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1. 发明专利

JP2011079834A Neuroprotective iron chelators and pharmaceutical compositions containing the same 审中-公开
标题翻译：神经保护性铁器和包含其的药物组合物
公开(公告)号：JP2011079834A
公开(公告)日：2011-04-21
申请号：JP2010238156
申请日：2010-10-25
申请人： Technion Research & Development Foundation Ltd , Yeda Research & Development Co Ltd , イエダリサーチアンドデベロップメントカンパニーリミテッド , テクニオンリサーチアンドディベラップメントファウンデイションリミテッド
发明人： YOUDIM MOUSSA B H , FRIDKIN MATITIYAHU , ZHENG HAILIN , WARSHAWSKY RIVKA , WARSHAWSKY ABRAHAM
IPC分类号： C07D213/69 , A61K31/16 , A61K31/165 , A61K31/192 , A61K31/47 , A61K31/495 , A61K31/496 , A61K38/00 , A61K45/00 , A61K45/06 , A61P1/04 , A61P3/10 , A61P3/12 , A61P7/06 , A61P9/00 , A61P17/00 , A61P17/06 , A61P17/16 , A61P17/18 , A61P19/02 , A61P21/00 , A61P25/00 , A61P25/08 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/10 , A61P31/12 , A61P31/14 , A61P31/18 , A61P33/02 , A61P33/06 , A61P35/00 , A61P37/06 , A61P39/06 , C07C239/16 , C07D215/26 , C07D295/14 , C07D295/15 , C07D295/20 , C07D295/205 , C07K5/06 , C07K5/11 , C07K7/06 , C07K7/22 , C07K7/23 , C07K14/575 , C07K14/70
CPC分类号： C07D295/15 , A61K38/00 , A61K45/06 , A61K47/547 , C07D213/69 , C07D215/26 , C07D295/205 , C07K7/06 , C07K7/22 , C07K7/23 , C07K14/57563 , C07K14/70
摘要： PROBLEM TO BE SOLVED: To provide a new iron chelator or the like exhibiting neuroprotective characteristics and good transport characteristics. SOLUTION: The new iron chelator exhibiting neuroprotective characteristics and good transport characteristics is useful in iron chelation therapy for treatment of a disease, disorder or condition associated with iron overload and oxidative stress (for example, a neurodegenerative or cerebrovascular disease or disorder, a neoplastic disease, hemochromatosis, thalassemia, a cardiovascular disease, diabetes, an inflammatory disorder, anthracycline cardiotoxicity, a viral infection, a protozoal infection, an yeast infection), retarding ageing, prevention and/or treatment of skin ageing and skin protection against sunlight and/or UV light. The iron chelator function is provided by a 8-hydroxyquinoline, hydroxypyridinone or hydroxamate moiety. The neuroprotective function is imparted to the compound by, for example, a neuroprotective peptide, while a combined antiapoptotic and neuroprotective function is imparted to the compound by a propargyl group. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供具有神经保护特性和良好的运输特性的新的铁螯合剂等。解决方案：具有神经保护特征和良好运输特性的新型铁螯合剂可用于铁螯合治疗用于治疗与铁过载和氧化应激相关的疾病，病症或病状（例如，神经变性或脑血管疾病或病症，肿瘤性疾病，血色素沉着病，地中海贫血，心血管疾病，糖尿病，炎性疾病，蒽环类心脏毒性，病毒感染，原生动物感染，酵母菌感染），延缓衰老，预防和/或治疗皮肤老化和防止阳光的皮肤保护和/或UV光。铁螯合剂功能由8-羟基喹啉，羟基吡啶酮或异羟肟基部分提供。神经保护功能通过例如神经保护肽赋予化合物，而通过炔丙基赋予化合物的组合的抗细胞凋亡和神经保护功能。版权所有（C）2011，JPO＆INPIT

2. 发明专利

JP2013238620A Three dimensional video scanner 有权
标题翻译：三维视频扫描仪
公开(公告)号：JP2013238620A
公开(公告)日：2013-11-28
申请号：JP2013161790
申请日：2013-08-02
申请人： Technion Research & Development Foundation Ltd , テクニオンリサーチアンドディベロップメントファウンデーションリミテッド
发明人： RON KIMMEL
IPC分类号： G01B11/25 , G06K9/00
CPC分类号： G01B11/2513
摘要： PROBLEM TO BE SOLVED: To provide a method and apparatus for three dimensional video sampling or scanning with high precision and at a low cost.SOLUTION: A projector 20 projects a light beam that has been modulated by a digital micromirror device 22, typically contained within the projector. A modulation inserts information into the light beam that later allows depth information to be decoded. Specifically structural information is modulated into the light beam. A preferred embodiment uses a simple pattern of black and white stripes. The modulated beam is projected onto an object or scene and detected at high frame rate CMOS-based camera 24. A detected signal, summed from all pixels, is directed to a processor device 26, which extracts the depth information. The depth information is extracted from a way in which striping in an original signal has become distorted in reflection.
摘要翻译：要解决的问题：提供一种以高精度和低成本进行三维视频采样或扫描的方法和装置。解决方案：投影仪20投影由数字微镜装置22调制的光束，通常包含在投影机。 A调制将信息插入到光束中，后来允许深度信息被解码。具体的结构信息被调制到光束中。优选实施例使用黑色和白色条纹的简单图案。调制的光束被投影到物体或场景上，并在高帧速CMOS基于相机24的情况下被检测。从所有像素相加的检测信号被引导到提取深度信息的处理器装置26。从原始信号中的条带化在反射中变形的方式提取深度信息。

3. 发明专利

JP2017113003A 角膜細胞の作製方法および該角膜細胞を含む細胞集団审中-公开
公开(公告)号：JP2017113003A
公开(公告)日：2017-06-29
申请号：JP2017004692
申请日：2017-01-13
申请人：テクニオンリサーチアンドディベロップメントファウンデーションリミテッド , Technion Research & Development Foundation Ltd , テクニオンリサーチアンドディベロップメントファウンデーションリミテッド , アンスティテュトナショナルドラサンテエドラルシェルシュメディカル (アンセルム) , Inst National De La Sante & De La Recherche Medicale (Inserm) , アンスティテュトナショナルドラサンテエドラルシェルシュメディカル (アンセルム)
发明人： JOSEPH ITSKOVITZ-ELDOR , DANIEL ABERDAM , RUBY SHALOM-FEUERSTEIN
IPC分类号： C12N5/071 , A61K35/30 , A61L27/36 , A61L27/38 , A61P27/02 , C12N5/10
CPC分类号： A61K35/30 , C12N5/0062 , C12N5/0621 , C12N2501/11 , C12N2501/155 , C12N2501/33 , C12N2502/085 , C12N2502/1323 , C12N2506/02 , C12N2506/45 , C12N2533/52 , C12N2533/54 , C12N2533/90 , G01N33/5058 , G01N33/53
摘要：【課題】角膜上皮細胞の集団及びそれを用いて角膜組織を作製する方法の提供。【解決手段】ヒト多能性幹細胞を、BMP−4、インスリン、ヒドロコルチゾン及びEGFを含む角膜線維芽細胞馴化培地において、コラーゲンIV等の細胞外マトリックス成分を含む固体表面で培養し作製した角膜上皮細胞の集団、及びこの細胞集団を解離後コラーゲンI等を含む足場において培養し作製する角膜組織の提供。【選択図】図1A−1E

4. 发明专利

JP2015053489A 有機半導体のための誘導体化されたフラーレン系ドーパント审中-公开
标题翻译：用于有机半导体的基于富勒烯的DOPANT
公开(公告)号：JP2015053489A
公开(公告)日：2015-03-19
申请号：JP2014197706
申请日：2014-09-29
申请人：テクニオンリサーチアンドディベロップメントファウンデーションリミテッド , Technion Research & Development Foundation Ltd , テクニオンリサーチアンドディベロップメントファウンデーションリミテッド
发明人： NIR TESSLER , OLGA SOLOMESHCH
IPC分类号： H01L51/30 , H01L29/786 , H01L51/05 , H01L51/40 , H01L51/46 , H01L51/50
CPC分类号： H01L51/0047 , B82Y10/00 , C08G2261/141 , C08G2261/3223 , C08G2261/92 , C08L65/00 , H01L51/001 , H01L51/0036 , H01L51/0038 , H01L51/0039 , H01L51/004 , H01L51/0042 , H01L51/0052 , H01L51/0059 , H01L51/0071 , H01L51/0078 , H01L51/0566 , H01L51/42 , H01L51/50 , H01L51/5096 , H01L2251/552 , Y02E10/549 , Y02P70/521
摘要：【課題】有機半導体材料に新規なドーパントを添加することによって、電荷キャリア密度を高め、有効電荷キャリア易動度を高める製造方法を提供する。【解決手段】有機半導体材料を、共有結合により結合する少なくとも1つの電子吸引置換基を有し、かつ、有機半導体材料の最高被占分子軌道(HOMO)から最低空分子軌道(LUMO)への電子移動を可能にするために十分であるLUMOを有するフラーレン誘導体によりドープすることを含む。【選択図】なし
摘要翻译：要解决的问题：提供一种向有机半导体材料添加新的掺杂剂的制造方法，从而增强电荷载流子密度并提高有效的电荷载流子迁移率。解决方案：一种制造半导体材料的方法包括掺杂具有至少一个通过共价键偶联的吸电子取代基的富勒烯衍生物的有机半导体材料，并且具有足以使电子从最高占据分子轨道（HOMO）转移到最低未占分子轨道（LUMO）的LUMO ）有机半导体材料。

5. 发明专利

JP2013217946A Method and device for converging particle 有权
标题翻译：用于混合颗粒的方法和装置
公开(公告)号：JP2013217946A
公开(公告)日：2013-10-24
申请号：JP2013161659
申请日：2013-08-02
申请人： Technion Research & Development Foundation Ltd , テクニオンリサーチアンドディベロップメントファウンデーションリミテッド
发明人： ALEXANDER LESHANSKY , AVISHAY BRANSKY , KORIN NATANEL
IPC分类号： G01N15/14
CPC分类号： G01N33/5306 , B01L3/502776 , G01N15/1404 , G01N2015/1409 , G01N2203/0094
摘要： PROBLEM TO BE SOLVED: To provide a method for converging particles.SOLUTION: A method for converging particles includes processes of: preparing suspension liquid of the particles in a first suspension medium; and supplying the suspension liquid in a channel having a longitudinal axis and a cross section perpendicular to the longitudinal axis, and having at least one cross sectional dimension which is smaller than 100 μm, in which the first suspension medium has viscoelastic characteristics so that the process of supplying the suspension liquid in the channel concentrates concentration of the particles in a convergence area including the center of the channel, and the concentration of the particles becomes maximum at the center of the channel.
摘要翻译：要解决的问题：提供一种会聚颗粒的方法。解决方案：一种用于会聚颗粒的方法包括以下步骤：在第一悬浮介质中制备颗粒的悬浮液; 并将所述悬浮液供给在具有与所述纵向轴线垂直的纵向轴线和横截面的通道中，并且具有至少一个小于100μm的横截面尺寸，其中所述第一悬浮介质具有粘弹性特征，使得所述方法在通道中提供悬浮液的浓缩将颗粒的浓度集中在包括通道中心的会聚区域中，并且颗粒的浓度在通道的中心变得最大。

6. 发明专利

JP2005232148A Use of propargylamine as neuroprotective agent 审中-公开
标题翻译：丙基胺作为神经保护剂使用
公开(公告)号：JP2005232148A
公开(公告)日：2005-09-02
申请号：JP2004104176
申请日：2004-03-31
申请人： Technion Research & Development Foundation Ltd , テクニオンリサーチアンドディベロップメントファウンデーションリミテッド
发明人： YOUDIM MOUSSA B H , AMIT TAMAR , WEINREB ORLY , BAR-AM ORIT , YOGEV-FALACH MERAV
IPC分类号： A61P9/10 , A61K9/20 , A61K31/13 , A61K31/131 , A61K31/135 , A61P9/00 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/28 , A61P25/30 , A61P31/18
CPC分类号： A61K31/13 , A61K31/135
摘要： PROBLEM TO BE SOLVED: To provide a method for treating diseases, abnormalities or states such as neurodegenerative diseases. SOLUTION: This method is provided for treating diseases, abnormalities or states selected from the group consisting of (i) neurodegenerative diseases; (ii) dementia; (iii) mental or emotional abnormalities; (iv) drug dependence; (v) amnesia; (vi) acute neurological traumatic diseases or neural trauma; (vii) demyelinating diseases; (viii) paroxysmal diseases; (ix) cerebrovascular diseases; (x) behavioral abnormalities; (xi) neurotoxic disorders and (xii) cardiovascular diseases, including the administration of an effective amount of propargylamine or its medicinally acceptable salts effective to the diseases, abnormalities or states of a patient to a required patient. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供治疗疾病，异常或状态如神经退行性疾病的方法。解决方案：该方法用于治疗选自以下的疾病，异常或状态：（i）神经变性疾病; （二）痴呆症; （iii）精神或情绪异常; （iv）药物依赖; （v）健忘; （vi）急性神经外伤性疾病或神经创伤; （vii）脱髓鞘疾病; （八）阵发性疾病; （ix）脑血管疾病; （x）行为异常（xi）神经毒性疾病和（xii）心血管疾病，包括向所需患者施用有效量的对患者的疾病，异常或状态有效的炔丙胺或其药学上可接受的盐。版权所有（C）2005，JPO＆NCIPI

7. 发明专利

JP2010018626A N-propargyl-1-aminoindan, salt and composition thereof and use thereof 审中-公开
标题翻译： N-丙烷-1-氨基茚，盐及其组合物及其用途
公开(公告)号：JP2010018626A
公开(公告)日：2010-01-28
申请号：JP2009219662
申请日：2009-09-24
申请人： Technion Research & Development Foundation Ltd , Teva Pharmaceutical Industries Ltd , テクニオン・リサーチ・アンド・ディベロップメント・ファウンデーション・リミテッド , テバファーマシューティカルインダストリーズリミテッドTeva Pharmaceutical Industries Ltd.
发明人： YOUDIM MOUSSA B H , FINBERG JOHN P M , LEVY RUTH , STERLING JEFFREY , LERNER DAVID , BERGER-PASKIN TIRTSAH , YELLIN HAIM , VEINBERG ALEX
IPC分类号： A61K31/135 , A61P9/10 , A61K31/137 , A61K31/165 , A61K31/195 , A61K31/215 , A61K45/06 , A61P9/08 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/26 , A61P25/28 , A61P25/30 , A61P25/32 , A61P25/36 , A61P27/02 , A61P37/00 , A61P43/00 , C07C211/30 , C07C211/42
CPC分类号： C07C211/30 , A61K31/195 , A61K31/215 , A61K45/06 , C07C2602/08 , A61K2300/00
摘要： PROBLEM TO BE SOLVED: To provide R(+)-N-propargyl-1-aminoindan and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions containing the same.
SOLUTION: There are provided methods of treating a subject afflicted with Parkinson's disease, a memory disorder, dementia, depression, hyperactive syndrome, an emotional disease, a neurodegenerative disease, a neurotoxic injury, brain ischemia, a head trauma injury, a spinal trauma injury, schizophrenia, an attention deficit disorder, multiple sclerosis, or withdrawal symptoms, using R(+)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof, and methods of preventing nerve damage in a subject. Methods of producing R(+)-N-propargyl-1-aminoindan, a salt thereof, and racemic N-propargyl-1-aminoindan are also provided.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供R（+） - N-炔丙基-1-氨基茚满及其药学上可接受的盐以及含有它们的药物组合物。解决方案：提供了治疗患有帕金森病，记忆障碍，痴呆，抑郁症，多动症综合征，情绪疾病，神经变性疾病，神经毒性损伤，脑缺血，头部创伤损伤，使用R（+） - N-炔丙基-1-氨基茚满或其药学上可接受的盐，以及在受试者中预防神经损伤的方法来治疗脊髓损伤，精神分裂症，注意力缺陷障碍，多发性硬化或戒断症状。还提供了制备R（+） - N-炔丙基-1-氨基茚满及其盐和外消旋N-炔丙基-1-氨基茚满的方法。版权所有（C）2010，JPO＆INPIT

8. 发明专利

ZA8702145B METHOD FOR THE DETECTION OF PREGNANCY DISORDERS 未知
公开(公告)号：ZA8702145B
公开(公告)日：1988-09-26
申请号：ZA8702145
申请日：1987-03-24
申请人： TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD , MICHAEL SILBERMAN
发明人： MICHAEL SILBERMAN
IPC分类号： G01N33/68 , G01N
CPC分类号： G01N33/689 , G01N2800/368

9. 发明专利

DE2647159C2 未知
公开(公告)号：DE2647159C2
公开(公告)日：1985-05-09
申请号：DE2647159
申请日：1976-10-19
申请人： TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD., HAIFA, IL
发明人： ZASLAVSKY, DAN, DR. , BIRAN, GIORA , SINAI, GIDEON, HAIFA, IL
IPC分类号： A01G15/00 , A01G25/00 , A01G25/06 , E02B11/02 , E02B13/00 , E02D19/18 , E02F5/10 , E01C3/06 , E02D3/10 , E02D31/00
摘要： A method for laying subsoil membranes includes dragging a hollow cutting blade through the soil at a predetermined depth, providing a supply of sheeting to the interior of the blade and feeding the sheeting from the interior of the blade through an opening therein. The hollow blade has a cutting edge, a rear edge and an upper section having an upwardly sloping front portion and a downwardly sloping rear portion connected by a center portion. The bottom portion of the blade slopes in an upward direction from its front to form a release angle. The sheet material is fed out of an opening in the rear of the blade.

10. 发明专利

DE8131958U1 未知
公开(公告)号：DE8131958U1
公开(公告)日：1982-10-21
申请号：DE8131958
申请日：1981-11-02
申请人： TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD., 32000 HAIFA, IL
IPC分类号： G02B13/16 , G02B23/12
摘要： A night-vision instrument for presenting a 1:1 image comprises an objective, an image intensifier or converter tube, an ocular, a flat double-sided input mirror, and an optical system adapted to transfer the image appearing on the phosphor screen of the intensifier to the ocular. The ocular axis is in line with the viewed object, while the objective and the intensifier have their axis positioned at a right angle to the viewing axis. The input mirror is positioned in front of the ocular inclined at 45 DEG to its axis and to the axis of the objective, so as to direct the light rays received from the viewed object through the objective onto the cathode of the intensifier. The intensified image appearing on the phosphor screen is directed to the rear side of the input mirror by one single prism, one inclined mirror, one double prism and an optical lens system. The rear side of the input mirror projects the image through the ocular into the eye of the observer. The geometry of the instrument is such that the image of the object appears in the eye under the same visual angle as if viewed from the same distance by the unaided eye, which is obtained by making the distance between the optical center of the input mirror and the eye lens equal to the distance between the said mirror center and the optical center of the objective, and by designing the optical system accordingly.

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