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1. 发明公开

CN107532192A 用于设计靶向高化学计量复合物从而治疗疾病的化合物和组合物的方法有权
公开(公告)号：CN107532192A
公开(公告)日：2018-01-02
申请号：CN201680026334.3
申请日：2016-05-06
申请人：肯塔基大学研究基金会
发明人：郭培宣 , 舒丹
IPC分类号： C12Q1/02 , C12Q3/00 , G01N21/77 , G01N33/50 , G06G7/58
CPC分类号： G01N33/68 , C12Q3/00 , G01N33/94 , G01N2333/005 , G01N2500/00 , G06G7/58
摘要：描述了一种用于鉴别多亚基生物复合物药物靶点的方法。该方法包括鉴别执行生物学功能的靶点，其中所述靶点包含一个或多个亚基，其中所述一个或多个亚基的最小数量被灭活以阻止该生物学功能。该方法还包括选择以目标概率与所述一个或多个亚基中的每个亚基特异性结合的药物。该方法还包括使用二项分布描述所述药物的抑制效率与所述一个或多个亚基的总数之间的关系，其中所述抑制效率包括所递送的药物阻止所述生物学功能的概率。该方法还包括使用实验靶点来经验证实所述关系。该方法包括将所述药物施用于所述靶点以治疗多重耐药性疾病，其中，所述靶点包含哺乳动物受试者中的生物复合物。

2. 发明公开

EP0083409A3 Electrochemical cell simulator circuit 失效
标题翻译：电化学电池模拟电路
公开(公告)号：EP0083409A3
公开(公告)日：1986-05-07
申请号：EP82110350
申请日：1982-11-10
申请人： International Business Machines Corporation
发明人： Kanazawa, Kay Keiji
IPC分类号： G06G07/58 , G06G07/62
CPC分类号： G06G7/62 , G06G7/58
摘要： electrochemical cell simulator circuit provides current flow simulating the faradaic current, oxidation reduction potential and the like of an electrochemical cell. The circuit comprises a pair of interconnection terminals 37, 38 across which a resistance is to be established substantially simulating the faradaic resistance of a cell. A differential amplifier 41 has one input terminal connected to the terminal 37 and Its output terminal connected to the other input terminal and through a resistor 121 to an input terminal of a differential amplifier 42, whose output terminal is connected through a resistor 129 to the other input terminal and to the input of a pair of back-to-back diodes 46, 48, whose output is connected to differential amplifier 50. A compensating operational amplifier 80 with an adjustable feedback resistor 82 is connected across the diode device which acts as a resistance simulator circuit. The output of the amplifier 50 is to a switch 52 connected alternatively to a capacitor 56 or to a Warburg impedance network 58 leading to the input of an amplifier circuit 60. There are two key concepts. The first recognises that because the semi-integral of the cell current effectively deconvolves the diffusion aspect of the phenomenon with the resultant describing the surface concentration of reacted species, then the semiderivative of a function describing a surface concentration of reacted species results in an output representing the cell current, including diffusion. The second is embodied in a circuit arrangement properly simulating this concentration behaviour cell double layer potential and in yielding an output proportional to the surface concentration of reactant species corresponding to that potential in response to applied cell barrier potential.

3. 发明申请

WO2016179531A1 METHOD FOR DESIGNING COMPOUNDS AND COMPOSITIONS USEFUL FOR TARGETING HIGH STOICHIOMETRIC COMPLEXES TO TREAT CONDITIONS 审中-公开
标题翻译：用于设计高分子量复合物以适应条件的化合物和组合物的方法
公开(公告)号：WO2016179531A1
公开(公告)日：2016-11-10
申请号：PCT/US2016/031292
申请日：2016-05-06
申请人： UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
发明人： GUO, Peixuan , SHU, Dan
IPC分类号： C12Q1/02 , C12Q3/00 , G01N21/77 , G01N33/50 , G06G7/58
CPC分类号： G01N33/68 , C12Q3/00 , G01N33/94 , G01N2333/005 , G01N2500/00 , G06G7/58
摘要： A method is described for the identification of multi-subunit biocomplex drug targets. The method includes identifying a target that performs a biological function, wherein the target comprises one or more subunits, wherein a minimum number of the one or more subunits is inactivated to inhibit the biological function. The method includes selecting a drug that binds specifically to each subunit of the one or more subunits with a target probability. The method describes a relationship between inhibition efficiency of the drug and total number of the one or more subunits using a binomial distribution, wherein the inhibition efficiency comprises a probability that the delivered drug blocks the biological function. The method includes confirming empirically the relationship using an experimental target. The method includes administering the drug to the target to treat a multi-drug resistant disease, wherein the target comprises a biological complex in a mammalian subject.
摘要翻译：描述了用于鉴定多亚单位生物复合物药物靶标的方法。所述方法包括鉴定执行生物学功能的靶，其中所述靶包含一个或多个亚基，其中所述一个或多个亚基的最小数目被失活以抑制所述生物学功能。该方法包括选择以目标概率特异性结合一个或多个亚基的每个亚基的药物。该方法描述了使用二项分布的药物的抑制效率和一个或多个亚基的总数之间的关系，其中抑制效率包括递送的药物阻断生物学功能的概率。该方法包括使用实验目标经验证实关系。该方法包括将药物施用于靶标以治疗多重耐药性疾病，其中所述靶包含哺乳动物受试者中的生物复合物。

4. 发明申请

WO2010096129A1 ELECTRONIC SYSTEM FOR MODELING CHEMICAL REACTIONS AND BIOCHEMICAL PROCESSES 审中-公开
标题翻译：用于建立化学反应和生物化学过程的电子系统
公开(公告)号：WO2010096129A1
公开(公告)日：2010-08-26
申请号：PCT/US2009/062828
申请日：2009-10-30
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , MANDAL, Soumyajit , SARPESHKAR, Rahul
发明人： MANDAL, Soumyajit , SARPESHKAR, Rahul
IPC分类号： G06G7/24 , G05B17/02
CPC分类号： G05B17/02 , G06F19/12 , G06F19/702 , G06G7/58
摘要： A system for modeling chemical reactions using analog or hybrid-analog-digital electronic circuits. The system exploits similarities between the kinetic rates of chemical reaction and the rates governing current flow in electronic devices such as bipolar junction transistors (BJTs) and metal oxide semiconductor field effect transistors (MOSFETs) operating at subthreshold conditions. These devices, which accurately model the stochastics of chemical processes, can networked into large array to model chemical reaction networks, including biochemical reactions and genetic processes such as activation, induction, transcription, and translation.
摘要翻译：使用模拟或混合模拟数字电子电路建模化学反应的系统。该系统利用化学反应的动力学速率和控制电流器件（例如双极结型晶体管（BJT））和在亚阈值条件下工作的金属氧化物半导体场效应晶体管（MOSFET）的电流的速率之间的相似性。这些准确地模拟化学工艺随机化的装置可以联网到大型阵列，以建立化学反应网络，包括生化反应和遗传过程如活化，诱导，转录和翻译。

5. 发明授权

EP0083409B1 Electrochemical cell simulator circuit 失效
标题翻译：电化学电池模拟电路
公开(公告)号：EP0083409B1
公开(公告)日：1989-02-08
申请号：EP82110350.4
申请日：1982-11-10
申请人： International Business Machines Corporation
发明人： Kanazawa, Kay Keiji
IPC分类号： G06G7/58 , G06G7/62
CPC分类号： G06G7/62 , G06G7/58

6. 发明公开

EP0083409A2 Electrochemical cell simulator circuit 失效
标题翻译：模拟器电路用于电化学电池。
公开(公告)号：EP0083409A2
公开(公告)日：1983-07-13
申请号：EP82110350.4
申请日：1982-11-10
申请人： International Business Machines Corporation
发明人： Kanazawa, Kay Keiji
IPC分类号： G06G7/58 , G06G7/62
CPC分类号： G06G7/62 , G06G7/58
摘要： electrochemical cell simulator circuit provides current flow simulating the faradaic current, oxidation reduction potential and the like of an electrochemical cell. The circuit comprises a pair of interconnection terminals 37, 38 across which a resistance is to be established substantially simulating the faradaic resistance of a cell. A differential amplifier 41 has one input terminal connected to the terminal 37 and Its output terminal connected to the other input terminal and through a resistor 121 to an input terminal of a differential amplifier 42, whose output terminal is connected through a resistor 129 to the other input terminal and to the input of a pair of back-to-back diodes 46, 48, whose output is connected to differential amplifier 50. A compensating operational amplifier 80 with an adjustable feedback resistor 82 is connected across the diode device which acts as a resistance simulator circuit. The output of the amplifier 50 is to a switch 52 connected alternatively to a capacitor 56 or to a Warburg impedance network 58 leading to the input of an amplifier circuit 60.
There are two key concepts. The first recognises that because the semi-integral of the cell current effectively deconvolves the diffusion aspect of the phenomenon with the resultant describing the surface concentration of reacted species, then the semiderivative of a function describing a surface concentration of reacted species results in an output representing the cell current, including diffusion. The second is embodied in a circuit arrangement properly simulating this concentration behaviour cell double layer potential and in yielding an output proportional to the surface concentration of reactant species corresponding to that potential in response to applied cell barrier potential.

7. 发明授权

US08285523B2 Electronic system for modeling chemical reactions and biochemical processes 有权
标题翻译：用于化学反应和生化过程建模的电子系统
公开(公告)号：US08285523B2
公开(公告)日：2012-10-09
申请号：US12575291
申请日：2009-10-07
申请人： Soumyajit Mandal , Rahul Sarpeshkar
发明人： Soumyajit Mandal , Rahul Sarpeshkar
IPC分类号： G06F17/10 , G06G7/48
CPC分类号： G05B17/02 , G06F19/12 , G06F19/702 , G06G7/58
摘要： A system for modeling chemical reactions using analog or hybrid-analog-digital electronic circuits. The system exploits similarities between the kinetic rates of chemical reaction and the rates governing current flow in electronic devices such as bipolar junction transistors (BJTs) and metal oxide semiconductor field effect transistors (MOSFETs) operating at subthreshold conditions. These devices, which accurately model the stochastics of chemical processes, can be networked into large arrays to model chemical reaction networks, including biochemical reactions and genetic processes such as activation, induction, transcription, and translation.
摘要翻译：使用模拟或混合模拟数字电子电路建模化学反应的系统。该系统利用化学反应的动力学速率和控制电流器件（例如双极结型晶体管（BJT））和在亚阈值条件下工作的金属氧化物半导体场效应晶体管（MOSFET）的电流的速率之间的相似性。这些准确地模拟化学过程随机化的装置可以联网成大型阵列，以建立化学反应网络，包括生化反应和遗传过程，如激活，诱导，转录和翻译。

8. 发明申请

US20100211364A1 ELECTRONIC SYSTEM FOR MODELING CHEMICAL REACTIONS AND BIOCHEMICAL PROCESSES 有权
标题翻译：用于建立化学反应和生物化学过程的电子系统
公开(公告)号：US20100211364A1
公开(公告)日：2010-08-19
申请号：US12575291
申请日：2009-10-07
申请人： Soumyajit Mandal , Rahul Sarpeshkar
发明人： Soumyajit Mandal , Rahul Sarpeshkar
IPC分类号： G06G7/58 , G06F17/10
CPC分类号： G05B17/02 , G06F19/12 , G06F19/702 , G06G7/58
摘要： A system for modeling chemical reactions using analog or hybrid-analog-digital electronic circuits. The system exploits similarities between the kinetic rates of chemical reaction and the rates governing current flow in electronic devices such as bipolar junction transistors (BJTs) and metal oxide semiconductor field effect transistors (MOSFETs) operating at subthreshold conditions. These devices, which accurately model the stochastics of chemical processes, can networked into large array to model chemical reaction networks, including biochemical reactions and genetic processes such as activation, induction, transcription, and translation.
摘要翻译：使用模拟或混合模拟数字电子电路建模化学反应的系统。该系统利用化学反应的动力学速率和控制电流器件（例如双极结型晶体管（BJT））和在亚阈值条件下工作的金属氧化物半导体场效应晶体管（MOSFET）的电流的速率之间的相似性。这些准确地模拟化学工艺随机化的装置可以联网到大型阵列，以建立化学反应网络，包括生化反应和遗传过程如活化，诱导，转录和翻译。

9. 发明授权

US4307453A Sloping baseline compensation for a chromatographic analyzer 失效
标题翻译：斜率色谱分析仪的基线补偿
公开(公告)号：US4307453A
公开(公告)日：1981-12-22
申请号：US46411
申请日：1979-06-07
申请人： Louis D. Kleiss
发明人： Louis D. Kleiss
IPC分类号： G01N30/86 , G06G7/184 , G06G7/58 , G06G7/186 , G01N31/08
CPC分类号： G06G7/58 , G01N30/8641 , G06G7/184 , G01N30/8606
摘要： A method and apparatus is disclosed for correcting errors in a chromatographic analysis wherein the trailing edge of a strong peak interferes with the integration of the trailing peak which follows the strong peak. In one embodiment of the invention two functions of the trailing peak are electrically integrated and summed to produce a correct peak integration. In a second embodiment of the invention the baseline is shifted and the integration of the trailing peak is performed with respect to the shifted baseline to produce a correct peak integration.
摘要翻译：公开了用于校正色谱分析中的误差的方法和装置，其中强峰的后沿干扰跟随强峰的尾峰的积分。在本发明的一个实施例中，尾部峰值的两个功能被电气集成并相加以产生正确的峰值积分。在本发明的第二实施例中，基线被移动，并且相对于偏移的基线执行尾部峰值的积分以产生正确的峰积分。

10. 发明授权

US4199808A Inverse timer with non-interacting potentiometer settings 失效
标题翻译：具有非相互作用的电位器设置的反时限
公开(公告)号：US4199808A
公开(公告)日：1980-04-22
申请号：US864891
申请日：1977-12-27
申请人： Robert S. Peterson
发明人： Robert S. Peterson
IPC分类号： B21B39/00 , B21C51/00 , G06G7/58 , G06G7/66 , H03K17/28 , G05B6/02 , G06G7/48
CPC分类号： G06G7/58 , G06G7/66
摘要： An inverse timer for a process line is disclosed in which the forward end of the material is detected at a known distance from an instrument which is to be activated. The inverse timer is initiated upon forward end detection, and in a small increment of time, .DELTA.T seconds later, the instrument is activated; .DELTA.T is equal to the time required for the material to move from the point of detection to the location of the instrument, i.e., the transport time minus the reaction time of the instrument. The inverse timer includes two potentiometers for independently adjusting the transport time and the reaction times. Since the velocity of the material may vary widely during production, the inverse timer enables rapid adjustments to be made to accommodate for these new conditions without the laborious empirical determination of optimum settings of interacting potentiometers.
摘要翻译：公开了一种用于处理线的反向定时器，其中材料的前端在距待被激活的仪器已知距离处被检测。反向定时器在前端检测时启动，并且在一小段时间内，DELTA T秒后，仪器被激活; DELTA T等于材料从检测点移动到仪器位置所需的时间，即运输时间减去仪器的反应时间。逆定时器包括两个用于独立调节传输时间和反应时间的电位器。由于材料的速度在生产过程中可能会有很大变化，所以反时限计器能够进行快速调整以适应这些新条件，而无需经验确定相互作用的电位计的最佳设置。

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