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1. 发明申请

WO2022223994A1 METHODS AND APPARATUS FOR CALCULATING AND MAINTAINING AN OPTIMAL SAMPLE POSITION IN AN INTERFEROMETRIC MICROSCOPE 审中-公开
公开(公告)号：WO2022223994A1
公开(公告)日：2022-10-27
申请号：PCT/GB2022/051035
申请日：2022-04-22
申请人： REFEYN LTD
发明人： YOUNG, Gavin , COLE, Daniel
IPC分类号： G02B21/14 , G02B21/24 , G02B21/36
摘要： There is provided a method of calculating a temperature corrected sample position in an interferometric microscope, the method comprising projecting an autofocus beam onto the sample location to form a reflected ring of radiation, detecting an uncalibrated radius, R, of a peak of the annulus of the reflected ring which indicates an uncalibrated sample position, detecting one or more of the width of the annulus or an intensity of the annulus and calculating a calibrated radius Rnorm using at least one of the width of the annulus or the intensity of the annulus to determine the temperature dependent corrected sample position.

2. 发明申请

WO2022058759A1 DETECTION OF BIOMARKERS 审中-公开
公开(公告)号：WO2022058759A1
公开(公告)日：2022-03-24
申请号：PCT/GB2021/052451
申请日：2021-09-21
申请人： REFEYN LTD
发明人： FERREIRA, Ana Sofia De Jesus , LANGHORST, Matthias Karl Franz
IPC分类号： G01N33/543 , B82Y20/00
摘要： A method and kit is described for the detection of a biomarker in a sample, by light scattering microscopy. The invention is particularly useful for the detection of low abundance biomarker in complex samples, and is suitable for use in a point of care setting. In an embodiment, the method of the invention describes detection of a biomarker in a sample using mass photometry.

3. 发明申请

WO2023012473A1 INTERFEROMETRIC SCATTERING MICROSCOPY 审中-公开
公开(公告)号：WO2023012473A1
公开(公告)日：2023-02-09
申请号：PCT/GB2022/052036
申请日：2022-08-02
申请人： REFEYN LTD
发明人： LANGHORST, Matthias Karl Franz , COLE, Daniel Richard , GRAHAM, David John Lehar
IPC分类号： G01N15/14 , B08B7/00 , C23C4/00 , G01N33/53 , G11B7/1387 , G01N15/10 , G01N1/10
摘要： A method for measuring a property of an object, the method comprising: dipping a solid immersion lens into a solution comprising the object, such that the object interacts with the surface of the solid immersion lens; illuminating the surface of the solid immersion lens with an illumination source and detecting the scattered light from the object using an interferometric scattering microscope; measuring a property of the object using the detected scattered light; withdrawing the solid immersion lens from the solution; and subsequently cleaning the solid immersion lens such that the object is removed from the surface of the solid immersion lens.

4. 发明申请

WO2023285842A1 METHOD OF DETERMINING THE IDENTITY OF A BIOMOLECULE 审中-公开
公开(公告)号：WO2023285842A1
公开(公告)日：2023-01-19
申请号：PCT/GB2022/051853
申请日：2022-07-18
申请人： REFEYN LTD
发明人： LANGHORST, Matthias , BISHOP, Joshua
IPC分类号： G01N15/02 , G01N15/14 , G01N33/557 , G03H1/00 , G01N15/00 , G01N15/10
摘要： The present invention relates to an improved method for determining the identity of a biomolecule using interferometric light scattering apparatus, notably distinguishing between variants of biomolecules, such as viral serotypes and the like. Such a method has potential to simplify the testing for biological manufacture and for diagnosing disease, monitoring environmental issues and determination of contaminants.

5. 发明申请

WO2021186154A1 METHODS AND APPARATUS FOR OPTIMISED INTERFEROMETRIC SCATTERING MICROSCOPY 审中-公开
公开(公告)号：WO2021186154A1
公开(公告)日：2021-09-23
申请号：PCT/GB2021/050639
申请日：2021-03-15
申请人： REFEYN LTD
发明人： KANE, Josiah , HANTKE, Max Felix , CARNEY, Lewis
IPC分类号： G02B21/14 , G01N15/14 , G02B21/36
摘要： A method of imaging a sample by interferometric scattering microscopy, the method comprising illuminating a sample with at least one light source, the sample being held at a sample location comprising a reflective surface, such that a reflected signal is formed; the reflected signal comprising light from the light source and light scattered by the sample; detecting the output light over a first time window for a first frame N1; detecting the output light over a second time window for a second frame N2; calculating a ratiometric signal R which is the ratio of N1 and N2 minus 1; estimating the ratiometric motion signature S = (Sx, Sy) from frames N1 and N2 with S defined as the ratiometric image which would be measured from an invariant sample moving along x and y for a given motion vector m = (mx, my); estimating m as the most consistent vector such that R is approximated using S and m; calculating the corrected ratiometric contrast image R* from R, S and m.

6. 发明申请

WO2021069921A1 METHODS AND APPARATUS FOR OPTIMISED INTERFEROMETRIC SCATTERING MICROSCOPY 审中-公开
公开(公告)号：WO2021069921A1
公开(公告)日：2021-04-15
申请号：PCT/GB2020/052522
申请日：2020-10-09
申请人： REFEYN LTD , OXFORD UNIVERSITY INNOVATION LIMITED
发明人： LANGHORST, Matthias Karl Franz , COLE, Daniel Richard , GRAHAM, David John Lehar
IPC分类号： G02B21/14 , G02B21/18 , G01B9/00 , G01N21/00 , G02B21/36 , G02B21/00
摘要： The application discloses a method and apparatus for imaging a sample by interferometric scattering microscopy, the method comprising illuminating a sample with at least one coherent light source, the sample being held at a sample location comprising an interface having a refractive index change, illuminating the sample with illuminating radiation to generate a backpropagating signal from the sample comprising light reflected at the interface and light scattered by the sample, splitting the backpropagating signal into first and second signals, modifying the second signal using a modifying element such that the second signal differs from the first signal, directing the first and second signals onto first and second detectors to generate, respectively, first and second images and comparing, by a processor, the first and second images to determine one or more characteristics of the sample.

7. 发明专利

GB2593194A Methods and apparatus for optimised interferometric scattering microscopy 未知
公开(公告)号：GB2593194A
公开(公告)日：2021-09-22
申请号：GB202003946
申请日：2020-03-18
申请人： REFEYN LTD
发明人： JOSIAH KANE , MAX FELIX HANTKE , LEWIS CAMEY
IPC分类号： G02B21/00 , G02B21/14
摘要： A method of imaging a sample by interferometric scattering microscopy (IScat), the method comprising illuminating a sample with at least one light source, the sample being held at a sample location comprising a reflective surface, such that a reflected signal is formed; the reflected signal comprising light from the light source and light scattered by the sample; detecting the output light over a first time window for a first frame N1; detecting the output light over a second time window for a second frame N2; calculating a ratiometric signal R which is the ratio of N1 and N2 minus 1; estimating the ratiometric motion signature S = (Sx, Sy) from frames N1 and N2 with S defined as the ratiometric image which would be measured from an invariant sample moving along x and y for a given motion vector m = (mx, my); estimating m as the most consistent vector such that R is approximated using S and m;calculating the corrected ratiometric contrast image R* from R, S and m. An interferometric scattering microscope configured to carry out the method comprises a spatial filter positioned to filter the output light. Figure shows image where motion correction has been applied

8. 发明专利

DE202022104890U1 Verbesserungen an oder in Bezug auf Aufbewahrungsbehälter 未知
公开(公告)号：DE202022104890U1
公开(公告)日：2022-11-14
申请号：DE202022104890
申请日：2022-08-30
申请人： REFEYN LTD
IPC分类号： B65D85/30
摘要： Aufbewahrungsbehälter für ein Deckglas, wobei das Deckglas eine obere und eine untere Fläche hat, die durch einen Rand verbunden sind, und der Aufbewahrungsbehälter Folgendes aufweist:einen Halter mit einer Öffnung, die eine obere Öffnung und eine seitliche Öffnung aufweist, wobei die obere Öffnung so konfiguriert ist, dass sie das Deckglas aufnimmt und Zugang zu dessen oberer Fläche bietet, und wobei die seitliche Öffnung so konfiguriert ist, dass sie Zugang zu einem Bereich des Randes des Deckglases innerhalb des Halters bietet;einen abnehmbaren Abstandshalter mit einem inneren und einem äußeren Bereich, die über einen Schaft verbunden sind, wobei der Schaft so bemessen ist, dass er von der seitlichen Öffnung aufgenommen wird, so dass der innere Bereich des Abstandshalters innerhalb des Halters und der äußere Bereich des Abstandshalters außerhalb des Halters angeordnet ist; undeinen Deckel, der so konfiguriert ist, dass er die obere Öffnung des Halters zeitweise abdeckt.

9. 发明专利

GB202105758D0 Methods and apparatus for calculating and maintaining the optimal sample position in focus an interferometric microscope 未知
公开(公告)号：GB202105758D0
公开(公告)日：2021-06-09
申请号：GB202105758
申请日：2021-04-22
申请人： REFEYN LTD

10. 发明专利

GB202111102D0 Interferometric scattering microscopy 未知
公开(公告)号：GB202111102D0
公开(公告)日：2021-09-15
申请号：GB202111102
申请日：2021-08-02
申请人： REFEYN LTD

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