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1. 发明授权

US08703480B1 Biological function effecting viral vectors and chimeric cells useful as packaging cell lines and target cells 失效
标题翻译：影响可用作包装细胞系和靶细胞的病毒载体和嵌合细胞的生物学功能
公开(公告)号：US08703480B1
公开(公告)日：2014-04-22
申请号：US09007123
申请日：1998-01-14
申请人： Dakai Liu , Elazar Rabbani
发明人： Dakai Liu , Elazar Rabbani
IPC分类号： A61K39/295 , A61K39/145
CPC分类号： C12N15/86 , C12N2740/11043 , C12N2740/13043 , C12N2740/13044 , C12N2740/13052 , C12N2750/14143 , C12N2750/14151 , C12N2810/6054 , C12N2810/609
摘要： Provided are novel vectors comprising virus or viral portions in which biological function is effected by components on the surface or envelope. Biological function includes viral nucleic acid propagation and delivery in the same vector as well as other important functions such as enhanced target cell specificity and other favorable properties for endocytosis, nuclear localization, integration into the target cell genome and enhanced transduction efficiency functions. Also provided by this invention are chimeric cells useful as packaging cell lines or as target cells or even as both. By virtue of their unique sequences, such chimeric cells provide the machinery for viral nucleic acid propagation and packaging combined with other useful properties for delivering genetic information to any target cells of interest. Also provided are other vectors including those comprising initial nucleic acid wherein the initial nucleic acid has been modified and novel reconstituted vectors and fused vectors.
摘要翻译：提供了包含病毒或病毒部分的新载体，其中生物功能由表面或信封上的组分实现。生物学功能包括在相同载体中的病毒核酸繁殖和递送以及其他重要功能，例如增强的靶细胞特异性和其他有利的内吞，核定位，整合入靶细胞基因组和增强的转导效率功能的有利特征。本发明还提供了可用作包装细胞系或靶细胞或甚至两者的嵌合细胞。由于其独特的序列，这种嵌合细胞为病毒核酸传播和包装提供了与用于将遗传信息传递给感兴趣的任何靶细胞的其它有用特性的机制。还提供了其它载体，包括那些包含初始核酸的载体，其中初始核酸已经被修饰和新的重构载体和融合载体。

2. 发明申请

US20040086485A1 Chemeric viral vectors for gene therapy 审中-公开
标题翻译：用于基因治疗的Chemeric病毒载体
公开(公告)号：US20040086485A1
公开(公告)日：2004-05-06
申请号：US10264839
申请日：2002-10-04
发明人： Carlos Estuardo Aguilar-Cordova
IPC分类号： A61K048/00 , C12N015/861
CPC分类号： C12N15/86 , A61K48/00 , A61K48/0008 , C12N2710/10343 , C12N2710/10344 , C12N2710/10345 , C12N2740/13044 , C12N2810/6081
摘要： A nucleic acid sequence in a plasmid form comprising all the necessary elements for the production of a viral vector and this plasmid is delivered in-vivo with the intent of in-vivo viral vector production. The delivery of this vector may be further directed to specific targeted tissues by the addition of conjugated molecules, such as polycations, peptides, antibodies, single chain antibodies or combinations of the above.
摘要翻译：包含用于产生病毒载体的所有必需元件的质粒形式的核酸序列，并且该体内产生体内病毒载体生产的目的。通过加入共轭分子，如聚阳离子，肽，抗体，单链抗体或上述组合，可将该载体的递送进一步导向特异性靶向组织。

3. 发明授权

US11957715B2 Method for NK cell transduction 有权
公开(公告)号：US11957715B2
公开(公告)日：2024-04-16
申请号：US16954912
申请日：2018-12-19
申请人： MILTENYI BIOTEC B.V. & CO. KG
发明人： Rafijul Bari , Markus Granzin , Wing Leung , Nina Moker , Volker Huppert
IPC分类号： A61K35/17 , C07K14/54 , C07K14/545 , C07K14/55 , C12N15/867
CPC分类号： A61K35/17 , C07K14/5443 , C07K14/545 , C07K14/55 , C12N15/867 , C07K2319/85 , C12N2740/13044
摘要： The present invention discloses an in-vitro method for transferring biological material into activated NK cells with a pseudotyped retroviral vector particle or a virus-like particle thereof, comprising the steps a) activation of NK cells, and b) addition of said pseudotyped retroviral vector particle or virus-like particle thereof to said activated NK cells, wherein said pseudotyped retroviral vector particle or virus-like particle thereof comprises a modified baboon endogenous retrovirus (BaEV) envelope glycoprotein that is able of binding to and fusing with a hematopoietic cell membrane, thereby transferring biological material into said activated NK cells. Preferentially, the activating of NK cells is performed by the addition of a IL-1 family cytokine to the NK cells.

4. 发明申请

US20030003565A1 Functional lentiviral vector from an MLV-based backbone 审中-公开
标题翻译：来自基于MLV的骨架的功能性慢病毒载体
公开(公告)号：US20030003565A1
公开(公告)日：2003-01-02
申请号：US09996073
申请日：2001-11-27
发明人： Thomas W. Dubensky JR. , Mehdi Gasmi , Sybille Sauter
IPC分类号： A61K039/21 , C12N007/00 , C12N015/867
CPC分类号： C12N15/86 , A61K48/00 , A61K2039/525 , C12N2740/13044 , C12N2740/15043 , C12N2830/42 , C12N2830/48 , C12N2830/50
摘要： Disclosed are gene therapy vectors based on chimeric murine leukemia virus-feline immunodeficiency virus gene therapy vectors which are suitable for a wide variety of gene therapy applications. Also disclosed are related packaging cell lines, methods for production, and methods of use.
摘要翻译：公开了基于适合各种基因治疗应用的嵌合鼠白血病病毒 - 猫免疫缺陷病毒基因治疗载体的基因治疗载体。还公开了相关的包装细胞系，生产方法和使用方法。

5. 发明授权

US06352856B1 Chimeric poxvirus comprising sequences of a retroviral vector component 失效
标题翻译：包含逆转录病毒载体组分序列的嵌合痘病毒
公开(公告)号：US06352856B1
公开(公告)日：2002-03-05
申请号：US09228625
申请日：1999-01-12
申请人： Falko-Guenter Falkner , Georg Holzer , Friedrich Dorner
发明人： Falko-Guenter Falkner , Georg Holzer , Friedrich Dorner
IPC分类号： C12N1500
CPC分类号： C12N15/86 , C12N2710/24143 , C12N2740/13044
摘要： A chimeric poxvirus is disclosed, which comprises the sequences of the vector component of a retroviral vector particle and optionally the packaging component of a defective retroviral particle. The chimeric poxvirus according to the invention particularly can be used for applications in gene therapy or tumor therapy.
摘要翻译：公开了一种嵌合痘病毒，其包含逆转录病毒载体颗粒的载体组分和任选的缺陷型逆转录病毒颗粒的包装组分的序列。根据本发明的嵌合痘病毒特别可用于基因治疗或肿瘤治疗中的应用。

6. 发明申请

WO0242482A3 FUNCTIONAL LENTIVIRAL VECTOR FROM AN MLV-BASED BACKBONE 审中-公开
标题翻译：来自基于MLV的背景的功能活动矢量
公开(公告)号：WO0242482A3
公开(公告)日：2003-05-15
申请号：PCT/US0144617
申请日：2001-11-27
申请人： CHIRON CORP , DUBENSKY THOMAS W JR , GASMI MEHDI , SAUTER SYBILLE L
发明人： DUBENSKY THOMAS W JR , GASMI MEHDI , SAUTER SYBILLE L
IPC分类号： A61K48/00 , C12N15/867 , C12N15/79 , C12N15/86
CPC分类号： C12N15/86 , A61K48/00 , A61K2039/525 , C12N2740/13044 , C12N2740/15043 , C12N2830/42 , C12N2830/48 , C12N2830/50
摘要： Disclosed are gene therapy vectors based on chimeric murine leukemia virus-feline immunodeficiency virus gene therapy vectors which are suitable for a wide variety of gene therapy applications. Also disclosed are related packaging cell lines, methods for production, and methods of use.
摘要翻译：公开了基于适合于各种基因治疗应用的嵌合鼠白血病病毒 - 猫免疫缺陷病毒基因治疗载体的基因治疗载体。还公开了相关的包装细胞系，生产方法和使用方法。

7. 发明公开

EP1442125A4 CHIMERIC VIRAL VECTORS FOR GENE THERAPY 审中-公开
标题翻译：嵌合病毒载体的基因治疗
公开(公告)号：EP1442125A4
公开(公告)日：2004-12-08
申请号：EP02784026
申请日：2002-10-04
申请人： AGUILAR-CORDOVA CARLOS ESTUARD
发明人： AGUILAR-CORDOVA CARLOS ESTUARD
IPC分类号： C12N15/09 , A61K31/711 , A61K35/76 , A61K39/125 , A61K39/21 , A61K39/23 , A61K39/245 , A61K48/00 , A61P1/16 , A61P3/00 , A61P3/10 , A61P7/04 , A61P25/16 , A61P25/28 , A61P31/14 , A61P31/20 , A61P35/00 , C12N15/861 , C12N15/63 , A61K35/00 , C12N5/00
CPC分类号： C12N15/86 , A61K48/00 , A61K48/0008 , C12N2710/10343 , C12N2710/10344 , C12N2710/10345 , C12N2740/13044 , C12N2810/6081

8. 发明公开

EP1442125A2 CHIMERIC VIRAL VECTORS FOR GENE THERAPY 审中-公开
标题翻译：用于基因治疗的CHIMERIC病毒载体
公开(公告)号：EP1442125A2
公开(公告)日：2004-08-04
申请号：EP02784026.3
申请日：2002-10-04
申请人： Aguilar-Cordova, Carlos, Estuardo
发明人： Aguilar-Cordova, Carlos, Estuardo
IPC分类号： C12N15/63 , C12N5/00 , A61K35/00 , A61K48/00
CPC分类号： C12N15/86 , A61K48/00 , A61K48/0008 , C12N2710/10343 , C12N2710/10344 , C12N2710/10345 , C12N2740/13044 , C12N2810/6081
摘要： The invention relates to a single nucleic acid vector comprising both adenoviral and retroviral sequences for gene therapy. The vectors described herein are capable of transducing all cis and trans components of a retroviral vector for the generation of high tier recombinant retroviral vectors. The chimeric vectors are used for the delivery and stable integration of therapeutic constructs and eliminate limitations currently encountered with in vivo gene transfer applications.
摘要翻译：本发明涉及包含用于基因治疗的腺病毒和逆转录病毒序列的单一核酸载体。本文描述的载体能够转导逆转录病毒载体的所有顺式和反式组分以产生高层重组逆转录病毒载体。嵌合载体用于治疗构建体的递送和稳定整合，并且消除了体内基因转移应用目前遇到的限制。

9. 发明授权

EP0933429B1 Chimäres Poxvirus, das ein retrovirales Vektorgenom enthält 有权
标题翻译：包含逆转录病毒载体基因组嵌合痘病毒
公开(公告)号：EP0933429B1
公开(公告)日：2003-12-10
申请号：EP99890004.7
申请日：1999-01-15
申请人： Baxter Aktiengesellschaft
发明人： Falkner, Falko-Günter, Dr. , Holzer, Georg, Dr. , Dorner, Friedrich, Prof.
IPC分类号： C12N15/86 , C12N7/01 , A61K48/00
CPC分类号： C12N15/86 , C12N2710/24143 , C12N2740/13044

10. 发明公开

EP0933429A1 Chimäres Poxvirus, das ein retrovirales Vektorgenom enthält 有权
标题翻译： Chimäres痘病毒，das ein retrovirales Vektorgenomenthält
公开(公告)号：EP0933429A1
公开(公告)日：1999-08-04
申请号：EP99890004.7
申请日：1999-01-15
申请人： IMMUNO AG
发明人： Falkner, Falko-Günther, Dr. , Holzer, Georg, Dr. , Dorner, Friedrich, Prof.
IPC分类号： C12N15/86 , C12N7/01 , A61K48/00
CPC分类号： C12N15/86 , C12N2710/24143 , C12N2740/13044
摘要： Beschrieben wird ein chimäres Poxvirus, das die Sequenzen der Vektorkomponente eines retroviralen Vektorpartikels und gegebenenfalls die Verpackungskomponente eines defekten retroviralen Partikels enthält. Das erfindungsgemäße chimäre Poxvirus kann insbesondere für den Einsatz in der Gentherapie oder Tumortherapie verwendet werden.
摘要翻译：含有源自逆转录病毒载体的序列（I）的嵌合痘病毒（A）是新的。包括含有内含子的基因组的缺陷型逆转录病毒颗粒也包括独立权利要求。

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