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1. 发明申请

WO9712545A3 APPARATUS AND METHOD FOR MEASURING AN INDUCED PERTURBATION TO DETERMINE A PHYSIOLOGICAL PARAMETER 审中-公开
标题翻译：用于测量诱导性刺激以确定生理参数的装置和方法
公开(公告)号：WO9712545A3
公开(公告)日：1997-05-09
申请号：PCT/US9615820
申请日：1996-10-02
申请人： VITAL INSITE INC
发明人： CARO RICHARD G , SHER MARK H , FLAHERTY BRYAN P
IPC分类号： A61B5/022
CPC分类号： A61B5/022 , A61B5/02133
摘要： A monitor for determining a patient's physiological parameter includes a calibration device (110) configured to provide a calibration signal representative of the patient's physiological parameter. An exciter (202) is positioned over a blood vessel (220) of the patient for inducing a transmitted exciter waveform into the patient. A noninvasive sensor (210) is positioned over the blood vessel (220), where the noninvasive sensor (210) is configured to sense a hemoparameter and to generate a noninvasive sensor signal representative of the hemoparameter containing a component of a physiological parameter waveform and a component of a received exciter waveform. In this context, a hemoparameter is defined as any physiological parameter related to vessel blood such as pressure, flow, volume, velocity, blood vessel wall motion, blood vessel wall position and other related parameters. A processor (100) is configured to determine a relationship between a property of the received exciter waveform and a property of the physiological parameter. The processor (100) is connected to receive the calibration signal and the noninvasive sensor signal, and the processor is configured to process the calibration signal and the noninvasive sensor signal to determine the physiological parameter. In the preferred embodiment, the physiological parameter measured is blood pressure, however, the present invention can also be used to analyze and track other physiological parameters such as vascular wall compliance, strength of ventricular contractions, vascular resistance, fluid volum, cardiac output, myocardial contractility and other related parameters.

2. 发明申请

WO1997014356A1 APPARATUS AND METHOD FOR MEASURING AN INDUCED PERTURBATION TO DETERMINE A PHYSICAL CONDITION OF THE HUMAN ARTERIAL SYSTEM 审中-公开
标题翻译：用于测量诱导性刺激以确定人造体系的物理条件的装置和方法
公开(公告)号：WO1997014356A1
公开(公告)日：1997-04-24
申请号：PCT/US1996015956
申请日：1996-10-03
申请人： VITAL INSITE, INC.
发明人： VITAL INSITE, INC. , CARO, Richard, G. , SHER, Mark, H. , FLAHERTY, Bryan, P.
IPC分类号： A61B05/022
CPC分类号： A61B5/02133 , A61B5/022 , A61B5/7239
摘要： A monitor (120) determining a patient's physical condition includes a calibration device (104) configured to provide a calibration signal representative of a patient's physiological parameter. An exciter (202) is positioned over a blood vessel of the patient for inducing a transmitted exciter waveform into the patient. A noninvasive sensor (210) is positioned over the blood vessel, where the noninvasive sensor is configured to sense a hemoparameter and to generate a noninvasive sensor signal representative of the hemoparameter containing a component of a physiological parameter waveform and a component of a received exciter waveform. In this context, a hemoparameter is defined as any physiological parameter related to vessel blood such as pressure, flow, volume, velocity, blood vessel wall motion, blood vessel wall position and other related parameters. A processor (100) is configured to determine a relationship between a property of the received exciter waveform and a property of the physiological parameter. The processor is connected to receive the calibration signal and the noninvasive sensor signal, and the processor is configured to process the calibration signal and the noninvasive sensor signal to determine the physical condition. In an exemplary embodiment, the physical condition is arterial stiffness that represents cardiovascular disease, however, many additional physical conditions can be measured and determined such as arterial elasticity, arterial thickness, arterial wall compliance and other conditions. Also, in an exemplary embodiment, the physiological parameter measured is blood pressure, however, the present invention can also be used to analyze and track other physiological parameters.
摘要翻译：确定患者身体状况的监视器（120）包括被配置为提供表示患者生理参数的校准信号的校准装置（104）。激励器（202）位于患者的血管上方，用于将传输的激励器波形诱导到患者体内。无创传感器（210）位于血管上方，其中无创传感器被配置为感测血液参数并且产生代表血液参数的无创传感器信号，该参数包含生理参数波形的分量和接收到的激励器波形的分量。在这种情况下，血液参数被定义为与血管血液相关的任何生理参数，例如压力，流量，体积，速度，血管壁运动，血管壁位置和其他相关参数。处理器（100）被配置为确定所接收的激励器波形的特性与生理参数的特性之间的关系。处理器被连接以接收校准信号和非侵入式传感器信号，并且处理器被配置为处理校准信号和非侵入式传感器信号以确定物理状况。在示例性实施例中，身体状况是代表心血管疾病的动脉硬度，然而，可以测量和确定许多额外的身体状况，例如动脉弹性，动脉厚度，动脉壁顺应性和其他状况。此外，在示例性实施例中，测量的生理参数是血压，然而，本发明也可以用于分析和跟踪其他生理参数。

3. 发明申请

WO1995028126A1 APPARATUS AND METHOD FOR MEASURING AN INDUCED PERTURBATION TO DETERMINE BLOOD PRESSURE 审中-公开
标题翻译：用于测量诱导性刺激以测定血压的装置和方法
公开(公告)号：WO1995028126A1
公开(公告)日：1995-10-26
申请号：PCT/US1995004124
申请日：1995-04-03
申请人： VITAL INSITE, INC.
发明人： VITAL INSITE, INC. , CARO, Richard, G. , SHER, Mark, H.
IPC分类号： A61B05/022
CPC分类号： A61B5/02108 , A61B5/02133 , A61B5/022
摘要： A monitor for continuously determining a patient's physiological parameter includes a means for obtaining a periodic calibration measurement of the patient's physiological parameter. An exciter, positioner over an artery of the patient induces an exciter waveform into the patient's arterial blood. A noninvasive sensor, positioned over the artery, senses a hemoparameter and provides a noninvasive sensor signal output representative of the hemoparameter. A processor receives the calibration measurement and noninvasive sensor signal output. The processor determines a DC offset based on the calibration measurement and processes the noninvasive sensor signal to continously determine the patient's physiological parameter. A method includes steps for performing the present invention. In the preferred embodiment, the physiological parameter measured is blood pressure, however, the present invention can also be used to analyze and track other physiological parameters such as vascular wall compliance, strength of ventricular contractions, vascular resistance, fluid volume, cardiac output, myocardial contractility and other related parameters.
摘要翻译：用于连续确定患者生理参数的监视器包括用于获得患者生理参数的周期性校准测量的装置。激励器，位于患者动脉上的定位器将激励器波形引导到患者的动脉血中。位于动脉上方的无创传感器感测血液参数，并提供代表血液参数的无创传感器信号输出。处理器接收校准测量和无创传感器信号输出。处理器基于校准测量确定DC偏移，并且处理无创传感器信号以连续地确定患者的生理参数。一种方法包括执行本发明的步骤。在优选实施例中，测量的生理参数是血压，然而，本发明也可用于分析和跟踪其他生理参数，例如血管壁顺应性，心室收缩强度，血管阻力，流体体积，心输出量，心肌收缩性等相关参数。

4. 发明申请

WO1997012543A1 APPARATUS AND METHOD FOR MEASURING AN INDUCED PERTURBATION TO DETERMINE A PHYSIOLOGICAL PARAMETER 审中-公开
标题翻译：用于测量诱导性刺激以确定生理参数的装置和方法
公开(公告)号：WO1997012543A1
公开(公告)日：1997-04-10
申请号：PCT/US1996015879
申请日：1996-10-02
申请人： VITAL INSITE, INC.
发明人： VITAL INSITE, INC. , CARO, Richard, G. , SHER, Mark, H.
IPC分类号： A61B05/00
CPC分类号： A61B5/02133 , A61B5/022
摘要： A monitor for determining a patient's physiological parameter includes a calibration device (110) to provide a calibration signal representative of the patient's physiological parameter. An exciter (202) is positioned over a blood vessel for inducing a transmitted exciter waveform into the patient. A noninvasive sensor (210) senses a hemoparameter and generates a sensor signal representative of the hemoparameter, containing a component of a received exciter waveform. A hemoparameter is any parameter related to blood such as pressure, flow, volume, velocity, blood vessel wall motion, blood vessel wall position, and related parameters. A processor (100) determines a relationship between a property of the received exciter waveform and a property of the physiological parameter. The processor (100) receives the calibration signal and the noninvasive sensor signal, and processes the calibration signal and the noninvasive sensor signal to determine the physiological parameter. In the preferred embodiment, the physiological parameter is blood pressure.
摘要翻译：用于确定患者生理参数的监测器包括校准装置（110），用于提供表示患者生理参数的校准信号。激励器（202）位于血管上方，用于将发射的激励器波形诱导到患者体内。无创传感器（210）感测血液参数并产生代表血液参数的传感器信号，其包含接收的激励器波形的分量。血液参数是与血液相关的任何参数，例如压力，流量，体积，速度，血管壁运动，血管壁位置和相关参数。处理器（100）确定所接收的激励器波形的特性与生理参数的特性之间的关系。处理器（100）接收校准信号和非侵入式传感器信号，并处理校准信号和非侵入式传感器信号以确定生理参数。在优选实施例中，生理参数是血压。

5. 发明申请

WO1998006327A1 MOTION INSENSITIVE PULSE DETECTOR 审中-公开
标题翻译：运动灵敏脉冲检测器
公开(公告)号：WO1998006327A1
公开(公告)日：1998-02-19
申请号：PCT/US1997013743
申请日：1997-08-05
申请人： VITAL INSITE, INC.
发明人： VITAL INSITE, INC. , FLAHERTY, Bryan, P. , SHER, Mark, H. , CARO, Richard, G.
IPC分类号： A61B05/0245
CPC分类号： A61B5/02007 , A61B5/02133 , A61B5/022 , A61B5/02225 , A61B5/024 , A61B5/6824 , A61B5/7207 , A61B5/7228 , A61B8/04 , A61B8/488
摘要： A motion insensitive pulse detector for detecting a patient's pulse includes an exciter adapted to be positioned over a blood vessel of the patient and configured to induce a transmitted exciter waveform into the patient. A noninvasive sensor is adapted to be positioned over the blood vessel and configured to sense a hemoparameter and to generate a noninvasive sensor signal representative of the hemoparameter containing a component of a received exciter waveform. A processor is coupled to the noninvasive sensor and configured to process the noninvasive sensor signal to determine the patient's pulse. Advantages of the invention include the ability to detect a patient's pulse even when the patient is moving or being moved by medical personnel.
摘要翻译：用于检测患者脉搏的运动不敏感脉冲检测器包括适于定位在患者的血管上并被配置为将传输的激励器波形诱导到患者体内的激励器。非侵入式传感器适于定位在血管上方并且被配置为感测血液参数并且产生代表包含接收的激励器波形的分量的血液参数的无创传感器信号。处理器耦合到无创传感器并且被配置为处理无创传感器信号以确定患者的脉搏。本发明的优点包括甚至当患者正在由医务人员移动或移动时检测患者脉搏的能力。

6. 发明申请

WO1997014355A2 EXCITER-DETECTOR UNIT FOR MEASURING PHYSIOLOGICAL PARAMETERS 审中-公开
标题翻译：用于测量生理参数的EXCITER检测器单元
公开(公告)号：WO1997014355A2
公开(公告)日：1997-04-24
申请号：PCT/US1996015951
申请日：1996-10-03
申请人： VITAL INSITE, INC.
发明人： VITAL INSITE, INC. , CARO, Richard, G. , SHER, Mark, H. , FLAHERTY, Bryan, P. , WOHLTMANN, William, J.
IPC分类号： A61B05/021
CPC分类号： A61B5/02007 , A61B5/021 , A61B5/02133 , A61B5/0507 , A61B5/6824 , A61B8/04 , A61B8/488
摘要： An exciter-detector unit is disclosed which includes an exciter (104) and a detector (105) mounted on a common support (101) for inducing perturbations into the body and detecting the perturbations after they travel a distance through the body.
摘要翻译：公开了一种激励器检测器单元，其包括安装在公共支撑件（101）上的激励器（104）和检测器（105），用于引导人体内的扰动，并在它们行进一段距离通过身体之后检测扰动。

7. 发明申请

WO9714355A3 EXCITER-DETECTOR UNIT FOR MEASURING PHYSIOLOGICAL PARAMETERS 审中-公开
标题翻译：用于测量生理参数的EXCITER检测器单元
公开(公告)号：WO9714355A3
公开(公告)日：1997-05-15
申请号：PCT/US9615951
申请日：1996-10-03
申请人： VITAL INSITE INC
发明人： CARO RICHARD G , SHER MARK H , FLAHERTY BRYAN P , WOHLTMANN WILLIAM J
IPC分类号： A61B5/021 , A61B8/04 , A61B8/08 , A61B9/00
CPC分类号： A61B5/02007 , A61B5/021 , A61B5/02133 , A61B5/0507 , A61B5/6824 , A61B8/04 , A61B8/488
摘要： An exciter-detector unit is disclosed which includes an exciter (104) and a detector (105) mounted on a common support (101) for inducing perturbations into the body and detecting the perturbations after they travel a distance through the body.

8. 发明申请

WO1997012545A2 APPARATUS AND METHOD FOR MEASURING AN INDUCED PERTURBATION TO DETERMINE A PHYSIOLOGICAL PARAMETER 审中-公开
标题翻译：用于测量诱导性刺激以确定生理参数的装置和方法
公开(公告)号：WO1997012545A2
公开(公告)日：1997-04-10
申请号：PCT/US1996015820
申请日：1996-10-02
申请人： VITAL INSITE, INC.
发明人： VITAL INSITE, INC. , CARO, Richard, G. , SHER, Mark, H. , FLAHERTY, Bryan, P.
IPC分类号： A61B05/022
CPC分类号： A61B5/022 , A61B5/02133
摘要： A monitor for determining a patient's physiological parameter includes a calibration device (110) configured to provide a calibration signal representative of the patient's physiological parameter. An exciter (202) is positioned over a blood vessel (220) of the patient for inducing a transmitted exciter waveform into the patient. A noninvasive sensor (210) is positioned over the blood vessel (220), where the noninvasive sensor (210) is configured to sense a hemoparameter and to generate a noninvasive sensor signal representative of the hemoparameter containing a component of a physiological parameter waveform and a component of a received exciter waveform. In this context, a hemoparameter is defined as any physiological parameter related to vessel blood such as pressure, flow, volume, velocity, blood vessel wall motion, blood vessel wall position and other related parameters. A processor (100) is configured to determine a relationship between a property of the received exciter waveform and a property of the physiological parameter. The processor (100) is connected to receive the calibration signal and the noninvasive sensor signal, and the processor is configured to process the calibration signal and the noninvasive sensor signal to determine the physiological parameter. In the preferred embodiment, the physiological parameter measured is blood pressure, however, the present invention can also be used to analyze and track other physiological parameters such as vascular wall compliance, strength of ventricular contractions, vascular resistance, fluid volum, cardiac output, myocardial contractility and other related parameters.
摘要翻译：用于确定患者生理参数的监测器包括被配置为提供表示患者生理参数的校准信号的校准装置（110）。激励器（202）位于患者的血管（220）上方，用于将发射的激励器波形诱导到患者体内。无创传感器（210）位于血管（220）上方，其中无创传感器（210）被配置为感测血液参数并且产生代表包含生理参数波形的分量的血液参数的无创传感器信号，以及接收到的激励器波形的分量。在这种情况下，血液参数被定义为与血管血液相关的任何生理参数，例如压力，流量，体积，速度，血管壁运动，血管壁位置和其他相关参数。处理器（100）被配置为确定所接收的激励器波形的特性与生理参数的特性之间的关系。处理器（100）被连接以接收校准信号和无创传感器信号，并且处理器被配置为处理校准信号和非侵入式传感器信号以确定生理参数。在优选实施例中，测量的生理参数是血压，然而，本发明也可用于分析和跟踪其他生理参数，例如血管壁依从性，心室收缩强度，血管阻力，液体体积，心输出量，心肌收缩性等相关参数。

9. 发明申请

WO1996011625A1 AUTOMATICALLY ACTIVATED BLOOD PRESSURE MEASUREMENT DEVICE 审中-公开
标题翻译：自动激活血压测量装置
公开(公告)号：WO1996011625A1
公开(公告)日：1996-04-25
申请号：PCT/US1995012452
申请日：1995-09-28
申请人： VITAL INSITE, INC.
发明人： VITAL INSITE, INC. , CARO, Richard, G. , SHER, Mark, H. , FLAHERTY, Bryan, P.
IPC分类号： A61B05/00
CPC分类号： A61B5/02125 , A61B5/02255
摘要： A monitor for activating a sphygmomanometer (20, 22) attached to a patient includes a sensor (42, 52, 62A, 62B) to generate a sensor signal indicative of a physiological parameter. The sensor (42, 52, 62A, 62B) can be, for example, a non-invasive sensor (42, 52, 62A, 62B) that generates a signal responsive to blood pressure. The monitor also has a processor (30) coupled to the sensor (42, 52, 62A, 62B) and to the sphygmomanometer (20, 22). The processor (30) is configured to process the sensor signal and to send a signal to activate the sphygmomanometer (20, 22) when the sensor signal meets predetermined criteria.
摘要翻译：用于激活附接到患者的血压计（20,22）的监视器包括用于产生指示生理参数的传感器信号的传感器（42,52,62A，62B）。传感器（42,52,62A，62B）可以是例如产生响应于血压的信号的非侵入式传感器（42,52,62A，62B）。监视器还具有耦合到传感器（42,52,62A，62B）和血压计（20,22）的处理器（30）。处理器（30）被配置为当传感器信号满足预定标准时，处理传感器信号并发送信号以激活血压计（20,22）。

10. 发明申请

WO1995018564A1 APPARATUS AND METHOD FOR MEASURING BLOOD PRESSURE 审中-公开
标题翻译：用于测量血压的装置和方法
公开(公告)号：WO1995018564A1
公开(公告)日：1995-07-13
申请号：PCT/US1995000242
申请日：1995-01-03
申请人： VITAL INSITE, INC.
发明人： VITAL INSITE, INC. , KASPARI, William, John , STERN, Roger, Alan
IPC分类号： A61B05/00
CPC分类号： A61B5/02007 , A61B5/022 , A61B5/7257 , Y10S128/925
摘要： A blood pressure monitor for determining a patient's blood pressure includes a processor (9) attached to a first input device (1) for receiving an initial input representing the patient's absolute blood pressure, and a noninvasive sensor (7) attached to the patient for measuring at least one physiological function. The processor (9) executes a procedure for evaluating the initial input and the sensed physiological function to determine the patient's physiological blood pressure. A method for determining a patient's blood pressure includes the steps of storing an initial input representing a patient's absolute blood pressure, noninvasively sensing at least one of the patient's physiological functions, and evaluating the initial input and the sensed input to determine the patient's blood pressure. The present invention can also be used to analyze and track other physiological variables such as vascular wall compliance, changes in the strength of ventricular contractions, changes in vascular resistance, changes in fluid volume, changes in cardiac output, and other related factors.
摘要翻译：用于确定患者血压的血压监测器包括附接到第一输入装置（1）的处理器（9），用于接收表示患者绝对血压的初始输入;以及附接到患者的无创传感器（7），用于测量至少一个生理功能。处理器（9）执行用于评估初始输入和感测的生理功能以确定患者的生理血压的过程。用于确定患者血压的方法包括以下步骤：存储表示患者绝对血压的初始输入，非侵入性地感测患者生理功能中的至少一个，以及评估初始输入和感测输入以确定患者的血压。本发明还可用于分析和跟踪其他生理变量，如血管壁依从性，心室收缩强度变化，血管阻力变化，体积变化，心输出量变化等相关因素。

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