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1. 发明申请

WO2009071829A3 CONNECTION OF AN ACCESSORY TO A VESSEL 审中-公开
标题翻译：附件到船只的连接
公开(公告)号：WO2009071829A3
公开(公告)日：2009-07-30
申请号：PCT/FR2008052117
申请日：2008-11-24
申请人： SARTORIUS STEDIM BIOTECH SA , BERNARD FREDERIC , CHEVALIER ERIC
发明人： BERNARD FREDERIC , CHEVALIER ERIC
IPC分类号： A61J1/14 , A61M39/18 , C12M1/34
CPC分类号： G01D11/245 , A61J1/10 , A61J1/1475 , C12M23/48 , G01L19/14 , Y10T29/49826
摘要： The invention relates to a device (1) for connecting to a vessel (2) an accessory having an active portion (9) that comprises a first member (15), a second member (16), a third member (17) and a chamber (18). The function of the first member (15) is to ensure the rigid attachment of the connection device (1) to the vessel (2), to define a passageway, to act as a holder for the second member (16) and as a translation guide between a first distal state and a second proximal state, to contribute as a guide for the third member (17) and to participate in the definition of the chamber (18). The function of the second member (16) is to act as a holder for the third member (17) which is rigidly attached thereon, to define a mobile member capable of sliding between the first distal state and the second proximal state. The function of the third member (17), that comprises a head (14), is to act as a holder for the accessory (3) which is rigidly attached thereon, to define a mobile member capable of sliding between the first distal state and the second proximal state, to ensure in the first distal state the tight closing of the opening (7) using the head (14), to ensure in the second proximal state a protection of the active proximal portion (9) using the head (14), and to participate in the definition of the chamber (18). The chamber (18) is tightly closed in the first distal state and, in the second proximal state, communicates with the inside (4), and the function of the chamber is to house therein or to place at the periphery thereof the active proximal portion (9), to contain a storage liquid, to contain a liquid for adjusting, controlling or calibrating the accessory (3), or to define a tightly closed chamber in which the accessory (3) is placed before being used.
摘要翻译：本发明涉及一种用于连接到容器（2）的装置（1），具有活动部分（9）的附件包括第一部件（15），第二部件（16），第三部件（17）和室（18）。第一构件（15）的功能是确保连接装置（1）与容器（2）的刚性附接，以限定通道，用作第二构件（16）的保持器和翻译在第一远端状态和第二近端状态之间的引导，作为第三构件（17）的引导件并且参与腔室（18）的定义。第二构件（16）的功能是用作刚性地附接在其上的第三构件（17）的保持器，以限定能够在第一远侧状态和第二近端状态之间滑动的移动构件。包括头部（14）的第三构件（17）的功能是用作刚性地附接在其上的附件（3）的保持器，以限定能够在第一远端状态和第二近端状态，以确保在第一远侧状态下使用头部（14）紧密关闭开口（7），以确保在第二近端状态下使用头部（14）保护主动近端部分（9）），并参与对房间的定义（18）。腔室（18）在第一远侧状态下紧密地关闭，并且在第二近端状态下与内部（4）连通，并且腔室的功能将容纳在其中或者在其周围放置主动近端部分（9），以容纳储存液体，以容纳用于调节，控制或校准附件（3）的液体，或者在使用之前限定其中放置附件（3）的紧密封闭的室。

2. 发明申请

WO2010100387A2 ASSEMBLY HAVING A SELF-CLAMPING SKIRT FOR CLOSING AN ANNULAR COLLAR OR CONNECTING TO SAME, WHICH CAN BE RAPIDLY POSITIONED AND REMOVED, AND USED IN THE BIOPHARMACEUTICAL FIELD 审中-公开
标题翻译：具有用于闭合环形胶片或连接到相同的自动夹持装置的组件，其可以被快速定位和移除并且用于生物医学领域
公开(公告)号：WO2010100387A2
公开(公告)日：2010-09-10
申请号：PCT/FR2010050382
申请日：2010-03-05
申请人： SARTORIUS STEDIM BIOTECH SA , BERNARD FREDERIC , CHEVALIER ERIC
发明人： BERNARD FREDERIC , CHEVALIER ERIC
IPC分类号： F16J13/06
CPC分类号： B65D43/0216 , B65D41/16 , B65D43/0218 , B65D88/26 , B65D88/54 , B65D88/68 , B65D90/00 , B65D90/046 , B65D90/56 , B65D2590/046 , F16J13/06 , Y10T29/49826
摘要： The invention relates to a first assembly piece (1) to be mounted in a fixed, detachable, and sealed manner, on a rigid, annular collar (8) of a second piece (2) having an end opening (3), the first piece (1) comprising an annular peripheral wall (15) having an inner face (15a) that can come into contact with the outer face (10) of the collar (8). Said first piece is designed such that it comprises a transversal wall (14) that is either continuous and full or has at least one through-opening (23) that enters the opening (3); and an annular wall forming a skirt (15), the inner face (15a) of said skirt including a part (39a) with a larger diameter, a part (39b) with a smaller diameter and an intermediate part (39c) that can come into contact with the conjugated parts (10a, 10b et 10c) of the outer face (10) by clamping in a holding manner. The transversal wall (14) and the skirt (15) form one component and are made of a material providing an intrinsic tightness for the biopharmaceutical field. Said material has a high degree of flexibility enabling the first piece (1), that has a natural determined shape in the inactive state, to be bent with a large amplitude, by a manual external action, without causing any deterioration. Said material has a stretching capacity in an elastic deformation range such that the first piece (1) can be brought from the inactive state into an intermediate state wherein, remaining in the elastic deformation range, it is transversally stretched and sufficiently enlarged to be slipped over or removed from the second piece (2), and in the active state wherein the first piece (1) is mounted on the second piece (2), the parts (39a, 39b and 39c) of the skirt (15) come into contact with the conjugated parts (10a, 10b et 10c) of the outer face (10) of the collar (8) of the second piece (2), by elastic clamping in a holding and sealing manner. The invention can be applied to rigid and tight connections and fittings in the biopharmaceutical field.
摘要翻译：本发明涉及一种以固定，可拆卸和密封的方式安装在具有端部开口（3）的第二件（2）的刚性环形套环（8）上的第一组件（1），第一组件（1）包括具有可与套环（8）的外表面（10）接触的内表面（15a）的环形周壁（15）。所述第一件被设计成使得其包括连续且满的横向壁（14），或具有进入开口（3）的至少一个通孔（23）; 和形成裙部（15）的环形壁，所述裙部的内表面（15a）包括具有较大直径的部分（39a），具有较小直径的部分（39b）和可以到达的中间部分（39c）通过夹持方式与外表面（10）的共轭部分（10a，10b等）10c接触。横向壁（14）和裙部（15）形成一个部件，并且由为生物药物领域提供固有密封性的材料制成。所述材料具有高度的灵活性，使得能够通过手动外部动作以具有大幅度弯曲的处于无效状态的自然确定形状的第一部件（1）不会发生任何劣化。所述材料具有在弹性变形范围内的拉伸能力，使得第一片（1）可以从非活性状态变成中间状态，其中保持在弹性变形范围内，其被横向拉伸并充分扩大以滑动或从第二件（2）移除，并且在第一件（1）安装在第二件（2）上的活动状态下，裙部（15）的部件（39a，39b和39c）接触与第二部件（2）的轴环（8）的外表面（10）的共轭部分（10a，10b等于10c）通过以保持和密封的方式弹性夹紧。本发明可以应用于生物制药领域中刚性和紧密的连接和配件。

3. 发明申请

WO2011051638A3 MULTILAYER FILM OF A WALL OF A BAG HAVING SEAMS AND INTENDED FOR A BIOPHARMACEUTICAL PRODUCT 审中-公开
标题翻译：具有海绵的袋子的多层薄膜和针对生物制品产品
公开(公告)号：WO2011051638A3
公开(公告)日：2011-09-01
申请号：PCT/FR2010052336
申请日：2010-10-29
申请人： SARTORIUS STEDIM BIOTECH SA , BARBAROUX MAGALI , CHEVALIER ERIC , WASTERLAIN STEVE
发明人： BARBAROUX MAGALI , CHEVALIER ERIC , WASTERLAIN STEVE
IPC分类号： B32B27/08 , B32B37/20 , B65D65/40 , C08J5/18
CPC分类号： B32B27/08 , B32B2307/7242 , B32B2439/46 , B65D65/40 , Y10T428/31913
摘要： The invention relates to a single-layer contact film (8) intended, once secured to a multilayer functional film (9), for forming a final multilayer film (7) of a wall (2) of a bag (1); the bag (1) comprising seams (3) at least on said bag and intended for being filled with a biopharmaceutical product, made of a material selected so as to be suitable for: being used in the formation of a final multilayer film (7) of a wall of a bag; being in contact with the biopharmaceutical product, without damaging the film (7) and the biopharmaceutical product; being sealable on the bag, having a thickness that is less than the thickness of a single contact layer of a final multilayer film (7) of a wall of a bag suitable for the formation of seams of the single contact layer on said layer, one of the surfaces of which has the purpose of providing a securing interface with a first securing interface of the multilayer functional film (9), the other of the surfaces having the ultimate purpose of forming the contact surface between the final multilayer film and the biopharmaceutical product.
摘要翻译：本发明涉及一旦固定到多层功能膜（9）上以形成袋（1）的壁（2）的最终多层膜（7）的单层接触膜（8）; 所述袋（1）至少在所述袋上包括接缝（3），并且用于填充生物药物产品，所述生物药物产品由选择为适合于用于形成最终多层膜（7）的材料制成; 一个袋子的墙壁; 与生物药物产品接触，而不损害膜（7）和生物药物产品; 在袋子上可密封，其厚度小于适于在所述层上形成单个接触层的接缝的袋壁的最终多层膜（7）的单个接触层的厚度，一个其表面的目的是提供与多层功能膜（9）的第一固定界面的固定界面，另一个表面具有在最终多层膜和生物药物产品之间形成接触表面的最终目的。

4. 发明申请

WO2010100388A3 ASSEMBLY HAVING A HOLDING TORIC BODY FOR CLOSING AN ANNULAR COLLAR, OR CONNECTING TO SAME 审中-公开
标题翻译：具有闭合环状胶片或与之连接的保持性体温的组件
公开(公告)号：WO2010100388A3
公开(公告)日：2010-11-04
申请号：PCT/FR2010050383
申请日：2010-03-05
申请人： SARTORIUS STEDIM BIOTECH SA , BERNARD FREDERIC , CHEVALIER ERIC
发明人： BERNARD FREDERIC , CHEVALIER ERIC
IPC分类号： F16J13/06
CPC分类号： F16J13/065 , B65D88/26 , B65D88/54 , B65D88/68 , B65D90/00 , B65D90/046 , B65D90/56 , B65D2590/046 , F16J15/46
摘要： The invention relates to a piece (1) mounted in a fixed and rigid manner on a rigid annular collar (8) of a second piece (2) having an end opening (3). Said piece (1) comprises a transversal wall (14); an annular wall forming a skirt (15), the inner face (15a) of said skirt including a part (39a) having a larger diameter and a part (39b) having a smaller diameter; a holding toric body (45) adjacent to the inner face (15a), deformable between a retracted state and an expanded state, and filled with a swelling medium; and at least one inlet/outlet port (46) for the swelling media, communicating with the holding body (45). The dimensions of the first piece are selected in relation to those of the collar (8), in such a way as to enable the first piece to be able to be slipped onto, or removed from, the second piece (2), when the holding body (45) is in the retracted state, and to be mounted onto the collar (8) in a fixed, rigid and tight manner, when the holding body (45) is in the expanded state.
摘要翻译：本发明涉及一种以固定和刚性方式安装在具有端部开口（3）的第二件（2）的刚性环形套环（8）上的件（1）。所述片（1）包括横向壁（14）; 形成裙部（15）的环形壁，所述裙部的内表面（15a）包括具有较大直径的部分（39a）和具有较小直径的部分（39b）; 相对于内表面（15a）的保持复曲面体（45），在缩回状态和膨胀状态之间可变形，并且填充有溶胀介质; 和用于溶胀介质的至少一个入口/出口（46），与保持体（45）连通。第一件的尺寸相对于套环（8）的尺寸选择为使得第一件能够被滑动到第二件（2）上或从第二件（2）移除时，当第保持体（45）处于缩回状态，并且当保持体（45）处于展开状态时，以固定，刚性和紧密的方式安装到轴环（8）上。

5. 发明申请

WO2009118494A2 3D CONTAINER WITH RIGID FRAME, DEFORMABLE CONTAINER AND FUNCTIONAL MEANS FOR PROCESSING THE CONTENT AND INCLUDING AN INNER MEMBER FOR BIOPHARMACEUTICAL APPLICATIONS 审中-公开
标题翻译：具有刚性框架的3D容器，可变容器和用于处理内容的功能手段，并且包括用于生物应用的内部成员
公开(公告)号：WO2009118494A2
公开(公告)日：2009-10-01
申请号：PCT/FR2009050313
申请日：2009-02-27
申请人： SARTORIUS STEDIM BIOTECH SA , BARBAROUX MAGALI DOMINIQUE COR , CHEVALIER ERIC , GAY ISABELLE VALERIE CHRISTINE
发明人： BARBAROUX MAGALI DOMINIQUE CORINNE , CHEVALIER ERIC , GAY ISABELLE VALERIE CHRISTINE
IPC分类号： B65D37/00 , A61J1/10 , B65D85/00 , B65D88/16 , B65D90/20
CPC分类号： B65D77/06 , A61J1/05 , B01F7/163 , B01F15/00831 , B01F15/0085 , B65D21/086 , B65D37/00 , B65D88/16 , B65D88/68 , B65D90/205
摘要： According to the invention, the frame defines an inner space and comprises a peripherally closed side wall and two transverse openings or one transverse opening and an end transverse wall. The frame is adapted for ensuring the sealed connection of the open free edge of a side wall in the form of a film of an at least partially deformable container. The frame is specially adapted for making a 3D container. The frame can further be used as a bearing for at least one functional port or port for attaching a functional means. The axial size thereof is sufficient for defining a space having dimensions at least equal to the axial overall dimensions of the functional means so that the latter can be entirely housed within the inner space.
摘要翻译：根据本发明，框架限定内部空间并且包括周向封闭的侧壁和两个横向开口或一个横向开口和端部横向壁。框架适于确保以至少部分可变形的容器的薄膜形式的侧壁的敞开的自由边缘的密封连接。该框架专门用于制作3D容器。该框架还可以用作用于至少一个用于附接功能装置的功能端口的轴承。其轴向尺寸足以限定具有至少等于功能装置的轴向总体尺寸的尺寸的空间，使得后者可以完全容纳在内部空间内。

6. 发明申请

WO2011039472A3 PRODUCTION OF A BIOPHARMACEUTICAL PRODUCT 审中-公开
标题翻译：生产生物制品
公开(公告)号：WO2011039472A3
公开(公告)日：2012-03-22
申请号：PCT/FR2010052048
申请日：2010-09-29
申请人： SARTORIUS STEDIM BIOTECH SA , BARBAROUX MAGALI , DOREY SAMUEL , GUENERON MAREVA , REIF OSCAR
发明人： BARBAROUX MAGALI , DOREY SAMUEL , GUENERON MAREVA , REIF OSCAR
IPC分类号： C12M1/00
CPC分类号： C12M23/14 , C12M29/00 , C12M29/04
摘要： The invention relates to a method for producing a biopharmaceutical product, consisting in: obtaining a pouch unit (1) including a pouch (2) and at least one port (4) and, where necessary, a functional device (5); filling the pouch (2) with a biopharmaceutical product or components thereof; carrying out the production process and, at at least one moment or step thereof, using or generating a liquid or small solid incident body located inside the biopharmaceutical product; arranging the pouch unit (1) which includes a support and exchange means (6) formed by, or incorporated into the wall (3) of the pouch (2) or into the at least one port (4) or functional device (5), such that this means can be accessed from the internal space (2a) and can be in direct physical contact with the contents of the pouch (2), whereby said means is arranged so that it can be loaded with the incident body and can allow the passage of the body from the support and exchange means (6) into the contents and vice versa, said means being functionally active either permanently or following a dedicated activation operation; and using the pouch unit (1) such that the support and exchange means is in direct physical contact with the contents and such that, when said means is active, the incident body passes from the support and exchange means (6) into the contents and vice versa, and, consequently, the incident body is loaded on the support and exchange means (6) when it is not, or should not be, inside the biopharmaceutical product.
摘要翻译：本发明涉及一种用于生产生物药物产品的方法，包括：获得包括袋（2）和至少一个端口（4）的袋单元（1），并且在必要时获得功能装置（5）; 用生物药物产品或其组分填充袋（2）; 执行生产过程，并且在其至少一个时刻或步骤，使用或产生位于生物药物产品内部的液体或小固体入口体; 将包括由袋子（2）形成或组合到袋（2）的壁（3）中的支撑件和交换装置（6）或包含至少一个端口（4）或功能装置（5）的袋单元（1），使得可以从内部空间（2a）访问该装置并且可以与袋（2）的内容物直接物理接触，由此所述装置被布置成使得其可以装载入射体并且可以允许身体从支撑件和交换装置（6）通过到内容物中，反之亦然，所述装置在功能上永久地或者在专用激活操作之后起作用; 并且使用所述袋单元（1）使得所述支撑和交换装置与所述内容物直接物理接触，并且使得当所述装置有效时，所述入射体从所述支撑件和交换装置（6）传入所述内容物中，并且反之亦然，因此，当生物制药产品中不存在或不应该存在时，入射体被装载在支撑和交换装置（6）上。

7. 发明授权

US07784997B2 Closed single-use system for mixing, storing and homogenizing liquids in clean or sterile conditions 有权
标题翻译：用于在清洁或无菌条件下混合，储存和均化液体的封闭的一次性系统
公开(公告)号：US07784997B2
公开(公告)日：2010-08-31
申请号：US10563257
申请日：2004-07-01
申请人： Christian Neumann
发明人： Christian Neumann
IPC分类号： B01F15/02
CPC分类号： B65D77/06 , B01F5/10 , B65D77/26 , B65D90/046
摘要： A closed single-use system for mixing, storing and homogenizing liquids, comprising an assembly constituted by a rigid container (1) fitted with a non-invasive pump (4), the container (1) enclosing a generally parallelepipedic single-use bag (2), the lower face and the upper face of which are connected in fixed manner by means of a mixing duct (3) which is inserted into the pump (4) and which, during operation, allows the closed-circuit circulation of the liquid in said bag (2), for example from the bottom of the bag to its top, the pump (4) being open so that the mixing duct (3) can be inserted into it and removed from it.
摘要翻译：一种用于混合，储存和均质液体的封闭的一次性系统，包括由装配有非侵入式泵（4）的刚性容器（1）构成的组件，所述容器（1）包围大致平行六面体的一次性使用袋 2），其下表面和上表面通过插入泵（4）的混合管道（3）以固定方式连接，并且在操作期间允许液体的闭路循环在所述袋（2）中，例如从袋的底部到其顶部，泵（4）打开，使得混合管道（3）可以插入其中并从其中移除。

8. 发明专利

FR2946032B1 CONTENEUR RIGIDE POUR POCHE SOUPLE 3D DESTINEE A CONTENIR UN FLUIDE BIOPHARMACEUTIQUE ; POCHE 3D DESTINEE A UN TEL CONTENEUR ; PROCEDE DE MISE EN OEUVRE. 未知
公开(公告)号：FR2946032B1
公开(公告)日：2015-02-20
申请号：FR0953513
申请日：2009-05-27
申请人： SARTORIUS STEDIM BIOTECH SA
发明人： BAUD STEPHANE , GUILLOT BASTIEN
IPC分类号： B65D90/04

9. 发明专利

FR2939346B1 PINCEMENT DE FERMETURE D'UN TUBE SOUPLE DESTINE A DES APPLICATIONS BIOPHARMACEUTIQUES 未知
公开(公告)号：FR2939346B1
公开(公告)日：2014-09-12
申请号：FR0806952
申请日：2008-12-10
申请人： SARTORIUS STEDIM BIOTECH SA
发明人： GAY ISABELLE , BATES MIKE , BASSETTS RAY , BIDDELL CHRIS
IPC分类号： B25B7/00 , A61M39/00 , B26D3/16

10. 发明专利

FR2978131B1 PERFECTIONNEMENT AU RACCORDEMENT D'UN ACCESSOIRE A UN RECIPIENT. 未知
公开(公告)号：FR2978131B1
公开(公告)日：2013-09-13
申请号：FR1156540
申请日：2011-07-19
申请人： SARTORIUS STEDIM BIOTECH SA
发明人： BERNARD FREDERIC , CHAUSSIN SEBASTIEN , GIBELIN JEREMY
IPC分类号： B65D90/48 , A61J1/14 , A61M39/18 , C12M1/00

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