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1. 发明授权

US08415619B2 Methods and systems for mass spectrometry 有权
标题翻译：质谱方法和系统
公开(公告)号：US08415619B2
公开(公告)日：2013-04-09
申请号：US13296793
申请日：2011-11-15
申请人： David R. Goodlett , Scott R. Heron , Jonathan Cooper
发明人： David R. Goodlett , Scott R. Heron , Jonathan Cooper
IPC分类号： H01J49/26 , G01N23/00
CPC分类号： H01J49/0454 , H01J49/0031
摘要： The present invention relates generally to mass spectrometry. The present invention relates more particularly to methods and systems for use in mass spectrometric identification of a variety of analytes, including high molecular weight species such as proteins. One embodiment of the invention is a method for analyzing an analyte. The method includes nebulizing a suspension of the analyte in a solvent with a surface acoustic wave transducer; and performing mass spectrometry on the nebulized suspension. The surface acoustic wave transducer can be used, for example, to transfer non-volatile peptides and proteins (as well as other analyztes, such as oligonucleotides and polymers) to the gas phase at atmospheric pressure. Nebulization using surface acoustic waves can be conducted in a discontinuous or pulsed mode, similar to that used in MALDI, or in a continuous mode, as in ESI.
摘要翻译：本发明一般涉及质谱法。本发明更具体地涉及用于各种分析物（包括高分子量物质如蛋白质）的质谱鉴定中的方法和系统。本发明的一个实施方案是分析分析物的方法。该方法包括将分析物在溶剂中的悬浮液与表面声波换能器雾化; 并对雾化悬浮液进行质谱分析。例如，表面声波换能器可以用于将大气压下的非挥发性肽和蛋白质（以及其它分析物，例如寡核苷酸和聚合物）转移到气相中。使用表面声波的雾化可以以不连续或脉冲模式进行，类似于在MALDI中使用的模式，或者以连续模式进行，如在ESI中。

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