专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1997031128A1 APPARATUS AND METHODS FOR CULTURING MAMMALIAN CELLS 审中-公开
标题翻译：用于培养MAMMALIAN细胞的装置和方法
公开(公告)号：WO1997031128A1
公开(公告)日：1997-08-28
申请号：PCT/US1997002704
申请日：1997-02-21
申请人： VIVORX PHARMACEUTICALS, INC. , SPAULDING, Glenn, F.
发明人： VIVORX PHARMACEUTICALS, INC.
IPC分类号： C12Q03/00
CPC分类号： C12M41/26 , C12M23/08 , C12M41/48 , C12Q3/00
摘要： In accordance with the present invention, there are provided a cell culture apparatus (10) and methods for the replenishment of cell culture media in a cell culture container (12) without disturbing the cell culture media therein. The cell culture apparatus (10) is made up of a cell culture container (12) shaped to hold cell culture media; a tube (14) comprising a first portion (16) and a second portion (18), wherein said first portion (16) is within said cell culture container (12), and said second portion (18) is outside said cell culture container (12); a pH sensor (20) capable of operative communication with the cell culture media in which the cell culture is growing; a pump (22), wherein said pump (22) is in operative communication with said second portion (18) of said tube (14); a source (24) of fresh culture media in fluid communication with said second portion (18) of said tube (14); a receptacle (26) for waste cell culture media in fluid communication with said second portion (18) of said tube (14); and a control device (28), wherein said control device (28) is in operative communication with said pump (22) and said pH sensor (20), said control device (28) controlling said pump (22) in response to said pH sensor (20).
摘要翻译：根据本发明，提供了一种细胞培养装置（10）以及在细胞培养容器（12）中补充细胞培养基而不干扰细胞培养基的方法。细胞培养装置（10）由容纳细胞培养基的细胞培养容器（12）构成，包括第一部分（16）和第二部分（18）的管（14），其中所述第一部分（16）在所述细胞培养容器（12）内，所述第二部分（18）在所述细胞培养容器（12）; 能够与细胞培养物生长的细胞培养基进行操作性连通的pH传感器（20）; 泵（22），其中所述泵（22）与所述管（14）的所述第二部分（18）操作连通; 与所述管（14）的所述第二部分（18）流体连通的新鲜培养基源（24）; 用于与所述管（14）的所述第二部分（18）流体连通的废细胞培养基的容器（26）; 和控制装置（28），其中所述控制装置（28）与所述泵（22）和所述pH传感器（20）操作连通，所述控制装置（28）响应于所述pH控制所述泵（22）传感器（20）。

2. 发明申请

WO1996014838A1 NOVEL DIACETYLDAPSONE-CONTAINING COMPOSITIONS AND THE USE THEREOF FOR THE TREATMENT OF VARIOUS DISEASE STATES 审中-公开
标题翻译：新颖的含二氢DA PS PS ING ING ING ING ING ING S S S S S S S S S S S S S S S S S
公开(公告)号：WO1996014838A1
公开(公告)日：1996-05-23
申请号：PCT/US1995013343
申请日：1995-10-17
申请人： VIVORX PHARMACEUTICALS, INC.
发明人： VIVORX PHARMACEUTICALS, INC. , SMITH, Timothy, J.
IPC分类号： A61K31/16
CPC分类号： B82Y5/00 , A61K31/167 , A61K31/505 , A61K47/6951 , Y02A50/411 , A61K2300/00
摘要： Diacetyldapsone has been demonstrated to be effective against Pneumocystis carinii in a mouse model. The solubility of this highly insoluble drug can be greatly enhanced by formulation in a molecular inclusion complex with a cyclodextrin (such as, for example, hydroxypropyl-beta-cyclodextrin). The formulation of diacetyldapsone in cyclodextrin enhances the stability thereof, presumably by protecting the drug against hydrolysis of the amide substituents thereof. Oral administration of the resulting formulation results in the absorption of diacetyldapsone and systemic conversion thereof to monoacetyldapsone and dapsone. These results illustrate the utility of a cyclodextrin formulation of diacetyldapsone as a chemoprophylactic adjunct in the management of disease states such as Pneumocystis pneumonia in acquired immune deficiency syndrome (AIDS).
摘要翻译：已经证明二乙酰基蝶呤在小鼠模型中对卡氏肺囊虫有效。通过在与环糊精（例如羟丙基-β-环糊精）的分子包合配合物中配制，可以大大提高该高度不溶性药物的溶解度。环糊精中二乙酰基二苯酮的配方增强了其稳定性，大概是通过保护药物免受其酰胺取代基的水解。所得制剂的口服给药导致二乙酰基二苯酮的吸收和其全身转化为单乙酰基二氢脑酮和氨苯砜。这些结果说明了二乙酰二苯醚的环糊精制剂作为化学预防辅助剂治疗疾病状态如获得性免疫缺陷综合征（AIDS）中的肺孢子虫肺炎的效用。

3. 发明申请

WO1997035958A1 STORAGE ARTICLES FOR PROLONGED VIABILITY AND FUNCTION OF LIVING CELLS 审中-公开
标题翻译：用于生活细胞的可变性和功能的存储文章
公开(公告)号：WO1997035958A1
公开(公告)日：1997-10-02
申请号：PCT/US1997001731
申请日：1997-01-30
申请人： VIVORX PHARMACEUTICALS, INC. , SOON-SHIONG, Patrick , DESAI, Neil, P. , MOLONEY, Molly , YAO, Qiang, X.
发明人： VIVORX PHARMACEUTICALS, INC.
IPC分类号： C12N05/06
CPC分类号： C12N5/0614 , A61K9/1652 , A61K2035/126 , C12N5/0677 , C12N2500/34
摘要： An article has been developed which unexpectedly prolongs the viability of living cells or cell aggregates and which maintains the biological function and viability of the stored cells for very long periods of time. Also provided is a novel method of storing and culturing cells which is especially useful for accumulating large numbers of cells for therapeutic purposes, including transplantation into human patients to alleviate disease processes. The invention method involves surrounding cells or cell aggregates with a suitable cell-protective layer, thereby providing articles of various sizes and shapes.
摘要翻译：已经开发了一种意外地延长活细胞或细胞聚集体的活力并且保持储存的细胞的生物学功能和存活力很长时间段的文章。还提供了一种储存和培养细胞的新方法，其特别可用于积累大量用于治疗目的的细胞，包括移植到人类患者中以减轻疾病过程。本发明方法涉及用合适的细胞保护层围绕细胞或细胞聚集体，从而提供各种尺寸和形状的制品。

4. 发明申请

WO1997031100A1 METHOD FOR GROWING PLANT CELLS IN LIQUID SUSPENSION CULTURES, AND CHEMOTHERAPEUTIC AGENTS DERIVED FROM PLANTS 审中-公开
标题翻译：在液体悬浮培养物中生长植物细胞的方法和从植物衍生的化学药剂
公开(公告)号：WO1997031100A1
公开(公告)日：1997-08-28
申请号：PCT/US1997002935
申请日：1997-02-20
申请人： VIVORX PHARMACEUTICALS, INC. , SOON-SHIONG, Patrick
发明人： VIVORX PHARMACEUTICALS, INC.
IPC分类号： C12N05/00
CPC分类号： C12N5/04 , C12P17/02
摘要： A microgravity liquid-suspension culture method has been developed for growing aggregates of plant cells which produce naturally occurring chemical products for use as therapeutic agents, including chemotherapy for cancer and other diseases. The invention method involves the use of a complex cell-culture medium containing necessary nutrients and growth factors, a microgravity culture vessel for promoting three-dimensional growth, and a set of growth-promoting plant growth factors.
摘要翻译：已经开发了微重力液体悬浮培养方法，用于生长用作治疗剂的天然存在的化学产品的植物细胞的聚集体，包括用于癌症和其它疾病的化学疗法。本发明方法涉及使用含有必需营养素和生长因子的复合细胞培养基，用于促进三维生长的微重力培养容器和一组生长促进植物生长因子。

5. 发明申请

WO1997037708A1 DRY POWDER INHALER 审中-公开
标题翻译：干粉吸入器
公开(公告)号：WO1997037708A1
公开(公告)日：1997-10-16
申请号：PCT/US1997004278
申请日：1997-03-19
申请人： VIVORX PHARMACEUTICALS, INC. , VAGHEFI, Farid
发明人： VIVORX PHARMACEUTICALS, INC.
IPC分类号： A61M15/00
CPC分类号： A61M15/0086 , A61M11/02 , A61M15/0031 , A61M15/0036 , A61M15/0045 , A61M15/0048 , A61M15/02 , A61M2202/064 , A61M2205/8225
摘要： A dry powder inhaler (10) includes a housing (50), a dosing cartridge (12), and a spacer (42). Within the housing are a source of pressurized gas (34), a pressure gauge, a metered valve (26) controlled by a trigger (36), a safety valve, and an electrostatic charger (40) also controlled by the trigger. The dosing cartridge contains individual doses in airtight cells (14) with one or more openings (16, 18), each covered by an airtight cover sheet. The system uses gas pressure or a penetration device to rupture one of the airtight cells, suspending the powder and directing it to a spacer for subsequent inhalation. The electrostatic charger discharges on the spacer, establishing an electrostatic charge thereon. The spacer includes a non-stick lining. The housing is designed so that it can retract into the spacer.
摘要翻译：干粉吸入器（10）包括壳体（50），计量筒（12）和间隔件（42）。在壳体内是由触发器（36）控制的加压气体源（34），压力表，计量阀（26），安全阀以及也由触发器控制的静电充电器（40）。所述计量筒包含具有一个或多个开口（16,18）的气密单元（14）中的各个剂量，每个开口由气密覆盖片覆盖。该系统使用气体压力或穿透装置来破坏其中一个气密细胞，悬浮粉末并将其引导到间隔物以用于随后的吸入。静电充电器在间隔件上放电，在其上形成静电电荷。间隔件包括不粘衬里。外壳被设计成可以缩回到间隔件中。

6. 发明申请

WO1997008523A1 METHOD AND APPARATUS FOR DETERMINING CHARACTERISTICS OF A SAMPLE IN THE PRESENCE OF AMBIENT LIGHT 审中-公开
标题翻译：用于确定环境光下样品特性的方法和装置
公开(公告)号：WO1997008523A1
公开(公告)日：1997-03-06
申请号：PCT/US1996013523
申请日：1996-08-22
申请人： VIVORX PHARMACEUTICALS, INC. , SPAULDING, Glenn, F.
发明人： VIVORX PHARMACEUTICALS, INC.
IPC分类号： G01J03/50
CPC分类号： G01J1/4204 , G01J1/44 , G01J3/10 , G01J3/42 , G01J3/4406 , G01J3/50 , G01J3/501 , G01J3/524 , G01J2001/4242 , G01N2201/1244
摘要： A device (20) determines an optical intensity of light emanating from a sample (22) situated under periodically varying ambient light (34). The device (20) includes a selectively illuminating light source (26a, 26b) that can be switched between on and off states that illuminates the sample (22). A detector (36) detects the optical intensities of the sample (22) a first plurality of times with the effects of the illuminating light source (26a, 26b) to produce a plurality of collective light intensity measurements, and a second plurality of times without the effects of the light source (26a, 26b) to produce a plurality of ambient light intensity measurements. A processor quantitatively determines, based upon the multiple collective intensity measurements and the multiple ambient light intensity measurements, the intensity amount of each of the collective light intensity measurements that results from the illuminating source (26a, 26b).
摘要翻译：装置（20）确定从位于周期性变化的环境光（34）周围的样品（22）发出的光的光强度。设备（20）包括可以在照亮样品（22）的开和关状态之间切换的选择性照明光源（26a，26b）。检测器（36）利用照明光源（26a，26b）的作用第一次多次检测样品（22）的光强度，以产生多个集体光强度测量值，并且第二次多次没有光源（26a，26b）的作用产生多个环境光强测量。处理器基于多个集体强度测量和多个环境光强度测量，定量地确定由照明源（26a，26b）产生的每个聚光强度测量的强度量。

7. 发明申请

WO1996040091A1 DUAL FUNCTIONAL CYTOTOXIC/RADIOSENSITIZER COMPOUNDS AND METHODS FOR THE PREPARATION THEREOF 审中-公开
标题翻译：双功能细胞毒素/放射性增敏剂化合物及其制备方法
公开(公告)号：WO1996040091A1
公开(公告)日：1996-12-19
申请号：PCT/US1996007422
申请日：1996-05-21
申请人： VIVORX PHARMACEUTICALS, INC. , TAO, Chunlin , DESAI, Neil, P. , SOON-SHIONG, Patrick , SANDFORD, Paul, A.
发明人： VIVORX PHARMACEUTICALS, INC.
IPC分类号： A61K31/04
CPC分类号： C07D305/14 , A61K41/0038
摘要： In accordance with the present invention, there are provided derivatives of chemotherapeutic agents (e.g., paclitaxel), which serve as bifunctional agents. Invention derivatives retain the antitumor activity of the parent compound, and, coupled with the electron affinic substituents thereon, produce compounds which show a strong capability for radiosensitizing tumor cells growing in vitro. It is expected that a single drug which combines the properties of a radiosensitizer with chemotherapeutic activity will offer significant advantages not only to patients, but also to radiotherapists seeking improved modes of treatment. The combination of antitumor properties with electron-affinic function produces novel radiosensitizers, a second generation of drugs which are more powerful to fight cancers. Bifunctional agents with the dual properties of tubulin assembly and electron affinity will make the compounds useful not only as radiosensitizers, but also as cytotoxins.
摘要翻译：根据本发明，提供了用作双功能试剂的化学治疗剂（例如紫杉醇）的衍生物。本发明衍生物保留了母体化合物的抗肿瘤活性，并且与其上的电子亲和取代基一起产生显示出对体外生长的肿瘤细胞放射增敏的强大能力的化合物。预期将放射增敏剂的性质与化疗活性相结合的单一药物将不仅对患者具有显着的优点，而且还将提供寻求改善治疗方式的放射治疗师的显着优点。抗肿瘤性质与电子亲和功能的组合产生新型放射增敏剂，第二代更强大的抗癌药物。具有微管蛋白装配和电子亲和力的双重特性的双功能试剂将使得该化合物不仅用作放射增敏剂，而且用作细胞毒素。

8. 发明申请

WO1998014175A1 TOTAL NUTRIENT ADMIXTURES AS STABLE MULTICOMPONENT LIQUIDS OR DRY POWDERS AND METHODS FOR THE PREPARATION THEREOF 审中-公开
标题翻译：作为稳定的多组分液体或干粉的总营养物质及其制备方法
公开(公告)号：WO1998014175A1
公开(公告)日：1998-04-09
申请号：PCT/US1997017649
申请日：1997-09-29
申请人： VIVORX PHARMACEUTICALS, INC. , MAGDASSI, Shlomo , YANG, Andrew , TAO, Chunlin , DESAI, Neil, P. , YAO, Zhiwen , SOON-SHIONG, Patrick
发明人： VIVORX PHARMACEUTICALS, INC.
IPC分类号： A61K09/14
CPC分类号： A61K9/0029 , A23L33/40 , A61K9/0026 , A61K9/5052 , A61K9/5169 , B82Y5/00
摘要： In accordance with the present invention, there are provided stabilized total nutrient admixture (TNA) compositions which are useful for the in vivo parenteral delivery of pharmacologically acceptable lipids or fats, as well as methods for the preparation thereof. In particular, the pharmacologically acceptable lipid or fat is contained within a protein walled shell. In a particular embodiment of the invention, a TNA composition using human serum albumin (HSA) as a stabilizer has been prepared as a convenient three-in-one formulation (i.e., containing a fat emulsion, dextrose, and amino acids plus electrolytes). This "three-in-one" formulation can be prepared in liquid form or in dry form (comprising submicron-sized nanoparticles). The dried material is stable, even under long term storage, and is easily reconstituted immediately before use by simply adding sterile water (with or without vitamin supplementation). This serves to rehydrate the powder into a TNA suitable for injection. The long shelf life, ease of reconstitution, and single-component injectability of invention compositions provide significant cost savings, as such compositions can be reconstituted and administered safely, even in the home. In addition, HSA, the stabilizing agent of choice for use in the practice of the present invention, has been shown to improve survival and wellness when given as a supplement to patients receiving conventional forms of total nutrient admixtures.
摘要翻译：根据本发明，提供了可用于体内胃肠外递送药理学上可接受的脂质或脂肪的稳定的总营养混合物（TNA）组合物，以及其制备方法。特别地，药理学上可接受的脂质或脂肪包含在蛋白质壁壳内。在本发明的一个具体实施方案中，已经制备了使用人血清白蛋白（HSA）作为稳定剂的TNA组合物作为方便的三合一制剂（即含有脂肪乳剂，葡萄糖，氨基酸和电解质）。这种“三合一”制剂可以以液体形式或干燥形式（包括亚微米尺寸的纳米颗粒）制备。干燥的材料即使在长期储存下也是稳定的，并且在使用前立即通过简单地加入无水（有或没有补充维生素）容易地重建。这用于将粉末再水合成适合注射的TNA。本发明组合物的长保存期限，易于重构和单组分可注射性提供显着的成本节约，因为即使在家中也可以安全地重构和施用这些组合物。此外，HSA是用于本发明实践的选择的稳定剂已被证明可以提供存活和健康，当给予作为补充常规形式的总营养混合物的患者时。

9. 发明申请

WO1998014174A1 PROTEIN STABILIZED PHARMACOLOGICALLY ACTIVE AGENTS, METHODS FOR THE PREPARATION THEREOF AND METHODS FOR THE USE THEREOF 审中-公开
标题翻译：蛋白质稳定的药物活性剂，其制备方法及其使用方法
公开(公告)号：WO1998014174A1
公开(公告)日：1998-04-09
申请号：PCT/US1997017157
申请日：1997-09-24
申请人： VIVORX PHARMACEUTICALS, INC. , DESAI, Neil, P. , TAO, Chunlin , YANG, Andrew , LOUIE, Leslie , ZHENG, Tianli , YAO, Zhiwen , SOON-SHIONG, Patrick , MAGDASSI, Shlomo
发明人： VIVORX PHARMACEUTICALS, INC.
IPC分类号： A61K09/14
CPC分类号： A61K9/5169 , A23L33/40 , A61K9/0019 , A61K9/1075 , A61K9/19 , A61K9/5192 , B82Y5/00 , Y10S977/907 , Y10S977/915 , Y10S977/927
摘要： In accordance with the present invention, there are provided compositions and methods useful for the in vivo delivery of substantially water-insoluble pharmacologically active agents (such as the anticancer drug paclitaxel) in which the pharmacologically active agent is delivered in the form of suspended particles coated with protein (which acts as a stabilizing agent). In particular, protein and pharmacologically active agent in a biocompatible dispersing medium are subjected to high shear, in the absence of any conventional surfactants, and also in the absence of any polymeric core material for the particles. The procedure yields particles with a diameter of less than about 1 micron. The use of specific composition and preparation conditions (e.g., addition of a polar solvent to the organic phase), and careful selection of the proper organic phase and phase fraction, enables the reproducible production of unusually small nanoparticles of less than 200 nm diameter, which can be sterile-filtered. The particulate system produced according to the invention can be converted into a redispersible dry power comprising nanoparticles of water-insoluble drug coated with a protein, and free protein to which molecules of the pharmacological agent are bound. This results in a unique delivery system, in which part of the pharmacologically active agent is readily bioavailable (in the form of molecules bound to the protein), and part of the agent is present within particles without any polymeric matrix therein.
摘要翻译：根据本发明，提供了用于体内递送基本上不溶于水的药物活性剂（例如抗癌药物紫杉醇）的组合物和方法，其中药理活性剂以悬浮颗粒的形式递送蛋白质（其作为稳定剂）。特别地，生物相容性分散介质中的蛋白质和药理学活性剂在没有任何常规表面活性剂的情况下进行高剪切，并且在没有用于颗粒的任何聚合物芯材料的情况下进行。该方法产生直径小于约1微米的颗粒。使用特定的组合物和制备条件（例如，向有机相中加入极性溶剂）以及仔细选择合适的有机相和相分数使得能够可重复地生产直径小于200nm的异常小的纳米颗粒，其中可以无菌过滤。根据本发明生产的颗粒系统可以转化成可再分散的干燥功能，其包括用蛋白质包被的水不溶性药物的纳米颗粒，以及结合有药理学分子的游离蛋白质。这导致独特的递送系统，其中部分药理活性剂容易生物利用（以与蛋白质结合的分子的形式），并且部分药剂存在于颗粒内而没有其中的任何聚合物基质。

10. 发明申请

WO1997049796A1 METHODS AND APPARATUS FOR AUGMENTING MASS TRANSFER IN A ROTATING CELL CULTURE SYSTEM 审中-公开
标题翻译：在旋转细胞培养系统中促进大量转运的方法和装置
公开(公告)号：WO1997049796A1
公开(公告)日：1997-12-31
申请号：PCT/US1997011022
申请日：1997-06-25
申请人： VIVORX PHARMACEUTICALS, INC.
发明人： VIVORX PHARMACEUTICALS, INC. , SPAULDING, Glenn, F. , ZERKUS, Mike
IPC分类号： C12N05/00
CPC分类号： C12M27/10
摘要： A horizontally rotating cell culture system with enhanced oxygenation is described. The system achieves greater oxygenation through the use of a multiphase motor and non-linear acceleration/deceleration, to disrupt the establishment of boundary layers.
摘要翻译：描述了具有增强氧合作用的水平旋转的细胞培养系统。该系统通过使用多相电机和非线性加速/减速来实现更大的氧合，以破坏边界层的建立。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式