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1. 发明专利

AT10427T 未知
公开(公告)号：AT10427T
公开(公告)日：1984-12-15
申请号：AT82810401
申请日：1982-09-24
申请人： SCHERING-PLOUGH CORPORATION
发明人： BUTTON, STANLEY JAMES
IPC分类号： A43B9/00

2. 发明申请

WO2003053365A3 SYN3 COMPOSITIONS AND METHODS 审中-公开
公开(公告)号：WO2003053365A3
公开(公告)日：2003-07-03
申请号：PCT/US2002/041198
申请日：2002-12-20
申请人： SCHERING-PLOUGH CORPORATION , IHNAT, Peter, M. , WITCHEY-LAKSHMANAN, Leonore, C. , SANDWEISS, Varda , UGWU, Sydney, O.
发明人： IHNAT, Peter, M. , WITCHEY-LAKSHMANAN, Leonore, C. , SANDWEISS, Varda , UGWU, Sydney, O.
IPC分类号： C12N15/00
摘要： Disclosed are aqueous and nonaqueous solution formulations containing agents that are useful for treating cancer.

3. 发明申请

WO2003053365A2 SYN3 COMPOSITIONS AND METHODS 审中-公开
标题翻译： SYN3组成和方法
公开(公告)号：WO2003053365A2
公开(公告)日：2003-07-03
申请号：PCT/US2002/041198
申请日：2002-12-20
申请人： SCHERING-PLOUGH CORPORATION , IHNAT, Peter, M. , WITCHEY-LAKSHMANAN, Leonore, C. , SANDWEISS, Varda , UGWU, Sydney, O.
发明人： IHNAT, Peter, M. , WITCHEY-LAKSHMANAN, Leonore, C. , SANDWEISS, Varda , UGWU, Sydney, O.
IPC分类号： A61K
CPC分类号： A61K31/7028 , A61K9/0019 , A61K9/19 , A61K31/70 , A61K31/704 , A61K38/212 , A61K47/10 , A61K47/12 , A61K47/18 , A61K47/26 , A61K48/00 , A61K48/0008 , C07J41/0061 , C12N15/86 , C12N2710/10343 , C12N2710/10351
摘要： Disclosed are aqueous and nonaqueous solution formulations containing agents that are useful for treating cancer.
摘要翻译：公开了含有可用于治疗癌症的药剂的含水和非水溶液制剂。

4. 发明授权

US07846946B2 Heteroatom-linked substituted piperidines and derivatives thereof useful as histamine H3 antagonists 失效
标题翻译：杂原子取代的哌啶及其衍生物可用作组胺H3拮抗剂
公开(公告)号：US07846946B2
公开(公告)日：2010-12-07
申请号：US12507563
申请日：2009-07-22
申请人： Robert G. Aslanian , Michael Y. Berlin , Christopher W. Boyce , Jianhua Chao , Manuel de Lera Ruiz , Pietro Mangiaracina , Kevin D. McCormick , Mwangi W. Mutahi , Stuart B. Rosenblum , Neng-Yang Shih , Daniel M. Solomon , Wing C. Tom , Henry A. Vaccaro , Junying Zheng , Xiaohong Zhu
发明人： Robert G. Aslanian , Michael Y. Berlin , Christopher W. Boyce , Jianhua Chao , Manuel de Lera Ruiz , Pietro Mangiaracina , Kevin D. McCormick , Mwangi W. Mutahi , Stuart B. Rosenblum , Neng-Yang Shih , Daniel M. Solomon , Wing C. Tom , Henry A. Vaccaro , Junying Zheng , Xiaohong Zhu
IPC分类号： A61K31/4545 , C07D401/14
CPC分类号： C07D295/185 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , Y02P20/582
摘要： Disclosed are novel compounds of the formula or a pharmaceutically acceptable salt thereof, wherein: M1 and M3 are CH or N; M2 is CH, CF or N; Y is —C(═O)—, —C(═S)—, —(CH2)q—, —C(═NOR7)— or —SO1-2—; Z is a bond or optionally substituted alkylene or alkenylene; R1 is H, or alkyl, cycloalkyl, aryl, heteroaryl, heterocycloalkyl, all optionally substituted, or a group of the formula: where ring A is a heteroaryl ring; R2 is optionally substituted alkyl, alkenyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl; R3 is H, —C(O)NH2, or alkyl, aryl, cycloalkyl, heterocycloalkyl or heteroaryl, all optionally substituted; and the remaining variables are as defined in the specification; compositions and methods of treating allergy-induced airway responses, congestion, obesity, metabolic syndrome, alcoholic fatty liver disease, hepatic steatosis, nonalcoholic steatohepatitis, cirrhosis, hepatacellular carcinoma and cognition deficit disorders using said compounds, alone or in combination with other agents.
摘要翻译：公开了下式的新化合物或其药学上可接受的盐，其中：M1和M3是CH或N; M2是CH，CF或N; Y是-C（= O） - ， - C（= S） - ， - （CH 2）q - ， - C（= NOR 7） - 或-SO 1 2- Z是键或任选取代的亚烷基或亚烯基; R 1是H或烷基，环烷基，芳基，杂芳基，杂环烷基，全部被取代，或下式的基团：其中环A是杂芳基环; R 2是任选取代的烷基，烯基，芳基，杂芳基，环烷基或杂环烷基; R 3是H，-C（O）NH 2或烷基，芳基，环烷基，杂环烷基或杂芳基，全部被取代; 剩余的变量如规范中所定义; 使用所述化合物单独或与其它试剂组合治疗过敏引起的气道反应，充血，肥胖，代谢综合征，酒精性脂肪肝疾病，肝脂肪变性，非酒精性脂肪性肝炎，肝硬化，肝细胞癌和认知缺陷障碍的组合物和方法。

5. 发明申请

US20050176648A1 Novel peptides as NS3-serine protease inhibitors of hepatitis C virus 有权
标题翻译：新型肽作为丙型肝炎病毒的NS3-丝氨酸蛋白酶抑制剂
公开(公告)号：US20050176648A1
公开(公告)日：2005-08-11
申请号：US11089192
申请日：2005-03-24
申请人： Anil Saksena , Viyyoor Girijavallabhan , Stephane Bogen , Raymond Lovey , Edwin Jao , Frank Bennett , Jinping McCormick , Haiyan Wang , Russell Pike , Yi-Tsung Liu , Tin-Yau Chan , Zhaoning Zhu , Ashok Arasappan , Kevin Chen , Srikanth Venkatraman , Tejal Parekh , Patrick Pinto , Bama Santhanam , F. Njoroge , Ashit Ganguly , Henry Vaccaro , Scott Kemp , Odile Levy , Marguerita Lim-Wilby , Susan Tamura
发明人： Anil Saksena , Viyyoor Girijavallabhan , Stephane Bogen , Raymond Lovey , Edwin Jao , Frank Bennett , Jinping McCormick , Haiyan Wang , Russell Pike , Yi-Tsung Liu , Tin-Yau Chan , Zhaoning Zhu , Ashok Arasappan , Kevin Chen , Srikanth Venkatraman , Tejal Parekh , Patrick Pinto , Bama Santhanam , F. Njoroge , Ashit Ganguly , Henry Vaccaro , Scott Kemp , Odile Levy , Marguerita Lim-Wilby , Susan Tamura
IPC分类号： C12N9/99 , A61K31/16 , A61K31/195 , A61K31/27 , A61K31/357 , A61K31/385 , A61K31/403 , A61K31/4164 , A61K31/445 , A61K31/7052 , A61K38/00 , A61K38/05 , A61K38/21 , A61K38/55 , A61K45/00 , A61P1/16 , A61P31/12 , A61P31/14 , A61P43/00 , C07C205/51 , C07C229/00 , C07D209/02 , C07K5/02 , C07K5/103 , C07K7/02 , C07K7/04 , C07K7/06 , A61K38/06 , A61K31/165 , A61K38/08
CPC分类号： C07K7/06 , A61K31/16 , A61K31/195 , A61K31/27 , A61K31/357 , A61K31/385 , A61K31/403 , A61K31/4164 , A61K31/445 , A61K38/05 , C07C205/51 , C07K5/101 , C07K7/02 , A61K2300/00
摘要： The present invention discloses novel peptide compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译：本发明公开了具有HCV蛋白酶抑制活性的新型肽化合物及其制备方法。在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。

6. 发明申请

US20040067950A1 High affinity ligands for nociceptin receptor ORL-1 审中-公开
标题翻译：伤害感受器受体ORL-1的高亲和力配体
公开(公告)号：US20040067950A1
公开(公告)日：2004-04-08
申请号：US10464580
申请日：2003-06-17
申请人： Schering-Plough Corporation
发明人： Deen Tulshian , Ginny D. Ho , Lisa S. Silverman , Julius J. Matasi , Robbie L. McLeod , John A. Hey , Richard W. Chapman , Ana Bercovici , Francis M. Cuss
IPC分类号： A61K031/517 , A61K031/498 , A61K031/4439 , C07D43/02
CPC分类号： A61K31/4535 , A61K31/00 , A61K31/438 , A61K31/439 , A61K31/451 , A61K31/454 , A61K45/06
摘要： The present invention relates to the method of treating cough with ORL-1 agonists, alone or in combination with additional agents for treating symptoms of cough, allergy or asthma, pharmaceutical compositions comprising the combinations, and to compounds of the formula 1 or a pharmaceutically acceptable salt or solvate thereof, wherein: the dotted line represents an optional double bond; X1 is optionally substituted alkyl, cycloalkyl, aryl, heteroaryl or heterocycloalkyl; X2 is nullCHO, nullCN, optionally substituted amino, alkyl, or aryl; or X1 is optionally substituted benzofused heterocyclyl and X2 is hydrogen; or X1 and X2 together form an optionally benzofused spiro heterocyclyl group R1, R2, R3 and R4 are independently H and alkyl, or (R1 and R4) or (R2 and R3) or (R1 and R3) or (R2 and R4) together can form an alkylene bridge of 1 to 3 carbon atoms; Z1 is optionally substituted alkyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl, or nullCO2(alkyl or substituted amino) or CN ; Z2 is H or Z1; Z3 is H or alkyl; or Z1, Z2 and Z3, together with the carbon to which they are attached, form bicyclic saturated or unsaturated rings; pharmaceutical compositions therefore, and the use of said compounds as nociceptin receptor inhibitors useful in the treatment of pain, anxiety, cough, asthma, depression and alcohol abuse.
摘要翻译：本发明涉及用ORL-1激动剂治疗咳嗽的方法，其单独或与另外用于治疗咳嗽，过敏或哮喘症状的药物组合，包含该组合的药物组合物，以及下式的化合物或其药学上可接受的盐或其溶剂合物，其中：虚线表示任选的双键; X 1是任选取代的烷基，环烷基，芳基，杂芳基或杂环烷基; X 2是-CHO，-CN，任选取代的氨基，烷基或芳基; 或X 1是任选取代的苯并稠合的杂环基，X 2是氢; 或X 1和X 2一起形成任选的苯并稠合的螺杂环基R 1，R 2，R 3和R 4独立地为H和烷基，或（R 1和 R 4）或（R 2和R 3）或（R 1和R 3）或（R 2和R 4）可以形成1至 3个碳原子; Z 1是任选取代的烷基，芳基，杂芳基，环烷基或杂环烷基，或-CO 2（烷基或取代的氨基）或CN; Z 2是H或Z 1; Z 3是H或烷基; 或Z 1，Z 2和Z 3与它们所连接的碳一起形成双环饱和或不饱和环; 因此，药物组合物以及所述化合物用作疼痛，焦虑，咳嗽，哮喘，抑郁和酒精滥用的伤害感受肽受体抑制剂的用途。

7. 发明授权

US5686646A Chiral hydrazine derivatives 失效
标题翻译：手性肼衍生物
公开(公告)号：US5686646A
公开(公告)日：1997-11-11
申请号：US448151
申请日：1995-05-23
申请人： David R. Andrews , Anantha Sudhakar
发明人： David R. Andrews , Anantha Sudhakar
IPC分类号： C07C243/14 , C07C243/28 , C07C271/08
CPC分类号： C07C243/28 , C07C243/14 , Y02P20/55
摘要： Disclosed are chiral hydrazine derivatives of the formula (Ia), (Ib), (Ic) and (Id) ##STR1## wherein: R.sup.1 and R.sup.2 are independently C.sub.1 -C.sub.10 alkyl; R.sup.3 is H or R.sup.4 wherein R.sup.4 is a hydroxy protecting group; and Z is H, --CHO, --C(O)OC(CH.sub.3).sub.3 or --C(O)OCH.sub.2 C.sub.6 H.sub.5.Also described is a process for preparing chiral hydrazines of the formula (Ia), (Ib), (Ic) and (Id).
摘要翻译：公开了式（Ia），（Ib），（Ic）和（Id）的手性肼衍生物其中：R 1和R 2独立地为C 1 -C 10烷基; R3是H或R4，其中R4是羟基保护基; Z是H，-CHO，-C（O）OC（CH 3）3或-C（O）OCH 2 C 6 H 5。还描述了制备式（Ia），（Ib），（Ic）和（Id）的手性肼的方法。

8. 发明授权

US5391706A Purification of GM-CSF 失效
标题翻译： GM-CSF的纯化
公开(公告)号：US5391706A
公开(公告)日：1995-02-21
申请号：US125356
申请日：1993-09-21
申请人： Paul P. Trotta , Gail F. Seelig , Robert A. Kosecki , Paul Reichert
发明人： Paul P. Trotta , Gail F. Seelig , Robert A. Kosecki , Paul Reichert
IPC分类号： C07K14/535 , C07K3/20
CPC分类号： C07K14/535
摘要： A method of purifying granulocyte-macrophage colony-stimulating factor (GM-CSF), particularly recombinant human GM-CSF, in good yield and with retention of biological activity, comprising sequential anion-exchange, dye-ligand affinity, gel filtration and reversed-phase chromatography is disclosed.
摘要翻译：一种纯化粒细胞巨噬细胞集落刺激因子（GM-CSF），特别是重组人GM-CSF的方法，具有良好的产量和保留生物活性，包括顺序阴离子交换，染料 - 配体亲和力，凝胶过滤，公开了相色谱法。

9. 发明授权

US4011390A Semi-synthetic aminocyclitol aminoglycoside antibiotics and methods for the preparation thereof 失效
标题翻译：半合成氨基磺酰胺氨基酰胺抗生素及其制备方法
公开(公告)号：US4011390A
公开(公告)日：1977-03-08
申请号：US476638
申请日：1974-06-05
申请人： Marvin J. Weinstein , Peter J. L. Daniels , Gerald H. Wagman , Raymond Testa
发明人： Marvin J. Weinstein , Peter J. L. Daniels , Gerald H. Wagman , Raymond Testa
IPC分类号： C07H15/236 , C07H15/22
CPC分类号： C07H15/236 , Y10S435/863
摘要： Micromonospora inyoensis strain 1550F-1G NRRL 5742 is incapable of producing antibiotics unless an aminocyclitol is added to the fermentation medium. When such a compound is added, mutamicins are produced, said mutamicins being analogs of known aminoglycoside antibiotics differing therefrom with respect to the aminocyclitol subunit.

10. 发明申请

US20110034705A1 Process For the Synthesis of 3- Amino-3-Cyclobuthylmethyl-2-Hydroxypropionamide or Salts Thereof 失效
标题翻译： 3-氨基-3-环丙基甲基-2-羟基丙酰胺或其盐的合成方法
公开(公告)号：US20110034705A1
公开(公告)日：2011-02-10
申请号：US12809775
申请日：2008-12-17
申请人： Shuan Dong , Jeonghan Park , Eugene John Vater
发明人： Shuan Dong , Jeonghan Park , Eugene John Vater
IPC分类号： C07D209/52 , C07C231/06
CPC分类号： C07C231/12 , C07C2601/04 , C07C237/14
摘要： A process for preparing 3-amino-3-cyclobutylmethyl-2-hydroxypropionamide of the Formula I: or a salt thereof involves providing a compound of the Formula VI described herein in a solution comprising predominately dimethylsulfoxide (DMSO) and converting this compound directly to the compound of the Formula VIII described herein without working up or isolating the intermediate compound of the Formula VII described herein.
摘要翻译：制备式I的3-氨基-3-环丁基甲基-2-羟基丙酰胺或其盐的方法包括提供本文所述的式VI化合物在主要包含二甲基亚砜（DMSO）的溶液中，并直接将该化合物转化为本文所述的式VIII的化合物，而不处理或分离本文所述的式VII的中间体化合物。

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