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1. 发明专利

AU2006343306A1 Parathyroid hormone analogues and methods of use 未知
公开(公告)号：AU2006343306A1
公开(公告)日：2007-11-15
申请号：AU2006343306
申请日：2006-09-06
申请人： ZELOS THERAPEUTICS INC
发明人： MORLEY PAUL
IPC分类号： A61K38/29 , A61K31/59 , A61K33/06

2. 发明专利

CA2659846A1 PARATHYROID HORMONE ANALOGUES AND USES THEREOF 未知
公开(公告)号：CA2659846A1
公开(公告)日：2008-02-07
申请号：CA2659846
申请日：2007-05-02
申请人： ZELOS THERAPEUTICS INC
发明人： PALEPU NAGESH R , MACDONALD BRIAN , MORLEY PAUL , STOGNIEW MARTIN , MERUTKA GENE SCOTT
IPC分类号： A61K38/29 , A61K9/08 , A61K38/12 , A61P19/08
摘要： The present invention is directed to novel methods of treating a subject with a bone deficit disorder. The methods generally include administering to a subject in need thereof a pharmaceutically acceptable formulation compris ing a parathyroid hormone (PTH) peptide analogue in a daily dose sufficient to result in an effective pharmacokinetic profile and maintained adenylate c yclase activity, while simultaneously reducing undesirable side effects.

3. 发明专利

CA2621264A1 PARATHYROID HORMONE ANALOGUES AND METHODS OF USE 未知
公开(公告)号：CA2621264A1
公开(公告)日：2007-11-15
申请号：CA2621264
申请日：2006-09-06
申请人： ZELOS THERAPEUTICS INC
发明人： MORLEY PAUL
IPC分类号： A61K38/29 , A61K31/59 , A61K33/06
摘要： The present invention is directed to novel methods of treating a subject with a bone deficit disorder. The methods generally include administering to a subject in need thereof a pharmaceutically acceptable formulation comprising a parathyroid hormone (PTH) peptide analogue in a daily dose of 2 .mu.g to 60 .mu.g, wherein said PTH peptide analogue has a reduced phospholipase-C activity and maintains adenylate cyclase activity.

4. 发明专利

CA2562133A1 COMPOSITIONS AND METHODS FOR DETECTING CYCLIC ANALOGS OF HUMAN PARATHYROID HORMONE (HPTH) 未知
公开(公告)号：CA2562133A1
公开(公告)日：2005-09-29
申请号：CA2562133
申请日：2005-03-17
申请人： ZELOS THERAPEUTICS INC , CA NAT RESEARCH COUNCIL , GAO PING
发明人： WILLICK GORDON E , MORLEY PAUL , GAO PING
IPC分类号： C07K16/26 , C07K4/12 , C07K7/64 , G01N33/577 , G01N33/74 , G01N33/78
摘要： The present invention is directed to novel antigens, antibodies and antigen binding fragments thereof, and to immunoassays and kits using these antigens and antibodies. The compositions and methods are useful in the determination of levels of cyclic analogs of human parathyroid hormone (hPTH) in sample fluids, such as serum or plasma. The antibodies and methods of the invention have the particular advantage of possessing binding specificity for cyclic analogs of human parathyroid hormone (hPTH).

5. 发明申请

WO2011139838A3 INTRANASAL FORMULATIONS 审中-公开
标题翻译： INTRANASAL公式
公开(公告)号：WO2011139838A3
公开(公告)日：2012-04-05
申请号：PCT/US2011034335
申请日：2011-04-28
申请人： ZELOS THERAPEUTICS INC , MACDONALD BRIAN , MERUTKA GENE SCOTT
发明人： MACDONALD BRIAN , MERUTKA GENE SCOTT
IPC分类号： A61K9/08 , A61K9/12 , A61K38/16 , A61K38/22 , A61P19/00 , A61P19/10
CPC分类号： A61K9/0043 , A61K9/19 , A61K38/29 , A61K47/183 , A61K47/26
摘要： The present disclosure relates to compositions and methods for treating bone deficit disorders in a subject in need thereof comprising intranasally administering a pharmaceutically effective amount of a PTH-related peptidic analogue and a transmucosal absorption enhancer.
摘要翻译：本公开涉及用于治疗有需要的受试者的骨缺损障碍的组合物和方法，其包括鼻内施用药学有效量的PTH相关肽类似物和经粘膜吸收增强剂。

6. 发明申请

WO2008016404A3 PARATHYROID HORMONE ANALOGUES AND USES THEREOF 审中-公开
标题翻译： PARATHYROID HORMONE ANALOGUES及其用途
公开(公告)号：WO2008016404A3
公开(公告)日：2009-01-15
申请号：PCT/US2007010720
申请日：2007-05-02
申请人： ZELOS THERAPEUTICS INC , MORLEY PAUL , STOGNIEW MARTIN , MACDONALD BRIAN , MERUTKA GENE SCOTT , PALEPU NAGESH R
发明人： MORLEY PAUL , STOGNIEW MARTIN , MACDONALD BRIAN , MERUTKA GENE SCOTT , PALEPU NAGESH R
IPC分类号： A61K38/29 , A61K9/08 , A61K38/12 , A61P19/08
CPC分类号： A61K9/0075 , A61K9/0019 , A61K9/19 , A61K38/29 , A61K47/10 , A61K47/14 , A61K47/18
摘要： The present invention is directed to novel methods of treating a subject with a bone deficit disorder. The methods generally include administering to a subject in need thereof a pharmaceutically acceptable formulation comprising a parathyroid hormone (PTH) peptide analogue in a daily dose sufficient to result in an effective pharmacokinetic profile and maintained adenylate cyclase activity, while simultaneously reducing undesirable side effects.
摘要翻译：本发明涉及用骨缺损障碍治疗受试者的新方法。所述方法通常包括向有需要的受试者施用包含甲状旁腺激素（PTH）肽类似物的药学上可接受的制剂，其日剂量足以导致有效的药代动力学特征并维持腺苷酸环化酶活性，同时减少不期望的副作用。

7. 发明申请

WO2008016404A2 PARATHYROID HORMONE ANALOGUES AND METHODS OF USE 审中-公开
公开(公告)号：WO2008016404A2
公开(公告)日：2008-02-07
申请号：PCT/US2007/010720
申请日：2007-05-02
申请人： ZELOS THERAPEUTICS, INC. , MORLEY, Paul , STOGNIEW, Martin , MACDONALD, Brian , MERUTKA, Gene, Scott , PALEPU, Nagesh, R.
发明人： MORLEY, Paul , STOGNIEW, Martin , MACDONALD, Brian , MERUTKA, Gene, Scott , PALEPU, Nagesh, R.
IPC分类号： A61K38/29 , A61K38/12 , A61K9/08 , A61P19/08
CPC分类号： A61K9/0075 , A61K9/0019 , A61K9/19 , A61K38/29 , A61K47/10 , A61K47/14 , A61K47/18
摘要： The present invention is directed to novel methods of treating a subject with a bone deficit disorder. The methods generally include administering to a subject in need thereof a pharmaceutically acceptable formulation comprising a parathyroid hormone (PTH) peptide analogue in a daily dose sufficient to result in an effective pharmacokinetic profile and maintained adenylate cyclase activity, while simultaneously reducing undesirable side effects.
摘要翻译：本发明涉及用骨缺损障碍治疗受试者的新方法。所述方法通常包括向有需要的受试者施用包含甲状旁腺激素（PTH）肽类似物的药学上可接受的制剂，其日剂量足以产生有效的药代动力学特征并维持腺苷酸环化酶活性，同时减少不期望的副作用。

8. 发明申请

WO2007130113A2 PARATHYROID HORMONE ANALOGUES AND METHODS OF USE 审中-公开
公开(公告)号：WO2007130113A2
公开(公告)日：2007-11-15
申请号：PCT/US2006/034546
申请日：2006-09-06
申请人： ZELOS THERAPEUTICS, INC. , MORLEY, Paul
发明人： MORLEY, Paul
IPC分类号： A61K38/29 , A61K31/59 , A61K33/06
CPC分类号： A61K31/59 , A61K33/06 , A61K38/29 , A61K2300/00
摘要： The present invention is directed to novel methods of treating a subject with a bone deficit disorder. The methods generally include administering to a subject in need thereof a pharmaceutically acceptable formulation comprising a parathyroid hormone (PTH) peptide analogue in a daily dose of 2 μg to 60 μg, wherein said PTH peptide analogue has a reduced phospholipase-C activity and maintains adenylate cyclase activity.
摘要翻译：本发明涉及用骨缺损障碍治疗受试者的新方法。所述方法通常包括向有需要的受试者施用包含甲状旁腺激素（PTH）肽类似物的药学上可接受的制剂，其剂量为2μg至60μg，其中所述PTH肽类似物具有降低的磷脂酶C活性并维持腺苷酸环化酶活性。

9. 发明申请

WO2010151707A1 STABILIZING ALKYLGLYCOSIDE COMPOSITIONS AND METHODS THEREOF 审中-公开
标题翻译：稳定烷基硅氧烷组合物及其方法
公开(公告)号：WO2010151707A1
公开(公告)日：2010-12-29
申请号：PCT/US2010/039874
申请日：2010-06-24
申请人： AEGIS THERAPEUTICS, LLC , ZELOS THERAPEUTICS, INC , MAGGIO, Edward, T. , MERUTKA, Gene
发明人： MAGGIO, Edward, T. , MERUTKA, Gene
IPC分类号： A61K38/12
CPC分类号： A61K38/29 , A61K9/0043 , A61K9/127 , A61K9/19 , A61K31/70 , A61K38/162 , A61K38/1816 , A61K38/21 , A61K38/27 , A61K38/28 , A61K38/31 , A61K47/26
摘要： The present invention relates to alkylglycoside-containing compositions and methods for preventing loss of a parathyroid hormone (PTH) analog or octreotide via denaturation due to adherence upon contact with glass.
摘要翻译：本发明涉及含有烷基糖苷的组合物和通过与玻璃接触时粘附而变性而防止甲状旁腺激素（PTH）类似物或奥曲肽失去的方法。

10. 发明申请

WO2007133580A3 USE OF PTH (1-31) AND OPTIONALLY G-CSF FOR HEMATOPOIETIC STIMULATION 审中-公开
标题翻译：使用PTH（1-31）和选择性G-CSF用于HEMATOPOIETIC刺激
公开(公告)号：WO2007133580A3
公开(公告)日：2008-12-24
申请号：PCT/US2007011176
申请日：2007-05-07
申请人： ZELOS THERAPEUTICS INC , MORLEY PAUL
发明人： MORLEY PAUL
IPC分类号： A61K38/29 , A61K38/19 , A61P43/00
CPC分类号： A61K38/29 , A61K38/1816 , A61K38/193 , A61K38/196 , A61K38/20 , A61K38/204 , A61K2300/00
摘要： The present invention is directed to new methods for treating a subject in need of hematopoietic stimulation. The present invention is also directed to new methods of neutrophil stimulation in a subject in need thereof. The present invention is also directed to new methods of platelet stimulation in a subject in need thereof. The methods comprise administering to the subject an effective amount of a peptide optionally in combination of a hematopoietic growth factor, wherein the peptide is: (i) Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser- Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Xaa-Leu-Gln-Asp-Val-NH2 (SEQ ED NO: 1), where Xaa = Lys, Leu, He, NIe or Met, preferably Xaa = Lys; or (ii) Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser- Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Xaa-Leu-Gln-Asp-Val-Y (SEQ ID NO: 2), cyclized in the form of a lactam between GIu22 and Lys26, Xaa = Leu, He, NIe or Met, Y = NH2 Or OH. Preferably, Xaa is Leu and Y is NH2.
摘要翻译：本发明涉及用于治疗需要造血刺激的受试者的新方法。本发明还涉及有需要的受试者中嗜中性粒细胞刺激的新方法。本发明还涉及有需要的受试者中血小板刺激的新方法。所述方法包括向受试者施用有效量的任选地与造血生长因子组合的肽，其中所述肽是：（i）Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn- Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Xaa-Leu-Gln-Asp-Val-NH2（SEQ ID NO：1）其中Xaa = Lys，Leu，He，NIe或Met，优选Xaa = Lys; 或（ii）Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp- Leu-Arg-Lys-Xaa-Leu-Gln-Asp-Val-Y（SEQ ID NO：2），在Glu22和Lys26之间以内酰胺的形式环化，Xaa = Leu，He，NIe或Met，Y = NH 2 或OH。优选地，Xaa是Leu，Y是NH 2。

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