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    • 10. 发明申请
    • HUMAN PROTEINS HAVING TRANSMEMBRANE DOMAINS AND cDNAs ENCODING THESE PROTEINS
    • 具有跨膜结构域的人蛋白质和编码这些蛋白质的cDNA
    • WO9918202A3
    • 1999-08-05
    • PCT/JP9804474
    • 1998-10-05
    • SAGAMI CHEM RESPROTEGENE INCKATO SEISHISEKINE SHINGO
    • KATO SEISHISEKINE SHINGO
    • C07K14/705C12N15/12C12N5/10
    • C07K14/705
    • The invention provides human proteins having transmembrane domains and cDNAs coding for these proteins as well as eucaryotic cells expressing said cDNAs. All of the proteins exist in the cell membrane, so that they are considered to be proteins controlling the proliferation and the differentiation of the cells. Accordingly, the proteins can be employed as pharmaceuticals such as carcinostatic agents relating to the control of the proliferation and the differentiation of the cells or as antigens for preparing antibodies against said proteins. The cDNAs can be utilized as probes for the gene diagnosis and gene sources for the gene therapy. Furthermore, the cDNAs can be utilized for large-scale expression of said proteins. Cells, wherein these membrane protein genes are introduced and membrane proteins are expressed in large amounts, can be utilized for detection of the corresponding ligands, screening of novel low-molecular pharmaceuticals, and so on.
    • 本发明提供了具有跨膜结构域的人蛋白质和编码这些蛋白质的cDNA以及表达所述cDNA的真核细胞。 所有的蛋白质都存在于细胞膜中,因此它们被认为是控制细胞增殖和分化的蛋白质。 因此,蛋白质可以作为药物使用,例如涉及控制细胞增殖和分化的抗癌剂或作为抗所述蛋白质的抗体的抗原。 这些cDNA可以用作基因诊断的探针和用于基因治疗的基因来源。 此外,该cDNA可以用于所述蛋白质的大规模表达。 其中引入这些膜蛋白基因并且大量表达膜蛋白的细胞可用于检测相应的配体,筛选新的低分子药物等。