专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

AU2002307359B2 Universal multi-variant detection system 未知
公开(公告)号：AU2002307359B2
公开(公告)日：2007-09-13
申请号：AU2002307359
申请日：2002-04-17
申请人： THE NEW YORK BLOOD CENTER INC
发明人： ANDRUS LINDA , NICHOLS CARMEN NICOLA
IPC分类号： G01N33/53 , C12N15/09 , C12Q1/68 , C12Q1/6818 , C12Q1/6858 , C12Q1/70 , G01N21/78 , G01N33/569
摘要： The present invention provides a method to diagnostically detect the variants of a given pathogen, such as HIV, hepatitis C, hepatitis B (HBV), Parvovirus B19, etc., with the use of a single detection probe.

2. 发明专利

AU2005299802A1 Duffy antigen receptor for chemokines and use thereof 未知
公开(公告)号：AU2005299802A1
公开(公告)日：2006-05-04
申请号：AU2005299802
申请日：2005-10-20
申请人： THE NEW YORK BLOOD CENTER INC
发明人： CHAUDHURI ASOK
IPC分类号： A61K38/19 , A61K39/395 , G01N33/567
摘要： The invention relates to Duffy antigen receptor for chemokines and uses thereof. In one embodiment, the invention provides a method for screening for drug candidates that inhibit angiogenesis. The method comprises contacting a molecule with a Duffy antigen receptor for chemokines and determining whether the molecule binds to the Duffy antigen receptor for chemokines. In another embodiment, the invention provides a method for inhibiting tumor growth. In yet another embodiment, the invention provides a method for inhibiting angiogenesis. In a further embodiment, the invention provides a method for promoting tumor necrosis.

3. 发明专利

AU2005254087B2 Adjuvancy and immune potentiating properties of natural products of Onchocerca volvulus 未知
公开(公告)号：AU2005254087B2
公开(公告)日：2010-12-09
申请号：AU2005254087
申请日：2005-06-15
申请人： THE NEW YORK BLOOD CENTER INC
发明人： MACDONALD ANGUS J , LUSTIGMAN SARA
IPC分类号： A61K39/39 , A61K31/739 , A61K39/21 , A61K39/215 , C07K14/435
摘要： The present disclosure relates to a method for inducing an antigen-specific immune response to an antigen in a mammal in need thereof, or potentiating an immune response, by administering to the mammal an effective amount of an isolated Ov-ASP, or at least one subunit of Ov-ASP.

4. 发明申请

WO2002083927A2 UNIVERSAL MULTI-VARIANT DETECTION SYSTEM 审中-公开
标题翻译：通用多变量检测系统
公开(公告)号：WO2002083927A2
公开(公告)日：2002-10-24
申请号：PCT/US2002/012035
申请日：2002-04-17
申请人： THE NEW YORK BLOOD CENTER, INC. , ANDRUS, Linda , NICHOLS, Carmen, Nicola
发明人： ANDRUS, Linda , NICHOLS, Carmen, Nicola
IPC分类号： C12Q
CPC分类号： C12Q1/707 , C12Q1/6818 , C12Q1/6858 , C12Q1/701 , C12Q1/702 , C12Q1/703 , C12Q1/706 , C12Q2537/101 , C12Q2525/301 , C12Q2561/113 , C12Q2535/125
摘要： The present invention provides a method to diagnostically detect the variants of a given pathogen, such as HIV, hepatitis C, hepatitis B (HBV), Parvovirus B19, etc., with the use of a single detection probe.
摘要翻译：本发明提供了使用单个检测探针来诊断性检测给定病原体如HIV，丙型肝炎，乙型肝炎（HBV），细小病毒B19等的变体的方法。

5. 发明申请

WO1998021316A1 METHOD OF MAKING MONOCLONAL ANTIBODIES USING POLYMORPHIC TRANSGENIC ANIMALS 审中-公开
标题翻译：使用多态性转基因动物制备单克隆抗体的方法
公开(公告)号：WO1998021316A1
公开(公告)日：1998-05-22
申请号：PCT/US1997020783
申请日：1997-11-14
申请人： THE NEW YORK BLOOD CENTER, INC.
发明人： THE NEW YORK BLOOD CENTER, INC. , REID, Marion, E.
IPC分类号： C12N05/28
CPC分类号： C12N15/8509 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2227/105 , A01K2267/01 , C07K16/34
摘要： The invention relates to a method for making monoclonal antibodies having pre-defined specificity of an epitope characteristic of or unique to a single form of a polymorphic protein. The method includes constructing a first transgenic animal to express a first form of a polymorphic protein encoded by a first allele of a gene encoding the protein; constructing a second transgenic animal to express a second form of the polymorphic protein encoded by a second allele of the gene encoding the protein; and immunizing the first transgenic animal with cells from the second transgenic animal expressing the second form of the polymorphic protein to induce an immune response in the first transgenic animal yielding an antibody specific for an epitope peculiar to the second form of the polymorphic protein. The invention further includes hybridoma cells secreting a monoclonal antibody specific for the second form of the protein. The invention is particularly advantageous in the context of making monoclonal antibodies and derivative reagents specifically identifying polymorphic blood group proteins, such as the Duffy gp-Fy protein.
摘要翻译：本发明涉及制备具有单一形式的多态性蛋白质特征性或独特性的表位的预定特异性的单克隆抗体的方法。该方法包括构建第一转基因动物以表达由编码该蛋白质的基因的第一等位基因编码的第一形式的多态性蛋白; 构建第二转基因动物以表达由编码蛋白质的基因的第二等位基因编码的第二形式的多态性蛋白质; 以及用表达第二形式的多态性蛋白质的第二转基因动物的细胞免疫第一转基因动物，以在第一转基因动物中诱导免疫应答，产生对第二形式的多态性蛋白质特异性表位的抗体。本发明还包括分泌针对第二种蛋白质特异性的单克隆抗体的杂交瘤细胞。本发明在制备单克隆抗体和特异性鉴定多形性血型蛋白如Duffy gp-Fy蛋白的衍生试剂的背景下是特别有利的。

6. 发明申请

WO1996015268A1 DIAGNOSTIC METHOD AND KIT FOR DETERMINING KELL BLOOD GROUP GENOTYPE 审中-公开
标题翻译：诊断方法和确定小鼠血液基因组的试剂盒
公开(公告)号：WO1996015268A1
公开(公告)日：1996-05-23
申请号：PCT/US1995014684
申请日：1995-11-09
申请人： THE NEW YORK BLOOD CENTER, INC.
发明人： THE NEW YORK BLOOD CENTER, INC. , LEE, Soohee , REDMAN, Colvin, L.
IPC分类号： C12Q01/68
CPC分类号： C07K14/705 , C12Q1/683 , C12Q1/6858 , C12Q1/6876 , C12Q2600/156
摘要： The invention provides a diagnostic method of determining Kell genotype by the identification of the molecular basis of a Kell polymorphism. Specifically, the invention provides a method for determining K1/K2 genotype with great accuracy, overcoming problems associated with traditional serological typing methods. The diagnostic method of the invention preferably employs amplification of K1/K2 nucleic acid sequences, and optionally employs differential cleavage of K1-K2-specific nucleic acid sequences by a restriction enzyme. Also provided are nucleic acid oligomers useful as probes or primers for the method of the invention. Furthermore, diagnostic kits for the determination of Kell genotype are provided.
摘要翻译：本发明提供了通过鉴定凯尔多态性的分子基础来确定凯尔基因型的诊断方法。具体地说，本发明提供了一种以高精度确定K1 / K2基因型的方法，克服了与传统血清学分型方法相关的问题。本发明的诊断方法优选使用K1 / K2核酸序列的扩增，并且可选地使用限制性内切酶进行K1-K2特异性核酸序列的差异切割。还提供了可用作本发明方法的探针或引物的核酸低聚物。此外，提供了用于确定凯尔基因型的诊断试剂盒。

7. 发明申请

WO2002016396A3 MAMMALIAN RH TYPE B GLYCOPROTEIN ION TRANSPORTER 审中-公开
公开(公告)号：WO2002016396A3
公开(公告)日：2002-02-28
申请号：PCT/US2001/025881
申请日：2001-08-17
申请人： THE NEW YORK BLOOD CENTER, INC. , HUANG, Cheng-Han , LIU, Zhi
发明人： HUANG, Cheng-Han , LIU, Zhi
IPC分类号： C12N5/10
摘要： The present invention provides nucleic acid sequences encoding novel mammalian nonerythroid Rh glycoprotein homologues, Rhbg including the human homologue RhBG. These RhBG, Rhbg glycoproteins are polytypic transporter-type proteins with 12 transmembrane domains and are predominantly expressed as a single major form in kidney, and as multiple forms in liver, skin and ovaries. Also provided are recombinant vectors and host vector systems containing these nucleic acid sequences, as well as fusion proteins incorporating Rhbg, RhBG or fragments of each. The invention further provides methods of detection of Rhbg and RhBG glycoproteins and also methods of detecting nucleic acids encoding Rhbg and RhBG.

8. 发明申请

WO1998021235A1 MALARIAL BINDING SITE ON DUFFY BLOOD GROUP PROTEIN 审中-公开
标题翻译：疟疾组合蛋白质中的疟疾结合位点
公开(公告)号：WO1998021235A1
公开(公告)日：1998-05-22
申请号：PCT/US1997021063
申请日：1997-11-14
申请人： THE NEW YORK BLOOD CENTER, INC.
发明人： THE NEW YORK BLOOD CENTER, INC. , POGO, Oscar, A. , CHAUDHURI, Asok
IPC分类号： C07K14/445
CPC分类号： C07K14/715 , A61K38/00 , A61K39/00 , Y02A50/412
摘要： A composition and method for inhibiting binding of malarial Duffy-binding ligand to Duffy blood group antigens on mammalian erythrocytes is disclosed. The composition includes a Duffy-related peptide which interferes with binding between Duffy antigen expressed on erythrocyte cell surfaces and the Duffy-binding ligands of merozoites. Particularly preferred peptides are the peptides having the sequences AELSPSTENSSQLDFEDVWNSSYGVNDSFPDGDYD (SEQ ID NO:1) or AELSPSTQNSSQLNSDLWNFSYDGNDSFPDVDYD (SEQ ID NO:4), as well as peptides which comprise either of those sequences in their primary structure, or other peptides having equivalent function. A method is disclosed which comprises administering a Duffy-based peptide which interferes with malarial binding to Duffy antigen in an amount sufficient to inhibit binding of merozoites to erythrocytes.
摘要翻译：公开了一种用于抑制疟疾Duffy结合配体与哺乳动物红细胞上的Duffy血型抗原结合的组合物和方法。组合物包含Duffy相关肽，其干扰在红细胞表面上表达的Duffy抗原与裂殖子的Duffy结合配体之间的结合。特别优选的肽是具有序列AELSPSTENSSQLDFEDVWNSSYGVNDSFPDGDYD（SEQ ID NO：1）或AELSPSTQNSSQLNSDLWNFSYDGNDSFPDVDYD（SEQ ID NO：4）的肽以及包含其一级结构的那些序列之一的肽或具有等同功能的其它肽。公开了一种方法，其包括以足以抑制裂殖子与红细胞结合的量施用干扰疟疾结合Duffy抗原的Duffy基肽。

9. 发明申请

WO1997017468A1 DIAGNOSTIC METHOD AND KIT FOR DETERMINING Rh BLOOD GROUP GENOTYPE 审中-公开
标题翻译：诊断方法和用于确定Rh血液组基因组的试剂盒
公开(公告)号：WO1997017468A1
公开(公告)日：1997-05-15
申请号：PCT/US1996017465
申请日：1996-10-28
申请人： THE NEW YORK BLOOD CENTER, INC.
发明人： THE NEW YORK BLOOD CENTER, INC. , HUANG, Cheng-Han
IPC分类号： C12Q01/68
CPC分类号： C12Q1/6881 , C12Q1/683 , C12Q2600/156 , C12Q2600/172 , Y10S435/81
摘要： The invention provides a diagnostic method of determining Rh genotypes by the identification of the molecular basis of Rh polymorphisms. Specifically, the invention provides a method for directly determining Dd and associated CcEe genotypes with great accuracy, overcoming problems associated with traditional serologic typing methods and leading to a direct discrimination of D/D, D/d, and d/d genetic status. The diagnostic method allows genotyping of fetuses to assess the risk of hemolytic diseases caused by Rh alloimmunization and genetic counseling and/or testing of couples to predict the outcome of pregnancies in relation to Rh incompatibilities. The method of the invention preferably employs amplification of Rh nucleic acid sequences, and employs differential cleavage of RhD-, RhCc- and/or RhEe-specific nucleic acid sequences by a restriction enzyme. Furthermore, diagnostic kits for the determination of Rh genotypes are provided.
摘要翻译：本发明提供了通过鉴定Rh多态性的分子基础来确定Rh基因型的诊断方法。具体地说，本发明提供了一种以高精度直接测定Dd和相关CcEe基因型的方法，克服了与传统血清学分型方法相关的问题，导致直接鉴别D / D，D / d和d / d基因状态。诊断方法允许胎儿进行基因分型，以评估Rh同种异体免疫和遗传咨询和/或夫妇检测引起的溶血性疾病的风险，以预测与Rh不相容性相关的妊娠结局。本发明的方法优选使用Rh核酸序列的扩增，并采用限制性酶对RhD-，RhCc-和/或RhEe-特异性核酸序列进行差异切割。此外，提供了用于确定Rh基因型的诊断试剂盒。

10. 发明申请

WO1994009121A1 PREPARATION OF ENZYME FOR CONVERSION OF SUB-TYPE A AND AB ERYTHROCYTES 审中-公开
标题翻译：用于转化亚型和AB型红细胞的酶的制备
公开(公告)号：WO1994009121A1
公开(公告)日：1994-04-28
申请号：PCT/US1993010122
申请日：1993-10-21
申请人： THE NEW YORK BLOOD CENTER, INC.
发明人： THE NEW YORK BLOOD CENTER, INC. , GOLDSTEIN, Jack , HURST, Rosa, S.
IPC分类号： C12N09/24
CPC分类号： C12Y302/01049 , A61K35/18 , C12N9/2402 , Y10S435/814
摘要： This invention relates to an improved method of purifying the enzyme alpha -N-acetylgalactosaminidase from avian liver, as well as to the purified enzyme. The enzyme is capable of removing A antigens from the surface of cells in blood products. The method of purifying the enzyme is simple and time efficient, and lends itself to large scale production.
摘要翻译：本发明涉及一种从禽肝中纯化酶α-N-乙酰半乳糖苷酶以及纯化酶的改进方法。该酶能够从血液制品中的细胞表面除去A抗原。纯化酶的方法简单，时间有效，适合大规模生产。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式