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1. 发明公开

KR20200128600A 가교결합된 양이온교환 폴리머, 조성물 및 고칼륨혈증 치료 용도 审中-公开
公开(公告)号：KR20200128600A
公开(公告)日：2020-11-13
申请号：KR20207032030
申请日：2009-08-22
申请人： RELYPSA INC
发明人： MANSKY PAUL , ALBRECHT DETLEF , BURDICK MICHAEL , CHANG HAN TING , CHARMOT DOMINIQUE , CONNOR ERIC , HALFON SHERIN , HUANG I ZU , LIU MINGJUN , CHIDAMBARAM RAMAKRISHNAN , MILLS JONATHAN , STRUEVER WERNER
IPC分类号： A61K31/7004 , A61K31/78 , C08F212/36 , C08F220/22
摘要： 본발명은플루오로그룹및 산그룹을포함하는가교결합된양이온교환폴리머, 이들폴리머의약제학적조성물, 선형폴리올의조성물및 그와같은폴리머의염에관한것이다. 입자크기, 입자형상, 입자크기분포, 점도, 항복응력, 압축성, 표면형상, 및/또는팽윤비의조합을포함하는, 유리한물리적특성을갖는가교결합된양이온교환폴리머를또한개시한다. 이들폴리머및 조성물은위장관에서칼륨을결합하는데유용하다.

2. 发明申请

WO2010132662A1 POWDER FORMULATIONS OF POTASSIUM-BINDING ACTIVE AGENTS 审中-公开
标题翻译：钾结合活性剂的粉末配方
公开(公告)号：WO2010132662A1
公开(公告)日：2010-11-18
申请号：PCT/US2010/034709
申请日：2010-05-13
申请人： RELYPSA, INC. , REDDY, Dasharatha , TYSON, George
发明人： REDDY, Dasharatha , TYSON, George
IPC分类号： A61K9/14 , A61K31/80 , A61K9/00
CPC分类号： A61K31/80 , A61K9/0095 , A61K31/7088 , A61K45/06 , A61K47/02 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61K2300/00
摘要： The present invention is directed to powder formulations of a potassium-binding active agent, a suspending agent, and a glidant; optionally, other excipients can be added to the formulations. These formulations can be in a powder form and are useful to bind potassium in the gastrointestinal tract.
摘要翻译：本发明涉及钾结合活性剂，悬浮剂和助流剂的粉末制剂; 任选地，可将其它赋形剂加入制剂中。这些制剂可以是粉末形式，并且可用于结合胃肠道中的钾。

3. 发明申请

WO2014058905A2 POTASSIUM-BINDING AGENTS FOR TREATING HYPERTENSION AND HYPERKALEMIA 审中-公开
标题翻译：用于治疗高血压和高血压的钾结合剂
公开(公告)号：WO2014058905A2
公开(公告)日：2014-04-17
申请号：PCT/US2013063921
申请日：2013-10-08
申请人： RELYPSA INC
发明人： KLAERNER GERRIT , BERMAN LANCE
IPC分类号： A61K31/78
CPC分类号： A61K31/78 , A61K9/14 , A61K31/7004 , A61K33/06 , A61K33/24 , B01J39/20
摘要： The present invention generally relates to methods of treating hypertension (HTN) in patients in need thereof wherein the patient optionally further suffers from chronic kidney disease (CKD) or Type II diabetes mellitus (T2DM). The invention also relates to methods of treating hyperkalemia in a patient in need thereof, wherein the patient suffers from CKD, T2DM or HTN and are optionally being treated with an effective amount of a renin-angiotensin-aldosterone system (RAAS) agent. The invention also relates to methods of treating kidney disease in a patient in need thereof, wherein the patient is optionally being treated with an effective amount of a renin-angiotensin-aldosterone system (RAAS) agent. The methods can comprise administering an effective amount of a potassium-binding agent to the patient to lower the patient's blood pressure and/or increase or stabilize the patient's kidney function.
摘要翻译：本发明一般涉及治疗有需要的患者的高血压（HTN）的方法，其中所述患者任选进一步患有慢性肾病（CKD）或II型糖尿病（T2DM）。本发明还涉及治疗有需要的患者的高钾血症的方法，其中所述患者患有CKD，T2DM或HTN，并任选地用有效量的肾素 - 血管紧张素 - 醛固酮系统（RAAS）剂治疗。本发明还涉及在有需要的患者中治疗肾病的方法，其中任选地用有效量的肾素 - 血管紧张素 - 醛固酮系统（RAAS）药剂治疗患者。该方法可以包括向患者施用有效量的钾结合剂以降低患者的血压和/或增加或稳定患者的肾功能。

4. 发明申请

WO2013003463A1 PROCESS FOR CONVERTING A POLYMERIC ESTER TO A POLYMERIC ACID 审中-公开
标题翻译：将聚合酯转化为聚合酸的方法
公开(公告)号：WO2013003463A1
公开(公告)日：2013-01-03
申请号：PCT/US2012/044404
申请日：2012-06-27
申请人： RELYPSA, INC. , CONNOR, Eric , SALAYMEH, Faleh
发明人： CONNOR, Eric , SALAYMEH, Faleh
IPC分类号： C08F8/12
CPC分类号： C08F8/12 , C08F20/12 , C08F22/10 , C08F120/22 , C08F220/22
摘要： The present invention generally relates to processes for converting an ester group to an acid group for polymers having a pendant ester of an acid group. This process is generally performed using an aqueous strong base.
摘要翻译：本发明一般涉及将具有酸基侧基的聚合物的酯基转化成酸基的方法。该方法通常使用水性强碱进行。

5. 发明申请

WO2014058905A3 POTASSIUM-BINDING AGENTS FOR TREATING HYPERTENSION AND HYPERKALEMIA 审中-公开
公开(公告)号：WO2014058905A3
公开(公告)日：2014-04-17
申请号：PCT/US2013/063921
申请日：2013-10-08
申请人： RELYPSA, INC.
发明人： KLAERNER, Gerrit , BERMAN, Lance
IPC分类号： A61K31/78 , A61K31/7004 , A61K33/06 , A61P9/12 , A61P13/12
摘要： The present invention generally relates to methods of treating hypertension (HTN) in patients in need thereof wherein the patient optionally further suffers from chronic kidney disease (CKD) or Type II diabetes mellitus (T2DM). The invention also relates to methods of treating hyperkalemia in a patient in need thereof, wherein the patient suffers from CKD, T2DM or HTN and are optionally being treated with an effective amount of a renin-angiotensin-aldosterone system (RAAS) agent. The invention also relates to methods of treating kidney disease in a patient in need thereof, wherein the patient is optionally being treated with an effective amount of a renin-angiotensin-aldosterone system (RAAS) agent. The methods can comprise administering an effective amount of a potassium-binding agent to the patient to lower the patient's blood pressure and/or increase or stabilize the patient's kidney function.

6. 发明申请

WO2011106542A2 CROSSLINKED POLYVRNYLAMINE, POLY ALL YLAMINE, AND POLYETHYLENEIMINE FOR USE AS BILE ACID SEQUESTRANTS 审中-公开
标题翻译：交联聚乙烯胺，聚烯丙基胺和聚乙烯亚胺用作胆汁酸分子
公开(公告)号：WO2011106542A2
公开(公告)日：2011-09-01
申请号：PCT/US2011026099
申请日：2011-02-24
申请人： RELYPSA INC , KOPPING JORDON , BIYANI KALPESH , CONNOR ERIC , HECKER SCOTT , LEES INEZ , QUAKER GRACE , SALAYMEH FALEH , ZHANG HONGMIN , BERGBREITER DAVID , MANSKY PAUL , MU YONGQI , COPE MICHAEL JAMES , GOKA ELIZABETH , LEE ANGELA , MADSEN DEIDRE , SHAO JUN
发明人： KOPPING JORDON , BIYANI KALPESH , CONNOR ERIC , HECKER SCOTT , LEES INEZ , QUAKER GRACE , SALAYMEH FALEH , ZHANG HONGMIN , BERGBREITER DAVID , MANSKY PAUL , MU YONGQI , COPE MICHAEL JAMES , GOKA ELIZABETH , LEE ANGELA , MADSEN DEIDRE , SHAO JUN
IPC分类号： C08F20/52
CPC分类号： A61K31/785 , A61K45/06 , C08F20/52 , C08F22/385 , C08F222/385 , C08F226/02 , C08F232/08
摘要： The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.
摘要翻译：本发明提供了有效用于从胃肠道结合和除去胆汁盐的交联胺和酰胺聚合物。这些胆汁酸结合聚合物或其药物组合物可以施用于受试者以治疗各种病症，包括高胆固醇血症，糖尿病，瘙痒症，肠易激综合征 - 腹泻（IBS-D），胆汁酸吸收不良等。

7. 发明申请

WO2010022383A2 CROSSLINKED CATION EXCHANGE POLYMERS, COMPOSITIONS AND USE IN TREATING HYPERKALEMIA 审中-公开
标题翻译：交联剂交联聚合物，组合物和用于治疗高血压
公开(公告)号：WO2010022383A2
公开(公告)日：2010-02-25
申请号：PCT/US2009054706
申请日：2009-08-22
申请人： RELYPSA INC , MANSKY PAUL , ALBRECHT DETLEF , BURDICK MICHAEL , CHANG HAN-TING , CHARMOT DOMINIQUE , CONNOR ERIC , HALFON SHERIN , HUANG I-ZU , LIU MINGJUN , CHIDAMBARAM RAMAKRISHNAN , MILLS JONATHAN , STRUEVER WERNER
发明人： MANSKY PAUL , ALBRECHT DETLEF , BURDICK MICHAEL , CHANG HAN-TING , CHARMOT DOMINIQUE , CONNOR ERIC , HALFON SHERIN , HUANG I-ZU , LIU MINGJUN , CHIDAMBARAM RAMAKRISHNAN , MILLS JONATHAN , STRUEVER WERNER
IPC分类号： C08F4/68
CPC分类号： A61K31/78 , A61K9/14 , A61K31/7004 , A61K47/26 , B01J39/20 , C08F212/36 , C08F220/22
摘要： The present invention is directed to crosslinked cation exchange polymers comprising a fluoro group and an acid group, pharmaceutical compositions of these polymers, compositions of a linear polyol and a salt of such polymer. Crosslinked cation exchange polymers having beneficial physical properties, including combinations of particle size, particle shape, particle size distribution, viscosity, yield stress, compressibility, surface morphology, and/or swelling ratio are also described. These polymers and compositions are useful to bind potassium in the gastrointestinal tract.
摘要翻译：本发明涉及包含氟基团和酸基团的交联阳离子交换聚合物，这些聚合物的药物组合物，线型多元醇的组合物和这种聚合物的盐。还描述了具有有益物理性质的交联阳离子交换聚合物，包括粒度，颗粒形状，粒度分布，粘度，屈服应力，压缩性，表面形态和/或溶胀比的组合。这些聚合物和组合物可用于结合胃肠道中的钾。

8. 发明申请

WO2010022381A1 TREATING HYPERKALEMIA WITH CROSSLINKED CATION EXCHANGE POLYMERS OF IMPROVED PHYSICAL PROPERTIES 审中-公开
标题翻译：用改进的物理特性的交联剂交换聚合物处理高分子量
公开(公告)号：WO2010022381A1
公开(公告)日：2010-02-25
申请号：PCT/US2009/054704
申请日：2009-08-22
申请人： RELYPSA, INC. , ALBRECHT, Detlef , MANSKY, Paul , BURDICK, Michael , CHANG, Han-Ting , CHARMOT, Dominique , CONNOR, Eric , HALFON, Sherin , HUANG, I-Zu , LIU, Mingjun , STRÜVER, Werner
发明人： ALBRECHT, Detlef , MANSKY, Paul , BURDICK, Michael , CHANG, Han-Ting , CHARMOT, Dominique , CONNOR, Eric , HALFON, Sherin , HUANG, I-Zu , LIU, Mingjun , STRÜVER, Werner
IPC分类号： A61K31/74 , A61P1/00
CPC分类号： A61K31/78 , A61K31/74
摘要： The present invention is directed to methods of removing potassium or treating hyperkalemia by administering pharmaceutical compositions of crosslinked cation exchange polymers having beneficial physical properties, including combinations of particle size, particle shape, particle size distribution, viscosity, yield stress, compressibility, surface morphology, and/or swelling ratio.
摘要翻译：本发明涉及通过施用具有有益物理性质的交联阳离子交换聚合物的药物组合物来除去钾或治疗高钾血症的方法，包括粒度，颗粒形状，粒度分布，粘度，屈服应力，压缩性，表面形态，和/或溶胀比。

9. 发明申请

WO2013003495A3 FLUORINATION OF ACRYLATE ESTERS AND DERIVATIVES 审中-公开
公开(公告)号：WO2013003495A3
公开(公告)日：2013-01-03
申请号：PCT/US2012/044455
申请日：2012-06-27
申请人： RELYPSA, INC. , MU, YongQi
发明人： MU, YongQi
IPC分类号： C07C67/307 , C07C51/363 , C07B39/00 , C07C53/21 , C07C53/50 , C07C69/63
摘要： The present invention generally relates to processes for converting acrylate esters or a derivative thereof to difluoropropionic acid or a derivative thereof. This process is generally performed using fluorine gas in a hydrofluorocarbon solvent.

10. 发明申请

WO2013003495A2 FLUORINATION OF ACRYLATE ESTERS AND DERIVATIVES 审中-公开
标题翻译：丙烯酸酯和衍生物的氟化
公开(公告)号：WO2013003495A2
公开(公告)日：2013-01-03
申请号：PCT/US2012044455
申请日：2012-06-27
申请人： RELYPSA INC , MU YONGQI
发明人： MU YONGQI
IPC分类号： C07C67/307
CPC分类号： C07C51/36 , C07C51/363 , C07C51/50 , C07C51/62 , C07C51/64 , C07C67/03 , C07C67/22 , C07C67/307 , C07C67/62 , C07C253/30 , C07C253/32 , C07C69/63 , C07C53/21 , C07C53/50 , C07C255/03
摘要： The present invention generally relates to processes for converting acrylate esters or a derivative thereof to difluoropropionic acid or a derivative thereof. This process is generally performed using fluorine gas in a hydrofluorocarbon solvent.
摘要翻译：本发明一般涉及将丙烯酸酯或其衍生物转化为二氟丙酸或其衍生物的方法。该处理通常在氢氟烃溶剂中使用氟气来进行。

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