发明人： Jaap Louw van der , Dirk Leysen , Roberta Buma Bursi
IPC分类号： A61K031/58 , C07J001/00
CPC分类号： C07J1/007 , C07J1/0074
摘要： Orally Active androgens are derivative of 7null-methyl-19-nortestosterone. The compounds satisfy formula (I) wherein R1 is O, (H,H), (H,OR), NOR, with R being hydrogen, (C1-6) alkyl, or (C1-6) acyl; R2 is ethyl optionally substituted by halogen; R3 is hydrogen, (C1-2) alkyl, or ethenyl; R4 is (C1-2) alkyl; R5 is hydrogen, or (C1-15)acyl; and the dotted lines indicate optional bonds. 1
摘要翻译：口服活性雄激素是7α-甲基-19-去睾酮的衍生物。化合物满足式（I）其中R 1为O，（H，H），（H，OR），NOR，其中R为氢，（C 1-6）烷基或（C 1-6）酰基; R2是任选被卤素取代的乙基; R3是氢，（C1-2）烷基或乙烯基; R4是（C1-2）烷基; R5是氢，或（C1-15）酰基; 虚线表示可选的债券。

7. 发明申请

US20040105818A1 Diuretic aerosols and methods of making and using them 审中-公开
标题翻译：利尿剂及其使用方法
公开(公告)号：US20040105818A1
公开(公告)日：2004-06-03
申请号：US10712365
申请日：2003-11-12
申请人： Alexza Molecular Delivery Corporation
发明人： Nathan R. Every , Ron L. Hale , Amy T. Lu , Joshua D. Rabinowitz
IPC分类号： A61L009/04 , A61K031/58
CPC分类号： A61K9/0073 , A61K9/007 , A61K31/58
摘要： Described herein are diuretic condensation aerosols and methods of making and using them. Kits for delivering a condensation aerosol are also described. The diuretic aerosols typically comprise diuretic condensation aerosol particles that comprise a diuretic compound. In some variations the diuretic compound is selected from the group consisting of bumetanide, ethacrynic acid, furosemide, muzolimine, spironolactone, torsemide, triamterene, tripamide, BG 9928, and BG 9719. Methods of treating edema using the described aerosols are also provided. In general, the methods typically comprise the step of administering a therapeutically effective amount of diuretic condensation aerosol to a person with edema. The diuretic condensation aerosol may be administered in a single inhalation, or may be administered in more than one inhalation. Methods of forming a diuretic condensation aerosol are also described. The methods typically comprise the steps of providing a diuretic composition, vaporizing the composition to form a vapor, and then condensing the diuretic composition vapor.
摘要翻译：本文描述的是利尿凝结气溶胶及其制备和使用方法。还描述了用于递送冷凝气雾剂的组件。利尿剂气溶胶通常包含利尿剂缩合气溶胶颗粒，其包含利尿剂。在一些变体中，利尿剂化合物选自布美他尼，依西醋酸，呋塞米，多佐立胺，螺内酯，托塞米明，扑热息痛，三酰胺，BG 9928和BG 9719.还提供了使用所述气溶胶治疗水肿的方法。通常，所述方法通常包括向具有水肿的人施用治疗有效量的利尿冷凝气雾剂的步骤。利尿冷凝气雾剂可以在单次吸入中施用，或者可以在多于一次的吸入中施用。还描述了形成利尿冷凝气雾剂的方法。所述方法通常包括提供利尿组合物，蒸发组合物以形成蒸气，然后冷凝利尿组合物蒸气的步骤。

8. 发明申请

US20040102426A1 16,17-carbocyclic condensed steroid compounds having selective estrogenic activity 有权
标题翻译：具有选择性雌激素活性的16,17-碳环缩合类固醇化合物
公开(公告)号：US20040102426A1
公开(公告)日：2004-05-27
申请号：US10297706
申请日：2002-12-06
发明人： Hubert Jan Jozef Loozen
IPC分类号： A61K031/58 , A61K031/56 , C07J053/00
CPC分类号： C07J53/002
摘要： The invention discloses a steroid compound having the formula (1), wherein dotted bonds represent optional double bonds; R6 is H, nullCH2, or nullCH3, or nullCH2nullCH3; R7 is H C1-4-alkyl, C2-5 alkenyl or C2-5-alkynyl, wherein the alkyl, alkenyl or alkynyl group may be substituted with 1 to 3 halogen atoms independently chosen from the group of fluorine or chlorine atoms; R11 is H, C1-4-alkyl, C2-4-alkenyl, C2-4-alkynyl or C1-4-alkylidene, wherein the alkyl, alkenyl, alkynyl or alkylidene group may be substituted with 1 to 3 halogen atoms independently chosen from the group of fluorine or chlorine atoms; E represents together with carbon atoms 16 and 17 of the steroid skeleton a four to seven-membered ring, said ring being null and in cis-configuration with respect to the steroid skeleton, optionally comprising one or two endocyclic bonds; or a prodrug thereof. Such compounds can be used in therapy and for methods for selective modification of the activity of estrogen receptors. 1
摘要翻译：本发明公开了具有式（1）的类固醇化合物，其中虚线键代表任选的双键; R 6是H，= CH 2或-CH 3或-CH 2 -CH 3; R 7是C 1-4 - 烷基，C 2-5烯基或C 2-5炔基，其中烷基，烯基或炔基可以被独立地选自氟或氯原子的1至3个卤素原子取代; R 11是H，C 1-4 - 烷基，C 2-4 - 烯基，C 2-4 - 炔基或C 1-4 - 亚烷基，其中烷基，烯基，炔基或亚烷基可以被1至3个独立地选自该组氟或氯原子; E与类固醇骨架的碳原子16和17一起形成4至7元环，所述环为α并且相对于类固醇骨架为顺式构型，任选包含一个或两个内环键; 或其前药。这些化合物可用于治疗和选择性修饰雌激素受体活性的方法。

9. 发明申请

US20040101549A1 Treatments 审中-公开
标题翻译：治疗
公开(公告)号：US20040101549A1
公开(公告)日：2004-05-27
申请号：US10302801
申请日：2002-11-22
发明人： Paul David Abel
IPC分类号： A61K039/395 , A61K031/58 , A61K031/56 , A61K009/70
CPC分类号： A61K31/58 , A61K9/7023 , A61K31/56
摘要： A method for the treatment of carcinoma of the prostate is provided. A compound having estrogenic activity is administered transdermally to a subject in need of such treatment.
摘要翻译：提供了一种治疗前列腺癌的方法。具有雌激素活性的化合物经皮给予需要这种治疗的个体。

10. 发明申请

US20040097477A1 Androgenic steroid compounds and a method of making and using the same 失效
标题翻译：雄激素类固醇化合物及其制备和使用方法
公开(公告)号：US20040097477A1
公开(公告)日：2004-05-20
申请号：US10699885
申请日：2003-11-04
申请人： Research Triangle Institute
发明人： C. Edgar Cook , John A. Kepler , Yue-Wei Lee , Mansukh C. Wani
IPC分类号： A61K031/58 , A61K031/573
CPC分类号： C07J1/00
摘要： An androgenic steroid compound of the formula: 1 wherein: X, Y, Z, R1, R2, R3, R5 and R6 are as defined herein.
摘要翻译：下式的雄激素类固醇化合物：其中：X，Y，Z，R 1，R 2，R 3，R 5和R 6如本文所定义。

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