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1. 发明专利

HK1105046A1 REAR PLANE IRRADIATION TYPE IMAGE PICKUP ELEMENT 未知
公开(公告)号：HK1105046A1
公开(公告)日：2008-02-01
申请号：HK07113419
申请日：2007-12-10
申请人： ETOH TAKEHARU , SHIMADZU CORPORATION
IPC分类号： H01L20100101
摘要： Aback illuminated imaging device 1 comprises a plurality charge blocking regions 19 which are arranged on a front surface 12 side, embedded in CCD charge transferring paths 21, and in which a first thickness T1 measured from the front surface 12 of first portions 19a extending along the CCD charge transferring paths 21 is larger than a first thickness T2 of second portions 19b extending along channel stops 20.

2. 发明申请

WO2023078564A1 IMPROVEMENTS IN AND RELATING TO MAGNETIC FIELD NULLING 审中-公开
公开(公告)号：WO2023078564A1
公开(公告)日：2023-05-11
申请号：PCT/EP2021/080826
申请日：2021-11-05
申请人： SHIMADZU CORPORATION , SHIMADZU RESEARCH LABORATORY (EUROPE) LTD
发明人： ANDRZEJEWSKI, Roch
IPC分类号： G01R33/025 , A61B2562/182 , A61B5/245 , G01R33/0094
摘要： An apparatus for nulling a magnetic field within a nulling region in an external ambient magnetic field comprising a plurality of separate magnetic field generating elements (102) are located at separate respective locations surrounding the nulling region for generating respective nulling magnetic fields extending into the nulling region. A plurality of magnetic field sensing elements (103) are positioned at a plurality of respective separate locations within the nulling region for sensing respective values of the magnetic field within the nulling region. A feedback control unit (150) controls the values of the respective nulling magnetic fields generated by each of the plurality of magnetic field generating elements in response to values of the magnetic field sensed by the plurality of magnetic field sensing elements by driving the magnetic field generating elements with respective electric currents that reduce the magnetic field values detected by respective magnetic field sensing elements to values not exceeding a pre-set threshold value corresponding to a pre-set nulling of the magnetic field within the nulling region.

3. 发明申请

WO2023025400A1 IMPROVEMENTS IN AND RELATING TO ION ANALYSIS 审中-公开
公开(公告)号：WO2023025400A1
公开(公告)日：2023-03-02
申请号：PCT/EP2021/073793
申请日：2021-08-27
申请人： SHIMADZU CORPORATION , SHIMADZU RESEARCH LABORATORY (EUROPE) LTD.
发明人： DING, Li , RUSINOV, Aleksandr
IPC分类号： H01J49/02 , H01J49/00
摘要： A method of processing data determined from an image-charge/current signal representative of ions of a given charge state (Q) undergoing oscillatory motion of a respective oscillation frequency (f) within an ion analyser apparatus. A data set comprises a measured signal frequency (f0) common to a plurality of a measured image-charge/current signals and a plurality of estimated ion charge values corresponding to respective amplitudes of each one of the plurality of measured image-charge/current signals. An integer charge value ([Qi]) is generated corresponding to a said estimated ion charge value rounded to the nearest integer value. Using the integer charge value ([Qi]) a plurality of different candidate image-charge/current signal frequency values (fiCand) are calculating according to said selected measured signal frequency (f0) and according to a corresponding one of one or more different candidate charge states of ion (e.g., protonation) and/or of ion isotope or isotopologue. The calculated plurality of different candidate image-charge/current signal frequency values (fiCand) are compared to a plurality of different signal frequencies (f) of the measured image-charge/current signals and a score value is calculated representing a degree of similarity therebetween according to the comparison. The charge state (Q) of the ion undergoing oscillatory motion of said selected measured signal frequency (f0), is then determined to be equal to the integer charge value ([Q̂l]) if the score value matches or exceeds a threshold score value.

4. 发明申请

WO2021038092A1 MASS ANALYSIS APPARATUSES AND METHODS 审中-公开
公开(公告)号：WO2021038092A1
公开(公告)日：2021-03-04
申请号：PCT/EP2020/074164
申请日：2020-08-28
申请人： WEBSTER, Jeremy , SHIMADZU CORPORATION
发明人： GILES, Roger , GILES, Alina
IPC分类号： H01J49/06 , H01J49/40
摘要： A device (1) for manipulating charged particles, the device comprising a series of electrodes (2, 3) that form a channel for transportation of the charged particles. A power supply unit (5, 6) provides a voltage to axially segmented bunching electrodes to create a potential well within the channel having one or more local minima between local maxima (50, 51). The well is translated along the channel. An axial extraction region (54) comprises electrodes defining an end of the channel. They receive a supply voltage to create a pseudo-potential within the channel such that the depth of the potential well varies according to the mass-to-charge ratio (m/z) of the charged particles transported therein and reduces as a local maxima of the potential well is translated axially towards the axial extraction region thereby to release the transported charged particles of different mass-to-charge ratio (m/z) at different respective times.

5. 发明申请

WO2020197943A1 PHOTOIMMUNOTHERAPY AND PHARMACEUTICAL AGENT USED THEREFOR 审中-公开
公开(公告)号：WO2020197943A1
公开(公告)日：2020-10-01
申请号：PCT/US2020/023680
申请日：2020-03-19
申请人： SHIMADZU CORPORATION
发明人： SATO, Taka-Aki , ISHIKAWA, Akihiro , NISHIMURA, Masayuki
IPC分类号： A61P35/00 , A61K45/06 , A61P35/02 , C07K16/30 , C07K16/32 , A61K31/704
摘要： Provided is a method and pharmaceutical agent which make it possible to efficiently implement PIT, and a method characterized by a step of administering a pharmaceutical agent, in which a substance that binds to tumor blood vessel specific marker molecules present in new blood vessels has been conjugated with at least a labeling substance, to an object associated with a disease or pathology, and changing a physical property of the labeling substance after the administration step.

6. 发明申请

WO2019003456A1 ION GUIDING DEVICE AND RELATED METHOD 审中-公开
公开(公告)号：WO2019003456A1
公开(公告)日：2019-01-03
申请号：PCT/JP2017/026695
申请日：2017-07-24
申请人： SHIMADZU CORPORATION
发明人： CHENG, Yupeng , ZHANG, Xiaoqiang , SUN, Wenjian
IPC分类号： H01J49/06
摘要： The present invention provides an ion guiding device and an ion guiding method. The ion guiding device comprises a first electrode assembly, the first electrode assembly comprising two parallel electrode units arranged along a spatial axis; a second electrode assembly, the second electrode assembly comprising at least two non-parallel electrode units arranged in a plane between the parallel electrode units along the spatial axis, wherein a space enclosed by the first electrode assembly and second electrode assembly forms an ion transmission channel along the spatial axis; and, a power supply device, which is configured to apply RF voltages with different polarities to the first electrode assembly and the second electrode assembly to generate a RF electric field in the directions perpendicular to the spatial axis to confine ions, and separately apply DC voltages to the first electrode assembly and the second electrode assembly to generate a certain DC voltage difference, so as to generate a DC electric field along the spatial axis to control the movement of ions. The ion guiding device and the ion guiding method of the present invention realize a curved ion guiding structure, and provide an electric field in both the axial direction and the radial direction.

7. 发明申请

WO2018189911A1 DETECTING METHOD AND DETECTING DEVICE 审中-公开
公开(公告)号：WO2018189911A1
公开(公告)日：2018-10-18
申请号：PCT/JP2017/015388
申请日：2017-04-14
申请人： SHIMADZU CORPORATION
发明人： LEVI, Mikael
IPC分类号： G01N30/88
CPC分类号： G01N30/88 , G01N30/8675 , G01N33/6848 , G01N33/743 , G01N2030/8813
摘要： A detecting method includes detecting simultaneously aldosterone, and a renin proteolysis product and/or a secondary product of the renin proteolysis in a sample using a liquid chromatograph and a mass spectrometer.

8. 发明申请

WO2018114442A1 A TRANSPORT DEVICE FOR TRANSPORTING CHARGED PARTICLES 审中-公开
公开(公告)号：WO2018114442A1
公开(公告)日：2018-06-28
申请号：PCT/EP2017/082286
申请日：2017-12-11
申请人： SHIMADZU CORPORATION , WEBSTER, Jeremy
发明人： GILL, Matthew , GILES, Roger , GILES, Alina
IPC分类号： H01J49/06
摘要： An apparatus for transporting charged particles. The apparatus includes a control unit and a transport device having a plurality of electrodes arranged around a transport channel, wherein the transport channel includes a bunch forming region configured to receive charged particles received by the transport device. The control unit is configured to control voltages applied to the electrodes to generate a transport potential in the transport channel, the transport potential having a plurality of potential wells which are configured to move so as to transport charged particles along the transport channel in one or more bunches. The control unit is further configured to control voltages applied to the electrodes: temporarily generate a gathering potential in the bunch forming region so that charged particles received by the transport device are gathered in the bunch forming region; and then generate the transport potential in the bunch forming region so that a selected potential well is formed in the bunch forming region with the selected potential well receiving a bunch of charged particles formed from the charged particles gathered in the bunch forming region by the gathering potential.

9. 发明申请

WO2017122484A1 ION MOBILITY SPECTROMETRY APPARATUS AND METHOD 审中-公开
标题翻译：离子迁移谱分析仪和方法
公开(公告)号：WO2017122484A1
公开(公告)日：2017-07-20
申请号：PCT/JP2016/087123
申请日：2016-12-13
申请人： SHIMADZU CORPORATION
发明人： ZHANG, Xiaoqiang , SUN, Wenjian
IPC分类号： G01N27/62 , H01J49/00
CPC分类号： H01J49/063 , G01N27/622
摘要： An ion mobility spectrometry apparatus and method are provided, wherein the ion mobility spectrometry apparatus comprises: an ion source for providing ions; an ion guiding device comprising: at least three ends internally communicated: a first guiding end, a second guiding end, and a third guiding end, wherein ions can enter or exit from the ion guiding device from any ends thereof, the first guiding end is used for entrance of ions provided by the ion source, and the third guiding end is communicated with a downstream device; at least one drift cell in correspondence to the second guiding end, for transmitting ions and/or performing ion mobility analysis, each drift cell comprising a first end and a second end which are internally communicated, wherein the second end of drift cell is communicated with said second guiding end; an ion storage device communicated with said first end of drift cell, for storing ions or ejecting ions. By selecting different ion paths, ion mobility spectrometry analysis may be performed, or direct ion transmission may be performed.
摘要翻译：提供了一种离子迁移率光谱测量设备和方法，其中该离子迁移率光谱测量设备包括：用于提供离子的离子源; 一种离子导向装置，包括：内部连通的至少三个端部：第一导向端，第二导向端和第三导向端，其中离子可以从离子导向装置的任何端部进入或离开离子导向装置，第一导向端是用于进入离子源提供的离子，第三引导端与下游装置连通; 至少一个对应于第二引导端的漂移单元，用于传输离子和/或执行离子迁移率分析，每个漂移单元包括内部连通的第一端和第二端，其中漂移单元的第二端与所述第二引导端; 与漂移单元的所述第一端连通的离子存储装置，用于存储离子或喷射离子。通过选择不同的离子路径，可以执行离子迁移谱分析，或者可以执行直接离子传输。

10. 发明申请

WO2015173616A1 MASS ANALYSER 审中-公开
标题翻译：质量分析仪
公开(公告)号：WO2015173616A1
公开(公告)日：2015-11-19
申请号：PCT/IB2015/000609
申请日：2015-04-29
申请人： SHIMADZU CORPORATION
发明人： DING, Li , RUSINOV, Aleksandr
IPC分类号： H01J49/40 , H01J49/28 , H01J49/06
CPC分类号： H01J49/401 , H01J49/065 , H01J49/067 , H01J49/068 , H01J49/282 , H01J49/406
摘要： A mass analyser comprises a pair of electrode arrays. Each array has a set of focusing electrodes which are supplied, in use, with voltage to create an electrostatic field in a space between the electrode arrays causing ions to undergo periodic, oscillatory motion in the space, ions passing between electrodes of the sets of focusing electrodes and being repeatedly focused at a centre plane, mid- way between the electrode arrays. At least one electrode of each set of focusing electrodes has an electrode surface closer to the centre plane than the electrode surfaces of other electrodes of the same set. The analyser may be an ion trap mass analyser or a multi-turn ToF mass analyser.
摘要翻译：质量分析器包括一对电极阵列。每个阵列具有一组聚焦电极，其在使用中被提供电压以在电极阵列之间的空间中产生静电场，导致离子在空间中经历周期性的振荡运动，离子通过聚焦组的电极之间电极并且在电极阵列之间的中间反复聚焦在中心平面处。每组聚焦电极的至少一个电极具有比相同组的其它电极的电极表面更靠近中心平面的电极表面。分析仪可以是离子阱质谱仪或多圈ToF质谱仪。

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