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1. 发明申请

WO2019108685A1 TUBULYSIN ANALOGUES AS ANTICANCER AGENTS AND PAYLOADS FOR ANTIBODY-DRUG CONJUGATES AND METHODS OF TREATMENT THEREWITH 审中-公开
公开(公告)号：WO2019108685A1
公开(公告)日：2019-06-06
申请号：PCT/US2018/062896
申请日：2018-11-28
申请人： WILLIAM MARCH RICE UNIVERSITY
发明人： NICOLAOU, Kyriacos, C. , ERANDE, Rohan, Diliprao , VOURLOUMIS, Dionisios , PULUKURI, Kiran, Kumar , RIGOL, Stephan
IPC分类号： A61K38/06 , C07C229/14
摘要： In one aspect, the present disclosure provides tubulysin analogs of the formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided.

2. 发明申请

WO2016007258A9 OMEGA-AMINATED CARBOXYLIC ACIDS 审中-公开
标题翻译： OMEGA-AMINATED CARBOXYLIC酸
公开(公告)号：WO2016007258A9
公开(公告)日：2016-01-14
申请号：PCT/US2015/035664
申请日：2015-06-12
申请人： WILLIAM MARCH RICE UNIVERSITY
发明人： GONZALEZ, Ramon , CLOMBURG, James, M.
IPC分类号： A01N63/00 , C12N15/00
摘要： Omega functionalized chemicals are made using a reverse beta oxidation cycle either by beginning with particular primers or by omega functionalization of β-oxidation intermediate(s)/product(s). Bacteria and methods for same are provided.
摘要翻译：使用反向β氧化循环或者通过从特定引物开始或者通过β-氧化中间体/产物的ω官能化来制备Ω官能化化学品。提供了相同的细菌和方法。

3. 发明申请

WO2016122741A2 A NEW CLASS OF ELECTROCATALYSTS 审中-公开
标题翻译：一类新的电化学
公开(公告)号：WO2016122741A2
公开(公告)日：2016-08-04
申请号：PCT/US2015/060094
申请日：2015-11-11
申请人： WILLIAM MARCH RICE UNIVERSITY
发明人： TOUR, James, M. , FEI, Huilong
IPC分类号： C25B1/04 , B01J23/40
CPC分类号： C25B11/0478 , C25B1/04 , H01M4/8825 , H01M4/8878 , H01M4/9016 , H01M4/9041 , H01M4/9075 , H01M4/9083 , H01M4/92 , H01M4/921 , H01M4/925 , Y02E60/366
摘要： Embodiments of the present disclosure pertain to electrocatalysts that include a surface and a plurality of catalytically active sites associated with the surface. The catalytically active sites include individually dispersed metallic atoms that are associated with heteroatoms. In some embodiments, the surface includes graphene oxide, the heteroatoms include nitrogen, and the metallic atoms include cobalt. Additional embodiments of the present disclosure pertain to methods of mediating an electrocatalytic reaction by exposing a precursor material to an electrocatalyst of the present disclosure. In some embodiments, the electrocatalytic reaction is a hydrogen evolution reaction that results in the formation of molecular hydrogen from the precursor material. Further embodiments of the present disclosure pertain to methods of making the electrocatalysts of the present disclosure by associating a surface with heteroatoms and metallic atoms.
摘要翻译：本公开的实施方案涉及包括与表面相关联的表面和多个催化活性位点的电催化剂。催化活性位点包括与杂原子相关的单独分散的金属原子。在一些实施方案中，表面包括氧化石墨烯，杂原子包括氮，并且金属原子包括钴。本公开的另外的实施方案涉及通过将前体材料暴露于本公开的电催化剂来介导电催化反应的方法。在一些实施方案中，电催化反应是析氢反应，其导致从前体材料形成分子氢。本公开的另外的实施方案涉及通过将表面与杂原子和金属原子缔合来制备本发明的电催化剂的方法。

4. 发明申请

WO2016007258A1 OMEGA-AMINATED CARBOXYLIC ACIDS 审中-公开
公开(公告)号：WO2016007258A1
公开(公告)日：2016-01-14
申请号：PCT/US2015/035664
申请日：2015-06-12
申请人： WILLIAM MARCH RICE UNIVERSITY
发明人： GONZALEZ, Ramon , CLOMBURG, James, M.
IPC分类号： A01N63/00 , C12N15/00
CPC分类号： C12N15/52 , C12P7/42 , C12P7/6409
摘要： Omega functionalized chemicals are made using a reverse beta oxidation cycle either by beginning with particular primers or by omega functionalization of β-oxidation intermediate(s)/product(s). Bacteria and methods for same are provided.

5. 发明申请

US20120034162A1 Fullerene Assisted Cell Penetrating Peptides 审中-公开
标题翻译：富勒烯辅助细胞穿透肽
公开(公告)号：US20120034162A1
公开(公告)日：2012-02-09
申请号：US12294991
申请日：2007-03-30
申请人： Andrew R. Barron , Jianzhong Yang , Jianhua Yang , Kuan Wang , Jonathan Driver
发明人： Andrew R. Barron , Jianzhong Yang , Jianhua Yang , Kuan Wang , Jonathan Driver
IPC分类号： A61K51/08 , C07K19/00 , C12N5/071 , A61K38/02 , A61K38/14 , A61K9/127 , C07K2/00 , C07K1/107 , B82Y5/00
CPC分类号： C07K7/08 , A61K47/645 , A61K47/6949 , B82Y5/00 , C07K1/1077 , C07K7/06
摘要： A composition and method is described for intracellular delivery of fullerene containing peptides. The composition and method involve fullerene-substituted phenylalanine as part of a peptide based delivery system. The presence of a fullerene-substituted amino acid in a peptide is found to alter the intracellular transport properties of the peptide.
摘要翻译：描述了用于含富勒烯的肽的细胞内递送的组合物和方法。组合物和方法涉及富勒烯取代的苯丙氨酸作为基于肽的递送系统的一部分。发现肽中富勒烯取代的氨基酸的存在会改变肽的细胞内转运性质。

6. 发明授权

US09312540B2 Conformal coating on nanostructured electrode materials for three-dimensional applications 有权
标题翻译：用于三维应用的纳米结构电极材料上的保形涂层
公开(公告)号：US09312540B2
公开(公告)日：2016-04-12
申请号：US13514438
申请日：2010-12-10
申请人： Pulickel M. Ajayan , Fung Suong Ou , Manikoth M. Shajiumon , Sanketh R. Gowda , Arava L. M. Reddy
发明人： Pulickel M. Ajayan , Fung Suong Ou , Manikoth M. Shajiumon , Sanketh R. Gowda , Arava L. M. Reddy
IPC分类号： H01M4/485 , H01M4/04 , H01M4/131 , H01M4/134 , H01M4/1391 , H01M4/1395 , H01M4/38 , H01M4/525 , H01M4/66 , H01M4/70 , H01M4/80 , H01M10/04 , H01M10/052 , H01M10/0565 , H01M10/058
CPC分类号： H01M4/485 , H01M4/0438 , H01M4/131 , H01M4/134 , H01M4/1391 , H01M4/1395 , H01M4/38 , H01M4/387 , H01M4/525 , H01M4/664 , H01M4/70 , H01M4/80 , H01M10/0436 , H01M10/0472 , H01M10/052 , H01M10/0565 , H01M10/058 , Y02E60/122
摘要： A fabrication process for conformal coating of a thin polymer electrolyte layer on nanostructured electrode materials for three-dimensional micro/nanobattery applications, compositions thereof, and devices incorporating such compositions. In embodiments, conformal coatings (such as uniform thickness of around 20-30 nanometer) of polymer Polymethylmethacralate (PMMA) electrolyte layers around individual Ni—Sn nanowires were used as anodes for Li ion battery. This configuration showed high discharge capacity and excellent capacity retention even at high rates over extended cycling, allowing for scalable increase in areal capacity with electrode thickness. Such conformal nanoscale anode-electrolyte architectures were shown to be efficient Li-ion battery system.
摘要翻译：用于三维微/纳米电池应用的纳米结构电极材料上的薄聚合物电解质层的共形涂覆的制造方法，其组合物和结合了这种组合物的装置。在实施方案中，使用围绕各个Ni-Sn纳米线的聚合物聚甲基丙烯酸甲酯（PMMA）电解质层的共形涂层（例如约20-30纳米的均匀厚度）用作锂离子电池的阳极。该配置显示出高放电容量和优异的容量保持率，即使在延长循环的高速率下，允许可扩展地增加电极厚度的面积容量。这种共形纳米级阳极 - 电解质结构被证明是有效的锂离子电池系统。

7. 发明申请

US20120178181A1 DEVICE AND METHOD FOR LABEL-FREE DETECTION OF DNA HYBRIDIZATION 审中-公开
标题翻译：用于无DNA检测DNA杂交的装置和方法
公开(公告)号：US20120178181A1
公开(公告)日：2012-07-12
申请号：US12857094
申请日：2010-08-16
申请人： Aoune Barhoumi , Dongmao Zhang , Nancy J. Halas
发明人： Aoune Barhoumi , Dongmao Zhang , Nancy J. Halas
IPC分类号： G01N21/65 , C07H21/04 , B82Y15/00 , B82Y40/00
CPC分类号： B82Y15/00 , C12Q1/6825 , C12Q2523/313 , C12Q2545/114
摘要： A device and method for detecting the hybridization of an unmodified target deoxyribonucleic acid (DNA) molecule including exposing a Raman substrate to the unmodified target DNA molecule, where the unmodified target DNA molecule is a complementary DNA molecule to a thiol-terminated probe DNA molecule covalently linked to the Raman substrate. Also, the thiol-terminated probe DNA molecule includes an adenine analog substituted for adenine. The hybridization of the unmodified target DNA molecule to the thiol-terminated probe DNA molecule is detected by measuring a Raman spectroscopic response of the Raman substrate.
摘要翻译：用于检测未修饰的靶脱氧核糖核酸（DNA）分子的杂交的装置和方法，包括将未修饰的靶DNA分子暴露于未修饰的靶DNA分子，其中未修饰的靶DNA分子是与硫醇封端的探针DNA分子共价的互补DNA分子连接到拉曼基板。此外，硫醇封端的探针DNA分子包括取代腺嘌呤的腺嘌呤类似物。通过测量拉曼光谱的拉曼光谱响应来检测未修饰的靶DNA分子与硫醇封端的探针DNA分子的杂交。

8. 发明申请

US20110110843A1 NEAT CARBON NANOTUBE ARTICLES PROCESSED FROM SUPER ACID SOLUTIONS AND METHODS FOR PRODUCTION THEREOF 审中-公开
标题翻译：从超酸溶液中处理的碳纳米管制品及其生产方法
公开(公告)号：US20110110843A1
公开(公告)日：2011-05-12
申请号：US12740529
申请日：2008-10-29
申请人： Matteo Pasquali , Wen-Fang Hwang , Howard K. Schmidt , Natneal Behabtu , Virginia Davis , A. Nicholas G. Parra-Vasquez , Micah J. Green , Richard Booker , Colin c. Young , Hua Fan
发明人： Matteo Pasquali , Wen-Fang Hwang , Howard K. Schmidt , Natneal Behabtu , Virginia Davis , A. Nicholas G. Parra-Vasquez , Micah J. Green , Richard Booker , Colin c. Young , Hua Fan
IPC分类号： D01F9/12 , C01B31/02 , B29C47/00 , B82Y30/00 , B82Y40/00
CPC分类号： D01F11/12 , B29C48/0018 , B29C48/05 , B29C48/11 , B29C48/475 , B29C48/919 , B29K2105/162 , B29K2105/167 , B82Y30/00 , B82Y40/00 , C01B32/168 , C01B32/174 , C01B2202/02 , C01B2202/04 , C01B2202/06 , C01B2202/28 , C01B2202/34 , D01D5/06 , D01F9/12
摘要： Articles comprising neat, aligned carbon nanotubes and methods for production thereof are disclosed. The articles and methods comprise extrusion of a super acid solution of carbon nanotubes followed by removal of the super acid solvent. The articles may be processed by wet-jet wet spinning, dry-jet wet spinning, and coagulant co-flow extrusion techniques.
摘要翻译：公开了包含整齐排列的碳纳米管的制品及其生产方法。制品和方法包括挤出碳纳米管的超酸溶液，然后除去超酸溶剂。制品可以通过湿喷湿纺，干喷湿法纺丝和凝结剂共流挤出技术加工。

9. 发明授权

US09718045B2 Composites for carbon dioxide capture 有权
公开(公告)号：US09718045B2
公开(公告)日：2017-08-01
申请号：US14371791
申请日：2013-01-11
申请人： WILLIAM MARSH RICE UNIVERSITY
发明人： James M. Tour , Chih-Chau Hwang
IPC分类号： B01D53/62 , B01J20/32 , B01D53/02 , B01J20/06 , B01J20/20 , B01J20/28 , B01J20/34 , C10L3/10
CPC分类号： B01J20/3293 , B01D53/02 , B01D53/62 , B01D2251/00 , B01D2253/102 , B01D2253/1124 , B01D2253/25 , B01D2257/504 , B01D2258/0283 , B01J20/06 , B01J20/20 , B01J20/28066 , B01J20/28078 , B01J20/2808 , B01J20/28083 , B01J20/28085 , B01J20/3204 , B01J20/3236 , B01J20/3248 , B01J20/3433 , B01J20/3491 , C10L3/104 , C10L2290/541 , Y02A50/2342 , Y02C10/04 , Y02C10/06 , Y02C10/08 , Y02C20/20
摘要： Composite materials and methods of preparing C02 capture include: (1) a porous solid support comprising a plurality of porous channels; and (2) a nucleophilic source associated with the porous channels of the porous solid support. The nucleophilic source is capable of converting the captured C02 to poly(C02). Methods of capturing C02 from an environment include associating the environment with the aforementioned composite materials to lead to the capture of C02 from the environment. Such methods may also include a step of releasing the captured C02 from the composite material. The associating step comprises a conversion of the captured C02 to poly(C02) in the composite material. A releasing step may also include a depolymerization of the formed poly(C02).

10. 发明申请

US20030163593A1 Method and system for implementing a fair, high-performance protocol for resilient packet ring networks 审中-公开
标题翻译：用于实现弹性分组环网络的公平，高性能协议的方法和系统
公开(公告)号：US20030163593A1
公开(公告)日：2003-08-28
申请号：US10374232
申请日：2003-02-25
申请人： William March Rice University
发明人： Edward Knightly
IPC分类号： G06F015/16
CPC分类号： H04L47/10 , H04L12/42 , H04L47/762 , H04L47/822 , H04Q11/0066 , H04Q2011/0081 , H04Q2011/0092
摘要： A system and method for dynamic bandwidth allocation is provided. The method provides one or more nodes to compute a simple lower bound of temporally and spatially aggregated virtual time using per-ingress counters of packet (byte) arrivals. Thus, when information is propagated along the ring, each node can remotely approximate the ideal fair rate for its own traffic at each downstream link. In this way, flows on the ring rapidly converge to their ring-wide fair rates while maximizing spatial reuse.
摘要翻译：提供了一种用于动态带宽分配的系统和方法。该方法提供一个或多个节点，使用分组（字节）到达的每个入口计数器来计算时间和空间聚集的虚拟时间的简单下限。因此，当沿着环传播信息时，每个节点可以在每个下游链路处远程地近似自身流量的理想公平率。以这种方式，环上的流动迅速地收敛到其环形公平的速率，同时最大化空间重用。

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