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1. 发明授权

US07776971B2 Processes for the synthesis of dentritic macromolecules from conventional monomers 有权
标题翻译：从常规单体合成牙质质大分子的方法
公开(公告)号：US07776971B2
公开(公告)日：2010-08-17
申请号：US10555599
申请日：2004-05-06
申请人： Virgil Percec
发明人： Virgil Percec
IPC分类号： C08F297/02 , C08F297/00 , C08F8/00
CPC分类号： C08F290/06 , C08F4/00 , C08F120/14 , C08F290/14 , C08F293/005 , C08G83/003
摘要： The inventive subject matter relates to novel synthetic processes which use a multifunctional compound (the “TERMINI compound”) having a masked or protected functional group, wherein the TERMINI compound is capable of quantitatively and irreversibly interrupting a living polymerization or a chain organic reaction. After deprotection or demasking of the functional group of the TERMINI compound, the same living polymerization or organic reaction resumes with 100% efficiency, or a different living polymerization or organic reaction resumes with 100% chemoselectivity, respectively. Once incorporated into a growing molecule, the TERMINI compound generates a branching point upon resumption of the polymerization or reaction.
摘要翻译：本发明涉及使用具有掩蔽或保护的官能团的多官能化合物（“TERMINI化合物”）的新型合成方法，其中TERMINI化合物能够定量和不可逆地中断活性聚合或链状有机反应。在TERMINI化合物的官能团脱保护或拆除后，相同的活性聚合反应或有机反应以100％的效率恢复，或者分别以100％的化学选择性恢复不同的活性聚合或有机反应。一旦掺入生长分子中，TERMINI化合物在恢复聚合或反应时产生支化点。

2. 发明授权

US09044179B2 Oxygen sensor for internal monitoring of tissue oxygen in vivo 有权
标题翻译：氧传感器用于体内组织氧的内部监测
公开(公告)号：US09044179B2
公开(公告)日：2015-06-02
申请号：US12087391
申请日：2007-01-04
申请人： David F. Wilson , Gregory J. Schears
发明人： David F. Wilson , Gregory J. Schears
IPC分类号： A61B5/1459 , A61B5/145 , A61B5/00 , A61B5/1455 , G02B6/032
CPC分类号： A61B5/14542 , A61B5/0059 , A61B5/14539 , A61B5/1455 , A61B5/14551 , A61B5/14552 , A61B5/1459 , A61B5/6846 , G02B6/032 , G02B2006/0325
摘要： Provided is a durable oxygen sensitive probe of sufficient strength to withstand direct tissue pressures in vivo, the probe comprising a sensor chamber within a biocompatible, gas-permeable membrane containing an oxygen sensitive analyte solution producing oxygen quenchable phosphorescence when excited. Further provided is a tissue oxygen detection and measurement system comprising the probe, and methods for use of the probe and the system to directly, rapidly and accurately measure tissue oxygen levels in a patient without reliance on blood vessels or fluid protection of the probe.
摘要翻译：提供了一种具有足够强度以耐受体内直接组织压力的耐用氧敏感探针，该探针包括在生物相容性气体可渗透膜内的传感器室，其中含有氧激活分析物溶液在激发时产生氧可淬灭磷光。进一步提供了包括探针的组织氧检测和测量系统，以及使用探针和系统直接，快速且准确地测量患者中的组织氧水平而不依赖于血管或探针的流体保护的方法。

3. 发明申请

US20070280513A1 Polarization and Reflection Based Non-Contact Latent Fingerprint Imaging and Lifting 有权
标题翻译：基于极化和反射的非接触潜在指纹成像和提升
公开(公告)号：US20070280513A1
公开(公告)日：2007-12-06
申请号：US11587349
申请日：2005-04-27
申请人： Nader Engheta , Edward Pugh , Shih-Schon Lin , Konstantin Yemelyanov
发明人： Nader Engheta , Edward Pugh , Shih-Schon Lin , Konstantin Yemelyanov
IPC分类号： G06K9/00
CPC分类号： G01N21/94 , A61B5/1172 , A61B5/441 , G01N21/21 , G06F19/00 , G06K9/00013 , G06K9/00033 , G06K9/4661
摘要： An optical fingerprinting method extracts high quality latent fingerprints from a surface without any invasive chemical or physical contact with the examined object, and requires no cooperation of the subject. Rather than employing extraneous material, the optical properties of the latent fingerprint are used to generate one or more images with sufficient contrast to distinguish the latent fingerprint or some other deformation in the surface. The system includes a light source oriented to apply light at an angle of incidence to the surface at the position to be examined for the latent fingerprint or deformation, a camera oriented to receive light specularly and diffusely reflected from the surface and/or by the fingerprint or deformation on the surface, and a processor that performs the computation for digital contrast enhancement and/or reprojection of the recovered fingerprint image to a frontal view if necessary. The technique uses optical polarization properties to enhance the images by placing a linearly polarized filter(s) in front of the observing camera. At least two pictures of the same scene with the same lighting and view angle arrangement are taken whereby each of the pictures differ only in that the orientations of the polarization filter are different. At least two light polarization parameters for each pixel are computed from the two or more images taken with different polarizer orientations. An image with each pixel value representing the value of one of the polarization parameters or a function of the polarization parameters is generated and displayed, with some digital contrast enhancement and/or reprojection applied. The hidden latent fingerprint pattern is revealed in at least one such image with the interfering background pattern significantly suppressed.
摘要翻译：光学指纹法从表面提取高质量的潜在指纹，而不会与被检查物体进行任何侵入性化学或物理接触，并且不需要对象的协作。不是使用外来材料，潜在指纹的光学性质被用于产生具有足够对比度的一个或多个图像以区分潜在指纹或表面中的一些其它变形。该系统包括光源，该光源定向成以与潜在指纹或变形的待检查位置处的表面成角度地施加光，照相机，其被定向成从镜面反射并从表面漫反射和/或指纹或变形，以及处理器，如果需要，则将恢复的指纹图像的数字对比度增强和/或再投影执行到正面视图。该技术使用光学偏振特性来通过在观察相机的前面放置线性偏振滤光器来增强图像。拍摄具有相同照明和视角配置的相同场景的至少两幅照片，由此每幅照片的差异仅在于偏振滤光片的取向不同。从使用不同偏振器取向拍摄的两个或更多个图像计算每个像素的至少两个光偏振参数。生成并显示具有表示极化参数之一的值的每个像素值的图像或者偏振参数的函数，并且应用一些数字对比度增强和/或重新投影。隐藏的潜在指纹图案在至少一个这样的图像中被显露，其中干扰背景图案被显着抑制。

4. 发明授权

US09249425B2 Proviral plasmids and production of recombinant adeno-associated virus 有权
标题翻译：丙型肝炎病毒质粒和重组腺相关病毒的产生
公开(公告)号：US09249425B2
公开(公告)日：2016-02-02
申请号：US14117312
申请日：2012-05-16
申请人： Jean Bennett , Jeannette L. Bennicelli
发明人： Jean Bennett , Jeannette L. Bennicelli
IPC分类号： C07K14/435 , C12N15/86 , C12N15/35 , C12N15/864
CPC分类号： C12N7/00 , C07K14/435 , C12N15/86 , C12N2750/14111 , C12N2750/14121 , C12N2750/14141 , C12N2750/14143 , C12N2750/14152 , C12N2800/107 , C12N2830/60 , C12N2830/90
摘要： Proviral plasmids contain a modular gene expression cassette with one or a combination of (i) a wildtype 5′ AAV2 ITR sequence flanked by unique restriction sites that permit ready removal or replacement of said ITR; (ii) a promoter flanked by unique restriction sites that permit ready removal or replacement of the entire promoter sequence; (iii) a polylinker sequence that permits insertion of a gene coding sequence without modification thereof, wherein the gene is operatively linked to, and under the regulatory control of, the aforementioned promoter; (iv) a bovine growth hormone polyadenylation sequence flanked by unique restriction sites that permit ready removal or replacement of said polyA sequence; and (v) a wildtype 3′ AAV2 ITR sequence flanked by unique restriction sites that permit ready removal or replacement of the 3′ ITR. These plasmids enable rapid manipulation of the components of the cassette, e.g., rapid mutation and/or replacement of any component, and thereby increase the efficiency of recombinant viral vector, e.g., rAAV, production.
摘要翻译：丙型肝炎病毒质粒包含一个或多个组合的模块化基因表达盒，（i）野生型5'AAV2 ITR序列，其侧翼是唯一的限制性位点，允许准备移除或替换所述ITR; （ii）侧翼为独特的限制性位点的启动子，其允许准备去除或置换整个启动子序列; （iii）允许插入基因编码序列而无需修饰的多接头序列，其中所述基因与上述启动子有效连接并在其调控下控制; （iv）两侧有唯一限制性位点的牛生长激素多聚腺苷酸化序列，其允许准备移除或替换所述polyA序列; 和（v）野生型3'AAV2 ITR序列，其侧翼是唯一的限制性位点，允许准备移除或替换3'ITR。这些质粒能够快速操作盒的组分，例如任何组分的快速突变和/或置换，从而提高重组病毒载体如rAAV产生的效率。

5. 发明申请

US20070231347A1 Immunization Regimen with E4-Deleted Adenovirus Prime and E1-Deleted Adenovirus Boost 有权
标题翻译： E4缺失腺病毒Prime和E1缺失腺病毒的免疫方案
公开(公告)号：US20070231347A1
公开(公告)日：2007-10-04
申请号：US11587549
申请日：2005-04-27
申请人： James Wilson , Yan Zhi
发明人： James Wilson , Yan Zhi
IPC分类号： A61K39/235
CPC分类号： A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/5258 , A61K2039/545 , A61K2039/57 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/10343 , C12N2710/10362 , C12N2750/14043 , C12N2760/14122 , C12N2760/14134 , Y02A50/484
摘要： An immunization regimen is provided which involves priming with an E1, E4-deleted adenovirus and boosting with an E1-deleted adenovirus. The second administered adenovirus has a capsid of a serotype which is not cross-reactive with the previously administered adenovirus. Each of the adenoviruses carries a heterologous expression cassette comprising a nucleic acid sequence encoding a product for inducing an immune response under the control of regulatory control sequences which direct expression of the product. The expression cassettes can have the same or different regulatory control sequences. Further, a product containing the adenoviruses necessary to perform the immunization regimen is provided.
摘要翻译：提供免疫方案，其包括用E1，E4缺失的腺病毒引发并用E1缺失的腺病毒加强。第二次施用的腺病毒具有不与先前施用的腺病毒交叉反应的血清型的衣壳。每个腺病毒携带异源表达盒，其包含编码产物的核酸序列的核酸序列，用于在引导产物表达的调节控制序列的控制下诱导免疫应答。表达盒可以具有相同或不同的调节控制序列。此外，提供了含有进行免疫方案所必需的腺病毒的产品。

6. 发明申请

US20050233971A1 Antibacterial compounds and methods for treating gram positive bacterial infections 有权
公开(公告)号：US20050233971A1
公开(公告)日：2005-10-20
申请号：US10516012
申请日：2003-06-02
申请人： Dewey McCafferty
发明人： Dewey McCafferty
IPC分类号： A61K38/00 , A61K38/08 , C07K7/06
CPC分类号： C07K7/06 , A61K38/00
摘要： The present inventive subject matter relates to novel antibacterial compounds that are capable of inhibiting bacterial multiplication and killing living bacteria. The present inventive subject matter further relates to methods for treating Gram positive bacterial infections using the inventive compounds. R1R2 1α-D-Mannosyl-(1→2)-α-D-mannoseNH3+ 2HNH3+ 3α-D-Mannosyl-(1→2)-α-D-mannoseHNC(NH)NH3+ 4α-D-Mannosyl-(1→2)-α-D-mannoseHN+(CH2)2CH(CH3)2 5α-D-Mannosyl-(1→2)-α-D-mannoseNHAc 6α-D-Mannosyl-(1→2)-α-D-mannoseNH3+ (Lactone hydrolyzed)

7. 发明授权

US09683026B2 WSX-1/P28 as a target for anti-inflammatory responses 有权
公开(公告)号：US09683026B2
公开(公告)日：2017-06-20
申请号：US11880121
申请日：2007-07-18
申请人： Christopher A. Hunter , Jason Scott Stumhofer
发明人： Christopher A. Hunter , Jason Scott Stumhofer
IPC分类号： A61K38/00 , C07K14/54 , C07K14/715 , A61K38/18 , A61K35/15 , A61K35/17 , G01N33/68
CPC分类号： C07K14/54 , A61K35/15 , A61K35/17 , A61K38/00 , A61K38/1841 , C07K14/7155 , C07K2319/00 , G01N33/6863 , A61K2300/00
摘要： Compositions and methods relating to WSX-1 and p28 (IL-30) are provided. In particular, methods of treating inflammatory conditions in mammalian subjects using various WSX-1, p28, EBI3, and gp130 polypeptides and complexes or moieties that bind to or modulate activity of such complexes are described. Isolated or recombinant complexes including soluble WSX-1 or gp130 polypeptides, isolated or recombinant WSX-1 fusion proteins, and isolated or recombinant p28 fusion proteins are also described.

8. 发明申请

US20170032100A1 USE OF MICRO-RIBONUCLEIC ACID (MIRNA) TO DIAGNOSE TRANSPLANT REJECTION AND TOLERANCE OF IMMUNOSUPPRESSION THERAPY 审中-公开
标题翻译：微乳液（MIRNA）用于诊断免疫抑制和免疫抑制治疗的耐药性
公开(公告)号：US20170032100A1
公开(公告)日：2017-02-02
申请号：US15302815
申请日：2015-04-10
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人： Abraham SHAKED , Bao-Li CHANG , Brendan KEATING , Toumy GUETTOUCHE
IPC分类号： G06F19/00 , A61B5/15 , A61B10/00 , G06F19/20
CPC分类号： A61B5/15 , A61B10/0038 , A61B10/007 , A61B2010/0061 , C12Q1/6883 , G16B25/00 , G16H50/50
摘要： The present invention relates to the discovery that the expression levels of some microRNAs (miRNAs) can use a diagnostic signature to predict transplant outcomes in a transplant recipient. Thus, in various embodiments described herein, the methods of the invention relate to methods of diagnosing a transplant subject for acute rejection such as acute cellular rejection (ACR), methods of predicting a subject's risk of having or developing ACR and methods of assessing in a subject the likelihood of a successful or failure minimization of immunosuppression therapy (IST) dosage from standard ranges.
摘要翻译：本发明涉及发现一些微小RNA（miRNA）的表达水平可以使用诊断特征来预测移植受体中的移植结果。因此，在本文描述的各种实施方案中，本发明的方法涉及诊断移植受试者的急性排斥反应的方法，例如急性细胞排斥反应（ACR），预测受试者患有或发展ACR的风险的方法和评估方法考虑标准范围内免疫抑制治疗（IST）剂量的成功或失败最小化的可能性。

9. 发明授权

US09238679B2 Nucleic acid molecule encoding hepatitis B virus core protein and surface antigen protein and vaccine comprising the same 有权
标题翻译：编码乙型肝炎病毒核心蛋白和表面抗原蛋白的核酸分子和包含其的疫苗
公开(公告)号：US09238679B2
公开(公告)日：2016-01-19
申请号：US13622965
申请日：2012-09-19
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人： David B Weiner , Jian Yan , Nyamekye Obeng-Adjei
IPC分类号： A61K39/29 , C07K14/005 , A61K39/00
CPC分类号： A61K39/29 , A61K39/39 , A61K2039/51 , A61K2039/525 , A61K2039/53 , A61K2039/555 , A61K2039/55527 , A61K2039/55538 , C07K14/005 , C07K2319/02 , C07K2319/50 , C12N7/00 , C12N2730/10122 , C12N2730/10134 , C12N2810/60
摘要： Provided herein are nucleic acid sequences encoding hepatitis B virus (HBV) core proteins, surface antigen proteins, fragments and combinations thereof as well as genetic constructs/vectors and vaccines that express said protein sequences. These vaccines are able to induce an immune response peripherally and in the liver by recruiting both cellular and humoral agents. Also provided are methods for prophylactically and/or therapeutically immunizing individuals against HBV. The combination vaccine can also be used for particular design vaccines for particular levels of immune responses to HBV challenge.
摘要翻译：本文提供了编码乙型肝炎病毒（HBV）核心蛋白，表面抗原蛋白，其片段及其组合以及表达所述蛋白质序列的遗传构建体/载体和疫苗的核酸序列。这些疫苗能够通过招募细胞和体液试剂在周围和肝脏中诱导免疫应答。还提供了用于预防和/或治疗免疫HBV的个体的方法。组合疫苗也可以用于特定设计疫苗，用于针对HBV挑战的特定水平的免疫应答。

10. 发明授权

US5602306A Synthesis of functional human hemoglobin and other proteins in erythroid tissues of transgenic animals 失效
标题翻译：在转基因动物的红细胞组织中合成功能性人血红蛋白和其他蛋白质
公开(公告)号：US5602306A
公开(公告)日：1997-02-11
申请号：US275313
申请日：1994-07-13
申请人： Tim M. Townes , Thomas M. Ryan , Richard D. Palmiter , Ralph L. Brinster , Richard R. Behringer
发明人： Tim M. Townes , Thomas M. Ryan , Richard D. Palmiter , Ralph L. Brinster , Richard R. Behringer
IPC分类号： A01K67/027 , A61K38/00 , A61K48/00 , C07K14/805 , C12N15/85 , C12N15/00
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0278 , A61K48/00 , C07K14/805 , C12N15/85 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2227/108 , A01K2267/01 , A01K2267/0306 , A01K2267/0381 , A61K38/00 , C12N2830/00 , C12N2830/008 , C12N2830/85 , Y10S435/948
摘要： The present invention relates to the synthesis of functional human hemoglobin and other proteins in erythroid tissues of transgenic non-human animals and erythroid cell lines. It is based on the discovery that two of the five hypersensitivity sites of the .beta.-globin locus are sufficient to result in high level expression of human .alpha.- or .beta.-globin transgenes. The present invention also provides for novel recombinant nucleic acid vectors which may be used to produce .alpha.-globin as well as other proteins of interest in quantity in the red blood cells of transgenic animals or cell cultures of erythroid lineage. The vectors of the invention comprise at least one of the major DNase I hypersensitivity sites associated with the .beta.-globin locus together with a gene of interest. In a specific embodiment of the invention, a vector which comprises two DNase I hypersensitivity sites together with the human .alpha.-globin gene is used to create transgenic animals which produce human .alpha.-globin protein in erythroid tissues, including red blood cells. In a preferred specific embodiment of the invention, transgenic animals are created which comprise human .alpha.-globin and .beta.-globin genes, each under the transcriptional influence of two .beta.-globin locus DNase hypersensitivity sites; these transgenic animals express human hemoglobin in their erythroid tissues, and can be used to produce human hemoglobin in quantity.
摘要翻译：本发明涉及转基因非人动物和红系细胞系的红细胞组织中功能性人血红蛋白和其他蛋白质的合成。基于以下发现：β-珠蛋白基因座的五个超敏性位点中的两个足以导致人α或β-珠蛋白转基因的高水平表达。本发明还提供新的重组核酸载体，其可用于在转基因动物或红细胞谱系的细胞培养物的红细胞中产生量的α-珠蛋白以及其它目标蛋白。本发明的载体包含与β-球蛋白基因座相关联的主要DNA酶I超敏反应位点与感兴趣的基因中的至少一种。在本发明的一个具体实施方案中，使用包含两个DNA酶I超敏反应位点与人α-珠蛋白基因一起的载体来产生在包括红细胞在内的红细胞组织中产生人α-珠蛋白的转基因动物。在本发明的优选具体实施方案中，产生包含人α-珠蛋白和β-珠蛋白基因的转基因动物，每个基因在两个β-球蛋白基因座DNA酶超敏位点的转录影响下; 这些转基因动物在其红细胞组织中表达人血红蛋白，并且可用于量产生人血红蛋白。

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