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1. 发明申请

WO2021150522A CRANIAL IMPLANT DEVICES AND RELATED METHODS 审中-公开
公开(公告)号：WO2021150522A
公开(公告)日：2021-07-29
申请号：PCT/US2021/014003
申请日：2021-01-19
申请人： THE JOHNS HOPKINS UNIVERSITY [US]/[US]
发明人： GORDON, Chad, R. , WEIDMAN, Deborah, I. , SCOTT, Nathan , ARMAND, Mehran , CAI, John , ESPOSITO, Caterina , KIM, Kibeom , CLAMPFFER, Cole
IPC分类号： A61M31/00 , A61M1/00 , F04B43/12 , A61M5/142
摘要： Provided herein are magnetic resonance imaging (MRI) compatible cranial implant devices and related methods for performing a wide array of therapeutic and/or monitoring applications. In one aspect, the cranial implant device includes a cranial implant housing configured for intercranial implantation in a cranial opening of a subject. The cranial implant housing comprises a substantially anatomically-compatible shape, at least first and second surfaces, and at least one fluidic circuit comprising at least one cavity and at least one port that fluidly communicates with the cavity through at least the second surface, in which the cavity comprises, or is capable of comprising, at least one fluidic therapeutic agent. The device also includes at least one pump operably connected to the fluidic circuit, which pump is configured to convey the fluidic therapeutic agent from the cavity through at least one fluid conduit when the fluid conduit is operably connected to the port to maintain at least one positive pressure gradient of the fluidic therapeutic agent at least proximal to an outlet of the fluid conduit. In addition, the device also includes at least one power source operably connected at least to the pump. The cranial implant housing, the pump, and the power source are typically fabricated from one or more MRI compatible materials. Other aspects relate to various methods of treating a neurologically-related disease using the cranial implant devices, methods of monitoring therapeutic agent administration in a plurality of subjects, and methods of fabricating a cranial implant device as well as surgical methods.

2. 发明申请

WO2022125936A1 USE OF ACTIVATED T-CELLS TO ENHANCE ANTI-TUMOR ACTIVITY OF BISPECIFIC ANTIBODIES OR BITES 审中-公开
公开(公告)号：WO2022125936A1
公开(公告)日：2022-06-16
申请号：PCT/US2021/062866
申请日：2021-12-10
申请人： THE JOHNS HOPKINS UNIVERSITY [US]/[US] , MEMORIAL SLOAN KETTERING CANCER CENTER [US]/[US]
发明人： BORRELLO, Ivan M. , THOMAS, Amy , SMITH, Eric L.
IPC分类号： A61K35/17 , A61K39/395 , C12N5/0783 , A61P35/00
摘要： Provided herein are methods of treatment including methods of treating cancer and methods of enhancing an anti-tumoral activity of a bispecific T-cell engager (BiTE) or of a bispecific antibody. The methods disclosed herein include activating T-cells and contacting activated T-cells with BiTEs or bispecific antibodies for administration to a subject.

3. 发明申请

WO2022125578A1 METHODS OF NK CELL ENGINEERING TO ENHANCE TUMOR TARGETING 审中-公开
公开(公告)号：WO2022125578A1
公开(公告)日：2022-06-16
申请号：PCT/US2021/062251
申请日：2021-12-07
申请人： THE JOHNS HOPKINS UNIVERSITY [US]/[US]
发明人： BONIFANT, Challice , CHRISTODOULOU, Ilias
摘要： Provided herein are, inter alia, methods, compositions and kits for treating cancer, e.g., acute myeloid leukemia, including an engineered cell including various CAR constructs. Also included herein are kits for treating cancer, including engineered cells comprising various CAR constructs.

4. 发明申请

WO2022126021A1 HEPARINIZED SMALL-DIAMETER VASCULAR GRAFTS 审中-公开
公开(公告)号：WO2022126021A1
公开(公告)日：2022-06-16
申请号：PCT/US2021/063128
申请日：2021-12-13
申请人： THE JOHNS HOPKINS UNIVERSITY [US]/[US]
发明人： GERECHT, Sharon , ELLIOT, Morgan B. , MAO, Hai-Quan , CHEN, Theresa , PRASAD, Khyati
IPC分类号： A61F2/82 , A61F2/07 , A61L31/00 , A61L31/16 , A61L33/00
摘要： Described are methods for embedding one or more therapeutic agents into vascular grafts and other scaffold-based devices, and methods of implanting vascular grafts comprising tubular scaffolds into subjects. The tubular scaffolds comprise hydrogel nanofibers that have internally aligned polymer chains and may contain one or more therapeutic agents.

5. 发明申请

WO2022125833A1 VIDEO-GUIDED PLACEMENT OF SURGICAL INSTRUMENTATION 审中-公开
公开(公告)号：WO2022125833A1
公开(公告)日：2022-06-16
申请号：PCT/US2021/062702
申请日：2021-12-09
申请人： THE JOHNS HOPKINS UNIVERSITY [US]/[US]
发明人： SIEWERDSEN, Jeffrey, H. , SHETH, Niral, M. , VAGDARGI, Prasad , OSGOOD, Greg, M. , DE SILVA, Wathudurage Tharindu
IPC分类号： A61B34/20 , A61B90/00 , A61B34/30
摘要： A system for surgical navigation, including an instrument for a medical procedure attached to a camera and having a spatial position relative to the camera, an x-ray system to acquire x-ray images, and multiple fiducial markers detectable by both the camera and x-ray system, having a radio-opaque material arranged as at least one of a line and a point. A computer receives an optical image from the camera and an x-ray image from the x-ray system, identifies fiducial markers visible in both the optical image and x-ray image, determines for each fiducial marker a spatial position relative to the camera based on the optical image and relative to the x-ray system based on the x-ray image, and determines a spatial position for the instrument relative to the x-ray system based on at least the spatial positions relative to the camera and x-ray system.

6. 发明申请

WO2022125727A1 LOCATING AN EPILEPTOGENIC ZONE FOR SURGICAL PLANNING 审中-公开
公开(公告)号：WO2022125727A1
公开(公告)日：2022-06-16
申请号：PCT/US2021/062523
申请日：2021-12-09
申请人： THE JOHNS HOPKINS UNIVERSITY [US]/[US]
发明人： SARMA, Sridevi, V. , GUNNARSDOTTIR, Kristin, M. , GONZALEZ-MARTINEZ, Jorge, A.
IPC分类号： G06N3/10 , A61B5/24
摘要： A machine-implemented method, computing device, and at least one non-transitory computer-readable medium are provided. A dynamical network model is parameterized by state transition matrices based on monitored interictal brain data. A node influence-to network score for each respective node is calculated indicating how influential the respective node is. An influenced-by score is calculated for the each respective node indicating an amount by which the respective node is influenced by the nodes. A score is calculated for the each respective node based on a sink index, a source influence index, and a sink connectivity index. Nodes that are in the epileptogenic zone are determined based on the calculated score for each of the nodes. An indication of the nodes in the epileptogenic zone is provided.

7. 发明申请

WO2021202530A CASPASE INHIBITORS TO ENHANCE INJURY REPAIR AND TO TREAT BACTERIAL AND VIRAL INFECTIONS 审中-公开
公开(公告)号：WO2021202530A
公开(公告)日：2021-10-07
申请号：PCT/US2021/024889
申请日：2021-03-30
申请人： THE JOHNS HOPKINS UNIVERSITY [US]/[US]
发明人： GARZA, Luis , MILLER, Lloyd , ALPHONSE, Martin , ISLAM, Mohameed
IPC分类号： A61K38/55 , A61P1/00 , A61P17/02 , A61P31/04 , A61P31/12 , A61P31/14
摘要： The present invention relates to the field of caspase inhibition. More specifically, the present invention provides compositions and methods utilizing caspase inhibitors to enhance injury repair and to treat bacterial and viral infections. In a specific embodiment, a method for treating a bacterial infection and skin lesions in a patient comprises the step of administering to the patient an effective amount of a caspase inhibitor.

9. 发明授权

EP2489350B1 N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors 有权转让
标题翻译： N-羟基磺酰胺衍生物生理生化硝基硝基
公开(公告)号：EP2489350B1
公开(公告)日：2013-12-04
申请号：EP12155608.8
申请日：2007-03-16
申请人： Johns Hopkins University School of Medicine , Cardioxyl Pharmaceuticals, Inc.
发明人： Toscano, John, P. , Brookfield, Frederick, Arthur , Cohen, Andrew, D. , Courtney, Stephen, Martin , Frost, Lisa, Marie , Kalish, Vincent, Jacob
IPC分类号： A61K31/18 , A61P9/04 , C07D207/36 , C07D213/71 , C07D213/74 , C07D231/18 , C07D233/84 , C07D239/38 , C07D241/18 , C07D249/12 , C07D261/10 , C07D277/36 , C07D285/12 , C07D295/096 , C07D307/64 , C07D307/82 , C07D333/34 , C07D333/62 , C07D263/58 , C07D285/125
CPC分类号： C07C311/48 , C07C317/14 , C07C323/67 , C07D213/74 , C07D231/18 , C07D261/10 , C07D263/58 , C07D285/125 , C07D295/096 , C07D307/82 , C07D309/12 , C07D317/14 , C07D333/34 , C07D333/62
摘要： The invention relates to N -hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N- hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N -hydroxysulfonamide derivatives.
摘要翻译：本发明涉及在生理条件下给予硝酰基（HNO）的N-羟基磺酰胺衍生物，并且可用于治疗和/或预防对硝酰病治疗有反应的疾病或病症的发作和/或发展，包括心力衰竭和缺血/再灌注伤害。新型N-羟基磺酰胺衍生物在生理条件下以控制速率释放NHO，并且通过改变N-羟基磺酰胺衍生物上官能团的性质和位置来调节HNO释放速率。

10. 发明授权

EP1897548B1 T cell regulation 有权转让
标题翻译： T细胞调控
公开(公告)号：EP1897548B1
公开(公告)日：2013-08-14
申请号：EP07021595.9
申请日：2004-03-01
申请人： The Johns Hopkins University , St. Jude Children's Research Hospital Inc.
发明人： Pardoll, Drew M. , Vignali, Dario A. , Huang, Chung-Tai , Workman, Creg J. , Powell, Jonathan , Drake, Charles
IPC分类号： C12N15/63 , A61K31/70 , A61K39/00 , A61K39/38 , A61K39/395 , G01N33/53 , A01N43/04 , C07K16/00 , C12P21/08 , C07K14/705 , C07K16/28 , C12N5/0783 , C12N5/074 , C12N5/071
CPC分类号： C07K16/2803 , A01K67/0271 , A01K67/0276 , A01K2267/0381 , A61K39/0011 , A61K39/3955 , A61K39/39558 , A61K2035/122 , A61K2039/505 , A61K2039/507 , A61K2039/5156 , A61K2039/55516 , C07K14/70503 , C07K16/18 , C07K16/42 , C12N5/0636 , C12N2501/599 , C12N2510/00 , C12N2799/027
摘要： Regulatory T cells (Treg) limit autoimmunity but can also attenuate the magnitude of anti-pathogen and anti-tumor immunity. Understanding the mechanism of Treg function and therapeutic manipulation of Treg in vivo requires identification of Treg selective receptors. A comparative analysis of gene expression arrays from antigen specific CD4+ T cells differentiating to either an effector/memory or a regulatory phenotype revealed Treg selective expression of LAG-3 (CD223), a CD4-related molecule that binds MHC class II. LAG-3 expression on CD4+ T cells correlates with the cells' in vitro suppressor activity, and ectopic expression of LAG-3 on CD4 T cells confers suppressor activity on the T cells. Antibodies to LAG-3 inhibit suppression both in vitro and in vivo. LAG-3 marks regulatory T cell populations and contributed to their suppressor activity.

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